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Protein

Beta-1,3-galactosyltransferase 1

Gene

B3galt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins.1 Publication

Cofactori

Mn2+1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • oligosaccharide biosynthetic process Source: MGI
  • protein glycosylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 1 (EC:2.4.1.-)
Short name:
Beta-1,3-GalTase 1
Short name:
Beta3Gal-T1
Short name:
Beta3GalT1
Alternative name(s):
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase-I
UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1
Gene namesi
Name:B3galt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1349403. B3galt1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence analysis
Transmembranei7 – 2620Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini27 – 326300LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Beta-1,3-galactosyltransferase 1PRO_0000219146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO54904.
PRIDEiO54904.

PTM databases

PhosphoSiteiO54904.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000034780.
ExpressionAtlasiO54904. baseline and differential.
GenevisibleiO54904. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041343.

Structurei

3D structure databases

ProteinModelPortaliO54904.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
HOGENOMiHOG000059604.
HOVERGENiHBG101354.
InParanoidiO54904.
KOiK07819.
OMAiDFLINEP.
OrthoDBiEOG091G0AXM.
PhylomeDBiO54904.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

O54904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKVSCLYV LTVVCWASAL WYLSITRPTS SYTGSKPFSH LTVARKNFTF
60 70 80 90 100
GNIRTRPINP HSFEFLINEP NKCEKNIPFL VILISTTHKE FDARQAIRET
110 120 130 140 150
WGDENNFKGI KIATLFLLGK NADPVLNQMV EQESQIFHDI IVEDFIDSYH
160 170 180 190 200
NLTLKTLMGM RWVATFCSKA KYVMKTDSDI FVNMDNLIYK LLKPSTKPRR
210 220 230 240 250
RYFTGYVING GPIRDVRSKW YMPRDLYPDS NYPPFCSGTG YIFSADVAEL
260 270 280 290 300
IYKTSLHTRL LHLEDVYVGL CLRKLGIHPF QNSGFNHWKM AYSLCRYRRV
310 320
ITVHQISPEE MHRIWNDMSS KKHLRC
Length:326
Mass (Da):37,993
Last modified:March 15, 2005 - v2
Checksum:i83271E99B2EE74F5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121T → S in strain: 129/SvJ. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029790 Genomic DNA. Translation: AAC53523.1.
AB039134 Genomic DNA. Translation: BAB68658.1.
AB039135 Genomic DNA. Translation: BAB68659.1.
AB039136 Genomic DNA. Translation: BAB68660.1.
AB039137 Genomic DNA. Translation: BAB68661.1.
AB039138 Genomic DNA. Translation: BAB68662.1.
AB039139 Genomic DNA. Translation: BAB68663.1.
AB039140 Genomic DNA. Translation: BAB68664.1.
AB039141 Genomic DNA. Translation: BAB68665.1.
AB039142 Genomic DNA. Translation: BAB68666.1.
CCDSiCCDS16083.1.
RefSeqiNP_064679.2. NM_020283.4.
XP_006499654.1. XM_006499591.2.
XP_011237873.1. XM_011239571.1.
XP_011237874.1. XM_011239572.1.
XP_011237875.1. XM_011239573.1.
UniGeneiMm.226435.
Mm.490783.

Genome annotation databases

EnsembliENSMUST00000042456; ENSMUSP00000041343; ENSMUSG00000034780.
ENSMUST00000112346; ENSMUSP00000107965; ENSMUSG00000034780.
GeneIDi26877.
KEGGimmu:26877.
UCSCiuc008jxm.3. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

b3GalT1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029790 Genomic DNA. Translation: AAC53523.1.
AB039134 Genomic DNA. Translation: BAB68658.1.
AB039135 Genomic DNA. Translation: BAB68659.1.
AB039136 Genomic DNA. Translation: BAB68660.1.
AB039137 Genomic DNA. Translation: BAB68661.1.
AB039138 Genomic DNA. Translation: BAB68662.1.
AB039139 Genomic DNA. Translation: BAB68663.1.
AB039140 Genomic DNA. Translation: BAB68664.1.
AB039141 Genomic DNA. Translation: BAB68665.1.
AB039142 Genomic DNA. Translation: BAB68666.1.
CCDSiCCDS16083.1.
RefSeqiNP_064679.2. NM_020283.4.
XP_006499654.1. XM_006499591.2.
XP_011237873.1. XM_011239571.1.
XP_011237874.1. XM_011239572.1.
XP_011237875.1. XM_011239573.1.
UniGeneiMm.226435.
Mm.490783.

3D structure databases

ProteinModelPortaliO54904.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041343.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSiteiO54904.

Proteomic databases

PaxDbiO54904.
PRIDEiO54904.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042456; ENSMUSP00000041343; ENSMUSG00000034780.
ENSMUST00000112346; ENSMUSP00000107965; ENSMUSG00000034780.
GeneIDi26877.
KEGGimmu:26877.
UCSCiuc008jxm.3. mouse.

Organism-specific databases

CTDi8708.
MGIiMGI:1349403. B3galt1.

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
HOGENOMiHOG000059604.
HOVERGENiHBG101354.
InParanoidiO54904.
KOiK07819.
OMAiDFLINEP.
OrthoDBiEOG091G0AXM.
PhylomeDBiO54904.
TreeFamiTF318639.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

PROiO54904.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034780.
ExpressionAtlasiO54904. baseline and differential.
GenevisibleiO54904. MM.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB3GT1_MOUSE
AccessioniPrimary (citable) accession number: O54904
Secondary accession number(s): Q91V52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.