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O54879

- HMGB3_MOUSE

UniProt

O54879 - HMGB3_MOUSE

Protein

High mobility group protein B3

Gene

Hmgb3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Binds preferentially single-stranded DNA and unwinds double-stranded DNA.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi9 – 7971HMG box 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi93 – 16169HMG box 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of B cell differentiation Source: MGI
    2. negative regulation of myeloid cell differentiation Source: MGI

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High mobility group protein B3
    Alternative name(s):
    High mobility group protein 2a
    Short name:
    HMG-2a
    High mobility group protein 4
    Short name:
    HMG-4
    Gene namesi
    Name:Hmgb3
    Synonyms:Hmg2a, Hmg4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1098219. Hmgb3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200High mobility group protein B3PRO_0000048540Add
    BLAST

    Proteomic databases

    MaxQBiO54879.
    PaxDbiO54879.
    PRIDEiO54879.

    PTM databases

    PhosphoSiteiO54879.

    Expressioni

    Developmental stagei

    Highly expressed in the embryo; barely detectable in the adult stage.

    Gene expression databases

    BgeeiO54879.
    CleanExiMM_HMGB3.
    GenevestigatoriO54879.

    Interactioni

    Protein-protein interaction databases

    BioGridi200336. 1 interaction.
    IntActiO54879. 1 interaction.
    MINTiMINT-4097577.

    Structurei

    3D structure databases

    ProteinModelPortaliO54879.
    SMRiO54879. Positions 1-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi181 – 20020Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the HMGB family.Curated
    Contains 2 HMG box DNA-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG320947.
    HOGENOMiHOG000197861.
    HOVERGENiHBG009000.
    InParanoidiO54879.
    KOiK11296.
    OMAiNEKQPYN.
    OrthoDBiEOG7WHHBQ.
    PhylomeDBiO54879.
    TreeFamiTF105371.

    Family and domain databases

    Gene3Di1.10.30.10. 2 hits.
    InterProiIPR009071. HMG_box_dom.
    IPR017967. HMG_boxA_CS.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    PF09011. HMG_box_2. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 2 hits.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 2 hits.
    PROSITEiPS00353. HMG_BOX_1. 1 hit.
    PS50118. HMG_BOX_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54879-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKGDPKKPK GKMSAYAFFV QTCREEHKKK NPEVPVNFAE FSKKCSERWK    50
    TMSSKEKSKF DEMAKADKVR YDREMKDYGP AKGGKKKKDP NAPKRPPSGF 100
    FLFCSEFRPK IKSTNPGISI GDVAKKLGEM WNNLSDNEKQ PYVTKAAKLK 150
    EKYEKDVADY KSKGKFDGAK GPAKVARKKV EEEEEEEEEE EEEEEEEEDE 200
    Length:200
    Mass (Da):23,010
    Last modified:January 23, 2007 - v3
    Checksum:i34A45470D4F1B1FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022465 mRNA. Translation: AAC16925.1.
    BC011276 mRNA. Translation: AAH11276.1.
    BC083352 mRNA. Translation: AAH83352.1.
    CCDSiCCDS30180.1.
    RefSeqiNP_032279.1. NM_008253.4.
    XP_006527905.1. XM_006527842.1.
    UniGeneiMm.336087.

    Genome annotation databases

    EnsembliENSMUST00000015361; ENSMUSP00000015361; ENSMUSG00000015217.
    ENSMUST00000072699; ENSMUSP00000110232; ENSMUSG00000015217.
    ENSMUST00000088874; ENSMUSP00000086260; ENSMUSG00000015217.
    ENSMUST00000114582; ENSMUSP00000110229; ENSMUSG00000015217.
    GeneIDi15354.
    KEGGimmu:15354.
    UCSCiuc009tkb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022465 mRNA. Translation: AAC16925.1 .
    BC011276 mRNA. Translation: AAH11276.1 .
    BC083352 mRNA. Translation: AAH83352.1 .
    CCDSi CCDS30180.1.
    RefSeqi NP_032279.1. NM_008253.4.
    XP_006527905.1. XM_006527842.1.
    UniGenei Mm.336087.

    3D structure databases

    ProteinModelPortali O54879.
    SMRi O54879. Positions 1-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200336. 1 interaction.
    IntActi O54879. 1 interaction.
    MINTi MINT-4097577.

    PTM databases

    PhosphoSitei O54879.

    Proteomic databases

    MaxQBi O54879.
    PaxDbi O54879.
    PRIDEi O54879.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000015361 ; ENSMUSP00000015361 ; ENSMUSG00000015217 .
    ENSMUST00000072699 ; ENSMUSP00000110232 ; ENSMUSG00000015217 .
    ENSMUST00000088874 ; ENSMUSP00000086260 ; ENSMUSG00000015217 .
    ENSMUST00000114582 ; ENSMUSP00000110229 ; ENSMUSG00000015217 .
    GeneIDi 15354.
    KEGGi mmu:15354.
    UCSCi uc009tkb.1. mouse.

    Organism-specific databases

    CTDi 3149.
    MGIi MGI:1098219. Hmgb3.

    Phylogenomic databases

    eggNOGi NOG320947.
    HOGENOMi HOG000197861.
    HOVERGENi HBG009000.
    InParanoidi O54879.
    KOi K11296.
    OMAi NEKQPYN.
    OrthoDBi EOG7WHHBQ.
    PhylomeDBi O54879.
    TreeFami TF105371.

    Miscellaneous databases

    NextBioi 287964.
    PROi O54879.
    SOURCEi Search...

    Gene expression databases

    Bgeei O54879.
    CleanExi MM_HMGB3.
    Genevestigatori O54879.

    Family and domain databases

    Gene3Di 1.10.30.10. 2 hits.
    InterProi IPR009071. HMG_box_dom.
    IPR017967. HMG_boxA_CS.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    PF09011. HMG_box_2. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 2 hits.
    PROSITEi PS00353. HMG_BOX_1. 1 hit.
    PS50118. HMG_BOX_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hmg4, a new member of the Hmg1/2 gene family."
      Vaccari T., Beltrame M., Ferrari S., Bianchi M.E.
      Genomics 49:247-252(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye.

    Entry informationi

    Entry nameiHMGB3_MOUSE
    AccessioniPrimary (citable) accession number: O54879
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 117 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3