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O54865

- GCYB1_MOUSE

UniProt

O54865 - GCYB1_MOUSE

Protein

Guanylate cyclase soluble subunit beta-1

Gene

Gucy1b3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    GTP = 3',5'-cyclic GMP + diphosphate.

    Cofactori

    Binds 1 or 2 heme groups per heterodimer.By similarity

    Enzyme regulationi

    Activated by nitric oxide in the presence of magnesium or manganese ions.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi105 – 1051Iron (heme proximal ligand)By similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. guanylate cyclase activity Source: UniProtKB-EC
    3. heme binding Source: Ensembl
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. nitric oxide mediated signal transduction Source: Ensembl

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cGMP biosynthesis

    Keywords - Ligandi

    GTP-binding, Heme, Iron, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanylate cyclase soluble subunit beta-1 (EC:4.6.1.2)
    Short name:
    GCS-beta-1
    Alternative name(s):
    Guanylate cyclase soluble subunit beta-3
    Short name:
    GCS-beta-3
    Soluble guanylate cyclase small subunit
    Gene namesi
    Name:Gucy1b3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1860604. Gucy1b3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. guanylate cyclase complex, soluble Source: Ensembl
    2. intracellular membrane-bounded organelle Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 620620Guanylate cyclase soluble subunit beta-1PRO_0000074117Add
    BLAST

    Proteomic databases

    MaxQBiO54865.
    PaxDbiO54865.
    PRIDEiO54865.

    PTM databases

    PhosphoSiteiO54865.

    Expressioni

    Gene expression databases

    ArrayExpressiO54865.
    BgeeiO54865.
    CleanExiMM_GUCY1B3.
    GenevestigatoriO54865.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.

    Protein-protein interaction databases

    IntActiO54865. 1 interaction.
    MINTiMINT-4105057.
    STRINGi10090.ENSMUSP00000029635.

    Structurei

    3D structure databases

    ProteinModelPortaliO54865.
    SMRiO54865. Positions 1-182, 212-334, 348-408, 412-610.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini421 – 554134Guanylate cyclasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2114.
    GeneTreeiENSGT00750000117642.
    HOGENOMiHOG000220903.
    HOVERGENiHBG051715.
    InParanoidiO54865.
    KOiK12319.
    OMAiVLMSEQF.
    OrthoDBiEOG7BS48T.
    PhylomeDBiO54865.
    TreeFamiTF351403.

    Family and domain databases

    Gene3Di3.30.70.1230. 1 hit.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR011645. Haem_no_assoc-bd.
    IPR011644. Heme_NO-bd.
    IPR024096. NO_sig/Golgi_transp_ligand-bd.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 1 hit.
    PF07700. HNOB. 1 hit.
    PF07701. HNOBA. 1 hit.
    [Graphical view]
    SMARTiSM00044. CYCc. 1 hit.
    [Graphical view]
    SUPFAMiSSF111126. SSF111126. 1 hit.
    SSF55073. SSF55073. 1 hit.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54865-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD    50
    LVAAASKVLN LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQN 100
    LDALHDHLAT IYPGMRAPSF RCTDAEKGKG LILHYYSERE GLQDIVIGII 150
    KTVAQQIHGT EIDMKVIQQR NEECDHTQFL IEEKESKEED FYEDLDRFEE 200
    NGTQESRISP YTFCKAFPFH IIFDRNLVVT QCGNAIYRVL PQLQPGNCSL 250
    LSVFSLVRPH IDISFHGILS HINTVFVLRS KEGLLDVEKL ECEDELTGAE 300
    ISCLRLKGQM IYLPEADSIL FLCSPSVMNL DDLTRRGLYL SDIPLHDATR 350
    DLVLLGEQFR EEYKLTQELE ILTDRLQLTL RALEDEKKKT DTLLYSVLPP 400
    SVANELRHKR PVPAKRYDNV TILFSGIVGF NAFCSKHASG EGAMKIVNLL 450
    NDLYTRFDTL TDSRKNPFVY KVETVGDKYM TVSGLPEPCI HHARSICHLA 500
    LDMMEIAGQV QVDGESVQIT IGIHTGEVVT GVIGQRMPRY CLFGNTVNLT 550
    SRTETTGEKG KINVSEYTYR CLMSPENSDP LFHLEHRGPV SMKGKKEPMQ 600
    VWFLSRKNTG TEETNEEDEN 620
    Length:620
    Mass (Da):70,598
    Last modified:June 1, 1998 - v1
    Checksum:iEED89ABF539F4EF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020339 mRNA. Translation: AAB94876.1.
    AF297083 mRNA. Translation: AAG17447.1.
    CCDSiCCDS38460.1.
    RefSeqiNP_059497.1. NM_017469.4.
    UniGeneiMm.9445.

    Genome annotation databases

    EnsembliENSMUST00000029635; ENSMUSP00000029635; ENSMUSG00000028005.
    GeneIDi54195.
    KEGGimmu:54195.
    UCSCiuc008por.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020339 mRNA. Translation: AAB94876.1 .
    AF297083 mRNA. Translation: AAG17447.1 .
    CCDSi CCDS38460.1.
    RefSeqi NP_059497.1. NM_017469.4.
    UniGenei Mm.9445.

    3D structure databases

    ProteinModelPortali O54865.
    SMRi O54865. Positions 1-182, 212-334, 348-408, 412-610.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O54865. 1 interaction.
    MINTi MINT-4105057.
    STRINGi 10090.ENSMUSP00000029635.

    PTM databases

    PhosphoSitei O54865.

    Proteomic databases

    MaxQBi O54865.
    PaxDbi O54865.
    PRIDEi O54865.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029635 ; ENSMUSP00000029635 ; ENSMUSG00000028005 .
    GeneIDi 54195.
    KEGGi mmu:54195.
    UCSCi uc008por.2. mouse.

    Organism-specific databases

    CTDi 2983.
    MGIi MGI:1860604. Gucy1b3.

    Phylogenomic databases

    eggNOGi COG2114.
    GeneTreei ENSGT00750000117642.
    HOGENOMi HOG000220903.
    HOVERGENi HBG051715.
    InParanoidi O54865.
    KOi K12319.
    OMAi VLMSEQF.
    OrthoDBi EOG7BS48T.
    PhylomeDBi O54865.
    TreeFami TF351403.

    Miscellaneous databases

    NextBioi 311038.
    PROi O54865.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O54865.
    Bgeei O54865.
    CleanExi MM_GUCY1B3.
    Genevestigatori O54865.

    Family and domain databases

    Gene3Di 3.30.70.1230. 1 hit.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR011645. Haem_no_assoc-bd.
    IPR011644. Heme_NO-bd.
    IPR024096. NO_sig/Golgi_transp_ligand-bd.
    [Graphical view ]
    Pfami PF00211. Guanylate_cyc. 1 hit.
    PF07700. HNOB. 1 hit.
    PF07701. HNOBA. 1 hit.
    [Graphical view ]
    SMARTi SM00044. CYCc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111126. SSF111126. 1 hit.
    SSF55073. SSF55073. 1 hit.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine soluble guanylate cyclase, beta-1 subunit."
      Gansemans Y., Brouckaert P., Fiers W.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Genomic organization of alpha 1 and beta 1 subunits of the mammalian soluble guanylyl cyclase genes."
      Sharina I.G., Krumenacker J.S., Martin E., Murad F.
      Proc. Natl. Acad. Sci. U.S.A. 97:10878-10883(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/10.

    Entry informationi

    Entry nameiGCYB1_MOUSE
    AccessioniPrimary (citable) accession number: O54865
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3