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O54852 (KCNH7_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily H member 7
Alternative name(s):
Ether-a-go-go-related gene potassium channel 3
Short name=ERG-3
Short name=Eag-related protein 3
Short name=Ether-a-go-go-related protein 3
Voltage-gated potassium channel subunit Kv11.3
Gene names
Name:Kcnh7
Synonyms:Erg3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1195 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.

Subunit structure

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Detected in total brain, in superior cervical, mesenteric and celiac ganglia, and at very low levels in retina. Found in pituitary. Ref.2

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily. [View classification]

Contains 1 cyclic nucleotide-binding domain.

Contains 1 PAC (PAS-associated C-terminal) domain.

Contains 1 PAS (PER-ARNT-SIM) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11951195Potassium voltage-gated channel subfamily H member 7
PRO_0000054017

Regions

Topological domain1 – 412412Cytoplasmic Potential
Transmembrane413 – 43321Helical; Name=Segment S1; Potential
Topological domain434 – 44916Extracellular Potential
Transmembrane450 – 47021Helical; Name=Segment S2; Potential
Topological domain471 – 49424Cytoplasmic Potential
Transmembrane495 – 51521Helical; Name=Segment S3; Potential
Topological domain516 – 5216Extracellular Potential
Transmembrane522 – 54221Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain543 – 5497Cytoplasmic Potential
Transmembrane550 – 57021Helical; Name=Segment S5; Potential
Topological domain571 – 61444Extracellular Potential
Intramembrane615 – 63521Pore-forming; Name=Segment H5; Potential
Topological domain636 – 6416Extracellular Potential
Transmembrane642 – 66221Helical; Name=Segment S6; Potential
Topological domain663 – 1195533Cytoplasmic Potential
Domain41 – 7030PAS
Domain92 – 14453PAC
Nucleotide binding745 – 862118cNMP
Motif627 – 6326Selectivity filter By similarity

Amino acid modifications

Glycosylation6001N-linked (GlcNAc...) Potential

Experimental info

Mutagenesis4801E → S: Lower channel activity.

Sequences

Sequence LengthMass (Da)Tools
O54852 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: BA24C54BB86C59B7

FASTA1,195134,901
        10         20         30         40         50         60 
MPVRRGHVAP QNTFLGTIIR KFEGQNKKFI IANARVQNCA IIYCNDGFCE MTGFSRPDVM 

        70         80         90        100        110        120 
QKPCTCDFLH GPETKRHDIA QIAQALLGSE ERKVEVTYYH KNGSTFICNT HIIPVKNQEG 

       130        140        150        160        170        180 
VAMMFIINFE YVTDEDNAAS PERVNPILPV KSVNRKLFGF KFPGLRVLTY RKQSLPQEDP 

       190        200        210        220        230        240 
DVVVIDSSKH SDDSVAMKHF KSPTKESCSP SEADDTKALI QPSQCSPLVN ISGPLDHSSP 

       250        260        270        280        290        300 
KRQWDRLYPD MLQSSSQLTH SRSRESLCSI RRASSVHDIE GFNVHPKNIF RDRHASEDNG 

       310        320        330        340        350        360 
RNVKGPFNHI KSSLLGSTSD SNLNKYSTIN KIPQLTLNFS DVKTEKKNTS PPSSDKTIIA 

       370        380        390        400        410        420 
PKVKERTHNV TEKVTQVLSL GADVLPEYKL QTPRINKFTI LHYSPFKAVW DWLILLLVIY 

       430        440        450        460        470        480 
TAIFTPYSAA FLLNDREEQK RRECGYSCSP LNVVDLIVDI MFIIDILINF RTTYVNQNEE 

       490        500        510        520        530        540 
VVSDPAKIAV HYFKGWFLID MVAAIPFDLL IFGSGSDETT TLIGLLKTAR LLRLVRVARK 

       550        560        570        580        590        600 
LDRYSEYGAA VLMLLMCIFA LIAHWLACIW YAIGNVERPY LTDKIGWLDS LGTQIGKRYN 

       610        620        630        640        650        660 
DSDSSSGPSI KDKYVTALYF TFSSLTSVGF GNVSPNTNSE KIFSICVMLI GSLMYASIFG 

       670        680        690        700        710        720 
NVSAIIQRLY SGTARYHMQM LRVKEFIRFH QIPNPLRQRL EEYFQHAWTY TNGIDMNMVL 

       730        740        750        760        770        780 
KGFPECLQAD ICLHLNQTLL QNCKAFRGAS KGCLRALAMK FKTTHAPPGD TLVHCGDVLT 

       790        800        810        820        830        840 
ALYFLSRGSI EILKDDIVVA ILGKNDIFGE MVHLYAKPGK SNADVRALTY CDLHKIQRED 

       850        860        870        880        890        900 
LLEVLDMYPE FSDHFLTNLE LTFNLRHESA KSQSINDSEG DTCKLRRRRL SFESEGDKDF 

       910        920        930        940        950        960 
SKENSANDAD DSTDTIRRYQ SSKKHFEEKK SRSSSFISSI DDEQKPLFLG TVDSTPRMVK 

       970        980        990       1000       1010       1020 
ASRHHGEEAA PPSGRIHTDK RSHSCKDITD THSWEREHAR AQPEECSPSG LQRAAWGISE 

      1030       1040       1050       1060       1070       1080 
TESDLTYGEV EQRLDLLQEQ LNRLESQMTT DIQAILQLLQ KQTTVVPPAY SMVTAGAEYQ 

      1090       1100       1110       1120       1130       1140 
RPILRLLRTS HPRASIKTDR SFSPSSQCPE FLDLEKSKLK SKESLSSGKR LNTASEDNLT 

      1150       1160       1170       1180       1190 
SLLKQDSDAS SELDPRQRKS YLHPIRHPSL PDSSLSTVGI LGLHRHVSDP GLPGK 

« Hide

References

[1]"Identification of two nervous system-specific members of the erg potassium channel gene family."
Shi W., Wymore R.S., Wang H.-S., Pan Z., Cohen I.S., McKinnon D., Dixon J.E.
J. Neurosci. 17:9423-9432(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary."
Wulfsen I., Hauber H.-P., Schiemann D., Bauer C.K., Schwarz J.R.
J. Neuroendocrinol. 12:263-272(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[3]"Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers."
Wimmers S., Wulfsen I., Bauer C.K., Schwarz J.R.
Pflugers Arch. 441:450-455(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KCNH2 AND KCNH6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF016191 mRNA. Translation: AAB94741.1.
RefSeqNP_571987.1. NM_131912.1.
UniGeneRn.10874.

3D structure databases

ProteinModelPortalO54852.
SMRO54852. Positions 26-135, 572-614.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid250984. 1 interaction.
STRING10116.ENSRNOP00000009920.

Chemistry

GuidetoPHARMACOLOGY574.

Protein family/group databases

TCDB1.A.1.20.3. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSiteO54852.

Proteomic databases

PaxDbO54852.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009920; ENSRNOP00000009920; ENSRNOG00000007528.
GeneID170739.
KEGGrno:170739.
UCSCRGD:621112. rat.

Organism-specific databases

CTD90134.
RGD621112. Kcnh7.

Phylogenomic databases

eggNOGCOG2202.
GeneTreeENSGT00680000099663.
HOGENOMHOG000230793.
HOVERGENHBG052232.
InParanoidO54852.
KOK04910.
OMAESQMTTD.
OrthoDBEOG75B879.
PhylomeDBO54852.
TreeFamTF313130.

Gene expression databases

GenevestigatorO54852.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSPR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsTIGR00229. sensory_box. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio621207.
PROO54852.

Entry information

Entry nameKCNH7_RAT
AccessionPrimary (citable) accession number: O54852
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: June 1, 1998
Last modified: May 14, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families