Potassium voltage-gated channel subfamily H member 7

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O54852 (KCNH7_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 108. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily H member 7

Alternative name(s):
Ether-a-go-go-related gene potassium channel 3
Short name=ERG-3
Short name=Eag-related protein 3
Short name=Ether-a-go-go-related protein 3
Voltage-gated potassium channel subunit Kv11.3

Gene names

Name:	Kcnh7
Synonyms:	Erg3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1195 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.
Subunit structure	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Detected in total brain, in superior cervical, mesenteric and celiac ganglia, and at very low levels in retina. Found in pituitary. Ref.2
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily. [View classification] Contains 1 cyclic nucleotide-binding domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 1 PAS (PER-ARNT-SIM) domain.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	circadian rhythm Inferred from expression pattern PubMed 17322986. Source: RGD protein heterooligomerization Inferred from direct assay Ref.3. Source: RGD regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	inward rectifier potassium channel activity Inferred from direct assay PubMed 15677682. Source: RGD signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1195

1195

Potassium voltage-gated channel subfamily H member 7

PRO_0000054017

Regions

Topological domain

1 – 412

412

Cytoplasmic Potential

Transmembrane

413 – 433

Helical; Name=Segment S1; Potential

Topological domain

434 – 449

Extracellular Potential

Transmembrane

450 – 470

Helical; Name=Segment S2; Potential

Topological domain

471 – 494

Cytoplasmic Potential

Transmembrane

495 – 515

Helical; Name=Segment S3; Potential

Topological domain

516 – 521

Extracellular Potential

Transmembrane

522 – 542

Helical; Voltage-sensor; Name=Segment S4; Potential

Topological domain

543 – 549

Cytoplasmic Potential

Transmembrane

550 – 570

Helical; Name=Segment S5; Potential

Topological domain

571 – 614

Extracellular Potential

Intramembrane

615 – 635

Pore-forming; Name=Segment H5; Potential

Topological domain

636 – 641

Extracellular Potential

Transmembrane

642 – 662

Helical; Name=Segment S6; Potential

Topological domain

663 – 1195

533

Cytoplasmic Potential

Domain

41 – 70

PAS

Domain

92 – 144

PAC

Nucleotide binding

745 – 862

118

cNMP

Motif

627 – 632

Selectivity filter By similarity

Amino acid modifications

Glycosylation

600

N-linked (GlcNAc...) Potential

Experimental info

Mutagenesis

480

E → S: Lower channel activity.

Sequences

Sequence

Length

Mass (Da)

Tools

O54852 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: BA24C54BB86C59B7
Show »

FASTA

1,195

134,901

        10         20         30         40         50         60 
MPVRRGHVAP QNTFLGTIIR KFEGQNKKFI IANARVQNCA IIYCNDGFCE MTGFSRPDVM 

        70         80         90        100        110        120 
QKPCTCDFLH GPETKRHDIA QIAQALLGSE ERKVEVTYYH KNGSTFICNT HIIPVKNQEG 

       130        140        150        160        170        180 
VAMMFIINFE YVTDEDNAAS PERVNPILPV KSVNRKLFGF KFPGLRVLTY RKQSLPQEDP 

       190        200        210        220        230        240 
DVVVIDSSKH SDDSVAMKHF KSPTKESCSP SEADDTKALI QPSQCSPLVN ISGPLDHSSP 

       250        260        270        280        290        300 
KRQWDRLYPD MLQSSSQLTH SRSRESLCSI RRASSVHDIE GFNVHPKNIF RDRHASEDNG 

       310        320        330        340        350        360 
RNVKGPFNHI KSSLLGSTSD SNLNKYSTIN KIPQLTLNFS DVKTEKKNTS PPSSDKTIIA 

       370        380        390        400        410        420 
PKVKERTHNV TEKVTQVLSL GADVLPEYKL QTPRINKFTI LHYSPFKAVW DWLILLLVIY 

       430        440        450        460        470        480 
TAIFTPYSAA FLLNDREEQK RRECGYSCSP LNVVDLIVDI MFIIDILINF RTTYVNQNEE 

       490        500        510        520        530        540 
VVSDPAKIAV HYFKGWFLID MVAAIPFDLL IFGSGSDETT TLIGLLKTAR LLRLVRVARK 

       550        560        570        580        590        600 
LDRYSEYGAA VLMLLMCIFA LIAHWLACIW YAIGNVERPY LTDKIGWLDS LGTQIGKRYN 

       610        620        630        640        650        660 
DSDSSSGPSI KDKYVTALYF TFSSLTSVGF GNVSPNTNSE KIFSICVMLI GSLMYASIFG 

       670        680        690        700        710        720 
NVSAIIQRLY SGTARYHMQM LRVKEFIRFH QIPNPLRQRL EEYFQHAWTY TNGIDMNMVL 

       730        740        750        760        770        780 
KGFPECLQAD ICLHLNQTLL QNCKAFRGAS KGCLRALAMK FKTTHAPPGD TLVHCGDVLT 

       790        800        810        820        830        840 
ALYFLSRGSI EILKDDIVVA ILGKNDIFGE MVHLYAKPGK SNADVRALTY CDLHKIQRED 

       850        860        870        880        890        900 
LLEVLDMYPE FSDHFLTNLE LTFNLRHESA KSQSINDSEG DTCKLRRRRL SFESEGDKDF 

       910        920        930        940        950        960 
SKENSANDAD DSTDTIRRYQ SSKKHFEEKK SRSSSFISSI DDEQKPLFLG TVDSTPRMVK 

       970        980        990       1000       1010       1020 
ASRHHGEEAA PPSGRIHTDK RSHSCKDITD THSWEREHAR AQPEECSPSG LQRAAWGISE 

      1030       1040       1050       1060       1070       1080 
TESDLTYGEV EQRLDLLQEQ LNRLESQMTT DIQAILQLLQ KQTTVVPPAY SMVTAGAEYQ 

      1090       1100       1110       1120       1130       1140 
RPILRLLRTS HPRASIKTDR SFSPSSQCPE FLDLEKSKLK SKESLSSGKR LNTASEDNLT 

      1150       1160       1170       1180       1190 
SLLKQDSDAS SELDPRQRKS YLHPIRHPSL PDSSLSTVGI LGLHRHVSDP GLPGK

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References

[1]	"Identification of two nervous system-specific members of the erg potassium channel gene family." Shi W., Wymore R.S., Wang H.-S., Pan Z., Cohen I.S., McKinnon D., Dixon J.E. J. Neurosci. 17:9423-9432(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary." Wulfsen I., Hauber H.-P., Schiemann D., Bauer C.K., Schwarz J.R. J. Neuroendocrinol. 12:263-272(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[3]	"Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers." Wimmers S., Wulfsen I., Bauer C.K., Schwarz J.R. Pflugers Arch. 441:450-455(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH KCNH2 AND KCNH6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF016191 mRNA. Translation: AAB94741.1.
IPI	IPI00199025.
RefSeq	NP_571987.1. NM_131912.1.
UniGene	Rn.10874.
3D structure databases
ProteinModelPortal	O54852.
SMR	O54852. Positions 26-135, 572-614.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000009920.
Protein family/group databases
TCDB	1.A.1.20.3. voltage-gated ion channel (VIC) superfamily.
PTM databases
PhosphoSite	O54852.
Proteomic databases
PaxDb	O54852.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000009920; ENSRNOP00000009920; ENSRNOG00000007528.
GeneID	170739.
KEGG	rno:170739.
UCSC	RGD:621112. rat.
Organism-specific databases
CTD	90134.
RGD	621112. Kcnh7.
Phylogenomic databases
eggNOG	COG2202.
GeneTree	ENSGT00680000099663.
HOGENOM	HOG000230793.
HOVERGEN	HBG052232.
InParanoid	O54852.
KO	K04910.
OMA	PERVNPI.
OrthoDB	EOG4STS3W.
Gene expression databases
ArrayExpress	O54852.
Genevestigator	O54852.
GermOnline	ENSRNOG00000007528. Rattus norvegicus.
Family and domain databases
Gene3D	2.60.120.10. 1 hit.
InterPro	IPR018490. cNMP-bd-like. IPR000595. cNMP-bd_dom. IPR005821. Ion_trans_dom. IPR003938. K_chnl_volt-dep_EAG/ELK/ERG. IPR003967. K_chnl_volt-dep_ERG. IPR001610. PAC. IPR000014. PAS. IPR014710. RmlC-like_jellyroll. [Graphical view]
Pfam	PF00027. cNMP_binding. 1 hit. PF00520. Ion_trans. 1 hit. [Graphical view]
PRINTS	PR01463. EAGCHANLFMLY. PR01470. ERGCHANNEL.
SMART	SM00100. cNMP. 1 hit. SM00086. PAC. 1 hit. SM00091. PAS. 1 hit. [Graphical view]
SUPFAM	SSF51206. cNMP_binding. 1 hit.
TIGRFAMs	TIGR00229. sensory_box. 1 hit.
PROSITE	PS00888. CNMP_BINDING_1. False negative. PS00889. CNMP_BINDING_2. False negative. PS50042. CNMP_BINDING_3. 1 hit. PS50113. PAC. False negative. PS50112. PAS. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	621207.

Entry information

Entry name

KCNH7_RAT

Accession

Primary (citable) accession number: O54852

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
Last sequence update:	June 1, 1998
Last modified:	April 3, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents