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O54879

- HMGB3_MOUSE

UniProt

O54879 - HMGB3_MOUSE

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Protein

High mobility group protein B3

Gene

Hmgb3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Binds preferentially single-stranded DNA and unwinds double-stranded DNA.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi9 – 7971HMG box 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi93 – 16169HMG box 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of B cell differentiation Source: MGI
  2. negative regulation of myeloid cell differentiation Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein B3
Alternative name(s):
High mobility group protein 2a
Short name:
HMG-2a
High mobility group protein 4
Short name:
HMG-4
Gene namesi
Name:Hmgb3
Synonyms:Hmg2a, Hmg4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1098219. Hmgb3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200High mobility group protein B3PRO_0000048540Add
BLAST

Proteomic databases

MaxQBiO54879.
PaxDbiO54879.
PRIDEiO54879.

PTM databases

PhosphoSiteiO54879.

Expressioni

Developmental stagei

Highly expressed in the embryo; barely detectable in the adult stage.

Gene expression databases

BgeeiO54879.
CleanExiMM_HMGB3.
ExpressionAtlasiO54879. baseline and differential.
GenevestigatoriO54879.

Interactioni

Protein-protein interaction databases

BioGridi200336. 1 interaction.
IntActiO54879. 1 interaction.
MINTiMINT-4097577.

Structurei

3D structure databases

ProteinModelPortaliO54879.
SMRiO54879. Positions 1-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 20020Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the HMGB family.Curated
Contains 2 HMG box DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG320947.
HOGENOMiHOG000197861.
HOVERGENiHBG009000.
InParanoidiO54879.
KOiK11296.
OMAiNEKQPYN.
OrthoDBiEOG7WHHBQ.
PhylomeDBiO54879.
TreeFamiTF105371.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiIPR009071. HMG_box_dom.
IPR017967. HMG_boxA_CS.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiPS00353. HMG_BOX_1. 1 hit.
PS50118. HMG_BOX_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54879-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKGDPKKPK GKMSAYAFFV QTCREEHKKK NPEVPVNFAE FSKKCSERWK
60 70 80 90 100
TMSSKEKSKF DEMAKADKVR YDREMKDYGP AKGGKKKKDP NAPKRPPSGF
110 120 130 140 150
FLFCSEFRPK IKSTNPGISI GDVAKKLGEM WNNLSDNEKQ PYVTKAAKLK
160 170 180 190 200
EKYEKDVADY KSKGKFDGAK GPAKVARKKV EEEEEEEEEE EEEEEEEEDE
Length:200
Mass (Da):23,010
Last modified:January 23, 2007 - v3
Checksum:i34A45470D4F1B1FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022465 mRNA. Translation: AAC16925.1.
BC011276 mRNA. Translation: AAH11276.1.
BC083352 mRNA. Translation: AAH83352.1.
CCDSiCCDS30180.1.
RefSeqiNP_001280552.1. NM_001293623.1.
NP_001280553.1. NM_001293624.1.
NP_001280554.1. NM_001293625.1.
NP_032279.1. NM_008253.4.
XP_006527905.1. XM_006527842.1.
UniGeneiMm.336087.

Genome annotation databases

EnsembliENSMUST00000015361; ENSMUSP00000015361; ENSMUSG00000015217.
ENSMUST00000072699; ENSMUSP00000110232; ENSMUSG00000015217.
ENSMUST00000088874; ENSMUSP00000086260; ENSMUSG00000015217.
ENSMUST00000114582; ENSMUSP00000110229; ENSMUSG00000015217.
GeneIDi15354.
KEGGimmu:15354.
UCSCiuc009tkb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022465 mRNA. Translation: AAC16925.1 .
BC011276 mRNA. Translation: AAH11276.1 .
BC083352 mRNA. Translation: AAH83352.1 .
CCDSi CCDS30180.1.
RefSeqi NP_001280552.1. NM_001293623.1.
NP_001280553.1. NM_001293624.1.
NP_001280554.1. NM_001293625.1.
NP_032279.1. NM_008253.4.
XP_006527905.1. XM_006527842.1.
UniGenei Mm.336087.

3D structure databases

ProteinModelPortali O54879.
SMRi O54879. Positions 1-164.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200336. 1 interaction.
IntActi O54879. 1 interaction.
MINTi MINT-4097577.

PTM databases

PhosphoSitei O54879.

Proteomic databases

MaxQBi O54879.
PaxDbi O54879.
PRIDEi O54879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015361 ; ENSMUSP00000015361 ; ENSMUSG00000015217 .
ENSMUST00000072699 ; ENSMUSP00000110232 ; ENSMUSG00000015217 .
ENSMUST00000088874 ; ENSMUSP00000086260 ; ENSMUSG00000015217 .
ENSMUST00000114582 ; ENSMUSP00000110229 ; ENSMUSG00000015217 .
GeneIDi 15354.
KEGGi mmu:15354.
UCSCi uc009tkb.1. mouse.

Organism-specific databases

CTDi 3149.
MGIi MGI:1098219. Hmgb3.

Phylogenomic databases

eggNOGi NOG320947.
HOGENOMi HOG000197861.
HOVERGENi HBG009000.
InParanoidi O54879.
KOi K11296.
OMAi NEKQPYN.
OrthoDBi EOG7WHHBQ.
PhylomeDBi O54879.
TreeFami TF105371.

Miscellaneous databases

NextBioi 287964.
PROi O54879.
SOURCEi Search...

Gene expression databases

Bgeei O54879.
CleanExi MM_HMGB3.
ExpressionAtlasi O54879. baseline and differential.
Genevestigatori O54879.

Family and domain databases

Gene3Di 1.10.30.10. 2 hits.
InterProi IPR009071. HMG_box_dom.
IPR017967. HMG_boxA_CS.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 2 hits.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 2 hits.
PROSITEi PS00353. HMG_BOX_1. 1 hit.
PS50118. HMG_BOX_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hmg4, a new member of the Hmg1/2 gene family."
    Vaccari T., Beltrame M., Ferrari S., Bianchi M.E.
    Genomics 49:247-252(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiHMGB3_MOUSE
AccessioniPrimary (citable) accession number: O54879
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3