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O54865

- GCYB1_MOUSE

UniProt

O54865 - GCYB1_MOUSE

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Protein

Guanylate cyclase soluble subunit beta-1

Gene
Gucy1b3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

Cofactori

Binds 1 or 2 heme groups per heterodimer By similarity.

Enzyme regulationi

Activated by nitric oxide in the presence of magnesium or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi105 – 1051Iron (heme proximal ligand) By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. guanylate cyclase activity Source: UniProtKB-EC
  3. heme binding Source: Ensembl
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. nitric oxide mediated signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cGMP biosynthesis

Keywords - Ligandi

GTP-binding, Heme, Iron, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclase soluble subunit beta-1 (EC:4.6.1.2)
Short name:
GCS-beta-1
Alternative name(s):
Guanylate cyclase soluble subunit beta-3
Short name:
GCS-beta-3
Soluble guanylate cyclase small subunit
Gene namesi
Name:Gucy1b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1860604. Gucy1b3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. guanylate cyclase complex, soluble Source: Ensembl
  2. intracellular membrane-bounded organelle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620Guanylate cyclase soluble subunit beta-1PRO_0000074117Add
BLAST

Proteomic databases

MaxQBiO54865.
PaxDbiO54865.
PRIDEiO54865.

PTM databases

PhosphoSiteiO54865.

Expressioni

Gene expression databases

ArrayExpressiO54865.
BgeeiO54865.
CleanExiMM_GUCY1B3.
GenevestigatoriO54865.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

IntActiO54865. 1 interaction.
MINTiMINT-4105057.
STRINGi10090.ENSMUSP00000029635.

Structurei

3D structure databases

ProteinModelPortaliO54865.
SMRiO54865. Positions 1-182, 212-334, 348-408, 412-610.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini421 – 554134Guanylate cyclaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00750000117642.
HOGENOMiHOG000220903.
HOVERGENiHBG051715.
InParanoidiO54865.
KOiK12319.
OMAiVLMSEQF.
OrthoDBiEOG7BS48T.
PhylomeDBiO54865.
TreeFamiTF351403.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR011645. Haem_no_assoc-bd.
IPR011644. Heme_NO-bd.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF07700. HNOB. 1 hit.
PF07701. HNOBA. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF111126. SSF111126. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54865-1 [UniParc]FASTAAdd to Basket

« Hide

MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD    50
LVAAASKVLN LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQN 100
LDALHDHLAT IYPGMRAPSF RCTDAEKGKG LILHYYSERE GLQDIVIGII 150
KTVAQQIHGT EIDMKVIQQR NEECDHTQFL IEEKESKEED FYEDLDRFEE 200
NGTQESRISP YTFCKAFPFH IIFDRNLVVT QCGNAIYRVL PQLQPGNCSL 250
LSVFSLVRPH IDISFHGILS HINTVFVLRS KEGLLDVEKL ECEDELTGAE 300
ISCLRLKGQM IYLPEADSIL FLCSPSVMNL DDLTRRGLYL SDIPLHDATR 350
DLVLLGEQFR EEYKLTQELE ILTDRLQLTL RALEDEKKKT DTLLYSVLPP 400
SVANELRHKR PVPAKRYDNV TILFSGIVGF NAFCSKHASG EGAMKIVNLL 450
NDLYTRFDTL TDSRKNPFVY KVETVGDKYM TVSGLPEPCI HHARSICHLA 500
LDMMEIAGQV QVDGESVQIT IGIHTGEVVT GVIGQRMPRY CLFGNTVNLT 550
SRTETTGEKG KINVSEYTYR CLMSPENSDP LFHLEHRGPV SMKGKKEPMQ 600
VWFLSRKNTG TEETNEEDEN 620
Length:620
Mass (Da):70,598
Last modified:June 1, 1998 - v1
Checksum:iEED89ABF539F4EF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF020339 mRNA. Translation: AAB94876.1.
AF297083 mRNA. Translation: AAG17447.1.
CCDSiCCDS38460.1.
RefSeqiNP_059497.1. NM_017469.4.
UniGeneiMm.9445.

Genome annotation databases

EnsembliENSMUST00000029635; ENSMUSP00000029635; ENSMUSG00000028005.
GeneIDi54195.
KEGGimmu:54195.
UCSCiuc008por.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF020339 mRNA. Translation: AAB94876.1 .
AF297083 mRNA. Translation: AAG17447.1 .
CCDSi CCDS38460.1.
RefSeqi NP_059497.1. NM_017469.4.
UniGenei Mm.9445.

3D structure databases

ProteinModelPortali O54865.
SMRi O54865. Positions 1-182, 212-334, 348-408, 412-610.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O54865. 1 interaction.
MINTi MINT-4105057.
STRINGi 10090.ENSMUSP00000029635.

PTM databases

PhosphoSitei O54865.

Proteomic databases

MaxQBi O54865.
PaxDbi O54865.
PRIDEi O54865.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029635 ; ENSMUSP00000029635 ; ENSMUSG00000028005 .
GeneIDi 54195.
KEGGi mmu:54195.
UCSCi uc008por.2. mouse.

Organism-specific databases

CTDi 2983.
MGIi MGI:1860604. Gucy1b3.

Phylogenomic databases

eggNOGi COG2114.
GeneTreei ENSGT00750000117642.
HOGENOMi HOG000220903.
HOVERGENi HBG051715.
InParanoidi O54865.
KOi K12319.
OMAi VLMSEQF.
OrthoDBi EOG7BS48T.
PhylomeDBi O54865.
TreeFami TF351403.

Miscellaneous databases

NextBioi 311038.
PROi O54865.
SOURCEi Search...

Gene expression databases

ArrayExpressi O54865.
Bgeei O54865.
CleanExi MM_GUCY1B3.
Genevestigatori O54865.

Family and domain databases

Gene3Di 3.30.70.1230. 1 hit.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR011645. Haem_no_assoc-bd.
IPR011644. Heme_NO-bd.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
[Graphical view ]
Pfami PF00211. Guanylate_cyc. 1 hit.
PF07700. HNOB. 1 hit.
PF07701. HNOBA. 1 hit.
[Graphical view ]
SMARTi SM00044. CYCc. 1 hit.
[Graphical view ]
SUPFAMi SSF111126. SSF111126. 1 hit.
SSF55073. SSF55073. 1 hit.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Murine soluble guanylate cyclase, beta-1 subunit."
    Gansemans Y., Brouckaert P., Fiers W.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Genomic organization of alpha 1 and beta 1 subunits of the mammalian soluble guanylyl cyclase genes."
    Sharina I.G., Krumenacker J.S., Martin E., Murad F.
    Proc. Natl. Acad. Sci. U.S.A. 97:10878-10883(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/10.

Entry informationi

Entry nameiGCYB1_MOUSE
AccessioniPrimary (citable) accession number: O54865
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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