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O54851

- CXD2_MOUSE

UniProt

O54851 - CXD2_MOUSE

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Protein
Gap junction delta-2 protein
Gene
Gjd2, Gja9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. action potential Source: MGI
  2. cell-cell signaling Source: MGI
  3. synaptic transmission Source: MGI
  4. visual perception Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction delta-2 protein
Alternative name(s):
Connexin-36
Short name:
Cx36
Gap junction alpha-9 protein
Gene namesi
Name:Gjd2
Synonyms:Gja9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1334209. Gjd2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei20 – 4223Helical; Reviewed prediction
Add
BLAST
Topological domaini43 – 7533Extracellular Reviewed prediction
Add
BLAST
Transmembranei76 – 9823Helical; Reviewed prediction
Add
BLAST
Topological domaini99 – 19799Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei198 – 22023Helical; Reviewed prediction
Add
BLAST
Topological domaini221 – 25232Extracellular Reviewed prediction
Add
BLAST
Transmembranei253 – 27523Helical; Reviewed prediction
Add
BLAST
Topological domaini276 – 32146Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. connexon complex Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Gap junction delta-2 protein
PRO_0000057836Add
BLAST

Proteomic databases

PRIDEiO54851.

PTM databases

PhosphoSiteiO54851.

Expressioni

Tissue specificityi

Highly expressed in neurons.

Gene expression databases

BgeeiO54851.
CleanExiMM_GJD2.
GenevestigatoriO54851.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

BioGridi199930. 1 interaction.
STRINGi10090.ENSMUSP00000087742.

Structurei

3D structure databases

ProteinModelPortaliO54851.
SMRiO54851. Positions 3-108, 182-275.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47775.
GeneTreeiENSGT00750000117663.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ6PDP3.
KOiK07373.
OMAiNKETEPD.
OrthoDBiEOG7FNC7T.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002260. Connexin36.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01131. CONNEXIN36.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54851-1 [UniParc]FASTAAdd to Basket

« Hide

MGEWTILERL LEAAVQQHST MIGRILLTVV VIFRILIVAI VGETVYDDEQ    50
TMFVCNTLQP GCNQACYDRA FPISHIRYWV FQIIMVCTPS LCFITYSVHQ 100
SAKQRERRYS TVFLALDRDP AESIGGPGGT GGGGSGGSKR EDKKLQNAIV 150
NGVLQNTETT SKETEPDCLE VKELTPHPSG LRTAARSKLR RQEGISRFYI 200
IQVVFRNALE IGFLVGQYFL YGFSVPGLYE CNRYPCIKEV ECYVSRPTEK 250
TVFLVFMFAV SGICVVLNLA ELNHLGWRKI KLAVRGAQAK RKSVYEIRNK 300
DLPRVSVPNF GRTQSSDSAY V 321
Length:321
Mass (Da):36,082
Last modified:July 27, 2011 - v2
Checksum:i77858B58CF4B5F5E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171Missing in AAF86379. 1 Publication
Sequence conflicti76 – 761I → V in AAD13684. 1 Publication
Sequence conflicti149 – 1491I → M in AAD13684. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016190 Genomic DNA. Translation: AAD13684.1.
AF226992 Genomic DNA. Translation: AAF86379.1.
AL844569 Genomic DNA. Translation: CAM18120.1.
CH466519 Genomic DNA. Translation: EDL27860.1.
BC058595 mRNA. Translation: AAH58595.1.
CCDSiCCDS16563.1.
RefSeqiNP_034420.2. NM_010290.2.
UniGeneiMm.389394.

Genome annotation databases

EnsembliENSMUST00000090275; ENSMUSP00000087742; ENSMUSG00000068615.
GeneIDi14617.
KEGGimmu:14617.
UCSCiuc008lpu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016190 Genomic DNA. Translation: AAD13684.1 .
AF226992 Genomic DNA. Translation: AAF86379.1 .
AL844569 Genomic DNA. Translation: CAM18120.1 .
CH466519 Genomic DNA. Translation: EDL27860.1 .
BC058595 mRNA. Translation: AAH58595.1 .
CCDSi CCDS16563.1.
RefSeqi NP_034420.2. NM_010290.2.
UniGenei Mm.389394.

3D structure databases

ProteinModelPortali O54851.
SMRi O54851. Positions 3-108, 182-275.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199930. 1 interaction.
STRINGi 10090.ENSMUSP00000087742.

PTM databases

PhosphoSitei O54851.

Proteomic databases

PRIDEi O54851.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090275 ; ENSMUSP00000087742 ; ENSMUSG00000068615 .
GeneIDi 14617.
KEGGi mmu:14617.
UCSCi uc008lpu.1. mouse.

Organism-specific databases

CTDi 57369.
MGIi MGI:1334209. Gjd2.

Phylogenomic databases

eggNOGi NOG47775.
GeneTreei ENSGT00750000117663.
HOGENOMi HOG000231127.
HOVERGENi HBG009576.
InParanoidi Q6PDP3.
KOi K07373.
OMAi NKETEPD.
OrthoDBi EOG7FNC7T.
TreeFami TF329606.

Miscellaneous databases

NextBioi 286432.
PROi O54851.
SOURCEi Search...

Gene expression databases

Bgeei O54851.
CleanExi MM_GJD2.
Genevestigatori O54851.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002260. Connexin36.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01131. CONNEXIN36.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons."
    Condorelli D.F., Parenti R., Spinella F., Trovato Salinaro A., Belluardo N., Cardile V., Cicirata F.
    Eur. J. Neurosci. 10:1202-1208(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genomic organization and chromosomal localization of the mouse Connexin36 (mCx36) gene."
    Cicirata F., Parenti R., Spinella F., Giglio S., Tuorto F., Zuffardi O., Gulisano M.
    Gene 251:123-130(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiCXD2_MOUSE
AccessioniPrimary (citable) accession number: O54851
Secondary accession number(s): Q6PDP3, Q9JII0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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