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Protein

Galectin-6

Gene

Lgals6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-6
Short name:
Gal-6
Gene namesi
Name:Lgals6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107535. Lgals6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Galectin-6PRO_0000076939Add
BLAST

Proteomic databases

PRIDEiO54891.

Expressioni

Gene expression databases

GenevisibleiO54891. MM.

Structurei

3D structure databases

ProteinModelPortaliO54891.
SMRiO54891. Positions 13-150, 159-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 149131Galectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini173 – 301129Galectin 2PROSITE-ProRule annotationAdd
BLAST

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG002412.
InParanoidiO54891.
KOiK10091.
PhylomeDBiO54891.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYVPAPGYQ PTYNPTLPYK RPIPGGLSVG MSFYIQGTAK ENMRRFHVNF
60 70 80 90 100
AVGQDDGADV AFHFNPRFDG WDKVVFNTKQ SGRWGKEEEK SMPFQKGKHF
110 120 130 140 150
ELVFMVMPEH YKVVVNGSPF YEYGHRLPVQ MVTHLQVDGD LELQSINFFG
160 170 180 190 200
VQPAETKYPA MTGPPVFNPC LPYVGALQGG FTVRRTIIIK GYVLPTAKTF
210 220 230 240 250
AINFRVGSSE DIALHINPRI GDCLVRNSYM NGSWGTEERM VAYNPFGPGQ
260 270 280 290 300
FFDLSIRCGM DRFKVFANGI HLFNFSHRFQ ALRKINTLEI NGDLTLSYVH

I
Length:301
Mass (Da):34,112
Last modified:June 1, 1998 - v1
Checksum:i9A4DD09944EDFAB9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541A → V in AAC27244 (PubMed:9446609).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026799
, AF026796, AF026797, AF026798 Genomic DNA. Translation: AAC04508.1.
AF026794 mRNA. Translation: AAC27244.1.
RefSeqiNP_034837.1. NM_010707.2.
UniGeneiMm.210336.

Genome annotation databases

GeneIDi16857.
KEGGimmu:16857.
UCSCiuc009gad.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026799
, AF026796, AF026797, AF026798 Genomic DNA. Translation: AAC04508.1.
AF026794 mRNA. Translation: AAC27244.1.
RefSeqiNP_034837.1. NM_010707.2.
UniGeneiMm.210336.

3D structure databases

ProteinModelPortaliO54891.
SMRiO54891. Positions 13-150, 159-301.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO54891.

Protocols and materials databases

DNASUi16857.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16857.
KEGGimmu:16857.
UCSCiuc009gad.2. mouse.

Organism-specific databases

CTDi16857.
MGIiMGI:107535. Lgals6.

Phylogenomic databases

HOVERGENiHBG002412.
InParanoidiO54891.
KOiK10091.
PhylomeDBiO54891.

Miscellaneous databases

NextBioi290800.
PROiO54891.
SOURCEiSearch...

Gene expression databases

GenevisibleiO54891. MM.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Galectin-4 and galectin-6 are two closely related lectins expressed in mouse gastrointestinal tract."
    Gitt M.A., Colnot C., Poirier F., Nani K.J., Barondes S.H., Leffler H.
    J. Biol. Chem. 273:2954-2960(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
  2. "Sequence, structure, and chromosomal mapping of the mouse Lgals6 gene, encoding galectin-6."
    Gitt M.A., Xia Y.-R., Atchison R.E., Lusis A.J., Barondes S.H., Leffler H.
    J. Biol. Chem. 273:2961-2970(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.

Entry informationi

Entry nameiLEG6_MOUSE
AccessioniPrimary (citable) accession number: O54891
Secondary accession number(s): O88352
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: June 24, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.