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O54910

- IKBE_MOUSE

UniProt

O54910 - IKBE_MOUSE

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Protein
NF-kappa-B inhibitor epsilon
Gene
Nfkbie, Ikbe
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. D-serine transport Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_199121. Activation of NF-kappaB in B cells.

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor epsilon
Short name:
NF-kappa-BIE
Alternative name(s):
I-kappa-B-epsilon
Short name:
IkB-E
Short name:
IkB-epsilon
Short name:
IkappaBepsilon
Gene namesi
Name:Nfkbie
Synonyms:Ikbe
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1194908. Nfkbie.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364NF-kappa-B inhibitor epsilon
PRO_0000067008Add
BLAST

Post-translational modificationi

Serine phosphorylated; followed by proteasome-dependent degradation.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO54910.
PRIDEiO54910.

PTM databases

PhosphoSiteiO54910.

Expressioni

Gene expression databases

BgeeiO54910.
GenevestigatoriO54910.

Interactioni

Subunit structurei

Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
RelbQ048632EBI-6688774,EBI-1209145

Protein-protein interaction databases

IntActiO54910. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO54910.
SMRiO54910. Positions 118-341.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati122 – 15534ANK 1
Add
BLAST
Repeati157 – 18630ANK 2
Add
BLAST
Repeati190 – 21930ANK 3
Add
BLAST
Repeati233 – 26230ANK 4
Add
BLAST
Repeati267 – 29630ANK 5
Add
BLAST
Repeati300 – 32930ANK 6
Add
BLAST

Sequence similaritiesi

Contains 6 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00550000074527.
HOGENOMiHOG000059576.
HOVERGENiHBG108320.
InParanoidiO54910.
KOiK05872.
OMAiKNQPLME.
OrthoDBiEOG7W154S.
PhylomeDBiO54910.
TreeFamiTF320166.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54910-1 [UniParc]FASTAAdd to Basket

« Hide

MSDARKGPDE ADDSQCDSGI ESLRSLRSLP EPTAAPGSGS SQSGCPQPWR    50
HAPETHKEPE KEDADGERAD STYASSSLTE SFPLLERPEA KDPSPPAPGS 100
PLPPAGVLSP QQLEALTYIS EDGDTLLHLA VIHEAPSVLF CCLAFLPQEV 150
LDIQNNLYQT ALHLAVHLDQ PDVVRALVLK GASRILQDQH GDTALHVACR 200
RQNLACACCL LEEQPEPGRQ LSHPLDLQLK NWQGLACLHI ATLQRNQPLI 250
ELLLQNGADI DVQEGTSGKT ALHLAVETQE RSLVQFLLQA GARVDARMLN 300
GCTPLHLAAG RGLNSISSTL CEAGADSLLL NVEDETPQDL AEDLLSYLPF 350
DDLKISGKPL LCTD 364
Length:364
Mass (Da):39,200
Last modified:June 20, 2001 - v2
Checksum:i4426B58424187F3A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971A → V in AAB97517. 1 Publication
Sequence conflicti182 – 19110ASRILQDQHG → PAEFCRSAC in BAB25924. 1 Publication
Sequence conflicti291 – 2911G → R in AAB97517. 1 Publication
Sequence conflicti345 – 36420LSYLP…LLCTD → GWVPTASHLEAGSAAAAVGT QAMSPLC in BAB27943. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030896 mRNA. Translation: AAB97517.1.
AK008843 mRNA. Translation: BAB25924.1.
AK011965 mRNA. Translation: BAB27943.1.
AK151450 mRNA. Translation: BAE30410.1.
AK153248 mRNA. Translation: BAE31839.1.
BC030923 mRNA. Translation: AAH30923.1.
CCDSiCCDS28811.1.
RefSeqiNP_032716.2. NM_008690.3.
XP_006523852.1. XM_006523789.1.
UniGeneiMm.57043.

Genome annotation databases

EnsembliENSMUST00000024742; ENSMUSP00000024742; ENSMUSG00000023947.
GeneIDi18037.
KEGGimmu:18037.
UCSCiuc008cqv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030896 mRNA. Translation: AAB97517.1 .
AK008843 mRNA. Translation: BAB25924.1 .
AK011965 mRNA. Translation: BAB27943.1 .
AK151450 mRNA. Translation: BAE30410.1 .
AK153248 mRNA. Translation: BAE31839.1 .
BC030923 mRNA. Translation: AAH30923.1 .
CCDSi CCDS28811.1.
RefSeqi NP_032716.2. NM_008690.3.
XP_006523852.1. XM_006523789.1.
UniGenei Mm.57043.

3D structure databases

ProteinModelPortali O54910.
SMRi O54910. Positions 118-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O54910. 1 interaction.

PTM databases

PhosphoSitei O54910.

Proteomic databases

PaxDbi O54910.
PRIDEi O54910.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024742 ; ENSMUSP00000024742 ; ENSMUSG00000023947 .
GeneIDi 18037.
KEGGi mmu:18037.
UCSCi uc008cqv.1. mouse.

Organism-specific databases

CTDi 4794.
MGIi MGI:1194908. Nfkbie.

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00550000074527.
HOGENOMi HOG000059576.
HOVERGENi HBG108320.
InParanoidi O54910.
KOi K05872.
OMAi KNQPLME.
OrthoDBi EOG7W154S.
PhylomeDBi O54910.
TreeFami TF320166.

Enzyme and pathway databases

Reactomei REACT_199121. Activation of NF-kappaB in B cells.

Miscellaneous databases

NextBioi 293137.
PROi O54910.
SOURCEi Search...

Gene expression databases

Bgeei O54910.
Genevestigatori O54910.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 6 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of mouse IkappaBepsilon."
    Simeonidis S., Liang S., Chen G., Thanos D.
    Proc. Natl. Acad. Sci. U.S.A. 94:14372-14377(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Embryo and Stomach.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiIKBE_MOUSE
AccessioniPrimary (citable) accession number: O54910
Secondary accession number(s): Q3U686, Q9CZZ9, Q9D7U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: September 3, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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