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Protein
Submitted name:

Cis-retinol androgen dehydrogenase 1

Gene

Rdh16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein homodimerization activity Source: MGI
  • retinol dehydrogenase activity Source: MGI

GO - Biological processi

  • 9-cis-retinoic acid biosynthetic process Source: MGI
Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.1.1.315. 3474.
ReactomeiR-MMU-5365859. RA biosynthesis pathway.

Chemistry

SwissLipidsiSLP:000000799.

Names & Taxonomyi

Protein namesi
Submitted name:
Cis-retinol androgen dehydrogenase 1Imported
Submitted name:
MCG17020Imported
Submitted name:
Protein Rdh16Imported
Submitted name:
Retinol dehydrogenase 16Imported
Gene namesi
Name:Rdh16Imported
Synonyms:Rdh6Imported
ORF Names:mCG_17020Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1201375. Rdh16.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum lumen Source: MGI
  • integral component of organelle membrane Source: MGI
Complete GO annotation...

PTM / Processingi

PTM databases

PhosphoSiteiO54909.

Expressioni

Gene expression databases

BgeeiENSMUSG00000069456.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

MINTiMINT-1862300.
STRINGi10090.ENSMUSP00000071573.

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00840000129713.
HOVERGENiHBG005482.
KOiK11154.
OMAiECVGDKG.
OrthoDBiEOG091G0LMI.
TreeFamiTF325617.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 2 hits.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLYLVALVG LWTLLRFFRV RQVVSHLQDK YVFITGCDSG FGTLLARQLD
60 70 80 90 100
RRGMRVLAAC LTEKGAEELR NKTSDRLETV ILDVTKTESI VTATQWVKEH
110 120 130 140 150
VGNRGLWGLV NNAGISTPSG PNEWMKKQDF AHVLDVNLLG MIEVTLSMLP
160 170 180 190 200
LVRKARGRVV NVSSVMGRVS LFGGGYCISK YGVEAFSDSL RRELSYFGVK
210 220 230 240 250
VAIIEPGFFL TGVTSSARLC SNTQMLWDQT SSEIREIYGE KYLASYLKRL
260 270 280 290 300
NKLDKRCNKD LSGVTDCMEH ALTACHPRTR YSAGWDAKLF YLPLSYLPTF
310
LVDALLYWTS LKPEKAL
Length:317
Mass (Da):35,744
Last modified:June 1, 1998 - v1
Checksum:iB3D82F3F1D5D57C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131690 Genomic DNA. No translation available.
AF030513 mRNA. Translation: AAB97166.1.
BC089612 mRNA. Translation: AAH89612.1.
CH466578 Genomic DNA. Translation: EDL24525.1.
RefSeqiNP_033066.1. NM_009040.3.
XP_006513452.1. XM_006513389.2.
UniGeneiMm.100276.

Genome annotation databases

EnsembliENSMUST00000071646; ENSMUSP00000071573; ENSMUSG00000069456.
GeneIDi19683.
KEGGimmu:19683.
UCSCiuc007hkq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131690 Genomic DNA. No translation available.
AF030513 mRNA. Translation: AAB97166.1.
BC089612 mRNA. Translation: AAH89612.1.
CH466578 Genomic DNA. Translation: EDL24525.1.
RefSeqiNP_033066.1. NM_009040.3.
XP_006513452.1. XM_006513389.2.
UniGeneiMm.100276.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1862300.
STRINGi10090.ENSMUSP00000071573.

Chemistry

SwissLipidsiSLP:000000799.

PTM databases

PhosphoSiteiO54909.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071646; ENSMUSP00000071573; ENSMUSG00000069456.
GeneIDi19683.
KEGGimmu:19683.
UCSCiuc007hkq.2. mouse.

Organism-specific databases

CTDi8608.
MGIiMGI:1201375. Rdh16.

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00840000129713.
HOVERGENiHBG005482.
KOiK11154.
OMAiECVGDKG.
OrthoDBiEOG091G0LMI.
TreeFamiTF325617.

Enzyme and pathway databases

BRENDAi1.1.1.315. 3474.
ReactomeiR-MMU-5365859. RA biosynthesis pathway.

Miscellaneous databases

ChiTaRSiRdh16. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069456.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 2 hits.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO54909_MOUSE
AccessioniPrimary (citable) accession number: O54909
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.