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O54905

- B3GT2_MOUSE

UniProt

O54905 - B3GT2_MOUSE

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Protein

Beta-1,3-galactosyltransferase 2

Gene

B3galt2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins.1 Publication

Cofactori

Mn2+1 Publication

Pathwayi

GO - Molecular functioni

  1. UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Source: MGI

GO - Biological processi

  1. oligosaccharide biosynthetic process Source: MGI
  2. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 2 (EC:2.4.1.-)
Short name:
Beta-1,3-GalTase 2
Short name:
Beta3Gal-T2
Short name:
Beta3GalT2
Alternative name(s):
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase-II
Gene namesi
Name:B3galt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1349461. B3galt2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei21 – 4323Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini44 – 422379LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Beta-1,3-galactosyltransferase 2PRO_0000219151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO54905.

PTM databases

PhosphoSiteiO54905.

Expressioni

Tissue specificityi

Detected in brain and heart.1 Publication

Gene expression databases

BgeeiO54905.
GenevestigatoriO54905.

Structurei

3D structure databases

ProteinModelPortaliO54905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG331548.
GeneTreeiENSGT00760000118879.
HOVERGENiHBG101354.
InParanoidiO54905.
KOiK07820.
OMAiCCFAKMS.
OrthoDBiEOG7C2R1D.
PhylomeDBiO54905.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54905-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQWRRRHCC FAKMTWSPKR SLLRTPLTGV LSLVFLFAMF LFFNHHDWLP
60 70 80 90 100
GRPGFKENPV TYTFRGFRST KSETNHSSLR TIWKEVAPQT LRPHTASNSS
110 120 130 140 150
NTELSPQGVT GLQNTLSANG SIYNEKGTGH PNSYHFKYII NEPEKCQEKS
160 170 180 190 200
PFLILLIAAE PGQIEARRAI RQTWGNETLA PGIQIIRVFL LGISIKLNGY
210 220 230 240 250
LQHAIQEESR QYHDIIQQEY LDTYYNLTIK TLMGMNWVAT YCPHTPYVMK
260 270 280 290 300
TDSDMFVNTE YLIHKLLKPD LPPRHNYFTG YLMRGYAPNR NKDSKWYMPP
310 320 330 340 350
DLYPSERYPV FCSGTGYVFS GDLAEKIFKV SLGIRRLHLE DVYVGICLAK
360 370 380 390 400
LRVDPVPPPN EFVFNHWRVS YSSCKYSHLI TSHQFQPSEL IKYWNHLQQN
410 420
KHNACANAAK EKAGRYRHRK LH
Length:422
Mass (Da):49,095
Last modified:March 15, 2005 - v2
Checksum:i58F5D3568143F4FB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951T → I in AAC53524. (PubMed:9417047)Curated
Sequence conflicti366 – 3661H → R in BAC28688. (PubMed:16141072)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441N → S in strain: HMI/Msf. 1 Publication
Natural varianti86 – 861V → A in strain: BLG2/Msf, MSM/Msf, SWN/Msf and NJL/Msf. 1 Publication
Natural varianti88 – 881P → S in strain: BLG2/Msf and NJL/Msf. 1 Publication
Natural varianti100 – 1001S → T in strain: CAST/Ei and HMI/Msf. 1 Publication
Natural varianti124 – 1241N → D in strain: BLG2/Msf, NJL/Msf, MSM/Msf and SWN/Msf. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029791 Genomic DNA. Translation: AAC53524.1.
AK034371 mRNA. Translation: BAC28688.1.
AK036141 mRNA. Translation: BAC29317.1.
AK083168 mRNA. Translation: BAC38793.1.
BC046322 mRNA. Translation: AAH46322.1.
AB039144 Genomic DNA. Translation: BAB68668.1.
AB039145 Genomic DNA. Translation: BAB68669.1.
AB039146 Genomic DNA. Translation: BAB68670.1.
AB039147 Genomic DNA. Translation: BAB68671.1.
AB039148 Genomic DNA. Translation: BAB68672.1.
AB039149 Genomic DNA. Translation: BAB68673.1.
AB039150 Genomic DNA. Translation: BAB68674.1.
AB039151 Genomic DNA. Translation: BAB68675.1.
AB039152 Genomic DNA. Translation: BAB68676.1.
CCDSiCCDS15342.1.
RefSeqiNP_064409.3. NM_020025.4.
UniGeneiMm.285580.

Genome annotation databases

EnsembliENSMUST00000038252; ENSMUSP00000046118; ENSMUSG00000033849.
GeneIDi26878.
KEGGimmu:26878.
UCSCiuc007cwy.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

b3GalT2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029791 Genomic DNA. Translation: AAC53524.1 .
AK034371 mRNA. Translation: BAC28688.1 .
AK036141 mRNA. Translation: BAC29317.1 .
AK083168 mRNA. Translation: BAC38793.1 .
BC046322 mRNA. Translation: AAH46322.1 .
AB039144 Genomic DNA. Translation: BAB68668.1 .
AB039145 Genomic DNA. Translation: BAB68669.1 .
AB039146 Genomic DNA. Translation: BAB68670.1 .
AB039147 Genomic DNA. Translation: BAB68671.1 .
AB039148 Genomic DNA. Translation: BAB68672.1 .
AB039149 Genomic DNA. Translation: BAB68673.1 .
AB039150 Genomic DNA. Translation: BAB68674.1 .
AB039151 Genomic DNA. Translation: BAB68675.1 .
AB039152 Genomic DNA. Translation: BAB68676.1 .
CCDSi CCDS15342.1.
RefSeqi NP_064409.3. NM_020025.4.
UniGenei Mm.285580.

3D structure databases

ProteinModelPortali O54905.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSitei O54905.

Proteomic databases

PRIDEi O54905.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038252 ; ENSMUSP00000046118 ; ENSMUSG00000033849 .
GeneIDi 26878.
KEGGi mmu:26878.
UCSCi uc007cwy.2. mouse.

Organism-specific databases

CTDi 8707.
MGIi MGI:1349461. B3galt2.

Phylogenomic databases

eggNOGi NOG331548.
GeneTreei ENSGT00760000118879.
HOVERGENi HBG101354.
InParanoidi O54905.
KOi K07820.
OMAi CCFAKMS.
OrthoDBi EOG7C2R1D.
PhylomeDBi O54905.
TreeFami TF318639.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 304691.
PROi O54905.
SOURCEi Search...

Gene expression databases

Bgeei O54905.
Genevestigatori O54905.

Family and domain databases

InterProi IPR002659. Glyco_trans_31.
[Graphical view ]
PANTHERi PTHR11214. PTHR11214. 1 hit.
Pfami PF01762. Galactosyl_T. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes."
    Hennet T., Dinter A., Kuhnert P., Mattu T.S., Rudd P.M., Berger E.G.
    J. Biol. Chem. 273:58-65(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, COFACTOR, TISSUE SPECIFICITY.
    Strain: 129/SvJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Diencephalon and Hippocampus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  4. "Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
    Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-415, VARIANTS SER-44; ALA-86; SER-88; THR-100 AND ASP-124.
    Strain: BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, Pgn2 and SWN/Msf.

Entry informationi

Entry nameiB3GT2_MOUSE
AccessioniPrimary (citable) accession number: O54905
Secondary accession number(s): Q8BH19
, Q8CBX4, Q91V19, Q91V58, Q91VE9, Q920V3, Q920V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 26, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3