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O54910

- IKBE_MOUSE

UniProt

O54910 - IKBE_MOUSE

Protein

NF-kappa-B inhibitor epsilon

Gene

Nfkbie

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. D-serine transport Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_199121. Activation of NF-kappaB in B cells.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NF-kappa-B inhibitor epsilon
    Short name:
    NF-kappa-BIE
    Alternative name(s):
    I-kappa-B-epsilon
    Short name:
    IkB-E
    Short name:
    IkB-epsilon
    Short name:
    IkappaBepsilon
    Gene namesi
    Name:Nfkbie
    Synonyms:Ikbe
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1194908. Nfkbie.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364NF-kappa-B inhibitor epsilonPRO_0000067008Add
    BLAST

    Post-translational modificationi

    Serine phosphorylated; followed by proteasome-dependent degradation.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO54910.
    PRIDEiO54910.

    PTM databases

    PhosphoSiteiO54910.

    Expressioni

    Gene expression databases

    BgeeiO54910.
    GenevestigatoriO54910.

    Interactioni

    Subunit structurei

    Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RelbQ048632EBI-6688774,EBI-1209145

    Protein-protein interaction databases

    IntActiO54910. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO54910.
    SMRiO54910. Positions 118-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati122 – 15534ANK 1Add
    BLAST
    Repeati157 – 18630ANK 2Add
    BLAST
    Repeati190 – 21930ANK 3Add
    BLAST
    Repeati233 – 26230ANK 4Add
    BLAST
    Repeati267 – 29630ANK 5Add
    BLAST
    Repeati300 – 32930ANK 6Add
    BLAST

    Sequence similaritiesi

    Belongs to the NF-kappa-B inhibitor family.Curated
    Contains 6 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    GeneTreeiENSGT00550000074527.
    HOGENOMiHOG000059576.
    HOVERGENiHBG108320.
    InParanoidiO54910.
    KOiK05872.
    OMAiKNQPLME.
    OrthoDBiEOG7W154S.
    PhylomeDBiO54910.
    TreeFamiTF320166.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF00023. Ank. 2 hits.
    PF12796. Ank_2. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 6 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54910-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDARKGPDE ADDSQCDSGI ESLRSLRSLP EPTAAPGSGS SQSGCPQPWR    50
    HAPETHKEPE KEDADGERAD STYASSSLTE SFPLLERPEA KDPSPPAPGS 100
    PLPPAGVLSP QQLEALTYIS EDGDTLLHLA VIHEAPSVLF CCLAFLPQEV 150
    LDIQNNLYQT ALHLAVHLDQ PDVVRALVLK GASRILQDQH GDTALHVACR 200
    RQNLACACCL LEEQPEPGRQ LSHPLDLQLK NWQGLACLHI ATLQRNQPLI 250
    ELLLQNGADI DVQEGTSGKT ALHLAVETQE RSLVQFLLQA GARVDARMLN 300
    GCTPLHLAAG RGLNSISSTL CEAGADSLLL NVEDETPQDL AEDLLSYLPF 350
    DDLKISGKPL LCTD 364
    Length:364
    Mass (Da):39,200
    Last modified:June 20, 2001 - v2
    Checksum:i4426B58424187F3A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971A → V in AAB97517. (PubMed:9405619)Curated
    Sequence conflicti182 – 19110ASRILQDQHG → PAEFCRSAC in BAB25924. (PubMed:16141072)Curated
    Sequence conflicti291 – 2911G → R in AAB97517. (PubMed:9405619)Curated
    Sequence conflicti345 – 36420LSYLP…LLCTD → GWVPTASHLEAGSAAAAVGT QAMSPLC in BAB27943. (PubMed:16141072)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030896 mRNA. Translation: AAB97517.1.
    AK008843 mRNA. Translation: BAB25924.1.
    AK011965 mRNA. Translation: BAB27943.1.
    AK151450 mRNA. Translation: BAE30410.1.
    AK153248 mRNA. Translation: BAE31839.1.
    BC030923 mRNA. Translation: AAH30923.1.
    CCDSiCCDS28811.1.
    RefSeqiNP_032716.2. NM_008690.3.
    XP_006523852.1. XM_006523789.1.
    UniGeneiMm.57043.

    Genome annotation databases

    EnsembliENSMUST00000024742; ENSMUSP00000024742; ENSMUSG00000023947.
    GeneIDi18037.
    KEGGimmu:18037.
    UCSCiuc008cqv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030896 mRNA. Translation: AAB97517.1 .
    AK008843 mRNA. Translation: BAB25924.1 .
    AK011965 mRNA. Translation: BAB27943.1 .
    AK151450 mRNA. Translation: BAE30410.1 .
    AK153248 mRNA. Translation: BAE31839.1 .
    BC030923 mRNA. Translation: AAH30923.1 .
    CCDSi CCDS28811.1.
    RefSeqi NP_032716.2. NM_008690.3.
    XP_006523852.1. XM_006523789.1.
    UniGenei Mm.57043.

    3D structure databases

    ProteinModelPortali O54910.
    SMRi O54910. Positions 118-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O54910. 1 interaction.

    PTM databases

    PhosphoSitei O54910.

    Proteomic databases

    PaxDbi O54910.
    PRIDEi O54910.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024742 ; ENSMUSP00000024742 ; ENSMUSG00000023947 .
    GeneIDi 18037.
    KEGGi mmu:18037.
    UCSCi uc008cqv.1. mouse.

    Organism-specific databases

    CTDi 4794.
    MGIi MGI:1194908. Nfkbie.

    Phylogenomic databases

    eggNOGi COG0666.
    GeneTreei ENSGT00550000074527.
    HOGENOMi HOG000059576.
    HOVERGENi HBG108320.
    InParanoidi O54910.
    KOi K05872.
    OMAi KNQPLME.
    OrthoDBi EOG7W154S.
    PhylomeDBi O54910.
    TreeFami TF320166.

    Enzyme and pathway databases

    Reactomei REACT_199121. Activation of NF-kappaB in B cells.

    Miscellaneous databases

    NextBioi 293137.
    PROi O54910.
    SOURCEi Search...

    Gene expression databases

    Bgeei O54910.
    Genevestigatori O54910.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF00023. Ank. 2 hits.
    PF12796. Ank_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 6 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional characterization of mouse IkappaBepsilon."
      Simeonidis S., Liang S., Chen G., Thanos D.
      Proc. Natl. Acad. Sci. U.S.A. 94:14372-14377(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow, Embryo and Stomach.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiIKBE_MOUSE
    AccessioniPrimary (citable) accession number: O54910
    Secondary accession number(s): Q3U686, Q9CZZ9, Q9D7U3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3