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Protein

Apoptosis regulatory protein Siva

Gene

Siva1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis (By similarity).By similarity1 Publication

Cofactori

Zn2+By similarityNote: Isoform 1 binds 3 zinc ions. Isoform 2 binds 2 zinc ions.By similarity

GO - Molecular functioni

  • CD27 receptor binding Source: HGNC
  • metal ion binding Source: UniProtKB-KW
  • tumor necrosis factor receptor binding Source: HGNC
  • virus receptor activity Source: HGNC

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis regulatory protein Siva
Alternative name(s):
CD27-binding protein
Short name:
CD27BP
Gene namesi
Name:Siva1
Synonyms:Siva
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1353606. Siva1.

Subcellular locationi

  • Cytoplasm
  • Nucleus By similarity

  • Note: In the nucleus, accumulates in dot-like structures.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977751 – 175Apoptosis regulatory protein SivaAdd BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34Phosphotyrosine; by ABL2By similarity1
Modified residuei70PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by ABL2/ARG in response to oxidative stress.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO54926.
MaxQBiO54926.
PaxDbiO54926.
PeptideAtlasiO54926.
PRIDEiO54926.

PTM databases

PhosphoSitePlusiO54926.

Expressioni

Tissue specificityi

Highly expressed in testis, heart, liver, lung, and muscle, and less in kidney, spleen and brain.

Inductioni

By p53, camptothecin, stroke injury and infection with coxsackievirus B3. This up-regulation is sufficient to induce apoptosis in neural tissue.2 Publications

Gene expression databases

BgeeiENSMUSG00000064326.
CleanExiMM_SIVA1.
GenevisibleiO54926. MM.

Interactioni

Subunit structurei

Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX.1 Publication

GO - Molecular functioni

  • CD27 receptor binding Source: HGNC
  • tumor necrosis factor receptor binding Source: HGNC

Protein-protein interaction databases

BioGridi206030. 1 interactor.
IntActiO54926. 1 interactor.
STRINGi10090.ENSMUSP00000021728.

Structurei

3D structure databases

ProteinModelPortaliO54926.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 55Interaction with BCL2L1 isoform Bcl-x(L) and inhibition of BCL2L1 anti-apoptotic activityBy similarityAdd BLAST20

Phylogenomic databases

eggNOGiENOG410IZ95. Eukaryota.
ENOG4112463. LUCA.
GeneTreeiENSGT00390000004842.
HOGENOMiHOG000253914.
HOVERGENiHBG044526.
InParanoidiO54926.
OMAiRALCGQC.
OrthoDBiEOG091G163Z.
PhylomeDBiO54926.
TreeFamiTF332962.

Family and domain databases

InterProiIPR022773. Siva_cd27-bd.
[Graphical view]
PANTHERiPTHR14365. PTHR14365. 1 hit.
PfamiPF05458. Siva. 1 hit.
[Graphical view]
PIRSFiPIRSF038096. Siva_cd27_bd. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O54926-1) [UniParc]FASTAAdd to basket
Also known as: Siva-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKRSCPFAD AAPLQLKVHV GLKELSHGVF AERYSREVFE RTKQLLFQGA
60 70 80 90 100
RAYRDHISSE DCSVNHLQES LKSGVVGAPQ PARGQMLIGP DGRLTRCQAQ
110 120 130 140 150
ASEGGLPRTA PIACSSCMRS VDGKAVCSQC ERALCGQCVY TCWGCGALAC
160 170
VLCGLADYAD DGEKTLCTSC AMFEA
Length:175
Mass (Da):18,770
Last modified:June 1, 1998 - v1
Checksum:i1E132C1580ABE3F2
GO
Isoform 2 (identifier: O54926-2) [UniParc]FASTAAdd to basket
Also known as: Siva-2

The sequence of this isoform differs from the canonical sequence as follows:
     40-104: Missing.

Note: Mouse isoform 2 has been shown to have no pro-apoptotic activity.1 Publication
Show »
Length:110
Mass (Da):11,737
Checksum:iD1B83DA9596503F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 15MPKRS…AAPLQ → MAKGRWRLAEAGAVE in BAB27029 (PubMed:16141072).CuratedAdd BLAST15
Sequence conflicti126V → A in AAH12279 (PubMed:15489334).Curated1
Sequence conflicti142C → S in AAD50060 (PubMed:10597319).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00752640 – 104Missing in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033115 Genomic DNA. Translation: AAC04706.1.
AF033113 mRNA. Translation: AAD50059.1.
AF033112 mRNA. Translation: AAD50058.1.
AF033114 mRNA. Translation: AAD50060.1.
AK010562 mRNA. Translation: BAB27029.1.
AK017570 mRNA. Translation: BAB30811.1.
AK153115 mRNA. Translation: BAE31732.1.
BC012279 mRNA. Translation: AAH12279.1.
CCDSiCCDS26193.1. [O54926-1]
CCDS49189.1. [O54926-2]
RefSeqiNP_001155209.1. NM_001161737.1. [O54926-2]
NP_038957.2. NM_013929.2. [O54926-1]
UniGeneiMm.289812.

Genome annotation databases

EnsembliENSMUST00000021728; ENSMUSP00000021728; ENSMUSG00000064326. [O54926-1]
ENSMUST00000109755; ENSMUSP00000105377; ENSMUSG00000064326. [O54926-2]
GeneIDi30954.
KEGGimmu:30954.
UCSCiuc007pev.2. mouse. [O54926-1]
uc007pew.2. mouse. [O54926-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033115 Genomic DNA. Translation: AAC04706.1.
AF033113 mRNA. Translation: AAD50059.1.
AF033112 mRNA. Translation: AAD50058.1.
AF033114 mRNA. Translation: AAD50060.1.
AK010562 mRNA. Translation: BAB27029.1.
AK017570 mRNA. Translation: BAB30811.1.
AK153115 mRNA. Translation: BAE31732.1.
BC012279 mRNA. Translation: AAH12279.1.
CCDSiCCDS26193.1. [O54926-1]
CCDS49189.1. [O54926-2]
RefSeqiNP_001155209.1. NM_001161737.1. [O54926-2]
NP_038957.2. NM_013929.2. [O54926-1]
UniGeneiMm.289812.

3D structure databases

ProteinModelPortaliO54926.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206030. 1 interactor.
IntActiO54926. 1 interactor.
STRINGi10090.ENSMUSP00000021728.

PTM databases

PhosphoSitePlusiO54926.

Proteomic databases

EPDiO54926.
MaxQBiO54926.
PaxDbiO54926.
PeptideAtlasiO54926.
PRIDEiO54926.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021728; ENSMUSP00000021728; ENSMUSG00000064326. [O54926-1]
ENSMUST00000109755; ENSMUSP00000105377; ENSMUSG00000064326. [O54926-2]
GeneIDi30954.
KEGGimmu:30954.
UCSCiuc007pev.2. mouse. [O54926-1]
uc007pew.2. mouse. [O54926-2]

Organism-specific databases

CTDi10572.
MGIiMGI:1353606. Siva1.

Phylogenomic databases

eggNOGiENOG410IZ95. Eukaryota.
ENOG4112463. LUCA.
GeneTreeiENSGT00390000004842.
HOGENOMiHOG000253914.
HOVERGENiHBG044526.
InParanoidiO54926.
OMAiRALCGQC.
OrthoDBiEOG091G163Z.
PhylomeDBiO54926.
TreeFamiTF332962.

Miscellaneous databases

PROiO54926.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064326.
CleanExiMM_SIVA1.
GenevisibleiO54926. MM.

Family and domain databases

InterProiIPR022773. Siva_cd27-bd.
[Graphical view]
PANTHERiPTHR14365. PTHR14365. 1 hit.
PfamiPF05458. Siva. 1 hit.
[Graphical view]
PIRSFiPIRSF038096. Siva_cd27_bd. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSIVA_MOUSE
AccessioniPrimary (citable) accession number: O54926
Secondary accession number(s): Q3U6J2
, Q921I8, Q9CWL1, Q9R1Q0, Q9R1Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.