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O54879 (HMGB3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
High mobility group protein B3
Alternative name(s):
High mobility group protein 2a
Short name=HMG-2a
High mobility group protein 4
Short name=HMG-4
Gene names
Name:Hmgb3
Synonyms:Hmg2a, Hmg4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds preferentially single-stranded DNA and unwinds double-stranded DNA By similarity.

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Developmental stage

Highly expressed in the embryo; barely detectable in the adult stage.

Sequence similarities

Belongs to the HMGB family.

Contains 2 HMG box DNA-binding domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200High mobility group protein B3
PRO_0000048540

Regions

DNA binding9 – 7971HMG box 1
DNA binding93 – 16169HMG box 2
Compositional bias181 – 20020Asp/Glu-rich (acidic)

Sequences

Sequence LengthMass (Da)Tools
O54879 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 34A45470D4F1B1FB

FASTA20023,010
        10         20         30         40         50         60 
MAKGDPKKPK GKMSAYAFFV QTCREEHKKK NPEVPVNFAE FSKKCSERWK TMSSKEKSKF 

        70         80         90        100        110        120 
DEMAKADKVR YDREMKDYGP AKGGKKKKDP NAPKRPPSGF FLFCSEFRPK IKSTNPGISI 

       130        140        150        160        170        180 
GDVAKKLGEM WNNLSDNEKQ PYVTKAAKLK EKYEKDVADY KSKGKFDGAK GPAKVARKKV 

       190        200 
EEEEEEEEEE EEEEEEEEDE 

« Hide

References

« Hide 'large scale' references
[1]"Hmg4, a new member of the Hmg1/2 gene family."
Vaccari T., Beltrame M., Ferrari S., Bianchi M.E.
Genomics 49:247-252(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/Sv.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF022465 mRNA. Translation: AAC16925.1.
BC011276 mRNA. Translation: AAH11276.1.
BC083352 mRNA. Translation: AAH83352.1.
CCDSCCDS30180.1.
RefSeqNP_032279.1. NM_008253.3.
XP_006527904.1. XM_006527841.1.
XP_006527905.1. XM_006527842.1.
UniGeneMm.336087.

3D structure databases

ProteinModelPortalO54879.
SMRO54879. Positions 1-164.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200336. 1 interaction.
IntActO54879. 1 interaction.
MINTMINT-4097577.

PTM databases

PhosphoSiteO54879.

Proteomic databases

MaxQBO54879.
PaxDbO54879.
PRIDEO54879.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000015361; ENSMUSP00000015361; ENSMUSG00000015217.
ENSMUST00000072699; ENSMUSP00000110232; ENSMUSG00000015217.
ENSMUST00000088874; ENSMUSP00000086260; ENSMUSG00000015217.
ENSMUST00000114582; ENSMUSP00000110229; ENSMUSG00000015217.
GeneID15354.
KEGGmmu:15354.
UCSCuc009tkb.1. mouse.

Organism-specific databases

CTD3149.
MGIMGI:1098219. Hmgb3.

Phylogenomic databases

eggNOGNOG320947.
HOGENOMHOG000197861.
HOVERGENHBG009000.
InParanoidO54879.
KOK11296.
OMANEKQPYN.
OrthoDBEOG7WHHBQ.
PhylomeDBO54879.
TreeFamTF105371.

Gene expression databases

BgeeO54879.
CleanExMM_HMGB3.
GenevestigatorO54879.

Family and domain databases

Gene3D1.10.30.10. 2 hits.
InterProIPR009071. HMG_box_dom.
IPR017967. HMG_boxA_CS.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMSSF47095. SSF47095. 2 hits.
PROSITEPS00353. HMG_BOX_1. 1 hit.
PS50118. HMG_BOX_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio287964.
PROO54879.
SOURCESearch...

Entry information

Entry nameHMGB3_MOUSE
AccessionPrimary (citable) accession number: O54879
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot