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O54852

- KCNH7_RAT

UniProt

O54852 - KCNH7_RAT

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Protein
Potassium voltage-gated channel subfamily H member 7
Gene
Kcnh7, Erg3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi745 – 862118cNMP
Add
BLAST

GO - Molecular functioni

  1. inward rectifier potassium channel activity Source: RGD
  2. potassium channel activity Source: RGD
  3. signal transducer activity Source: InterPro
  4. voltage-gated potassium channel activity Source: RGD

GO - Biological processi

  1. circadian rhythm Source: RGD
  2. potassium ion transmembrane transport Source: RefGenome
  3. potassium ion transport Source: RGD
  4. protein heterooligomerization Source: RGD
  5. regulation of membrane potential Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.20.3. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 7
Alternative name(s):
Ether-a-go-go-related gene potassium channel 3
Short name:
ERG-3
Short name:
Eag-related protein 3
Short name:
Ether-a-go-go-related protein 3
Voltage-gated potassium channel subunit Kv11.3
Gene namesi
Name:Kcnh7
Synonyms:Erg3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi621112. Kcnh7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 412412Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei413 – 43321Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Topological domaini434 – 44916Extracellular Reviewed prediction
Add
BLAST
Transmembranei450 – 47021Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini471 – 49424Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei495 – 51521Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Topological domaini516 – 5216Extracellular Reviewed prediction
Transmembranei522 – 54221Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini543 – 5497Cytoplasmic Reviewed prediction
Transmembranei550 – 57021Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Topological domaini571 – 61444Extracellular Reviewed prediction
Add
BLAST
Intramembranei615 – 63521Pore-forming; Name=Segment H5; Reviewed prediction
Add
BLAST
Topological domaini636 – 6416Extracellular Reviewed prediction
Transmembranei642 – 66221Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini663 – 1195533Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi480 – 4801E → S: Lower channel activity.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11951195Potassium voltage-gated channel subfamily H member 7
PRO_0000054017Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi600 – 6001N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO54852.

PTM databases

PhosphoSiteiO54852.

Expressioni

Tissue specificityi

Detected in total brain, in superior cervical, mesenteric and celiac ganglia, and at very low levels in retina. Found in pituitary.1 Publication

Gene expression databases

GenevestigatoriO54852.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2.

Protein-protein interaction databases

BioGridi250984. 1 interaction.
STRINGi10116.ENSRNOP00000009920.

Structurei

3D structure databases

ProteinModelPortaliO54852.
SMRiO54852. Positions 26-135, 572-614.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 7030PAS
Add
BLAST
Domaini92 – 14453PAC
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi627 – 6326Selectivity filter By similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2202.
GeneTreeiENSGT00680000099663.
HOGENOMiHOG000230793.
HOVERGENiHBG052232.
InParanoidiO54852.
KOiK04910.
OMAiESQMTTD.
OrthoDBiEOG75B879.
PhylomeDBiO54852.
TreeFamiTF313130.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54852-1 [UniParc]FASTAAdd to Basket

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MPVRRGHVAP QNTFLGTIIR KFEGQNKKFI IANARVQNCA IIYCNDGFCE     50
MTGFSRPDVM QKPCTCDFLH GPETKRHDIA QIAQALLGSE ERKVEVTYYH 100
KNGSTFICNT HIIPVKNQEG VAMMFIINFE YVTDEDNAAS PERVNPILPV 150
KSVNRKLFGF KFPGLRVLTY RKQSLPQEDP DVVVIDSSKH SDDSVAMKHF 200
KSPTKESCSP SEADDTKALI QPSQCSPLVN ISGPLDHSSP KRQWDRLYPD 250
MLQSSSQLTH SRSRESLCSI RRASSVHDIE GFNVHPKNIF RDRHASEDNG 300
RNVKGPFNHI KSSLLGSTSD SNLNKYSTIN KIPQLTLNFS DVKTEKKNTS 350
PPSSDKTIIA PKVKERTHNV TEKVTQVLSL GADVLPEYKL QTPRINKFTI 400
LHYSPFKAVW DWLILLLVIY TAIFTPYSAA FLLNDREEQK RRECGYSCSP 450
LNVVDLIVDI MFIIDILINF RTTYVNQNEE VVSDPAKIAV HYFKGWFLID 500
MVAAIPFDLL IFGSGSDETT TLIGLLKTAR LLRLVRVARK LDRYSEYGAA 550
VLMLLMCIFA LIAHWLACIW YAIGNVERPY LTDKIGWLDS LGTQIGKRYN 600
DSDSSSGPSI KDKYVTALYF TFSSLTSVGF GNVSPNTNSE KIFSICVMLI 650
GSLMYASIFG NVSAIIQRLY SGTARYHMQM LRVKEFIRFH QIPNPLRQRL 700
EEYFQHAWTY TNGIDMNMVL KGFPECLQAD ICLHLNQTLL QNCKAFRGAS 750
KGCLRALAMK FKTTHAPPGD TLVHCGDVLT ALYFLSRGSI EILKDDIVVA 800
ILGKNDIFGE MVHLYAKPGK SNADVRALTY CDLHKIQRED LLEVLDMYPE 850
FSDHFLTNLE LTFNLRHESA KSQSINDSEG DTCKLRRRRL SFESEGDKDF 900
SKENSANDAD DSTDTIRRYQ SSKKHFEEKK SRSSSFISSI DDEQKPLFLG 950
TVDSTPRMVK ASRHHGEEAA PPSGRIHTDK RSHSCKDITD THSWEREHAR 1000
AQPEECSPSG LQRAAWGISE TESDLTYGEV EQRLDLLQEQ LNRLESQMTT 1050
DIQAILQLLQ KQTTVVPPAY SMVTAGAEYQ RPILRLLRTS HPRASIKTDR 1100
SFSPSSQCPE FLDLEKSKLK SKESLSSGKR LNTASEDNLT SLLKQDSDAS 1150
SELDPRQRKS YLHPIRHPSL PDSSLSTVGI LGLHRHVSDP GLPGK 1195
Length:1,195
Mass (Da):134,901
Last modified:June 1, 1998 - v1
Checksum:iBA24C54BB86C59B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016191 mRNA. Translation: AAB94741.1.
RefSeqiNP_571987.1. NM_131912.1.
UniGeneiRn.10874.

Genome annotation databases

EnsembliENSRNOT00000009920; ENSRNOP00000009920; ENSRNOG00000007528.
GeneIDi170739.
KEGGirno:170739.
UCSCiRGD:621112. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016191 mRNA. Translation: AAB94741.1 .
RefSeqi NP_571987.1. NM_131912.1.
UniGenei Rn.10874.

3D structure databases

ProteinModelPortali O54852.
SMRi O54852. Positions 26-135, 572-614.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 250984. 1 interaction.
STRINGi 10116.ENSRNOP00000009920.

Chemistry

GuidetoPHARMACOLOGYi 574.

Protein family/group databases

TCDBi 1.A.1.20.3. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei O54852.

Proteomic databases

PaxDbi O54852.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000009920 ; ENSRNOP00000009920 ; ENSRNOG00000007528 .
GeneIDi 170739.
KEGGi rno:170739.
UCSCi RGD:621112. rat.

Organism-specific databases

CTDi 90134.
RGDi 621112. Kcnh7.

Phylogenomic databases

eggNOGi COG2202.
GeneTreei ENSGT00680000099663.
HOGENOMi HOG000230793.
HOVERGENi HBG052232.
InParanoidi O54852.
KOi K04910.
OMAi ESQMTTD.
OrthoDBi EOG75B879.
PhylomeDBi O54852.
TreeFami TF313130.

Enzyme and pathway databases

Reactomei REACT_199159. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 621207.
PROi O54852.

Gene expression databases

Genevestigatori O54852.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of two nervous system-specific members of the erg potassium channel gene family."
    Shi W., Wymore R.S., Wang H.-S., Pan Z., Cohen I.S., McKinnon D., Dixon J.E.
    J. Neurosci. 17:9423-9432(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary."
    Wulfsen I., Hauber H.-P., Schiemann D., Bauer C.K., Schwarz J.R.
    J. Neuroendocrinol. 12:263-272(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  3. "Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers."
    Wimmers S., Wulfsen I., Bauer C.K., Schwarz J.R.
    Pflugers Arch. 441:450-455(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KCNH2 AND KCNH6.

Entry informationi

Entry nameiKCNH7_RAT
AccessioniPrimary (citable) accession number: O54852
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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