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O54891 (LEG6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Galectin-6
Short name=Gal-6
Gene names
Name:Lgals6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Domain

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similarities

Contains 2 galectin domains.

Ontologies

Keywords
   DomainRepeat
   LigandLectin
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Galectin-6
PRO_0000076939

Regions

Domain19 – 149131Galectin 1
Domain173 – 301129Galectin 2

Experimental info

Sequence conflict1541A → V in AAC27244. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O54891 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 9A4DD09944EDFAB9

FASTA30134,112
        10         20         30         40         50         60 
MAYVPAPGYQ PTYNPTLPYK RPIPGGLSVG MSFYIQGTAK ENMRRFHVNF AVGQDDGADV 

        70         80         90        100        110        120 
AFHFNPRFDG WDKVVFNTKQ SGRWGKEEEK SMPFQKGKHF ELVFMVMPEH YKVVVNGSPF 

       130        140        150        160        170        180 
YEYGHRLPVQ MVTHLQVDGD LELQSINFFG VQPAETKYPA MTGPPVFNPC LPYVGALQGG 

       190        200        210        220        230        240 
FTVRRTIIIK GYVLPTAKTF AINFRVGSSE DIALHINPRI GDCLVRNSYM NGSWGTEERM 

       250        260        270        280        290        300 
VAYNPFGPGQ FFDLSIRCGM DRFKVFANGI HLFNFSHRFQ ALRKINTLEI NGDLTLSYVH 


I

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References

[1]"Galectin-4 and galectin-6 are two closely related lectins expressed in mouse gastrointestinal tract."
Gitt M.A., Colnot C., Poirier F., Nani K.J., Barondes S.H., Leffler H.
J. Biol. Chem. 273:2954-2960(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/Sv.
[2]"Sequence, structure, and chromosomal mapping of the mouse Lgals6 gene, encoding galectin-6."
Gitt M.A., Xia Y.-R., Atchison R.E., Lusis A.J., Barondes S.H., Leffler H.
J. Biol. Chem. 273:2961-2970(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF026799 expand/collapse EMBL AC list , AF026796, AF026797, AF026798 Genomic DNA. Translation: AAC04508.1.
AF026794 mRNA. Translation: AAC27244.1.
IPIIPI00118973.
RefSeqNP_034837.1. NM_010707.2.
UniGeneMm.210336.

3D structure databases

ProteinModelPortalO54891.
SMRO54891. Positions 13-150, 159-301.
ModBaseSearch...

Proteomic databases

PRIDEO54891.

Protocols and materials databases

DNASU16857.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID16857.
KEGGmmu:16857.
UCSCuc009gad.1. mouse.

Organism-specific databases

CTD16857.
MGIMGI:107535. Lgals6.

Phylogenomic databases

HOVERGENHBG002412.
KOK10091.

Gene expression databases

GenevestigatorO54891.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERPTHR11346:SF23. PTHR11346:SF23. 1 hit.
PfamPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMSSF49899. ConA_like_lec_gl. 2 hits.
PROSITEPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio290800.
SOURCESearch...

Entry information

Entry nameLEG6_MOUSE
AccessionPrimary (citable) accession number: O54891
Secondary accession number(s): O88352
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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