Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Potassium channel subfamily K member 3

Gene

Kcnk3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.By similarity

GO - Molecular functioni

  • open rectifier potassium channel activity Source: RGD
  • potassium ion leak channel activity Source: UniProtKB
  • protein C-terminus binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • brain development Source: RGD
  • cellular response to hypoxia Source: RGD
  • cellular response to zinc ion Source: RGD
  • cochlea development Source: RGD
  • mitophagy in response to mitochondrial depolarization Source: Ensembl
  • negative regulation of cytosolic calcium ion concentration Source: RGD
  • response to drug Source: RGD
  • stabilization of membrane potential Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-RNO-1299316. TWIK-releated acid-sensitive K+ channel (TASK).
R-RNO-5576886. Phase 4 - resting membrane potential.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 3
Alternative name(s):
Acid-sensitive potassium channel protein TASK-1
TWIK-related acid-sensitive K(+) channel 1
Two pore potassium channel KT3.1
Short name:
Two pore K(+) channel KT3.1
Gene namesi
Name:Kcnk3
Synonyms:Task, Task1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi61997. Kcnk3.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence analysis
Transmembranei9 – 2921HelicalSequence analysisAdd
BLAST
Intramembranei78 – 10124Pore-forming; Name=Pore-forming 1Sequence analysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST
Topological domaini129 – 15830CytoplasmicSequence analysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Intramembranei184 – 20724Pore-forming; Name=Pore-forming 2Sequence analysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence analysisAdd
BLAST
Topological domaini244 – 411168CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi515.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Potassium channel subfamily K member 3PRO_0000101746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO54912.
PRIDEiO54912.

PTM databases

PhosphoSiteiO54912.

Expressioni

Tissue specificityi

Strongest expression in heart. Moderate expression in lung and brain. Low levels in liver, kidney and skeletal muscle.

Gene expression databases

ExpressionAtlasiO54912. baseline and differential.
GenevisibleiO54912. RN.

Interactioni

Subunit structurei

Homodimer. Heterodimer with KCNK1.By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

DIPiDIP-61121N.
STRINGi10116.ENSRNOP00000013107.

Structurei

3D structure databases

ProteinModelPortaliO54912.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiO54912.
KOiK04914.
OMAiFRSLMKR.
OrthoDBiEOG7B05DC.
PhylomeDBiO54912.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
IPR005406. KCNK3.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01584. TASK1CHANNEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

O54912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQNVRTLA LIVCTFTYLL VGAAVFDALE SEPEMIERQR LELRQLELRA
60 70 80 90 100
RYNLSEGGYE ELERVVLRLK PHKAGVQWRF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PSTDGGKVFC MFYALLGIPL TLVMFQSLGE RINTFVRYLL HRAKRGLGMR
160 170 180 190 200
HAEVSMANMV LIGFVSCIST LCIGAAAFSY YERWTFFQAY YYCFITLTTI
210 220 230 240 250
GFGDYVALQK DQALQTQPQY VAFSFVYILT GLTVIGAFLN LVVLRFMTMN
260 270 280 290 300
AEDEKRDAEH RALLTHNGQA GGLGGLSCLS GSLGDGVRPR DPVTCAAAAG
310 320 330 340 350
GMGVGVGVGG SGFRNVYAEM LHFQSMCSCL WYKSREKLQY SIPMIIPRDL
360 370 380 390 400
STSDTCVEHS HSSPGGGGRY SDTPSHPCLC SGTQRSAISS VSTGLHSLAT
410
FRGLMKRRSS V
Length:411
Mass (Da):45,276
Last modified:June 1, 1998 - v1
Checksum:iD2778016E09E2BF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031384 mRNA. Translation: AAC39952.1.
RefSeqiNP_203694.1. NM_033376.1.
UniGeneiRn.15536.

Genome annotation databases

EnsembliENSRNOT00000013107; ENSRNOP00000013107; ENSRNOG00000009790.
GeneIDi29553.
KEGGirno:29553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031384 mRNA. Translation: AAC39952.1.
RefSeqiNP_203694.1. NM_033376.1.
UniGeneiRn.15536.

3D structure databases

ProteinModelPortaliO54912.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61121N.
STRINGi10116.ENSRNOP00000013107.

Chemistry

GuidetoPHARMACOLOGYi515.

PTM databases

PhosphoSiteiO54912.

Proteomic databases

PaxDbiO54912.
PRIDEiO54912.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013107; ENSRNOP00000013107; ENSRNOG00000009790.
GeneIDi29553.
KEGGirno:29553.

Organism-specific databases

CTDi3777.
RGDi61997. Kcnk3.

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiO54912.
KOiK04914.
OMAiFRSLMKR.
OrthoDBiEOG7B05DC.
PhylomeDBiO54912.
TreeFamiTF313947.

Enzyme and pathway databases

ReactomeiR-RNO-1299316. TWIK-releated acid-sensitive K+ channel (TASK).
R-RNO-5576886. Phase 4 - resting membrane potential.

Miscellaneous databases

PROiO54912.

Gene expression databases

ExpressionAtlasiO54912. baseline and differential.
GenevisibleiO54912. RN.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
IPR005406. KCNK3.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01584. TASK1CHANNEL.
PR01095. TASKCHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum."
    Leonoudakis D., Gray A.T., Winegar B.D., Kindler C.H., Harada M., Taylor D.M., Chavez R.A., Forsayeth J.R., Yost C.S.
    J. Neurosci. 18:868-877(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cerebellum.

Entry informationi

Entry nameiKCNK3_RAT
AccessioniPrimary (citable) accession number: O54912
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Inhibited by extracellular acidification, zinc, bupivacaine and phenytoin. Activated by protein kinase A.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.