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O54910 (IKBE_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NF-kappa-B inhibitor epsilon

Short name=NF-kappa-BIE
Alternative name(s):
I-kappa-B-epsilon
Short name=IkB-E
Short name=IkB-epsilon
Short name=IkappaBepsilon
Gene names
Name:Nfkbie
Synonyms:Ikbe
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes By similarity.

Subunit structure

Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit By similarity.

Subcellular location

Cytoplasm.

Post-translational modification

Serine phosphorylated; followed by proteasome-dependent degradation.

Sequence similarities

Belongs to the NF-kappa-B inhibitor family.

Contains 6 ANK repeats.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainANK repeat
Repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processD-serine transport

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 23086447. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RelbQ048632EBI-6688774,EBI-1209145

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364NF-kappa-B inhibitor epsilon
PRO_0000067008

Regions

Repeat122 – 15534ANK 1
Repeat157 – 18630ANK 2
Repeat190 – 21930ANK 3
Repeat233 – 26230ANK 4
Repeat267 – 29630ANK 5
Repeat300 – 32930ANK 6

Experimental info

Sequence conflict971A → V in AAB97517. Ref.1
Sequence conflict182 – 19110ASRILQDQHG → PAEFCRSAC in BAB25924. Ref.2
Sequence conflict2911G → R in AAB97517. Ref.1
Sequence conflict345 – 36420LSYLP…LLCTD → GWVPTASHLEAGSAAAAVGT QAMSPLC in BAB27943. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O54910 [UniParc].

Last modified June 20, 2001. Version 2.
Checksum: 4426B58424187F3A

FASTA36439,200
        10         20         30         40         50         60 
MSDARKGPDE ADDSQCDSGI ESLRSLRSLP EPTAAPGSGS SQSGCPQPWR HAPETHKEPE 

        70         80         90        100        110        120 
KEDADGERAD STYASSSLTE SFPLLERPEA KDPSPPAPGS PLPPAGVLSP QQLEALTYIS 

       130        140        150        160        170        180 
EDGDTLLHLA VIHEAPSVLF CCLAFLPQEV LDIQNNLYQT ALHLAVHLDQ PDVVRALVLK 

       190        200        210        220        230        240 
GASRILQDQH GDTALHVACR RQNLACACCL LEEQPEPGRQ LSHPLDLQLK NWQGLACLHI 

       250        260        270        280        290        300 
ATLQRNQPLI ELLLQNGADI DVQEGTSGKT ALHLAVETQE RSLVQFLLQA GARVDARMLN 

       310        320        330        340        350        360 
GCTPLHLAAG RGLNSISSTL CEAGADSLLL NVEDETPQDL AEDLLSYLPF DDLKISGKPL 


LCTD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional characterization of mouse IkappaBepsilon."
Simeonidis S., Liang S., Chen G., Thanos D.
Proc. Natl. Acad. Sci. U.S.A. 94:14372-14377(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow, Embryo and Stomach.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF030896 mRNA. Translation: AAB97517.1.
AK008843 mRNA. Translation: BAB25924.1.
AK011965 mRNA. Translation: BAB27943.1.
AK151450 mRNA. Translation: BAE30410.1.
AK153248 mRNA. Translation: BAE31839.1.
BC030923 mRNA. Translation: AAH30923.1.
CCDSCCDS28811.1.
RefSeqNP_032716.2. NM_008690.3.
XP_006523852.1. XM_006523789.1.
UniGeneMm.57043.

3D structure databases

ProteinModelPortalO54910.
SMRO54910. Positions 118-341.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO54910. 1 interaction.

PTM databases

PhosphoSiteO54910.

Proteomic databases

PaxDbO54910.
PRIDEO54910.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000024742; ENSMUSP00000024742; ENSMUSG00000023947.
GeneID18037.
KEGGmmu:18037.
UCSCuc008cqv.1. mouse.

Organism-specific databases

CTD4794.
MGIMGI:1194908. Nfkbie.

Phylogenomic databases

eggNOGCOG0666.
GeneTreeENSGT00550000074527.
HOGENOMHOG000059576.
HOVERGENHBG108320.
InParanoidO54910.
KOK05872.
OMAKNQPLME.
OrthoDBEOG7W154S.
PhylomeDBO54910.
TreeFamTF320166.

Gene expression databases

BgeeO54910.
GenevestigatorO54910.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio293137.
PROO54910.
SOURCESearch...

Entry information

Entry nameIKBE_MOUSE
AccessionPrimary (citable) accession number: O54910
Secondary accession number(s): Q3U686, Q9CZZ9, Q9D7U3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot