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O54857

- O54857_RAT

UniProt

O54857 - O54857_RAT

Protein
Submitted name:

Phosphatase and tensin homolog, isoform CRA_a

Gene

Pten

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity Source: Ensembl
    2. magnesium ion binding Source: InterPro
    3. PDZ domain binding Source: RGD
    4. phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Source: RGD
    5. phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity Source: Ensembl
    6. phosphatidylinositol-3-phosphatase activity Source: Ensembl
    7. platelet-derived growth factor receptor binding Source: RGD
    8. protein binding Source: UniProtKB
    9. protein serine/threonine phosphatase activity Source: Ensembl
    10. protein tyrosine/serine/threonine phosphatase activity Source: RGD
    11. protein tyrosine phosphatase activity Source: Ensembl

    GO - Biological processi

    1. activation of mitotic anaphase-promoting complex activity Source: Ensembl
    2. aging Source: RGD
    3. angiogenesis Source: Ensembl
    4. canonical Wnt signaling pathway Source: Ensembl
    5. cardiac muscle tissue development Source: Ensembl
    6. central nervous system myelin maintenance Source: Ensembl
    7. central nervous system neuron axonogenesis Source: Ensembl
    8. dendritic spine morphogenesis Source: Ensembl
    9. dentate gyrus development Source: Ensembl
    10. endothelial cell migration Source: Ensembl
    11. forebrain morphogenesis Source: Ensembl
    12. inositol phosphate dephosphorylation Source: Ensembl
    13. locomotor rhythm Source: Ensembl
    14. long term synaptic depression Source: RGD
    15. long-term synaptic potentiation Source: Ensembl
    16. male mating behavior Source: Ensembl
    17. maternal behavior Source: Ensembl
    18. memory Source: RGD
    19. multicellular organismal response to stress Source: Ensembl
    20. negative regulation of apoptotic process Source: Ensembl
    21. negative regulation of axonogenesis Source: Ensembl
    22. negative regulation of cell aging Source: Ensembl
    23. negative regulation of cell migration Source: Ensembl
    24. negative regulation of cell proliferation Source: RGD
    25. negative regulation of cell size Source: Ensembl
    26. negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: Ensembl
    27. negative regulation of dendritic spine morphogenesis Source: Ensembl
    28. negative regulation of epithelial cell proliferation Source: Ensembl
    29. negative regulation of excitatory postsynaptic membrane potential Source: Ensembl
    30. negative regulation of focal adhesion assembly Source: Ensembl
    31. negative regulation of myelination Source: Ensembl
    32. negative regulation of organ growth Source: Ensembl
    33. negative regulation of phagocytosis Source: RGD
    34. negative regulation of protein kinase B signaling Source: Ensembl
    35. negative regulation of ribosome biogenesis Source: Ensembl
    36. negative regulation of synaptic vesicle clustering Source: Ensembl
    37. neuron-neuron synaptic transmission Source: Ensembl
    38. neuron projection development Source: RGD
    39. phosphatidylinositol dephosphorylation Source: RGD
    40. platelet-derived growth factor receptor signaling pathway Source: RGD
    41. positive regulation of apoptotic process Source: RGD
    42. positive regulation of apoptotic signaling pathway Source: Ensembl
    43. positive regulation of cell proliferation Source: Ensembl
    44. positive regulation of excitatory postsynaptic membrane potential Source: Ensembl
    45. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
    46. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    47. postsynaptic density assembly Source: Ensembl
    48. prepulse inhibition Source: Ensembl
    49. presynaptic membrane assembly Source: Ensembl
    50. prostate gland growth Source: Ensembl
    51. protein kinase B signaling Source: Ensembl
    52. protein stabilization Source: Ensembl
    53. regulation of B cell apoptotic process Source: Ensembl
    54. regulation of myeloid cell apoptotic process Source: Ensembl
    55. response to arsenic-containing substance Source: RGD
    56. response to ATP Source: RGD
    57. response to drug Source: RGD
    58. response to estradiol Source: RGD
    59. response to ethanol Source: RGD
    60. response to glucose Source: RGD
    61. response to inorganic substance Source: RGD
    62. response to nutrient Source: RGD
    63. response to organic cyclic compound Source: RGD
    64. response to organic substance Source: RGD
    65. response to zinc ion Source: RGD
    66. rhythmic synaptic transmission Source: Ensembl
    67. social behavior Source: Ensembl
    68. synapse maturation Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_198600. Synthesis of PIPs at the plasma membrane.
    REACT_198661. Synthesis of IP3 and IP4 in the cytosol.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Phosphatase and tensin homolog, isoform CRA_aImported
    Submitted name:
    Protein PtenImported
    Submitted name:
    Protein tyrosine phosphatase and tensin homolog/mutated in multiple advanced cancers proteinImported
    Submitted name:
    Protein tyrosine phosphatase and tensin-like proteinImported
    Gene namesi
    Name:PtenImported
    Synonyms:PTEN/MMAC1Imported
    ORF Names:rCG_47874Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi61995. Pten.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. cytoplasmic side of plasma membrane Source: Ensembl
    3. dendritic spine Source: RGD
    4. mitochondrion Source: RGD
    5. myelin sheath adaxonal region Source: Ensembl
    6. neuron projection Source: RGD
    7. nucleus Source: RGD
    8. postsynaptic membrane Source: RGD
    9. Schmidt-Lanterman incisure Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriO54857.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Dbn1Q072663EBI-8074312,EBI-918187
    Dlg4P310165EBI-8074312,EBI-375655

    Protein-protein interaction databases

    MINTiMINT-4583512.
    STRINGi10116.ENSRNOP00000028143.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2K20NMR-B393-403[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO54857.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00620000087779.
    HOGENOMiHOG000008008.
    HOVERGENiHBG000239.
    InParanoidiO54857.
    KOiK01110.
    OMAiKEYLILT.
    OrthoDBiEOG7R2BJ5.
    TreeFamiTF324513.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR017361. Bifunc_PIno_P3_Pase/Pase_PTEN.
    IPR000008. C2_dom.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR014020. Tensin_C2-dom.
    IPR029023. Tensin_lipid_phosphatase_dom.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PfamiPF00782. DSPc. 1 hit.
    PF10409. PTEN_C2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038025. PTEN. 1 hit.
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF52799. SSF52799. 1 hit.
    PROSITEiPS51182. C2_TENSIN. 1 hit.
    PS51181. PPASE_TENSIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54857-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI    50
    DDVVRFLDSK HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL 100
    IKPFCEDLDQ WLSEDDNHVA AIHCKAGKGR TGVMICAYLL HRGKFLKAQE 150
    ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY LLKNHLDYRP VALLFHKMMF 200
    ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKLMY FEFPQPLPVC 250
    GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI 300
    DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT 350
    VEEPSNPEAS SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHSQI 400
    TKV 403
    Length:403
    Mass (Da):47,118
    Last modified:June 1, 1998 - v1
    Checksum:i243BFE35FE209FE5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06010605 Genomic DNA. No translation available.
    AABR06010606 Genomic DNA. No translation available.
    AABR06010607 Genomic DNA. No translation available.
    AF017185 mRNA. Translation: AAB96620.1.
    AF455569 mRNA. Translation: AAO31948.1.
    CH473953 Genomic DNA. Translation: EDM13141.1.
    RefSeqiNP_113794.1. NM_031606.1.
    UniGeneiRn.22158.

    Genome annotation databases

    EnsembliENSRNOT00000028143; ENSRNOP00000028143; ENSRNOG00000020723.
    GeneIDi50557.
    KEGGirno:50557.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06010605 Genomic DNA. No translation available.
    AABR06010606 Genomic DNA. No translation available.
    AABR06010607 Genomic DNA. No translation available.
    AF017185 mRNA. Translation: AAB96620.1 .
    AF455569 mRNA. Translation: AAO31948.1 .
    CH473953 Genomic DNA. Translation: EDM13141.1 .
    RefSeqi NP_113794.1. NM_031606.1.
    UniGenei Rn.22158.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2K20 NMR - B 393-403 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4583512.
    STRINGi 10116.ENSRNOP00000028143.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028143 ; ENSRNOP00000028143 ; ENSRNOG00000020723 .
    GeneIDi 50557.
    KEGGi rno:50557.

    Organism-specific databases

    CTDi 5728.
    RGDi 61995. Pten.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00620000087779.
    HOGENOMi HOG000008008.
    HOVERGENi HBG000239.
    InParanoidi O54857.
    KOi K01110.
    OMAi KEYLILT.
    OrthoDBi EOG7R2BJ5.
    TreeFami TF324513.

    Enzyme and pathway databases

    Reactomei REACT_198600. Synthesis of PIPs at the plasma membrane.
    REACT_198661. Synthesis of IP3 and IP4 in the cytosol.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.

    Miscellaneous databases

    EvolutionaryTracei O54857.
    NextBioi 610364.
    PROi O54857.

    Gene expression databases

    Genevestigatori O54857.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR017361. Bifunc_PIno_P3_Pase/Pase_PTEN.
    IPR000008. C2_dom.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR014020. Tensin_C2-dom.
    IPR029023. Tensin_lipid_phosphatase_dom.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    Pfami PF00782. DSPc. 1 hit.
    PF10409. PTEN_C2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038025. PTEN. 1 hit.
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF52799. SSF52799. 1 hit.
    PROSITEi PS51182. C2_TENSIN. 1 hit.
    PS51181. PPASE_TENSIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Roz L., Finocchiaro G.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
      Tissue: BrainImported.
    2. "Recurrent allelic imbalance at the rat Pten locus in DMBA-induced fibrosarcomas."
      Sjoling A., Samuelson E., Adamovic T., Behboudi A., Rohme D., Levan G.
      Genes Chromosomes Cancer 36:70-79(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    6. "Solution structure of Par-3 PDZ3 in complex with PTEN peptide."
      Feng W., Wu H., Chan L., Zhang M.
      Submitted (MAR-2008) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 393-403.
    7. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiO54857_RAT
    AccessioniPrimary (citable) accession number: O54857
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3