O54857 (O54857_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Phosphatase and tensin homolog, isoform CRA_a EMBL EDM13141.1

Submitted name:
Protein Pten Ensembl ENSRNOP00000028143
Submitted name:
Protein tyrosine phosphatase and tensin homolog/mutated in multiple advanced cancers protein EMBL AAB96620.1
Submitted name:
Protein tyrosine phosphatase and tensin-like protein EMBL AAO31948.1

Gene names

Name:	Pten RGD 61995 EMBL AAO31948.1 Ensembl ENSRNOP00000028143
Synonyms:	PTEN/MMAC1 EMBL AAB96620.1
ORF Names:	rCG_47874 EMBL EDM13141.1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 2K20 Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of mitotic anaphase-promoting complex activity Inferred from electronic annotation. Source: Compara angiogenesis Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara cardiac muscle tissue development Inferred from electronic annotation. Source: Compara central nervous system myelin maintenance Inferred from electronic annotation. Source: Compara central nervous system neuron axonogenesis Inferred from electronic annotation. Source: Compara dendritic spine morphogenesis Inferred from electronic annotation. Source: Compara dentate gyrus development Inferred from electronic annotation. Source: Compara endothelial cell migration Inferred from electronic annotation. Source: Compara forebrain morphogenesis Inferred from electronic annotation. Source: Compara induction of apoptosis Inferred from electronic annotation. Source: Compara inositol phosphate dephosphorylation Inferred from electronic annotation. Source: Compara learning or memory Inferred from electronic annotation. Source: Compara locomotor rhythm Inferred from electronic annotation. Source: Compara long-term synaptic potentiation Inferred from electronic annotation. Source: Compara male mating behavior Inferred from electronic annotation. Source: Compara maternal behavior Inferred from electronic annotation. Source: Compara multicellular organismal response to stress Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of axonogenesis Inferred from electronic annotation. Source: Compara negative regulation of cell aging Inferred from electronic annotation. Source: Compara negative regulation of cell migration Inferred from electronic annotation. Source: Compara negative regulation of cell size Inferred from electronic annotation. Source: Compara negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S Inferred from electronic annotation. Source: Compara negative regulation of dendritic spine morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of excitatory postsynaptic membrane potential Inferred from electronic annotation. Source: Compara negative regulation of focal adhesion assembly Inferred from electronic annotation. Source: Compara negative regulation of myelination Inferred from electronic annotation. Source: Compara negative regulation of organ growth Inferred from electronic annotation. Source: Compara negative regulation of protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara negative regulation of ribosome biogenesis Inferred from electronic annotation. Source: Compara negative regulation of synaptic vesicle clustering Inferred from electronic annotation. Source: Compara neuron-neuron synaptic transmission Inferred from electronic annotation. Source: Compara phosphatidylinositol dephosphorylation Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of excitatory postsynaptic membrane potential Inferred from electronic annotation. Source: Compara positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: Compara positive regulation of sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara postsynaptic density assembly Inferred from electronic annotation. Source: Compara prepulse inhibition Inferred from electronic annotation. Source: Compara presynaptic membrane assembly Inferred from electronic annotation. Source: Compara prostate gland growth Inferred from electronic annotation. Source: Compara protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara protein stabilization Inferred from electronic annotation. Source: Compara regulation of B cell apoptotic process Inferred from electronic annotation. Source: Compara regulation of myeloid cell apoptotic process Inferred from electronic annotation. Source: Compara rhythmic synaptic transmission Inferred from electronic annotation. Source: Compara social behavior Inferred from electronic annotation. Source: Compara synapse maturation Inferred from electronic annotation. Source: Compara
Cellular_component	Schmidt-Lanterman incisure Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara internal side of plasma membrane Inferred from electronic annotation. Source: Compara myelin sheath adaxonal region Inferred from electronic annotation. Source: Compara neuron projection Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity Inferred from electronic annotation. Source: Compara magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Inferred from electronic annotation. Source: Compara phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity Inferred from electronic annotation. Source: Compara phosphatidylinositol-3-phosphatase activity Inferred from electronic annotation. Source: Compara protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: Compara protein tyrosine phosphatase activity Inferred from electronic annotation. Source: Compara protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O54857 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 243BFE35FE209FE5	FASTA	403	47,118
	10 20 30 40 50 60 MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK 70 80 90 100 110 120 HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDQ WLSEDDNHVA 130 140 150 160 170 180 AIHCKAGKGR TGVMICAYLL HRGKFLKAQE ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY 190 200 210 220 230 240 LLKNHLDYRP VALLFHKMMF ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKLMY 250 260 270 280 290 300 FEFPQPLPVC GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI 310 320 330 340 350 360 DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT VEEPSNPEAS 370 380 390 400 SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHSQI TKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Roz L., Finocchiaro G. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAB96620.1. Tissue: Brain EMBL AAB96620.1.
[2]	"Recurrent allelic imbalance at the rat Pten locus in DMBA-induced fibrosarcomas." Sjoling A., Samuelson E., Adamovic T., Behboudi A., Rohme D., Levan G. Genes Chromosomes Cancer 36:70-79(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL AAO31948.1.
[3]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000028143.
[4]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM13141.1.
[5]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM13141.1.
[6]	"Solution structure of Par-3 PDZ3 in complex with PTEN peptide." Feng W., Wu H., Chan L., Zhang M. Submitted (MAR-2008) to the PDB data bank Cited for: STRUCTURE BY NMR OF 393-403.
[7]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000028143.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AABR06010605 Genomic DNA. No translation available.
AABR06010606 Genomic DNA. No translation available.
AABR06010607 Genomic DNA. No translation available.
AF017185 mRNA. Translation: AAB96620.1.
AF455569 mRNA. Translation: AAO31948.1.
CH473953 Genomic DNA. Translation: EDM13141.1.

IPI

IPI00199035.

RefSeq

NP_113794.1. NM_031606.1.

UniGene

Rn.22158.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2K20	NMR	-	B	393-403	[»]

SMR

O54857. Positions 14-351.

ModBase

Search...

Protein-protein interaction databases

STRING

10116.ENSRNOP00000028143.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSRNOT00000028143; ENSRNOP00000028143; ENSRNOG00000020723.

GeneID

50557.

KEGG

rno:50557.

Organism-specific databases

CTD

5728.

RGD

61995. Pten.

Phylogenomic databases

eggNOG

COG2453.

GeneTree

ENSGT00620000087779.

HOGENOM

HOG000008008.

HOVERGEN

HBG000239.

InParanoid

O54857.

KO

K01110.

OMA

TRREDKH.

OrthoDB

EOG434W64.

Gene expression databases

Genevestigator

O54857.

Family and domain databases

InterPro

IPR017361. Bifunc_PIno_P3_Pase/Pase_PTEN.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR014019. Phosphatase_tensin-typ.
IPR014020. Tensin_phosphatase_C2-dom.
IPR016130. Tyr_Pase_AS.
[Graphical view]

Pfam

PF00782. DSPc. 1 hit.
PF10409. PTEN_C2. 1 hit.
[Graphical view]

PIRSF

PIRSF038025. PTEN. 1 hit.

SUPFAM

SSF49562. C2_CaLB. 1 hit.

PROSITE

PS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

O54857.

NextBio

610364.

Entry information

Entry name

O54857_RAT

Accession

Primary (citable) accession number: O54857

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)