Reviewed, UniProtKB/Swiss-Prot O54879 (HMGB3_MOUSE)

Names and origin

Protein names

Recommended name:
    High mobility group protein B3
Alternative name(s):
    High mobility group protein 4
      Short name=HMG-4
    High mobility group protein 2a
      Short name=HMG-2a

Gene names

Name:	Hmgb3
Synonyms:	Hmg2a, Hmg4

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Binds preferentially single-stranded DNA and unwinds double stranded DNA By similarity.
Subcellular location	Nucleus By similarity.
Developmental stage	Highly expressed in the embryo; barely detectable in the adult stage.
Sequence similarities	Belongs to the HMGB family. Contains 2 HMG box DNA-binding domains.

Ontologies

Keywords
Cellular component	Chromosomal protein Nucleus
Domain	Repeat
Ligand	DNA-binding
Gene Ontology (GO)
Biological process	negative regulation of B cell differentiation Inferred from direct assay. Source: MGI negative regulation of myeloid cell differentiation Inferred from direct assay. Source: MGI
Cellular component	chromosome Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from direct assay. Source: MGI
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 200	199	High mobility group protein B3		PRO_0000048540
Regions
	DNA binding	9 – 79	71	HMG box 1
	DNA binding	93 – 161	69	HMG box 2
	Compositional bias	181 – 200	20	Asp/Glu-rich (acidic)

Sequences

	Sequence		Length	Mass (Da)
	O54879-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 34A45470D4F1B1FB	FASTA	200	23,010
	10 20 30 40 50 60 MAKGDPKKPK GKMSAYAFFV QTCREEHKKK NPEVPVNFAE FSKKCSERWK TMSSKEKSKF 70 80 90 100 110 120 DEMAKADKVR YDREMKDYGP AKGGKKKKDP NAPKRPPSGF FLFCSEFRPK IKSTNPGISI 130 140 150 160 170 180 GDVAKKLGEM WNNLSDNEKQ PYVTKAAKLK EKYEKDVADY KSKGKFDGAK GPAKVARKKV 190 200 EEEEEEEEEE EEEEEEEEDE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Hmg4, a new member of the Hmg1/2 gene family." Vaccari T., Beltrame M., Ferrari S., Bianchi M.E. Genomics 49:247-252(1998) [PubMed: 9598312] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/Sv.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF022465 mRNA. Translation: AAC16925.1. BC011276 mRNA. Translation: AAH11276.1. BC083352 mRNA. Translation: AAH83352.1.
IPI	IPI00228879.
RefSeq	NP_032279.1.
UniGene	Mm.336087
3D structure databases
HSSP	HSSP built from PDB template 1CKT based on UniProtKB P07155.
ModBase	Search...
PTM databases
PhosphoSite	O54879.
Proteomic databases
PRIDE	O54879.
Genome annotation databases
Ensembl	ENSMUSG00000015217. Mus musculus. [Contig view]
GeneID	15354.
KEGG	mmu:15354.
Organism-specific databases
MGI	MGI:1098219. Hmgb3.
Phylogenomic databases
HOGENOM	O54879.
HOVERGEN	O54879.
OMA	O54879. DNEKQPY.
Gene expression databases
Bgee	O54879.
CleanEx	MM_HMGB3.
GermOnline	ENSMUSG00000015217. Mus musculus.
Family and domain databases
InterPro	IPR017967. HMG_boxA_CS. IPR000910. HMG_HMG1/HMG2. IPR000135. HMG_HMG1/HMG2_subgr. [Graphical view]
Gene3D	G3DSA:1.10.30.10. HMG-box. 2 hits.
Pfam	PF00505. HMG_box. 2 hits. [Graphical view]
PRINTS	PR00886. HIGHMOBLTY12.
SMART	SM00398. HMG. 2 hits. [Graphical view]
PROSITE	PS00353. HMG_BOX_1. 1 hit. PS50118. HMG_BOX_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	287964.
SOURCE	Search...

Entry information

Entry name

HMGB3_MOUSE

Accession

Primary (citable) accession number: O54879

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 76 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)