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O54865

- GCYB1_MOUSE

UniProt

O54865 - GCYB1_MOUSE

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Protein

Guanylate cyclase soluble subunit beta-1

Gene

Gucy1b3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

Cofactori

hemeBy similarityNote: Binds 1 or 2 heme groups per heterodimer.By similarity

Enzyme regulationi

Activated by nitric oxide in the presence of magnesium or manganese ions.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi105 – 1051Iron (heme proximal ligand)By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. guanylate cyclase activity Source: UniProtKB-EC
  3. heme binding Source: Ensembl
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. nitric oxide mediated signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cGMP biosynthesis

Keywords - Ligandi

GTP-binding, Heme, Iron, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_245499. Nitric oxide stimulates guanylate cyclase.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclase soluble subunit beta-1 (EC:4.6.1.2)
Short name:
GCS-beta-1
Alternative name(s):
Guanylate cyclase soluble subunit beta-3
Short name:
GCS-beta-3
Soluble guanylate cyclase small subunit
Gene namesi
Name:Gucy1b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1860604. Gucy1b3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. guanylate cyclase complex, soluble Source: Ensembl
  2. intracellular membrane-bounded organelle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620Guanylate cyclase soluble subunit beta-1PRO_0000074117Add
BLAST

Proteomic databases

MaxQBiO54865.
PaxDbiO54865.
PRIDEiO54865.

PTM databases

PhosphoSiteiO54865.

Expressioni

Gene expression databases

BgeeiO54865.
CleanExiMM_GUCY1B3.
ExpressionAtlasiO54865. baseline and differential.
GenevestigatoriO54865.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

IntActiO54865. 1 interaction.
MINTiMINT-4105057.
STRINGi10090.ENSMUSP00000029635.

Structurei

3D structure databases

ProteinModelPortaliO54865.
SMRiO54865. Positions 1-182, 212-334, 348-408, 411-608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini421 – 554134Guanylate cyclasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000118959.
HOGENOMiHOG000220903.
HOVERGENiHBG051715.
InParanoidiO54865.
KOiK12319.
OMAiVLMSEQF.
OrthoDBiEOG7BS48T.
PhylomeDBiO54865.
TreeFamiTF351403.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR011645. Haem_no_assoc-bd.
IPR011644. Heme_NO-bd.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF07700. HNOB. 1 hit.
PF07701. HNOBA. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF111126. SSF111126. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54865-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD
60 70 80 90 100
LVAAASKVLN LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQN
110 120 130 140 150
LDALHDHLAT IYPGMRAPSF RCTDAEKGKG LILHYYSERE GLQDIVIGII
160 170 180 190 200
KTVAQQIHGT EIDMKVIQQR NEECDHTQFL IEEKESKEED FYEDLDRFEE
210 220 230 240 250
NGTQESRISP YTFCKAFPFH IIFDRNLVVT QCGNAIYRVL PQLQPGNCSL
260 270 280 290 300
LSVFSLVRPH IDISFHGILS HINTVFVLRS KEGLLDVEKL ECEDELTGAE
310 320 330 340 350
ISCLRLKGQM IYLPEADSIL FLCSPSVMNL DDLTRRGLYL SDIPLHDATR
360 370 380 390 400
DLVLLGEQFR EEYKLTQELE ILTDRLQLTL RALEDEKKKT DTLLYSVLPP
410 420 430 440 450
SVANELRHKR PVPAKRYDNV TILFSGIVGF NAFCSKHASG EGAMKIVNLL
460 470 480 490 500
NDLYTRFDTL TDSRKNPFVY KVETVGDKYM TVSGLPEPCI HHARSICHLA
510 520 530 540 550
LDMMEIAGQV QVDGESVQIT IGIHTGEVVT GVIGQRMPRY CLFGNTVNLT
560 570 580 590 600
SRTETTGEKG KINVSEYTYR CLMSPENSDP LFHLEHRGPV SMKGKKEPMQ
610 620
VWFLSRKNTG TEETNEEDEN
Length:620
Mass (Da):70,598
Last modified:June 1, 1998 - v1
Checksum:iEED89ABF539F4EF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020339 mRNA. Translation: AAB94876.1.
AF297083 mRNA. Translation: AAG17447.1.
CCDSiCCDS38460.1.
RefSeqiNP_059497.1. NM_017469.4.
UniGeneiMm.9445.

Genome annotation databases

EnsembliENSMUST00000029635; ENSMUSP00000029635; ENSMUSG00000028005.
GeneIDi54195.
KEGGimmu:54195.
UCSCiuc008por.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020339 mRNA. Translation: AAB94876.1 .
AF297083 mRNA. Translation: AAG17447.1 .
CCDSi CCDS38460.1.
RefSeqi NP_059497.1. NM_017469.4.
UniGenei Mm.9445.

3D structure databases

ProteinModelPortali O54865.
SMRi O54865. Positions 1-182, 212-334, 348-408, 411-608.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O54865. 1 interaction.
MINTi MINT-4105057.
STRINGi 10090.ENSMUSP00000029635.

PTM databases

PhosphoSitei O54865.

Proteomic databases

MaxQBi O54865.
PaxDbi O54865.
PRIDEi O54865.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029635 ; ENSMUSP00000029635 ; ENSMUSG00000028005 .
GeneIDi 54195.
KEGGi mmu:54195.
UCSCi uc008por.2. mouse.

Organism-specific databases

CTDi 2983.
MGIi MGI:1860604. Gucy1b3.

Phylogenomic databases

eggNOGi COG2114.
GeneTreei ENSGT00760000118959.
HOGENOMi HOG000220903.
HOVERGENi HBG051715.
InParanoidi O54865.
KOi K12319.
OMAi VLMSEQF.
OrthoDBi EOG7BS48T.
PhylomeDBi O54865.
TreeFami TF351403.

Enzyme and pathway databases

Reactomei REACT_245499. Nitric oxide stimulates guanylate cyclase.

Miscellaneous databases

NextBioi 311038.
PROi O54865.
SOURCEi Search...

Gene expression databases

Bgeei O54865.
CleanExi MM_GUCY1B3.
ExpressionAtlasi O54865. baseline and differential.
Genevestigatori O54865.

Family and domain databases

Gene3Di 3.30.70.1230. 1 hit.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR011645. Haem_no_assoc-bd.
IPR011644. Heme_NO-bd.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR029787. Nucleotide_cyclase.
[Graphical view ]
Pfami PF00211. Guanylate_cyc. 1 hit.
PF07700. HNOB. 1 hit.
PF07701. HNOBA. 1 hit.
[Graphical view ]
SMARTi SM00044. CYCc. 1 hit.
[Graphical view ]
SUPFAMi SSF111126. SSF111126. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Murine soluble guanylate cyclase, beta-1 subunit."
    Gansemans Y., Brouckaert P., Fiers W.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Genomic organization of alpha 1 and beta 1 subunits of the mammalian soluble guanylyl cyclase genes."
    Sharina I.G., Krumenacker J.S., Martin E., Murad F.
    Proc. Natl. Acad. Sci. U.S.A. 97:10878-10883(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/10.

Entry informationi

Entry nameiGCYB1_MOUSE
AccessioniPrimary (citable) accession number: O54865
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3