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O54851

- CXD2_MOUSE

UniProt

O54851 - CXD2_MOUSE

Protein

Gap junction delta-2 protein

Gene

Gjd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. action potential Source: MGI
    2. cell-cell signaling Source: MGI
    3. synaptic transmission Source: MGI
    4. visual perception Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction delta-2 protein
    Alternative name(s):
    Connexin-36
    Short name:
    Cx36
    Gap junction alpha-9 protein
    Gene namesi
    Name:Gjd2
    Synonyms:Gja9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1334209. Gjd2.

    Subcellular locationi

    GO - Cellular componenti

    1. connexon complex Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Gap junction delta-2 proteinPRO_0000057836Add
    BLAST

    Proteomic databases

    PRIDEiO54851.

    PTM databases

    PhosphoSiteiO54851.

    Expressioni

    Tissue specificityi

    Highly expressed in neurons.

    Gene expression databases

    BgeeiO54851.
    CleanExiMM_GJD2.
    GenevestigatoriO54851.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.

    Protein-protein interaction databases

    BioGridi199930. 1 interaction.
    STRINGi10090.ENSMUSP00000087742.

    Structurei

    3D structure databases

    ProteinModelPortaliO54851.
    SMRiO54851. Positions 3-108, 182-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini43 – 7533ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini99 – 19799CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini221 – 25232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini276 – 32146CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 22023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei253 – 27523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the connexin family. Delta-type subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47775.
    GeneTreeiENSGT00750000117663.
    HOGENOMiHOG000231127.
    HOVERGENiHBG009576.
    InParanoidiQ6PDP3.
    KOiK07373.
    OMAiNKETEPD.
    OrthoDBiEOG7FNC7T.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002260. Connexin36.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01131. CONNEXIN36.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54851-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEWTILERL LEAAVQQHST MIGRILLTVV VIFRILIVAI VGETVYDDEQ    50
    TMFVCNTLQP GCNQACYDRA FPISHIRYWV FQIIMVCTPS LCFITYSVHQ 100
    SAKQRERRYS TVFLALDRDP AESIGGPGGT GGGGSGGSKR EDKKLQNAIV 150
    NGVLQNTETT SKETEPDCLE VKELTPHPSG LRTAARSKLR RQEGISRFYI 200
    IQVVFRNALE IGFLVGQYFL YGFSVPGLYE CNRYPCIKEV ECYVSRPTEK 250
    TVFLVFMFAV SGICVVLNLA ELNHLGWRKI KLAVRGAQAK RKSVYEIRNK 300
    DLPRVSVPNF GRTQSSDSAY V 321
    Length:321
    Mass (Da):36,082
    Last modified:July 27, 2011 - v2
    Checksum:i77858B58CF4B5F5E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171Missing in AAF86379. (PubMed:10876089)Curated
    Sequence conflicti76 – 761I → V in AAD13684. (PubMed:9753189)Curated
    Sequence conflicti149 – 1491I → M in AAD13684. (PubMed:9753189)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016190 Genomic DNA. Translation: AAD13684.1.
    AF226992 Genomic DNA. Translation: AAF86379.1.
    AL844569 Genomic DNA. Translation: CAM18120.1.
    CH466519 Genomic DNA. Translation: EDL27860.1.
    BC058595 mRNA. Translation: AAH58595.1.
    CCDSiCCDS16563.1.
    RefSeqiNP_034420.2. NM_010290.2.
    UniGeneiMm.389394.

    Genome annotation databases

    EnsembliENSMUST00000090275; ENSMUSP00000087742; ENSMUSG00000068615.
    GeneIDi14617.
    KEGGimmu:14617.
    UCSCiuc008lpu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016190 Genomic DNA. Translation: AAD13684.1 .
    AF226992 Genomic DNA. Translation: AAF86379.1 .
    AL844569 Genomic DNA. Translation: CAM18120.1 .
    CH466519 Genomic DNA. Translation: EDL27860.1 .
    BC058595 mRNA. Translation: AAH58595.1 .
    CCDSi CCDS16563.1.
    RefSeqi NP_034420.2. NM_010290.2.
    UniGenei Mm.389394.

    3D structure databases

    ProteinModelPortali O54851.
    SMRi O54851. Positions 3-108, 182-275.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199930. 1 interaction.
    STRINGi 10090.ENSMUSP00000087742.

    PTM databases

    PhosphoSitei O54851.

    Proteomic databases

    PRIDEi O54851.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090275 ; ENSMUSP00000087742 ; ENSMUSG00000068615 .
    GeneIDi 14617.
    KEGGi mmu:14617.
    UCSCi uc008lpu.1. mouse.

    Organism-specific databases

    CTDi 57369.
    MGIi MGI:1334209. Gjd2.

    Phylogenomic databases

    eggNOGi NOG47775.
    GeneTreei ENSGT00750000117663.
    HOGENOMi HOG000231127.
    HOVERGENi HBG009576.
    InParanoidi Q6PDP3.
    KOi K07373.
    OMAi NKETEPD.
    OrthoDBi EOG7FNC7T.
    TreeFami TF329606.

    Miscellaneous databases

    NextBioi 286432.
    PROi O54851.
    SOURCEi Search...

    Gene expression databases

    Bgeei O54851.
    CleanExi MM_GJD2.
    Genevestigatori O54851.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002260. Connexin36.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01131. CONNEXIN36.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons."
      Condorelli D.F., Parenti R., Spinella F., Trovato Salinaro A., Belluardo N., Cardile V., Cicirata F.
      Eur. J. Neurosci. 10:1202-1208(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Genomic organization and chromosomal localization of the mouse Connexin36 (mCx36) gene."
      Cicirata F., Parenti R., Spinella F., Giglio S., Tuorto F., Zuffardi O., Gulisano M.
      Gene 251:123-130(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiCXD2_MOUSE
    AccessioniPrimary (citable) accession number: O54851
    Secondary accession number(s): Q6PDP3, Q9JII0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3