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O54852

- KCNH7_RAT

UniProt

O54852 - KCNH7_RAT

Protein

Potassium voltage-gated channel subfamily H member 7

Gene

Kcnh7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi745 – 862118cNMPAdd
    BLAST

    GO - Molecular functioni

    1. inward rectifier potassium channel activity Source: RGD
    2. potassium channel activity Source: RGD
    3. signal transducer activity Source: InterPro
    4. voltage-gated potassium channel activity Source: RGD

    GO - Biological processi

    1. circadian rhythm Source: RGD
    2. potassium ion transmembrane transport Source: RefGenome
    3. potassium ion transport Source: RGD
    4. protein heterooligomerization Source: RGD
    5. regulation of membrane potential Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199159. Voltage gated Potassium channels.

    Protein family/group databases

    TCDBi1.A.1.20.3. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily H member 7
    Alternative name(s):
    Ether-a-go-go-related gene potassium channel 3
    Short name:
    ERG-3
    Short name:
    Eag-related protein 3
    Short name:
    Ether-a-go-go-related protein 3
    Voltage-gated potassium channel subunit Kv11.3
    Gene namesi
    Name:Kcnh7
    Synonyms:Erg3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi621112. Kcnh7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi480 – 4801E → S: Lower channel activity.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11951195Potassium voltage-gated channel subfamily H member 7PRO_0000054017Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO54852.

    PTM databases

    PhosphoSiteiO54852.

    Expressioni

    Tissue specificityi

    Detected in total brain, in superior cervical, mesenteric and celiac ganglia, and at very low levels in retina. Found in pituitary.1 Publication

    Gene expression databases

    GenevestigatoriO54852.

    Interactioni

    Subunit structurei

    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2.

    Protein-protein interaction databases

    BioGridi250984. 1 interaction.
    STRINGi10116.ENSRNOP00000009920.

    Structurei

    3D structure databases

    ProteinModelPortaliO54852.
    SMRiO54852. Positions 26-135, 572-614.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 412412CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini434 – 44916ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini471 – 49424CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini516 – 5216ExtracellularSequence Analysis
    Topological domaini543 – 5497CytoplasmicSequence Analysis
    Topological domaini571 – 61444ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini636 – 6416ExtracellularSequence Analysis
    Topological domaini663 – 1195533CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei615 – 63521Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei413 – 43321Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei450 – 47021Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei495 – 51521Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei522 – 54221Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei550 – 57021Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei642 – 66221Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 7030PASAdd
    BLAST
    Domaini92 – 14453PACAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi627 – 6326Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2202.
    GeneTreeiENSGT00680000099663.
    HOGENOMiHOG000230793.
    HOVERGENiHBG052232.
    InParanoidiO54852.
    KOiK04910.
    OMAiESQMTTD.
    OrthoDBiEOG75B879.
    PhylomeDBiO54852.
    TreeFamiTF313130.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003967. K_chnl_volt-dep_ERG.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view]
    PRINTSiPR01463. EAGCHANLFMLY.
    PR01470. ERGCHANNEL.
    SMARTiSM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54852-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVRRGHVAP QNTFLGTIIR KFEGQNKKFI IANARVQNCA IIYCNDGFCE     50
    MTGFSRPDVM QKPCTCDFLH GPETKRHDIA QIAQALLGSE ERKVEVTYYH 100
    KNGSTFICNT HIIPVKNQEG VAMMFIINFE YVTDEDNAAS PERVNPILPV 150
    KSVNRKLFGF KFPGLRVLTY RKQSLPQEDP DVVVIDSSKH SDDSVAMKHF 200
    KSPTKESCSP SEADDTKALI QPSQCSPLVN ISGPLDHSSP KRQWDRLYPD 250
    MLQSSSQLTH SRSRESLCSI RRASSVHDIE GFNVHPKNIF RDRHASEDNG 300
    RNVKGPFNHI KSSLLGSTSD SNLNKYSTIN KIPQLTLNFS DVKTEKKNTS 350
    PPSSDKTIIA PKVKERTHNV TEKVTQVLSL GADVLPEYKL QTPRINKFTI 400
    LHYSPFKAVW DWLILLLVIY TAIFTPYSAA FLLNDREEQK RRECGYSCSP 450
    LNVVDLIVDI MFIIDILINF RTTYVNQNEE VVSDPAKIAV HYFKGWFLID 500
    MVAAIPFDLL IFGSGSDETT TLIGLLKTAR LLRLVRVARK LDRYSEYGAA 550
    VLMLLMCIFA LIAHWLACIW YAIGNVERPY LTDKIGWLDS LGTQIGKRYN 600
    DSDSSSGPSI KDKYVTALYF TFSSLTSVGF GNVSPNTNSE KIFSICVMLI 650
    GSLMYASIFG NVSAIIQRLY SGTARYHMQM LRVKEFIRFH QIPNPLRQRL 700
    EEYFQHAWTY TNGIDMNMVL KGFPECLQAD ICLHLNQTLL QNCKAFRGAS 750
    KGCLRALAMK FKTTHAPPGD TLVHCGDVLT ALYFLSRGSI EILKDDIVVA 800
    ILGKNDIFGE MVHLYAKPGK SNADVRALTY CDLHKIQRED LLEVLDMYPE 850
    FSDHFLTNLE LTFNLRHESA KSQSINDSEG DTCKLRRRRL SFESEGDKDF 900
    SKENSANDAD DSTDTIRRYQ SSKKHFEEKK SRSSSFISSI DDEQKPLFLG 950
    TVDSTPRMVK ASRHHGEEAA PPSGRIHTDK RSHSCKDITD THSWEREHAR 1000
    AQPEECSPSG LQRAAWGISE TESDLTYGEV EQRLDLLQEQ LNRLESQMTT 1050
    DIQAILQLLQ KQTTVVPPAY SMVTAGAEYQ RPILRLLRTS HPRASIKTDR 1100
    SFSPSSQCPE FLDLEKSKLK SKESLSSGKR LNTASEDNLT SLLKQDSDAS 1150
    SELDPRQRKS YLHPIRHPSL PDSSLSTVGI LGLHRHVSDP GLPGK 1195
    Length:1,195
    Mass (Da):134,901
    Last modified:June 1, 1998 - v1
    Checksum:iBA24C54BB86C59B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016191 mRNA. Translation: AAB94741.1.
    RefSeqiNP_571987.1. NM_131912.1.
    UniGeneiRn.10874.

    Genome annotation databases

    EnsembliENSRNOT00000009920; ENSRNOP00000009920; ENSRNOG00000007528.
    GeneIDi170739.
    KEGGirno:170739.
    UCSCiRGD:621112. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016191 mRNA. Translation: AAB94741.1 .
    RefSeqi NP_571987.1. NM_131912.1.
    UniGenei Rn.10874.

    3D structure databases

    ProteinModelPortali O54852.
    SMRi O54852. Positions 26-135, 572-614.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 250984. 1 interaction.
    STRINGi 10116.ENSRNOP00000009920.

    Chemistry

    GuidetoPHARMACOLOGYi 574.

    Protein family/group databases

    TCDBi 1.A.1.20.3. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei O54852.

    Proteomic databases

    PaxDbi O54852.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009920 ; ENSRNOP00000009920 ; ENSRNOG00000007528 .
    GeneIDi 170739.
    KEGGi rno:170739.
    UCSCi RGD:621112. rat.

    Organism-specific databases

    CTDi 90134.
    RGDi 621112. Kcnh7.

    Phylogenomic databases

    eggNOGi COG2202.
    GeneTreei ENSGT00680000099663.
    HOGENOMi HOG000230793.
    HOVERGENi HBG052232.
    InParanoidi O54852.
    KOi K04910.
    OMAi ESQMTTD.
    OrthoDBi EOG75B879.
    PhylomeDBi O54852.
    TreeFami TF313130.

    Enzyme and pathway databases

    Reactomei REACT_199159. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 621207.
    PROi O54852.

    Gene expression databases

    Genevestigatori O54852.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003967. K_chnl_volt-dep_ERG.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view ]
    PRINTSi PR01463. EAGCHANLFMLY.
    PR01470. ERGCHANNEL.
    SMARTi SM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two nervous system-specific members of the erg potassium channel gene family."
      Shi W., Wymore R.S., Wang H.-S., Pan Z., Cohen I.S., McKinnon D., Dixon J.E.
      J. Neurosci. 17:9423-9432(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary."
      Wulfsen I., Hauber H.-P., Schiemann D., Bauer C.K., Schwarz J.R.
      J. Neuroendocrinol. 12:263-272(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    3. "Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers."
      Wimmers S., Wulfsen I., Bauer C.K., Schwarz J.R.
      Pflugers Arch. 441:450-455(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KCNH2 AND KCNH6.

    Entry informationi

    Entry nameiKCNH7_RAT
    AccessioniPrimary (citable) accession number: O54852
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3