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O54865 (GCYB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate cyclase soluble subunit beta-1
Short name=GCS-beta-1
EC=4.6.1.2
Alternative name(s):
Guanylate cyclase soluble subunit beta-3
Short name=GCS-beta-3
Soluble guanylate cyclase small subunit
Gene names
Name:Gucy1b3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length620 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

GTP = 3',5'-cyclic GMP + diphosphate.

Cofactor

Binds 1 or 2 heme groups per heterodimer By similarity.

Enzyme regulation

Activated by nitric oxide in the presence of magnesium or manganese ions By similarity.

Subunit structure

Heterodimer of an alpha and a beta chain.

Subcellular location

Cytoplasm By similarity.

Miscellaneous

There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 1 guanylate cyclase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 620620Guanylate cyclase soluble subunit beta-1
PRO_0000074117

Regions

Domain421 – 554134Guanylate cyclase

Sites

Metal binding1051Iron (heme proximal ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O54865 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: EED89ABF539F4EF9

FASTA62070,598
        10         20         30         40         50         60 
MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD LVAAASKVLN 

        70         80         90        100        110        120 
LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQN LDALHDHLAT IYPGMRAPSF 

       130        140        150        160        170        180 
RCTDAEKGKG LILHYYSERE GLQDIVIGII KTVAQQIHGT EIDMKVIQQR NEECDHTQFL 

       190        200        210        220        230        240 
IEEKESKEED FYEDLDRFEE NGTQESRISP YTFCKAFPFH IIFDRNLVVT QCGNAIYRVL 

       250        260        270        280        290        300 
PQLQPGNCSL LSVFSLVRPH IDISFHGILS HINTVFVLRS KEGLLDVEKL ECEDELTGAE 

       310        320        330        340        350        360 
ISCLRLKGQM IYLPEADSIL FLCSPSVMNL DDLTRRGLYL SDIPLHDATR DLVLLGEQFR 

       370        380        390        400        410        420 
EEYKLTQELE ILTDRLQLTL RALEDEKKKT DTLLYSVLPP SVANELRHKR PVPAKRYDNV 

       430        440        450        460        470        480 
TILFSGIVGF NAFCSKHASG EGAMKIVNLL NDLYTRFDTL TDSRKNPFVY KVETVGDKYM 

       490        500        510        520        530        540 
TVSGLPEPCI HHARSICHLA LDMMEIAGQV QVDGESVQIT IGIHTGEVVT GVIGQRMPRY 

       550        560        570        580        590        600 
CLFGNTVNLT SRTETTGEKG KINVSEYTYR CLMSPENSDP LFHLEHRGPV SMKGKKEPMQ 

       610        620 
VWFLSRKNTG TEETNEEDEN

« Hide

References

[1]"Murine soluble guanylate cyclase, beta-1 subunit."
Gansemans Y., Brouckaert P., Fiers W.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"Genomic organization of alpha 1 and beta 1 subunits of the mammalian soluble guanylyl cyclase genes."
Sharina I.G., Krumenacker J.S., Martin E., Murad F.
Proc. Natl. Acad. Sci. U.S.A. 97:10878-10883(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/10.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF020339 mRNA. Translation: AAB94876.1.
AF297083 mRNA. Translation: AAG17447.1.
IPIIPI00118880.
RefSeqNP_059497.1. NM_017469.4.
UniGeneMm.9445.

3D structure databases

ProteinModelPortalO54865.
SMRO54865. Positions 1-182, 208-325, 348-408, 412-610.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000029635.

PTM databases

PhosphoSiteO54865.

Proteomic databases

PaxDbO54865.
PRIDEO54865.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029635; ENSMUSP00000029635; ENSMUSG00000028005.
GeneID54195.
KEGGmmu:54195.
UCSCuc008por.2. mouse.

Organism-specific databases

CTD2983.
MGIMGI:1860604. Gucy1b3.

Phylogenomic databases

eggNOGCOG2114.
GeneTreeENSGT00690000101902.
HOGENOMHOG000220903.
HOVERGENHBG051715.
InParanoidO54865.
KOK12319.
OMAQYGFVNH.
OrthoDBEOG41RPTG.

Gene expression databases

ArrayExpressO54865.
BgeeO54865.
CleanExMM_GUCY1B3.
GenevestigatorO54865.
GermOnlineENSMUSG00000028005. Mus musculus.

Family and domain databases

Gene3D3.30.70.1230. 1 hit.
InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR011645. Haem_no_assoc-bd.
IPR011644. Heme_NO-bd.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
[Graphical view]
PfamPF00211. Guanylate_cyc. 1 hit.
PF07700. HNOB. 1 hit.
PF07701. HNOBA. 1 hit.
[Graphical view]
SMARTSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMSSF55073. A/G_cyclase. 1 hit.
SSF111126. Haem_NO-bd. 1 hit.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311038.
SOURCESearch...

Entry information

Entry nameGCYB1_MOUSE
AccessionPrimary (citable) accession number: O54865
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 1998
Last modified: May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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