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Protein

Exocyst complex component 7

Gene

Exoc7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).By similarity

GO - Biological processi

  • exocytosis Source: RGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-264876. Insulin processing.
R-RNO-5620916. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 7
Alternative name(s):
Exocyst complex component Exo70
Short name:
rExo70
Gene namesi
Name:Exoc7
Synonyms:Exo70
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620236. Exoc7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 653653Exocyst complex component 7PRO_0000118962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei133 – 1331PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO54922.
PRIDEiO54922.

PTM databases

iPTMnetiO54922.

Expressioni

Gene expression databases

GenevisibleiO54922. RN.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249170. 2 interactions.
IntActiO54922. 1 interaction.
STRINGi10116.ENSRNOP00000059717.

Structurei

3D structure databases

ProteinModelPortaliO54922.
SMRiO54922. Positions 85-652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 384384SEC8 and ARHQ bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5 – 4238Sequence analysisAdd
BLAST
Coiled coili63 – 8523Sequence analysisAdd
BLAST

Domaini

The C-terminus is required for translocation to the plasma membrane.By similarity

Sequence similaritiesi

Belongs to the EXO70 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2344. Eukaryota.
ENOG410YIGI. LUCA.
GeneTreeiENSGT00390000003595.
HOGENOMiHOG000231194.
HOVERGENiHBG051515.
InParanoidiO54922.
KOiK07195.
OMAiWGHEALR.
OrthoDBiEOG7S4X64.
PhylomeDBiO54922.

Family and domain databases

InterProiIPR016159. Cullin_repeat-like_dom.
IPR004140. Exo70.
[Graphical view]
PANTHERiPTHR12542. PTHR12542. 2 hits.
PfamiPF03081. Exo70. 1 hit.
[Graphical view]
SUPFAMiSSF74788. SSF74788. 2 hits.

Sequencei

Sequence statusi: Complete.

O54922-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE
60 70 80 90 100
SRLMKLENSI IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI
110 120 130 140 150
IREGPTGRLE EYLGSMAKIQ KAVEYFQDNS PDSPELNKVK LLFERGKESL
160 170 180 190 200
ESEFRSLMTR HSKVISPVLV LDLISADDEL EVQEDVVLEH LPESVLQDVI
210 220 230 240 250
RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFRK SSSSSGVPYS
260 270 280 290 300
PAIPNKRKDT PTKKPIKRPG RDDMLDVETD AYIHCVSAFV RLAQSEYQLL
310 320 330 340 350
MGIIPEHHQK KTFDSLIQDA LDGLMLEGEN IVSAARKAII RHDFSTVLTV
360 370 380 390 400
FPILRHLKQT KPEFDQVLQG TAASTKNKLP GLITSMETIG AKALEDFADN
410 420 430 440 450
IKNDPDKEYN MPKDGTVHEL TSNAILFLQQ LLDFQETAGA MLASQETSSS
460 470 480 490 500
ATSYNSEFSK RLLSTYICKV LGNLQLNLLS KSKVYEDPAL SAIFLHNNYN
510 520 530 540 550
YILKSLEKSE LIQLVAVTQK TAERSYREHI EQQIQTYQRS WLKVTDYIAE
560 570 580 590 600
KNLPVFQPGV KLRDKERQMI KERFKGFNDG LEELCKIQKA WAIPDTEQRD
610 620 630 640 650
KIRQAQKSIV KETYGAFLHR YSSVPFTKNP EKYIKYRVEQ VGDMIDRLFD

TSA
Length:653
Mass (Da):75,046
Last modified:June 1, 1998 - v1
Checksum:iDA206444F767E794
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032667 mRNA. Translation: AAC01579.1.
RefSeqiNP_073182.1. NM_022691.1.
XP_006220984.1. XM_006220922.2.
XP_008766651.1. XM_008768429.1.
UniGeneiRn.45761.

Genome annotation databases

EnsembliENSRNOT00000013281; ENSRNOP00000013281; ENSRNOG00000009617.
ENSRNOT00000068050; ENSRNOP00000059717; ENSRNOG00000046594.
GeneIDi100911734.
64632.
KEGGirno:100911734.
rno:64632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032667 mRNA. Translation: AAC01579.1.
RefSeqiNP_073182.1. NM_022691.1.
XP_006220984.1. XM_006220922.2.
XP_008766651.1. XM_008768429.1.
UniGeneiRn.45761.

3D structure databases

ProteinModelPortaliO54922.
SMRiO54922. Positions 85-652.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249170. 2 interactions.
IntActiO54922. 1 interaction.
STRINGi10116.ENSRNOP00000059717.

PTM databases

iPTMnetiO54922.

Proteomic databases

PaxDbiO54922.
PRIDEiO54922.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013281; ENSRNOP00000013281; ENSRNOG00000009617.
ENSRNOT00000068050; ENSRNOP00000059717; ENSRNOG00000046594.
GeneIDi100911734.
64632.
KEGGirno:100911734.
rno:64632.

Organism-specific databases

CTDi23265.
RGDi620236. Exoc7.

Phylogenomic databases

eggNOGiKOG2344. Eukaryota.
ENOG410YIGI. LUCA.
GeneTreeiENSGT00390000003595.
HOGENOMiHOG000231194.
HOVERGENiHBG051515.
InParanoidiO54922.
KOiK07195.
OMAiWGHEALR.
OrthoDBiEOG7S4X64.
PhylomeDBiO54922.

Enzyme and pathway databases

ReactomeiR-RNO-264876. Insulin processing.
R-RNO-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

PROiO54922.

Gene expression databases

GenevisibleiO54922. RN.

Family and domain databases

InterProiIPR016159. Cullin_repeat-like_dom.
IPR004140. Exo70.
[Graphical view]
PANTHERiPTHR12542. PTHR12542. 2 hits.
PfamiPF03081. Exo70. 1 hit.
[Graphical view]
SUPFAMiSSF74788. SSF74788. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEXOC7_RAT
AccessioniPrimary (citable) accession number: O54922
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.