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O54845 (O54845_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Hnf4a MGI 109128
Synonyms:Hnf4 MGI 109128, HNF4alpha EMBL AAC02906.1
OrganismMus musculus (Mouse) EMBL AAC02906.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length100 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377

Contains nuclear receptor DNA-binding domain. SAAS SAAS001628

Ontologies

Keywords
   Biological processTranscription
Transcription regulation SAAS SAAS001628
   Cellular componentNucleus SAAS SAAS001628
   DomainZinc-finger SAAS SAAS001628
   LigandDNA-binding SAAS SAAS001628
Metal-binding
Zinc
Gene Ontology (GO)
   Biological_processSMAD protein signal transduction

Inferred from direct assay PubMed 9420335. Source: MGI

lipid metabolic process

Inferred from mutant phenotype PubMed 16498401. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10859308PubMed 15581617PubMed 16527247PubMed 17636037. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 9408084Ref.1. Source: MGI

regulation of gastrulation

Inferred from mutant phenotype PubMed 7958910. Source: MGI

regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 9053305. Source: MGI

sex differentiation

Inferred from mutant phenotype PubMed 17412818. Source: MGI

signal transduction involved in regulation of gene expression

Inferred from direct assay PubMed 18462699. Source: MGI

transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10859308. Source: GOC

   Cellular_componentnucleus

Inferred from direct assay PubMed 15767668PubMed 16537911PubMed 17021047PubMed 8306889PubMed 9408084Ref.1. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15014077PubMed 15581617PubMed 16912278. Source: MGI

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 10859308. Source: MGI

protein binding

Inferred from physical interaction PubMed 17636037. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 8306889. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 16498401. Source: MGI

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue1001 EMBL AAC02906.1

Sequences

Sequence LengthMass (Da)Tools
O54845 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: F70CC0C1E8D3C7E3

FASTA10010,964
        10         20         30         40         50         60 
MVSVNAPLGA PVASPYDTSP SEGANLNSSN SLGVSALCAI CGDRATAKHY GASSCDGCKG 

        70         80         90        100 
FFRRSVRKNH MYSCRFSRQC VVDKDKRNQC RYCRLKKCFR 

« Hide

References

[1]"An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types."
Nakhei H., Lingott A., Lemm I., Ryffel G.U.
Nucleic Acids Res. 26:497-504(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF015275 mRNA. Translation: AAC02906.1.
UniGeneMm.202383.

3D structure databases

ProteinModelPortalO54845.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:109128. Hnf4a.

Phylogenomic databases

HOVERGENHBG082808.

Gene expression databases

GenevestigatorO54845.

Family and domain databases

Gene3D3.30.50.10. 1 hit.
InterProIPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR00047. STROIDFINGER.
SMARTSM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHNF4A. mouse.
SOURCESearch...

Entry information

Entry nameO54845_MOUSE
AccessionPrimary (citable) accession number: O54845
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)