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O54891

- LEG6_MOUSE

UniProt

O54891 - LEG6_MOUSE

Protein

Galectin-6

Gene

Lgals6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galectin-6
    Short name:
    Gal-6
    Gene namesi
    Name:Lgals6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:107535. Lgals6.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Galectin-6PRO_0000076939Add
    BLAST

    Proteomic databases

    PRIDEiO54891.

    Expressioni

    Gene expression databases

    GenevestigatoriO54891.

    Structurei

    3D structure databases

    ProteinModelPortaliO54891.
    SMRiO54891. Positions 13-150, 159-301.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 149131Galectin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini173 – 301129Galectin 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Contains two homologous but distinct carbohydrate-binding domains.

    Sequence similaritiesi

    Contains 2 galectin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG002412.
    KOiK10091.
    PhylomeDBiO54891.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR015533. Galectin4/6.
    IPR001079. Galectin_CRD.
    [Graphical view]
    PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
    PfamiPF00337. Gal-bind_lectin. 2 hits.
    [Graphical view]
    SMARTiSM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    PROSITEiPS51304. GALECTIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54891-1 [UniParc]FASTAAdd to Basket

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    MAYVPAPGYQ PTYNPTLPYK RPIPGGLSVG MSFYIQGTAK ENMRRFHVNF    50
    AVGQDDGADV AFHFNPRFDG WDKVVFNTKQ SGRWGKEEEK SMPFQKGKHF 100
    ELVFMVMPEH YKVVVNGSPF YEYGHRLPVQ MVTHLQVDGD LELQSINFFG 150
    VQPAETKYPA MTGPPVFNPC LPYVGALQGG FTVRRTIIIK GYVLPTAKTF 200
    AINFRVGSSE DIALHINPRI GDCLVRNSYM NGSWGTEERM VAYNPFGPGQ 250
    FFDLSIRCGM DRFKVFANGI HLFNFSHRFQ ALRKINTLEI NGDLTLSYVH 300
    I 301
    Length:301
    Mass (Da):34,112
    Last modified:June 1, 1998 - v1
    Checksum:i9A4DD09944EDFAB9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541A → V in AAC27244. (PubMed:9446609)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026799
    , AF026796, AF026797, AF026798 Genomic DNA. Translation: AAC04508.1.
    AF026794 mRNA. Translation: AAC27244.1.
    RefSeqiNP_034837.1. NM_010707.2.
    UniGeneiMm.210336.

    Genome annotation databases

    GeneIDi16857.
    KEGGimmu:16857.
    UCSCiuc009gad.2. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Galectin-6

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026799
    , AF026796 , AF026797 , AF026798 Genomic DNA. Translation: AAC04508.1 .
    AF026794 mRNA. Translation: AAC27244.1 .
    RefSeqi NP_034837.1. NM_010707.2.
    UniGenei Mm.210336.

    3D structure databases

    ProteinModelPortali O54891.
    SMRi O54891. Positions 13-150, 159-301.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O54891.

    Protocols and materials databases

    DNASUi 16857.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 16857.
    KEGGi mmu:16857.
    UCSCi uc009gad.2. mouse.

    Organism-specific databases

    CTDi 16857.
    MGIi MGI:107535. Lgals6.

    Phylogenomic databases

    HOVERGENi HBG002412.
    KOi K10091.
    PhylomeDBi O54891.

    Miscellaneous databases

    NextBioi 290800.
    PROi O54891.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori O54891.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR015533. Galectin4/6.
    IPR001079. Galectin_CRD.
    [Graphical view ]
    PANTHERi PTHR11346:SF32. PTHR11346:SF32. 1 hit.
    Pfami PF00337. Gal-bind_lectin. 2 hits.
    [Graphical view ]
    SMARTi SM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    PROSITEi PS51304. GALECTIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Galectin-4 and galectin-6 are two closely related lectins expressed in mouse gastrointestinal tract."
      Gitt M.A., Colnot C., Poirier F., Nani K.J., Barondes S.H., Leffler H.
      J. Biol. Chem. 273:2954-2960(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
    2. "Sequence, structure, and chromosomal mapping of the mouse Lgals6 gene, encoding galectin-6."
      Gitt M.A., Xia Y.-R., Atchison R.E., Lusis A.J., Barondes S.H., Leffler H.
      J. Biol. Chem. 273:2961-2970(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.

    Entry informationi

    Entry nameiLEG6_MOUSE
    AccessioniPrimary (citable) accession number: O54891
    Secondary accession number(s): O88352
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3