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O54853

- KCNH6_RAT

UniProt

O54853 - KCNH6_RAT

Protein

Potassium voltage-gated channel subfamily H member 6

Gene

Kcnh6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current. Channel properties may be modulated by cAMP and subunit assembly.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi594 – 711118cNMPAdd
    BLAST

    GO - Molecular functioni

    1. inward rectifier potassium channel activity Source: RGD
    2. potassium channel activity Source: RGD
    3. signal transducer activity Source: InterPro
    4. voltage-gated potassium channel activity Source: RGD

    GO - Biological processi

    1. potassium ion transmembrane transport Source: RefGenome
    2. potassium ion transport Source: RGD
    3. protein heterooligomerization Source: RGD
    4. regulation of membrane potential Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Protein family/group databases

    TCDBi1.A.1.20.2. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily H member 6
    Alternative name(s):
    Ether-a-go-go-related gene potassium channel 2
    Short name:
    ERG-2
    Short name:
    Eag-related protein 2
    Short name:
    Ether-a-go-go-related protein 2
    Voltage-gated potassium channel subunit Kv11.2
    Gene namesi
    Name:Kcnh6
    Synonyms:Erg2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620304. Kcnh6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RGD

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi480 – 4801G → S: Dominant negative mutant; abolishes ERG current. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 950950Potassium voltage-gated channel subfamily H member 6PRO_0000054014Add
    BLAST

    Proteomic databases

    PRIDEiO54853.

    PTM databases

    PhosphoSiteiO54853.

    Expressioni

    Tissue specificityi

    Highly expressed in celiac and superior mesenteric ganglia, but not detected in brain or in heart. Detected at low levels in retina. Also found in pituitary. Also found in the olfactory bulb (granular and mitral cell layers) (PubMed:11425889).2 Publications

    Gene expression databases

    GenevestigatoriO54853.

    Interactioni

    Subunit structurei

    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH7/ERG3.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000010816.

    Structurei

    3D structure databases

    ProteinModelPortaliO54853.
    SMRiO54853. Positions 26-130, 421-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 261261CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini283 – 29816ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini320 – 34021CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini362 – 3709ExtracellularSequence Analysis
    Topological domaini392 – 3987CytoplasmicSequence Analysis
    Topological domaini420 – 46344ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini485 – 4906ExtracellularSequence Analysis
    Topological domaini512 – 950439CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei464 – 48421Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei262 – 28221Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei299 – 31921Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei341 – 36121Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei371 – 39121Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei491 – 51121Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 7030PASAdd
    BLAST
    Domaini92 – 14453PACAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi476 – 4816Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2202.
    HOGENOMiHOG000230793.
    HOVERGENiHBG052232.
    InParanoidiO54853.
    KOiK04909.
    PhylomeDBiO54853.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003967. K_chnl_volt-dep_ERG.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view]
    PRINTSiPR01463. EAGCHANLFMLY.
    PR01470. ERGCHANNEL.
    SMARTiSM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54853-1 [UniParc]FASTAAdd to Basket

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    MPVRRGHVAP QNTYLDTIIR KFEGQSRKFL IANAQMENCA IIYCNDGFCE    50
    LFGYSRVEVM QRPCTCDFLT GPNTPSSAVS RLAQALLGAE ECKVDILYYR 100
    KDASSFRCLV DVVPVKNEDG AVIMFILNFE DLAQLLAKSS SRSLTQRLLS 150
    HSFLGSEGSH SRPSGQGPGP GRGKYRTVSQ IPQFTLNFVE FNLEKHRSGS 200
    TTEIEIIAPH KVVERTQNVT EKVTQVLSLG ADVLPEYKLQ APRIHRGTIL 250
    HYSPFKAVWD WLILLLVIYT AVFTPYSAAF LLSDQDESQR GTCGYTCSPL 300
    TVVDLIVDIM FVVDIVINFR TTYVNTNDEV VSHPRRIAVH YFKGWFLIDM 350
    VAAIPFDLLI FRTGSDETTT LIGLLKTARL LRLVRVARKL DRYSEYGAAV 400
    LFLLMCTFAL IAHWLACIWY AIGNVERPYL EPKIGWLDSL GAQLGKQYNG 450
    SDPASGPSVQ DKYVTALYFT FSSLTSVGFG NVSPNTNSEK VFSICVMLIG 500
    SLMYASIFGN VSAIIQRLYS GTARYHTQML RVKEFIRFHQ IPNPLRQRLE 550
    EYFQHAWSYT NGIDMNAVLK GFPECLQADI CLHLHRALLQ HCPAFRGASK 600
    GCLRALAVKF KTTHAPPGDT LVHLGDVLST LYFISRGSIE ILRDDVVVAI 650
    LGKNDIFGEP ASLHARPGKS SADVRALTYC DLHKIHRADL LEVLDMYPAF 700
    ADTFWNKLEV TFNLRDADGG LQSTPRQAPG HQDPQGFFLN DSQSGAAPSL 750
    SISDTSALWP ELLQQMPPSP PNPRQDLDCW HRELGFKLEQ LQAQMNRLES 800
    RVSSDLSRIL QLLQHPQGRP SYILGASASS DLASFPETSV TRSSESTLLV 850
    GHVPSAQTLS YGDLDDHIQT PRNFSPRTPH VAMAMDKTLV PSSEQEQPGG 900
    LLSPLASPLR PLEVPGLGGS RFPSLPEHLS SVPKQLEFQR HGSDPGFTRS 950
    Length:950
    Mass (Da):105,706
    Last modified:June 1, 1998 - v1
    Checksum:iAB5AE674B08776F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016192 mRNA. Translation: AAB94742.1.
    RefSeqiNP_446389.1. NM_053937.1.
    UniGeneiRn.10875.

    Genome annotation databases

    GeneIDi116745.
    KEGGirno:116745.
    UCSCiRGD:620304. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016192 mRNA. Translation: AAB94742.1 .
    RefSeqi NP_446389.1. NM_053937.1.
    UniGenei Rn.10875.

    3D structure databases

    ProteinModelPortali O54853.
    SMRi O54853. Positions 26-130, 421-463.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000010816.

    Chemistry

    GuidetoPHARMACOLOGYi 573.

    Protein family/group databases

    TCDBi 1.A.1.20.2. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei O54853.

    Proteomic databases

    PRIDEi O54853.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 116745.
    KEGGi rno:116745.
    UCSCi RGD:620304. rat.

    Organism-specific databases

    CTDi 81033.
    RGDi 620304. Kcnh6.

    Phylogenomic databases

    eggNOGi COG2202.
    HOGENOMi HOG000230793.
    HOVERGENi HBG052232.
    InParanoidi O54853.
    KOi K04909.
    PhylomeDBi O54853.

    Miscellaneous databases

    NextBioi 619690.
    PROi O54853.

    Gene expression databases

    Genevestigatori O54853.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003967. K_chnl_volt-dep_ERG.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view ]
    PRINTSi PR01463. EAGCHANLFMLY.
    PR01470. ERGCHANNEL.
    SMARTi SM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two nervous system-specific members of the erg potassium channel gene family."
      Shi W., Wymore R.S., Wang H.-S., Pan Z., Cohen I.S., McKinnon D., Dixon J.E.
      J. Neurosci. 17:9423-9432(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cervical ganglion.
    2. "Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary."
      Wulfsen I., Hauber H.-P., Schiemann D., Bauer C.K., Schwarz J.R.
      J. Neuroendocrinol. 12:263-272(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    3. "Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers."
      Wimmers S., Wulfsen I., Bauer C.K., Schwarz J.R.
      Pflugers Arch. 441:450-455(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KCNH2 AND KCNH7, MUTAGENESIS OF GLY-480.
    4. "Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain."
      Saganich M.J., Machado E., Rudy B.
      J. Neurosci. 21:4609-4624(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiKCNH6_RAT
    AccessioniPrimary (citable) accession number: O54853
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3