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O54918

- B2L11_MOUSE

UniProt

O54918 - B2L11_MOUSE

Protein

Bcl-2-like protein 11

Gene

Bcl2l11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Induces apoptosis and anoikis. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL being the least potent.1 Publication

    GO - Molecular functioni

    1. microtubule binding Source: MGI
    2. protein binding Source: IntAct

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. apoptotic process involved in embryonic digit morphogenesis Source: MGI
    3. B cell apoptotic process Source: MGI
    4. B cell homeostasis Source: MGI
    5. brain development Source: Ensembl
    6. cell-matrix adhesion Source: MGI
    7. cellular process regulating host cell cycle in response to virus Source: MGI
    8. developmental pigmentation Source: MGI
    9. ear development Source: MGI
    10. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    11. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
    12. in utero embryonic development Source: MGI
    13. kidney development Source: MGI
    14. leukocyte homeostasis Source: MGI
    15. lymphocyte homeostasis Source: MGI
    16. male gonad development Source: MGI
    17. mammary gland development Source: MGI
    18. myeloid cell homeostasis Source: MGI
    19. odontogenesis of dentin-containing tooth Source: MGI
    20. positive regulation of apoptotic process Source: MGI
    21. positive regulation of apoptotic process by virus Source: MGI
    22. positive regulation of cell cycle Source: MGI
    23. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
    24. positive regulation of fibroblast apoptotic process Source: Ensembl
    25. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
    26. positive regulation of mitochondrial membrane permeability involved in apoptotic process Source: MGI
    27. positive regulation of neuron apoptotic process Source: MGI
    28. positive regulation of protein homooligomerization Source: Ensembl
    29. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
    30. post-embryonic development Source: MGI
    31. post-embryonic organ morphogenesis Source: MGI
    32. regulation of apoptotic process Source: MGI
    33. regulation of developmental pigmentation Source: MGI
    34. regulation of organ growth Source: MGI
    35. response to endoplasmic reticulum stress Source: UniProtKB
    36. spermatogenesis Source: MGI
    37. spleen development Source: MGI
    38. T cell homeostasis Source: MGI
    39. thymocyte apoptotic process Source: MGI
    40. thymus development Source: MGI
    41. tube formation Source: MGI

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_209641. NRAGE signals death through JNK.
    REACT_223399. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bcl-2-like protein 11
    Short name:
    Bcl2-L-11
    Alternative name(s):
    Bcl2-interacting mediator of cell death
    Gene namesi
    Name:Bcl2l11
    Synonyms:Bim
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1197519. Bcl2l11.

    Subcellular locationi

    Membrane 1 Publication; Peripheral membrane protein 1 Publication. Mitochondrion By similarity
    Note: Associated with intracytoplasmic membranes.

    GO - Cellular componenti

    1. BIM-BCL-2 complex Source: Ensembl
    2. BIM-BCL-xl complex Source: Ensembl
    3. cytoplasm Source: MGI
    4. cytosol Source: Ensembl
    5. extrinsic component of membrane Source: MGI
    6. intracellular membrane-bounded organelle Source: MGI
    7. microtubule Source: Ensembl
    8. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi55 – 551S → A: Loss of TRIM2-binding; when associated with A-65 and A-73. 1 Publication
    Mutagenesisi65 – 651S → A: Loss of TRIM2-binding; when associated with A-55 and A-73. 1 Publication
    Mutagenesisi73 – 731S → A: Loss of TRIM2-binding; when associated with A-55 and A-65. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 196196Bcl-2-like protein 11PRO_0000143110Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei65 – 651Phosphoserine; by MAPK1 Publication

    Post-translational modificationi

    Phosphorylation at Ser-65 by MAPK1/MAPK3 induces interaction with TRIM2, followed by ubiquitination.1 Publication
    Ubiquitinated by TRIM2 following phosphorylation by MAPK1/MAPK3, leading to degradation by the proteasome.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiO54918.
    PRIDEiO54918.

    PTM databases

    PhosphoSiteiO54918.

    Expressioni

    Tissue specificityi

    Expressed in a number of B- and T-lymphoid cell lines.1 Publication

    Inductioni

    By ER stress.1 Publication

    Gene expression databases

    ArrayExpressiO54918.
    BgeeiO54918.
    CleanExiMM_BCL2L11.
    GenevestigatoriO54918.

    Interactioni

    Subunit structurei

    Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK or BAK. Interacts with Bax (in vitro). Identified in a complex containing BCL2L11, DYNLL1 and BCL2L1 isoform Bcl-X(L). Interacts with YWHAZ. When phosphorylated, interacts with TRIM2; this interaction is associated with ubiquitination and degradation. Interacts with MCL1; may sequester BCL2L11 to prevent its pro-apoptotic activity.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Bcl2P104172EBI-526076,EBI-526314
    GNB2L1P632442EBI-526076,EBI-296739From a different organism.
    Mcl1P972874EBI-526067,EBI-707292
    Prkar1aQ9DBC72EBI-526076,EBI-645677

    Protein-protein interaction databases

    BioGridi198352. 12 interactions.
    DIPiDIP-29214N.
    IntActiO54918. 16 interactions.
    MINTiMINT-89451.

    Structurei

    Secondary structure

    1
    196
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi142 – 16827

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PQ1X-ray1.65B139-171[»]
    DisProtiDP00518.
    ProteinModelPortaliO54918.
    SMRiO54918. Positions 139-171.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO54918.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi146 – 16015BH3Add
    BLAST

    Domaini

    The BH3 motif is required for Bcl-2 binding and cytotoxicity.

    Sequence similaritiesi

    Belongs to the Bcl-2 family.Curated

    Phylogenomic databases

    eggNOGiNOG40262.
    GeneTreeiENSGT00390000003178.
    HOGENOMiHOG000231637.
    InParanoidiO54918.
    KOiK16341.
    OMAiIRLVWRM.
    PhylomeDBiO54918.
    TreeFamiTF335898.

    Family and domain databases

    InterProiIPR014771. Apoptosis_Bim_N.
    IPR017288. Bcl-2-like_11.
    IPR015040. Bcl-x_interacting_BH3_dom.
    [Graphical view]
    PfamiPF08945. Bclx_interact. 1 hit.
    PF06773. Bim_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037827. Bcl-2-like_p11. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform BimEL (identifier: O54918-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QGNPDGEGDR    50
    CPHGSPQGPL APPASPGPFA TRSPLFIFVR RSSLLSRSSS GYFSFDTDRS 100
    PAPMSCDKST QTPSPPCQAF NHYLSAMASI RQSQEEPEDL RPEIRIAQEL 150
    RRIGDEFNET YTRRVFANDY REAEDHPQMV ILQLLRFIFR LVWRRH 196
    Length:196
    Mass (Da):22,067
    Last modified:June 1, 1998 - v1
    Checksum:i531C176E5F1AC9AA
    GO
    Isoform BimL (identifier: O54918-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         42-97: Missing.

    Show »
    Length:140
    Mass (Da):16,205
    Checksum:iB127B40A190DA923
    GO
    Isoform BimS (identifier: O54918-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         42-127: Missing.

    Show »
    Length:110
    Mass (Da):12,954
    Checksum:i67AB421AC1E4D2CA
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei42 – 12786Missing in isoform BimS. CuratedVSP_000537Add
    BLAST
    Alternative sequencei42 – 9756Missing in isoform BimL. CuratedVSP_000536Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF032459 mRNA. Translation: AAC40029.1.
    AF032460 mRNA. Translation: AAC40030.1.
    AF032461 mRNA. Translation: AAC40031.1.
    AL805950 Genomic DNA. Translation: CAM14745.1.
    BC019556 mRNA. Translation: AAH19556.1.
    CCDSiCCDS16712.1. [O54918-3]
    CCDS16713.1. [O54918-1]
    CCDS16714.1. [O54918-2]
    RefSeqiNP_033884.1. NM_009754.3. [O54918-3]
    NP_997563.1. NM_207680.2. [O54918-1]
    NP_997564.1. NM_207681.2. [O54918-2]
    UniGeneiMm.141083.
    Mm.453214.

    Genome annotation databases

    EnsembliENSMUST00000019281; ENSMUSP00000019281; ENSMUSG00000027381. [O54918-3]
    ENSMUST00000103210; ENSMUSP00000099499; ENSMUSG00000027381. [O54918-2]
    ENSMUST00000103211; ENSMUSP00000099500; ENSMUSG00000027381. [O54918-3]
    ENSMUST00000110341; ENSMUSP00000105970; ENSMUSG00000027381. [O54918-1]
    GeneIDi12125.
    KEGGimmu:12125.
    UCSCiuc008mgh.1. mouse. [O54918-1]
    uc008mgk.1. mouse. [O54918-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF032459 mRNA. Translation: AAC40029.1 .
    AF032460 mRNA. Translation: AAC40030.1 .
    AF032461 mRNA. Translation: AAC40031.1 .
    AL805950 Genomic DNA. Translation: CAM14745.1 .
    BC019556 mRNA. Translation: AAH19556.1 .
    CCDSi CCDS16712.1. [O54918-3 ]
    CCDS16713.1. [O54918-1 ]
    CCDS16714.1. [O54918-2 ]
    RefSeqi NP_033884.1. NM_009754.3. [O54918-3 ]
    NP_997563.1. NM_207680.2. [O54918-1 ]
    NP_997564.1. NM_207681.2. [O54918-2 ]
    UniGenei Mm.141083.
    Mm.453214.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PQ1 X-ray 1.65 B 139-171 [» ]
    DisProti DP00518.
    ProteinModelPortali O54918.
    SMRi O54918. Positions 139-171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198352. 12 interactions.
    DIPi DIP-29214N.
    IntActi O54918. 16 interactions.
    MINTi MINT-89451.

    PTM databases

    PhosphoSitei O54918.

    Proteomic databases

    PaxDbi O54918.
    PRIDEi O54918.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019281 ; ENSMUSP00000019281 ; ENSMUSG00000027381 . [O54918-3 ]
    ENSMUST00000103210 ; ENSMUSP00000099499 ; ENSMUSG00000027381 . [O54918-2 ]
    ENSMUST00000103211 ; ENSMUSP00000099500 ; ENSMUSG00000027381 . [O54918-3 ]
    ENSMUST00000110341 ; ENSMUSP00000105970 ; ENSMUSG00000027381 . [O54918-1 ]
    GeneIDi 12125.
    KEGGi mmu:12125.
    UCSCi uc008mgh.1. mouse. [O54918-1 ]
    uc008mgk.1. mouse. [O54918-2 ]

    Organism-specific databases

    CTDi 10018.
    MGIi MGI:1197519. Bcl2l11.

    Phylogenomic databases

    eggNOGi NOG40262.
    GeneTreei ENSGT00390000003178.
    HOGENOMi HOG000231637.
    InParanoidi O54918.
    KOi K16341.
    OMAi IRLVWRM.
    PhylomeDBi O54918.
    TreeFami TF335898.

    Enzyme and pathway databases

    Reactomei REACT_209641. NRAGE signals death through JNK.
    REACT_223399. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.

    Miscellaneous databases

    EvolutionaryTracei O54918.
    NextBioi 280451.
    PROi O54918.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O54918.
    Bgeei O54918.
    CleanExi MM_BCL2L11.
    Genevestigatori O54918.

    Family and domain databases

    InterProi IPR014771. Apoptosis_Bim_N.
    IPR017288. Bcl-2-like_11.
    IPR015040. Bcl-x_interacting_BH3_dom.
    [Graphical view ]
    Pfami PF08945. Bclx_interact. 1 hit.
    PF06773. Bim_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037827. Bcl-2-like_p11. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Bim: a novel member of the Bcl-2 family that promotes apoptosis."
      O'Connor L., Strasser A., O'Reilly L.A., Hausmann G., Adams J.M., Cory S., Huang D.C.S.
      EMBO J. 17:384-395(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BIMEL).
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1."
      Maurer U., Charvet C., Wagman A.S., Dejardin E., Green D.R.
      Mol. Cell 21:749-760(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MCL1.
    5. "Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA."
      Galehdar Z., Swan P., Fuerth B., Callaghan S.M., Park D.S., Cregan S.P.
      J. Neurosci. 30:16938-16948(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    6. "Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection."
      Thompson S., Pearson A.N., Ashley M.D., Jessick V., Murphy B.M., Gafken P., Henshall D.C., Morris K.T., Simon R.P., Meller R.
      J. Biol. Chem. 286:19331-19339(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DYNLL1; TRIM2 AND YWHAZ, UBIQUITINATION, PHOSPHORYLATION AT SER-65, MUTAGENESIS OF SER-55; SER-65 AND SER-73.
    7. "The structure of a Bcl-xL/Bim fragment complex: implications for Bim function."
      Liu X., Dai S., Zhu Y., Marrack P., Kappler J.W.
      Immunity 19:341-352(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 139-171 IN COMPLEX WITH BCL2L1 ISOFORM BCL-XL, IDENTIFICATION IN A COMPLEX WITH DYNLL1 AND BCL-XL, INTERACTION WITH BAX.

    Entry informationi

    Entry nameiB2L11_MOUSE
    AccessioniPrimary (citable) accession number: O54918
    Secondary accession number(s): A2ALQ6, O54919, O54920
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3