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Protein

Potassium channel subfamily K member 3

Gene

Kcnk3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.By similarity

Miscellaneous

Inhibited by extracellular acidification, zinc, bupivacaine and phenytoin. Activated by protein kinase A.

GO - Molecular functioni

  • growth factor activity Source: InterPro
  • open rectifier potassium channel activity Source: RGD
  • potassium ion leak channel activity Source: UniProtKB
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • S100 protein binding Source: Ensembl

GO - Biological processi

  • brain development Source: RGD
  • cellular response to hypoxia Source: RGD
  • cellular response to zinc ion Source: RGD
  • cochlea development Source: RGD
  • negative regulation of cytosolic calcium ion concentration Source: RGD
  • response to drug Source: RGD
  • stabilization of membrane potential Source: GO_Central

Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-RNO-1299316 TWIK-releated acid-sensitive K+ channel (TASK)
R-RNO-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 3
Alternative name(s):
Acid-sensitive potassium channel protein TASK-1
TWIK-related acid-sensitive K(+) channel 1
Two pore potassium channel KT3.1
Short name:
Two pore K(+) channel KT3.1
Gene namesi
Name:Kcnk3
Synonyms:Task, Task1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi61997 Kcnk3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Intramembranei78 – 101Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST24
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 158CytoplasmicSequence analysisAdd BLAST30
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Intramembranei184 – 207Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST24
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 411CytoplasmicSequence analysisAdd BLAST168

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4294
GuidetoPHARMACOLOGYi515

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017461 – 411Potassium channel subfamily K member 3Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO54912
PRIDEiO54912

PTM databases

PhosphoSitePlusiO54912

Expressioni

Tissue specificityi

Strongest expression in heart. Moderate expression in lung and brain. Low levels in liver, kidney and skeletal muscle.

Gene expression databases

BgeeiENSRNOG00000009790
ExpressionAtlasiO54912 baseline and differential
GenevisibleiO54912 RN

Interactioni

Subunit structurei

Homodimer. Heterodimer with KCNK1.By similarity

GO - Molecular functioni

  • growth factor activity Source: InterPro
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • S100 protein binding Source: Ensembl

Protein-protein interaction databases

DIPiDIP-61121N
IntActiO54912, 2 interactors
STRINGi10116.ENSRNOP00000013107

Structurei

3D structure databases

ProteinModelPortaliO54912
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404 Eukaryota
ENOG410XRZJ LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000231463
HOVERGENiHBG052239
InParanoidiO54912
KOiK04914
OMAiCSGTQRS
OrthoDBiEOG091G08DH
PhylomeDBiO54912
TreeFamiTF313947

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR022341 IGF-I
IPR013099 K_chnl_dom
IPR005406 KCNK3
PANTHERiPTHR11003:SF138 PTHR11003:SF138, 1 hit
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PIRSFiPIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333 2POREKCHANEL
PR01584 TASK1CHANNEL
PR01095 TASKCHANNEL

Sequencei

Sequence statusi: Complete.

O54912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQNVRTLA LIVCTFTYLL VGAAVFDALE SEPEMIERQR LELRQLELRA
60 70 80 90 100
RYNLSEGGYE ELERVVLRLK PHKAGVQWRF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PSTDGGKVFC MFYALLGIPL TLVMFQSLGE RINTFVRYLL HRAKRGLGMR
160 170 180 190 200
HAEVSMANMV LIGFVSCIST LCIGAAAFSY YERWTFFQAY YYCFITLTTI
210 220 230 240 250
GFGDYVALQK DQALQTQPQY VAFSFVYILT GLTVIGAFLN LVVLRFMTMN
260 270 280 290 300
AEDEKRDAEH RALLTHNGQA GGLGGLSCLS GSLGDGVRPR DPVTCAAAAG
310 320 330 340 350
GMGVGVGVGG SGFRNVYAEM LHFQSMCSCL WYKSREKLQY SIPMIIPRDL
360 370 380 390 400
STSDTCVEHS HSSPGGGGRY SDTPSHPCLC SGTQRSAISS VSTGLHSLAT
410
FRGLMKRRSS V
Length:411
Mass (Da):45,276
Last modified:June 1, 1998 - v1
Checksum:iD2778016E09E2BF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031384 mRNA Translation: AAC39952.1
RefSeqiNP_203694.1, NM_033376.1
UniGeneiRn.15536

Genome annotation databases

EnsembliENSRNOT00000013107; ENSRNOP00000013107; ENSRNOG00000009790
GeneIDi29553
KEGGirno:29553

Similar proteinsi

Entry informationi

Entry nameiKCNK3_RAT
AccessioniPrimary (citable) accession number: O54912
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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