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O54905

- B3GT2_MOUSE

UniProt

O54905 - B3GT2_MOUSE

Protein

Beta-1,3-galactosyltransferase 2

Gene

B3galt2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins.1 Publication

    Cofactori

    Manganese.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Source: MGI

    GO - Biological processi

    1. oligosaccharide biosynthetic process Source: MGI
    2. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    Manganese

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT31. Glycosyltransferase Family 31.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-1,3-galactosyltransferase 2 (EC:2.4.1.-)
    Short name:
    Beta-1,3-GalTase 2
    Short name:
    Beta3Gal-T2
    Short name:
    Beta3GalT2
    Alternative name(s):
    UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase-II
    Gene namesi
    Name:B3galt2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1349461. B3galt2.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Beta-1,3-galactosyltransferase 2PRO_0000219151Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiO54905.

    PTM databases

    PhosphoSiteiO54905.

    Expressioni

    Tissue specificityi

    Detected in brain and heart.1 Publication

    Gene expression databases

    BgeeiO54905.
    GenevestigatoriO54905.

    Structurei

    3D structure databases

    ProteinModelPortaliO54905.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini44 – 422379LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4323Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 31 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG331548.
    GeneTreeiENSGT00740000114871.
    HOVERGENiHBG101354.
    InParanoidiO54905.
    KOiK07820.
    OMAiCCFAKMS.
    OrthoDBiEOG7C2R1D.
    PhylomeDBiO54905.
    TreeFamiTF318639.

    Family and domain databases

    InterProiIPR002659. Glyco_trans_31.
    [Graphical view]
    PANTHERiPTHR11214. PTHR11214. 1 hit.
    PfamiPF01762. Galactosyl_T. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54905-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQWRRRHCC FAKMTWSPKR SLLRTPLTGV LSLVFLFAMF LFFNHHDWLP    50
    GRPGFKENPV TYTFRGFRST KSETNHSSLR TIWKEVAPQT LRPHTASNSS 100
    NTELSPQGVT GLQNTLSANG SIYNEKGTGH PNSYHFKYII NEPEKCQEKS 150
    PFLILLIAAE PGQIEARRAI RQTWGNETLA PGIQIIRVFL LGISIKLNGY 200
    LQHAIQEESR QYHDIIQQEY LDTYYNLTIK TLMGMNWVAT YCPHTPYVMK 250
    TDSDMFVNTE YLIHKLLKPD LPPRHNYFTG YLMRGYAPNR NKDSKWYMPP 300
    DLYPSERYPV FCSGTGYVFS GDLAEKIFKV SLGIRRLHLE DVYVGICLAK 350
    LRVDPVPPPN EFVFNHWRVS YSSCKYSHLI TSHQFQPSEL IKYWNHLQQN 400
    KHNACANAAK EKAGRYRHRK LH 422
    Length:422
    Mass (Da):49,095
    Last modified:March 15, 2005 - v2
    Checksum:i58F5D3568143F4FB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 951T → I in AAC53524. (PubMed:9417047)Curated
    Sequence conflicti366 – 3661H → R in BAC28688. (PubMed:16141072)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441N → S in strain: HMI/Msf. 1 Publication
    Natural varianti86 – 861V → A in strain: BLG2/Msf, MSM/Msf, SWN/Msf and NJL/Msf. 1 Publication
    Natural varianti88 – 881P → S in strain: BLG2/Msf and NJL/Msf. 1 Publication
    Natural varianti100 – 1001S → T in strain: CAST/Ei and HMI/Msf. 1 Publication
    Natural varianti124 – 1241N → D in strain: BLG2/Msf, NJL/Msf, MSM/Msf and SWN/Msf. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029791 Genomic DNA. Translation: AAC53524.1.
    AK034371 mRNA. Translation: BAC28688.1.
    AK036141 mRNA. Translation: BAC29317.1.
    AK083168 mRNA. Translation: BAC38793.1.
    BC046322 mRNA. Translation: AAH46322.1.
    AB039144 Genomic DNA. Translation: BAB68668.1.
    AB039145 Genomic DNA. Translation: BAB68669.1.
    AB039146 Genomic DNA. Translation: BAB68670.1.
    AB039147 Genomic DNA. Translation: BAB68671.1.
    AB039148 Genomic DNA. Translation: BAB68672.1.
    AB039149 Genomic DNA. Translation: BAB68673.1.
    AB039150 Genomic DNA. Translation: BAB68674.1.
    AB039151 Genomic DNA. Translation: BAB68675.1.
    AB039152 Genomic DNA. Translation: BAB68676.1.
    CCDSiCCDS15342.1.
    RefSeqiNP_064409.3. NM_020025.4.
    UniGeneiMm.285580.

    Genome annotation databases

    EnsembliENSMUST00000038252; ENSMUSP00000046118; ENSMUSG00000033849.
    GeneIDi26878.
    KEGGimmu:26878.
    UCSCiuc007cwy.2. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - GTase

    b3GalT2

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029791 Genomic DNA. Translation: AAC53524.1 .
    AK034371 mRNA. Translation: BAC28688.1 .
    AK036141 mRNA. Translation: BAC29317.1 .
    AK083168 mRNA. Translation: BAC38793.1 .
    BC046322 mRNA. Translation: AAH46322.1 .
    AB039144 Genomic DNA. Translation: BAB68668.1 .
    AB039145 Genomic DNA. Translation: BAB68669.1 .
    AB039146 Genomic DNA. Translation: BAB68670.1 .
    AB039147 Genomic DNA. Translation: BAB68671.1 .
    AB039148 Genomic DNA. Translation: BAB68672.1 .
    AB039149 Genomic DNA. Translation: BAB68673.1 .
    AB039150 Genomic DNA. Translation: BAB68674.1 .
    AB039151 Genomic DNA. Translation: BAB68675.1 .
    AB039152 Genomic DNA. Translation: BAB68676.1 .
    CCDSi CCDS15342.1.
    RefSeqi NP_064409.3. NM_020025.4.
    UniGenei Mm.285580.

    3D structure databases

    ProteinModelPortali O54905.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT31. Glycosyltransferase Family 31.

    PTM databases

    PhosphoSitei O54905.

    Proteomic databases

    PRIDEi O54905.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038252 ; ENSMUSP00000046118 ; ENSMUSG00000033849 .
    GeneIDi 26878.
    KEGGi mmu:26878.
    UCSCi uc007cwy.2. mouse.

    Organism-specific databases

    CTDi 8707.
    MGIi MGI:1349461. B3galt2.

    Phylogenomic databases

    eggNOGi NOG331548.
    GeneTreei ENSGT00740000114871.
    HOVERGENi HBG101354.
    InParanoidi O54905.
    KOi K07820.
    OMAi CCFAKMS.
    OrthoDBi EOG7C2R1D.
    PhylomeDBi O54905.
    TreeFami TF318639.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    NextBioi 304691.
    PROi O54905.
    SOURCEi Search...

    Gene expression databases

    Bgeei O54905.
    Genevestigatori O54905.

    Family and domain databases

    InterProi IPR002659. Glyco_trans_31.
    [Graphical view ]
    PANTHERi PTHR11214. PTHR11214. 1 hit.
    Pfami PF01762. Galactosyl_T. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes."
      Hennet T., Dinter A., Kuhnert P., Mattu T.S., Rudd P.M., Berger E.G.
      J. Biol. Chem. 273:58-65(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, COFACTOR, TISSUE SPECIFICITY.
      Strain: 129/SvJ.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum, Diencephalon and Hippocampus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.
    4. "Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
      Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-415, VARIANTS SER-44; ALA-86; SER-88; THR-100 AND ASP-124.
      Strain: BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, Pgn2 and SWN/Msf.

    Entry informationi

    Entry nameiB3GT2_MOUSE
    AccessioniPrimary (citable) accession number: O54905
    Secondary accession number(s): Q8BH19
    , Q8CBX4, Q91V19, Q91V58, Q91VE9, Q920V3, Q920V4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3