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Protein

High mobility group protein B3

Gene

Hmgb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds preferentially single-stranded DNA and unwinds double-stranded DNA.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi9 – 7971HMG box 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi93 – 16169HMG box 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: GO_Central
  2. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. chromatin remodeling Source: GO_Central
  2. negative regulation of B cell differentiation Source: MGI
  3. negative regulation of myeloid cell differentiation Source: MGI
  4. regulation of transcription, DNA-templated Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein B3
Alternative name(s):
High mobility group protein 2a
Short name:
HMG-2a
High mobility group protein 4
Short name:
HMG-4
Gene namesi
Name:Hmgb3
Synonyms:Hmg2a, Hmg4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1098219. Hmgb3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200High mobility group protein B3PRO_0000048540Add
BLAST

Proteomic databases

MaxQBiO54879.
PaxDbiO54879.
PRIDEiO54879.

PTM databases

PhosphoSiteiO54879.

Expressioni

Developmental stagei

Highly expressed in the embryo; barely detectable in the adult stage.

Gene expression databases

BgeeiO54879.
CleanExiMM_HMGB3.
ExpressionAtlasiO54879. baseline.
GenevestigatoriO54879.

Interactioni

Protein-protein interaction databases

BioGridi200336. 1 interaction.
IntActiO54879. 1 interaction.
MINTiMINT-4097577.

Structurei

3D structure databases

ProteinModelPortaliO54879.
SMRiO54879. Positions 1-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 20020Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the HMGB family.Curated
Contains 2 HMG box DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG320947.
HOGENOMiHOG000197861.
HOVERGENiHBG009000.
InParanoidiO54879.
KOiK11296.
OMAiEEWKEDD.
OrthoDBiEOG7WHHBQ.
PhylomeDBiO54879.
TreeFamiTF105371.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiIPR009071. HMG_box_dom.
IPR017967. HMG_boxA_CS.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiPS00353. HMG_BOX_1. 1 hit.
PS50118. HMG_BOX_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54879-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKGDPKKPK GKMSAYAFFV QTCREEHKKK NPEVPVNFAE FSKKCSERWK
60 70 80 90 100
TMSSKEKSKF DEMAKADKVR YDREMKDYGP AKGGKKKKDP NAPKRPPSGF
110 120 130 140 150
FLFCSEFRPK IKSTNPGISI GDVAKKLGEM WNNLSDNEKQ PYVTKAAKLK
160 170 180 190 200
EKYEKDVADY KSKGKFDGAK GPAKVARKKV EEEEEEEEEE EEEEEEEEDE
Length:200
Mass (Da):23,010
Last modified:January 23, 2007 - v3
Checksum:i34A45470D4F1B1FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022465 mRNA. Translation: AAC16925.1.
BC011276 mRNA. Translation: AAH11276.1.
BC083352 mRNA. Translation: AAH83352.1.
CCDSiCCDS30180.1.
RefSeqiNP_001280552.1. NM_001293623.1.
NP_001280553.1. NM_001293624.1.
NP_001280554.1. NM_001293625.1.
NP_032279.1. NM_008253.4.
XP_006527905.1. XM_006527842.1.
UniGeneiMm.336087.

Genome annotation databases

EnsembliENSMUST00000015361; ENSMUSP00000015361; ENSMUSG00000015217.
ENSMUST00000072699; ENSMUSP00000110232; ENSMUSG00000015217.
ENSMUST00000088874; ENSMUSP00000086260; ENSMUSG00000015217.
ENSMUST00000114582; ENSMUSP00000110229; ENSMUSG00000015217.
GeneIDi15354.
KEGGimmu:15354.
UCSCiuc009tkb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022465 mRNA. Translation: AAC16925.1.
BC011276 mRNA. Translation: AAH11276.1.
BC083352 mRNA. Translation: AAH83352.1.
CCDSiCCDS30180.1.
RefSeqiNP_001280552.1. NM_001293623.1.
NP_001280553.1. NM_001293624.1.
NP_001280554.1. NM_001293625.1.
NP_032279.1. NM_008253.4.
XP_006527905.1. XM_006527842.1.
UniGeneiMm.336087.

3D structure databases

ProteinModelPortaliO54879.
SMRiO54879. Positions 1-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200336. 1 interaction.
IntActiO54879. 1 interaction.
MINTiMINT-4097577.

PTM databases

PhosphoSiteiO54879.

Proteomic databases

MaxQBiO54879.
PaxDbiO54879.
PRIDEiO54879.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015361; ENSMUSP00000015361; ENSMUSG00000015217.
ENSMUST00000072699; ENSMUSP00000110232; ENSMUSG00000015217.
ENSMUST00000088874; ENSMUSP00000086260; ENSMUSG00000015217.
ENSMUST00000114582; ENSMUSP00000110229; ENSMUSG00000015217.
GeneIDi15354.
KEGGimmu:15354.
UCSCiuc009tkb.1. mouse.

Organism-specific databases

CTDi3149.
MGIiMGI:1098219. Hmgb3.

Phylogenomic databases

eggNOGiNOG320947.
HOGENOMiHOG000197861.
HOVERGENiHBG009000.
InParanoidiO54879.
KOiK11296.
OMAiEEWKEDD.
OrthoDBiEOG7WHHBQ.
PhylomeDBiO54879.
TreeFamiTF105371.

Miscellaneous databases

NextBioi287964.
PROiO54879.
SOURCEiSearch...

Gene expression databases

BgeeiO54879.
CleanExiMM_HMGB3.
ExpressionAtlasiO54879. baseline.
GenevestigatoriO54879.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiIPR009071. HMG_box_dom.
IPR017967. HMG_boxA_CS.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiPS00353. HMG_BOX_1. 1 hit.
PS50118. HMG_BOX_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hmg4, a new member of the Hmg1/2 gene family."
    Vaccari T., Beltrame M., Ferrari S., Bianchi M.E.
    Genomics 49:247-252(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiHMGB3_MOUSE
AccessioniPrimary (citable) accession number: O54879
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.