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Protein

Potassium voltage-gated channel subfamily H member 6

Gene

Kcnh6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi594 – 711cNMPAdd BLAST118

GO - Molecular functioni

  • inward rectifier potassium channel activity Source: RGD
  • potassium channel activity Source: RGD
  • voltage-gated potassium channel activity Source: RGD

GO - Biological processi

  • potassium ion transport Source: RGD
  • protein heterooligomerization Source: RGD
  • regulation of membrane potential Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Protein family/group databases

TCDBi1.A.1.20.2. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 6
Alternative name(s):
Ether-a-go-go-related gene potassium channel 2
Short name:
ERG-2
Short name:
Eag-related protein 2
Short name:
Ether-a-go-go-related protein 2
Voltage-gated potassium channel subunit Kv11.2
Gene namesi
Name:Kcnh6
Synonyms:Erg2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620304. Kcnh6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 261CytoplasmicSequence analysisAdd BLAST261
Transmembranei262 – 282Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini283 – 298ExtracellularSequence analysisAdd BLAST16
Transmembranei299 – 319Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini320 – 340CytoplasmicSequence analysisAdd BLAST21
Transmembranei341 – 361Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini362 – 370ExtracellularSequence analysis9
Transmembranei371 – 391Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini392 – 398CytoplasmicSequence analysis7
Transmembranei399 – 419Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini420 – 463ExtracellularSequence analysisAdd BLAST44
Intramembranei464 – 484Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini485 – 490ExtracellularSequence analysis6
Transmembranei491 – 511Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini512 – 950CytoplasmicSequence analysisAdd BLAST439

GO - Cellular componenti

  • integral component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi480G → S: Dominant negative mutant; abolishes ERG current. 1 Publication1

Chemistry databases

GuidetoPHARMACOLOGYi573.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540141 – 950Potassium voltage-gated channel subfamily H member 6Add BLAST950

Proteomic databases

PaxDbiO54853.

PTM databases

PhosphoSitePlusiO54853.

Expressioni

Tissue specificityi

Highly expressed in celiac and superior mesenteric ganglia, but not detected in brain or in heart. Detected at low levels in retina. Also found in pituitary. Also found in the olfactory bulb (granular and mitral cell layers) (PubMed:11425889).2 Publications

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH7/ERG3.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010816.

Structurei

3D structure databases

ProteinModelPortaliO54853.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 70PASAdd BLAST30
Domaini92 – 144PACAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi476 – 481Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000230793.
HOVERGENiHBG052232.
InParanoidiO54853.
KOiK04909.
PhylomeDBiO54853.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR030172. KCNH6.
IPR000014. PAS.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10217:SF468. PTHR10217:SF468. 1 hit.
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54853-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVRRGHVAP QNTYLDTIIR KFEGQSRKFL IANAQMENCA IIYCNDGFCE
60 70 80 90 100
LFGYSRVEVM QRPCTCDFLT GPNTPSSAVS RLAQALLGAE ECKVDILYYR
110 120 130 140 150
KDASSFRCLV DVVPVKNEDG AVIMFILNFE DLAQLLAKSS SRSLTQRLLS
160 170 180 190 200
HSFLGSEGSH SRPSGQGPGP GRGKYRTVSQ IPQFTLNFVE FNLEKHRSGS
210 220 230 240 250
TTEIEIIAPH KVVERTQNVT EKVTQVLSLG ADVLPEYKLQ APRIHRGTIL
260 270 280 290 300
HYSPFKAVWD WLILLLVIYT AVFTPYSAAF LLSDQDESQR GTCGYTCSPL
310 320 330 340 350
TVVDLIVDIM FVVDIVINFR TTYVNTNDEV VSHPRRIAVH YFKGWFLIDM
360 370 380 390 400
VAAIPFDLLI FRTGSDETTT LIGLLKTARL LRLVRVARKL DRYSEYGAAV
410 420 430 440 450
LFLLMCTFAL IAHWLACIWY AIGNVERPYL EPKIGWLDSL GAQLGKQYNG
460 470 480 490 500
SDPASGPSVQ DKYVTALYFT FSSLTSVGFG NVSPNTNSEK VFSICVMLIG
510 520 530 540 550
SLMYASIFGN VSAIIQRLYS GTARYHTQML RVKEFIRFHQ IPNPLRQRLE
560 570 580 590 600
EYFQHAWSYT NGIDMNAVLK GFPECLQADI CLHLHRALLQ HCPAFRGASK
610 620 630 640 650
GCLRALAVKF KTTHAPPGDT LVHLGDVLST LYFISRGSIE ILRDDVVVAI
660 670 680 690 700
LGKNDIFGEP ASLHARPGKS SADVRALTYC DLHKIHRADL LEVLDMYPAF
710 720 730 740 750
ADTFWNKLEV TFNLRDADGG LQSTPRQAPG HQDPQGFFLN DSQSGAAPSL
760 770 780 790 800
SISDTSALWP ELLQQMPPSP PNPRQDLDCW HRELGFKLEQ LQAQMNRLES
810 820 830 840 850
RVSSDLSRIL QLLQHPQGRP SYILGASASS DLASFPETSV TRSSESTLLV
860 870 880 890 900
GHVPSAQTLS YGDLDDHIQT PRNFSPRTPH VAMAMDKTLV PSSEQEQPGG
910 920 930 940 950
LLSPLASPLR PLEVPGLGGS RFPSLPEHLS SVPKQLEFQR HGSDPGFTRS
Length:950
Mass (Da):105,706
Last modified:June 1, 1998 - v1
Checksum:iAB5AE674B08776F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016192 mRNA. Translation: AAB94742.1.
RefSeqiNP_446389.1. NM_053937.1.
UniGeneiRn.10875.

Genome annotation databases

GeneIDi116745.
KEGGirno:116745.
UCSCiRGD:620304. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016192 mRNA. Translation: AAB94742.1.
RefSeqiNP_446389.1. NM_053937.1.
UniGeneiRn.10875.

3D structure databases

ProteinModelPortaliO54853.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010816.

Chemistry databases

GuidetoPHARMACOLOGYi573.

Protein family/group databases

TCDBi1.A.1.20.2. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitePlusiO54853.

Proteomic databases

PaxDbiO54853.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116745.
KEGGirno:116745.
UCSCiRGD:620304. rat.

Organism-specific databases

CTDi81033.
RGDi620304. Kcnh6.

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000230793.
HOVERGENiHBG052232.
InParanoidiO54853.
KOiK04909.
PhylomeDBiO54853.

Miscellaneous databases

PROiO54853.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR030172. KCNH6.
IPR000014. PAS.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10217:SF468. PTHR10217:SF468. 1 hit.
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCNH6_RAT
AccessioniPrimary (citable) accession number: O54853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.