O54901 (OX2G_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
OX-2 membrane glycoprotein

Alternative name(s):
MRC OX-2 antigen
CD_antigen=CD200

Gene names

Name:	Cd200
Synonyms:	Mox2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues By similarity.
Subunit structure	Interacts with CD200R1.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 278	248	OX-2 membrane glycoprotein		PRO_0000015125
Regions
	Topological domain	31 – 232	202	Extracellular Potential
	Transmembrane	233 – 259	27	Helical; Potential
	Topological domain	260 – 278	19	Cytoplasmic Potential
	Domain	31 – 141	111	Ig-like V-type
	Domain	142 – 232	91	Ig-like C2-type
Amino acid modifications
	Glycosylation	95	1	N-linked (GlcNAc...) Potential
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Glycosylation	110	1	N-linked (GlcNAc...) Potential
	Glycosylation	157	1	N-linked (GlcNAc...) Potential
	Glycosylation	181	1	N-linked (GlcNAc...) Potential
	Glycosylation	190	1	N-linked (GlcNAc...) Potential
	Disulfide bond	51 ↔ 121		Potential
	Disulfide bond	160 ↔ 214		Potential
Experimental info
	Sequence conflict	22	1	M → I in AAB93980. Ref.2
	Sequence conflict	112 – 116	5	TLEDE → HIGDG in AAB93980. Ref.2
	Sequence conflict	154	1	D → H in AAB93980. Ref.2
	Sequence conflict	171	1	S → T in AAB93980. Ref.2
	Sequence conflict	251	1	V → I in AAB93980. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O54901 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 0D06A2DE0C60DF5A	FASTA	278	31,256
	10 20 30 40 50 60 MGSLVFRRPF CHLSTYSLIW GMAAVALSTA QVEVVTQDER KALHTTASLR CSLKTSQEPL 70 80 90 100 110 120 IVTWQKKKAV SPENMVTYSK THGVVIQPAY KDRINVTELG LWNSSITFWN TTLEDEGCYM 130 140 150 160 170 180 CLFNTFGSQK VSGTACLTLY VQPIVHLHYN YFEDHLNITC SATARPAPAI SWKGTGTGIE 190 200 210 220 230 240 NSTESHFHSN GTTSVTSILR VKDPKTQVGK EVICQVLYLG NVIDYKQSLD KGFWFSVPLL 250 260 270 LSIVSLVILL VLISILLYWK RHRNQERGES SQGMQRMK

References

[1]	"Cloning and characterization of the murine homologue of the rat/human MRC OX-2 gene." Chen Z., Zeng H., Gorczynski R.M. Biochim. Biophys. Acta 1362:6-10(1997) [PubMed: 9434094] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C3H/HeJ.
[2]	"Characterization and localization of Mox2, the gene encoding the murine homolog of the rat MRC OX-2 membrane glycoprotein." Borriello F., Tizard R., Rue E., Reeves R. Mamm. Genome 9:114-118(1998) [PubMed: 9457671] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129.
[3]	Preston S., Wright G.J., Starr K., Barclay A.N., Brown M.H. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-225. Strain: BALB/c.
[4]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 69-80, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF004023 mRNA. Translation: AAB93980.1. AF029215, AF029214 Genomic DNA. Translation: AAC15911.1. AF231126 mRNA. Translation: AAF61105.1.
IPI	IPI00119756.
UniGene	Mm.245851.
3D structure databases
ProteinModelPortal	O54901.
SMR	O54901. Positions 35-228.
ModBase	Search...
Protein-protein interaction databases
STRING	O54901.
Proteomic databases
PRIDE	O54901.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:1196990. Cd200.
Phylogenomic databases
eggNOG	roNOG14339.
HOGENOM	HBG282508.
HOVERGEN	HBG031790.
InParanoid	O54901.
OrthoDB	EOG40ZQZ2.
Gene expression databases
ArrayExpress	O54901.
Bgee	O54901.
CleanEx	MM_CD200.
Genevestigator	O54901.
GermOnline	ENSMUSG00000022661. Mus musculus.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003596. Ig_V-set_subgr. IPR013151. Immunoglobulin. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 2 hits.
Pfam	PF00047. ig. 2 hits. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

OX2G_MOUSE

Accession

Primary (citable) accession number: O54901
Secondary accession number(s): O54816, Q9JHD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
Last sequence update:	June 1, 1998
Last modified:	September 21, 2011
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program