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Protein

Probable G-protein coupled receptor 27

Gene

Gpr27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 27
Alternative name(s):
Super conserved receptor expressed in brain 1
Gene namesi
Name:Gpr27
Synonyms:Sreb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1202299. Gpr27.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 58CytoplasmicSequence analysisAdd BLAST11
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 142CytoplasmicSequence analysisAdd BLAST21
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 185ExtracellularSequence analysisAdd BLAST22
Transmembranei186 – 206Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini207 – 289CytoplasmicSequence analysisAdd BLAST83
Transmembranei290 – 310Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini311 – 324ExtracellularSequence analysisAdd BLAST14
Transmembranei325 – 345Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini346 – 379CytoplasmicSequence analysisAdd BLAST34

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695491 – 379Probable G-protein coupled receptor 27Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO54897.
PRIDEiO54897.

PTM databases

iPTMnetiO54897.
PhosphoSitePlusiO54897.

Expressioni

Gene expression databases

BgeeiENSMUSG00000072875.
CleanExiMM_GPR27.
GenevisibleiO54897. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098680.

Structurei

3D structure databases

ProteinModelPortaliO54897.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiO54897.
KOiK04301.
OMAiQATLPCD.
OrthoDBiEOG091G0AOZ.
PhylomeDBiO54897.
TreeFamiTF331163.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANASEPGGG GSGGGAEAAA LGLRLATLSL LLCVSLAGNV LFALLIVRER
60 70 80 90 100
SLHRAPYYLL LDLCLADGLR ALACLPAVML AARRAAAAAG TPPGALGCKL
110 120 130 140 150
LAFLAALFCF HAAFLLLGVG VTRYLAIAHH RFYAERLAGW PCAAMLVCAA
160 170 180 190 200
WALALAAAFP PVLDGGGADD EDAPCALEQR PDGAPGALGF LLLLAAVVGA
210 220 230 240 250
THLVYLRLLF FIHDRRKMRP ARLVPAVSHD WTFHGPGATG QAAANWTAGF
260 270 280 290 300
GRGPTPPALV GIRPAGPGRG ARRLLVLEEF KTEKRLCKMF YAITLLFLLL
310 320 330 340 350
WGPYVVASYL RVLVRPGAVP QAYLTASVWL TFAQAGINPV VCFLFNRELR
360 370
DCFRAQFPCC QSPQATQATL PCDLKGIGL
Length:379
Mass (Da):40,036
Last modified:June 1, 1998 - v1
Checksum:i9DAE96D2857E30D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027955 Genomic DNA. Translation: AAC53540.1.
CCDSiCCDS20387.1.
RefSeqiNP_032184.1. NM_008158.1.
UniGeneiMm.35009.

Genome annotation databases

EnsembliENSMUST00000101122; ENSMUSP00000098680; ENSMUSG00000072875.
GeneIDi14761.
KEGGimmu:14761.
UCSCiuc009dbs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027955 Genomic DNA. Translation: AAC53540.1.
CCDSiCCDS20387.1.
RefSeqiNP_032184.1. NM_008158.1.
UniGeneiMm.35009.

3D structure databases

ProteinModelPortaliO54897.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098680.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO54897.
PhosphoSitePlusiO54897.

Proteomic databases

PaxDbiO54897.
PRIDEiO54897.

Protocols and materials databases

DNASUi14761.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101122; ENSMUSP00000098680; ENSMUSG00000072875.
GeneIDi14761.
KEGGimmu:14761.
UCSCiuc009dbs.1. mouse.

Organism-specific databases

CTDi2850.
MGIiMGI:1202299. Gpr27.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00780000121897.
HOGENOMiHOG000231471.
HOVERGENiHBG051805.
InParanoidiO54897.
KOiK04301.
OMAiQATLPCD.
OrthoDBiEOG091G0AOZ.
PhylomeDBiO54897.
TreeFamiTF331163.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiO54897.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000072875.
CleanExiMM_GPR27.
GenevisibleiO54897. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR27_MOUSE
AccessioniPrimary (citable) accession number: O54897
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.