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O54851 (CXD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction delta-2 protein
Alternative name(s):
Connexin-36
Short name=Cx36
Gap junction alpha-9 protein
Gene names
Name:Gjd2
Synonyms:Gja9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subunit structure

A connexon is composed of a hexamer of connexins.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctiongap junction.

Tissue specificity

Highly expressed in neurons.

Sequence similarities

Belongs to the connexin family. Delta-type subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Gap junction delta-2 protein
PRO_0000057836

Regions

Topological domain1 – 1919Cytoplasmic Potential
Transmembrane20 – 4223Helical; Potential
Topological domain43 – 7533Extracellular Potential
Transmembrane76 – 9823Helical; Potential
Topological domain99 – 19799Cytoplasmic Potential
Transmembrane198 – 22023Helical; Potential
Topological domain221 – 25232Extracellular Potential
Transmembrane253 – 27523Helical; Potential
Topological domain276 – 32146Cytoplasmic Potential

Experimental info

Sequence conflict171Missing in AAF86379. Ref.2
Sequence conflict761I → V in AAD13684. Ref.1
Sequence conflict1491I → M in AAD13684. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O54851 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 77858B58CF4B5F5E

FASTA32136,082
        10         20         30         40         50         60 
MGEWTILERL LEAAVQQHST MIGRILLTVV VIFRILIVAI VGETVYDDEQ TMFVCNTLQP 

        70         80         90        100        110        120 
GCNQACYDRA FPISHIRYWV FQIIMVCTPS LCFITYSVHQ SAKQRERRYS TVFLALDRDP 

       130        140        150        160        170        180 
AESIGGPGGT GGGGSGGSKR EDKKLQNAIV NGVLQNTETT SKETEPDCLE VKELTPHPSG 

       190        200        210        220        230        240 
LRTAARSKLR RQEGISRFYI IQVVFRNALE IGFLVGQYFL YGFSVPGLYE CNRYPCIKEV 

       250        260        270        280        290        300 
ECYVSRPTEK TVFLVFMFAV SGICVVLNLA ELNHLGWRKI KLAVRGAQAK RKSVYEIRNK 

       310        320 
DLPRVSVPNF GRTQSSDSAY V 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons."
Condorelli D.F., Parenti R., Spinella F., Trovato Salinaro A., Belluardo N., Cardile V., Cicirata F.
Eur. J. Neurosci. 10:1202-1208(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genomic organization and chromosomal localization of the mouse Connexin36 (mCx36) gene."
Cicirata F., Parenti R., Spinella F., Giglio S., Tuorto F., Zuffardi O., Gulisano M.
Gene 251:123-130(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF016190 Genomic DNA. Translation: AAD13684.1.
AF226992 Genomic DNA. Translation: AAF86379.1.
AL844569 Genomic DNA. Translation: CAM18120.1.
CH466519 Genomic DNA. Translation: EDL27860.1.
BC058595 mRNA. Translation: AAH58595.1.
RefSeqNP_034420.2. NM_010290.2.
UniGeneMm.389394.

3D structure databases

ProteinModelPortalO54851.
SMRO54851. Positions 3-278.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199930. 1 interaction.
STRING10090.ENSMUSP00000087742.

PTM databases

PhosphoSiteO54851.

Proteomic databases

PRIDEO54851.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000090275; ENSMUSP00000087742; ENSMUSG00000068615.
GeneID14617.
KEGGmmu:14617.
UCSCuc008lpu.1. mouse.

Organism-specific databases

CTD57369.
MGIMGI:1334209. Gjd2.

Phylogenomic databases

eggNOGNOG47775.
GeneTreeENSGT00750000117663.
HOGENOMHOG000231127.
HOVERGENHBG009576.
InParanoidQ6PDP3.
KOK07373.
OMARDPPESM.
OrthoDBEOG7FNC7T.
TreeFamTF329606.

Gene expression databases

BgeeO54851.
CleanExMM_GJD2.
GenevestigatorO54851.

Family and domain databases

InterProIPR000500. Connexin.
IPR002260. Connexin36.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
PR01131. CONNEXIN36.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286432.
PROO54851.
SOURCESearch...

Entry information

Entry nameCXD2_MOUSE
AccessionPrimary (citable) accession number: O54851
Secondary accession number(s): Q6PDP3, Q9JII0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot