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O54853

- KCNH6_RAT

UniProt

O54853 - KCNH6_RAT

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Protein

Potassium voltage-gated channel subfamily H member 6

Gene

Kcnh6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi594 – 711118cNMPAdd
BLAST

GO - Molecular functioni

  1. inward rectifier potassium channel activity Source: RGD
  2. potassium channel activity Source: RGD
  3. signal transducer activity Source: InterPro
  4. voltage-gated potassium channel activity Source: RGD

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
  2. potassium ion transport Source: RGD
  3. protein heterooligomerization Source: RGD
  4. regulation of membrane potential Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Protein family/group databases

TCDBi1.A.1.20.2. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 6
Alternative name(s):
Ether-a-go-go-related gene potassium channel 2
Short name:
ERG-2
Short name:
Eag-related protein 2
Short name:
Ether-a-go-go-related protein 2
Voltage-gated potassium channel subunit Kv11.2
Gene namesi
Name:Kcnh6
Synonyms:Erg2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620304. Kcnh6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 261261CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei262 – 28221Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Topological domaini283 – 29816ExtracellularSequence AnalysisAdd
BLAST
Transmembranei299 – 31921Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini320 – 34021CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei341 – 36121Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Topological domaini362 – 3709ExtracellularSequence Analysis
Transmembranei371 – 39121Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini392 – 3987CytoplasmicSequence Analysis
Transmembranei399 – 41921Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Topological domaini420 – 46344ExtracellularSequence AnalysisAdd
BLAST
Intramembranei464 – 48421Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST
Topological domaini485 – 4906ExtracellularSequence Analysis
Transmembranei491 – 51121Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini512 – 950439CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi480 – 4801G → S: Dominant negative mutant; abolishes ERG current. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Potassium voltage-gated channel subfamily H member 6PRO_0000054014Add
BLAST

Proteomic databases

PRIDEiO54853.

PTM databases

PhosphoSiteiO54853.

Expressioni

Tissue specificityi

Highly expressed in celiac and superior mesenteric ganglia, but not detected in brain or in heart. Detected at low levels in retina. Also found in pituitary. Also found in the olfactory bulb (granular and mitral cell layers) (PubMed:11425889).2 Publications

Gene expression databases

GenevestigatoriO54853.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH7/ERG3.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010816.

Structurei

3D structure databases

ProteinModelPortaliO54853.
SMRiO54853. Positions 26-130, 421-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 7030PASAdd
BLAST
Domaini92 – 14453PACAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi476 – 4816Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2202.
HOGENOMiHOG000230793.
HOVERGENiHBG052232.
InParanoidiO54853.
KOiK04909.
PhylomeDBiO54853.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54853-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVRRGHVAP QNTYLDTIIR KFEGQSRKFL IANAQMENCA IIYCNDGFCE
60 70 80 90 100
LFGYSRVEVM QRPCTCDFLT GPNTPSSAVS RLAQALLGAE ECKVDILYYR
110 120 130 140 150
KDASSFRCLV DVVPVKNEDG AVIMFILNFE DLAQLLAKSS SRSLTQRLLS
160 170 180 190 200
HSFLGSEGSH SRPSGQGPGP GRGKYRTVSQ IPQFTLNFVE FNLEKHRSGS
210 220 230 240 250
TTEIEIIAPH KVVERTQNVT EKVTQVLSLG ADVLPEYKLQ APRIHRGTIL
260 270 280 290 300
HYSPFKAVWD WLILLLVIYT AVFTPYSAAF LLSDQDESQR GTCGYTCSPL
310 320 330 340 350
TVVDLIVDIM FVVDIVINFR TTYVNTNDEV VSHPRRIAVH YFKGWFLIDM
360 370 380 390 400
VAAIPFDLLI FRTGSDETTT LIGLLKTARL LRLVRVARKL DRYSEYGAAV
410 420 430 440 450
LFLLMCTFAL IAHWLACIWY AIGNVERPYL EPKIGWLDSL GAQLGKQYNG
460 470 480 490 500
SDPASGPSVQ DKYVTALYFT FSSLTSVGFG NVSPNTNSEK VFSICVMLIG
510 520 530 540 550
SLMYASIFGN VSAIIQRLYS GTARYHTQML RVKEFIRFHQ IPNPLRQRLE
560 570 580 590 600
EYFQHAWSYT NGIDMNAVLK GFPECLQADI CLHLHRALLQ HCPAFRGASK
610 620 630 640 650
GCLRALAVKF KTTHAPPGDT LVHLGDVLST LYFISRGSIE ILRDDVVVAI
660 670 680 690 700
LGKNDIFGEP ASLHARPGKS SADVRALTYC DLHKIHRADL LEVLDMYPAF
710 720 730 740 750
ADTFWNKLEV TFNLRDADGG LQSTPRQAPG HQDPQGFFLN DSQSGAAPSL
760 770 780 790 800
SISDTSALWP ELLQQMPPSP PNPRQDLDCW HRELGFKLEQ LQAQMNRLES
810 820 830 840 850
RVSSDLSRIL QLLQHPQGRP SYILGASASS DLASFPETSV TRSSESTLLV
860 870 880 890 900
GHVPSAQTLS YGDLDDHIQT PRNFSPRTPH VAMAMDKTLV PSSEQEQPGG
910 920 930 940 950
LLSPLASPLR PLEVPGLGGS RFPSLPEHLS SVPKQLEFQR HGSDPGFTRS
Length:950
Mass (Da):105,706
Last modified:June 1, 1998 - v1
Checksum:iAB5AE674B08776F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016192 mRNA. Translation: AAB94742.1.
RefSeqiNP_446389.1. NM_053937.1.
UniGeneiRn.10875.

Genome annotation databases

GeneIDi116745.
KEGGirno:116745.
UCSCiRGD:620304. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016192 mRNA. Translation: AAB94742.1 .
RefSeqi NP_446389.1. NM_053937.1.
UniGenei Rn.10875.

3D structure databases

ProteinModelPortali O54853.
SMRi O54853. Positions 26-130, 421-463.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000010816.

Chemistry

GuidetoPHARMACOLOGYi 573.

Protein family/group databases

TCDBi 1.A.1.20.2. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei O54853.

Proteomic databases

PRIDEi O54853.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 116745.
KEGGi rno:116745.
UCSCi RGD:620304. rat.

Organism-specific databases

CTDi 81033.
RGDi 620304. Kcnh6.

Phylogenomic databases

eggNOGi COG2202.
HOGENOMi HOG000230793.
HOVERGENi HBG052232.
InParanoidi O54853.
KOi K04909.
PhylomeDBi O54853.

Miscellaneous databases

NextBioi 619690.
PROi O54853.

Gene expression databases

Genevestigatori O54853.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of two nervous system-specific members of the erg potassium channel gene family."
    Shi W., Wymore R.S., Wang H.-S., Pan Z., Cohen I.S., McKinnon D., Dixon J.E.
    J. Neurosci. 17:9423-9432(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cervical ganglion.
  2. "Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary."
    Wulfsen I., Hauber H.-P., Schiemann D., Bauer C.K., Schwarz J.R.
    J. Neuroendocrinol. 12:263-272(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  3. "Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers."
    Wimmers S., Wulfsen I., Bauer C.K., Schwarz J.R.
    Pflugers Arch. 441:450-455(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KCNH2 AND KCNH7, MUTAGENESIS OF GLY-480.
  4. "Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain."
    Saganich M.J., Machado E., Rudy B.
    J. Neurosci. 21:4609-4624(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiKCNH6_RAT
AccessioniPrimary (citable) accession number: O54853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: June 1, 1998
Last modified: October 1, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3