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Protein

Dual specificity protein phosphatase 5

Gene

Dusp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei263 – 2631Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: RGD
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. endoderm formation Source: GO_Central
  2. inactivation of MAPK activity Source: GOC
  3. negative regulation of transcription, DNA-templated Source: RGD
  4. protein dephosphorylation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 5 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
MAP-kinase phosphatase CPG21
Gene namesi
Name:Dusp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620854. Dusp5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Dual specificity protein phosphatase 5PRO_0000094803Add
BLAST

Proteomic databases

PRIDEiO54838.

PTM databases

PhosphoSiteiO54838.

Expressioni

Gene expression databases

GenevestigatoriO54838.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018889.

Structurei

3D structure databases

ProteinModelPortaliO54838.
SMRiO54838. Positions 178-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 141123RhodanesePROSITE-ProRule annotationAdd
BLAST
Domaini180 – 384205Tyrosine-protein phosphataseAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi53 – 7422Nuclear localization signalSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi79 – 824Poly-Gly

Sequence similaritiesi

Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2453.
HOGENOMiHOG000294080.
HOVERGENiHBG007347.
InParanoidiO54838.
KOiK04459.
PhylomeDBiO54838.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTSLDGRR LRKMLRKEAE ARCVVLDCRP YLAFAASSVR GSLNVNLNSV
60 70 80 90 100
VLRRARGGAV SARYVLADEA ARARLLQEGG GGVAAVVVLD QGSRHWQKLR
110 120 130 140 150
EESAARVVLT SLLACLSAGP RVYFLKGGYE TFYSQYPECC VDAKPISQEK
160 170 180 190 200
LEGERGLLSQ CGKPILSVAY RPAYDQGGPV EILPFLYLGS AYHASKCEFL
210 220 230 240 250
ANLHITALLN VSRRTSEACT THLHYKWIPV EDSHTADISS HFQEAIDFID
260 270 280 290 300
CVREEGGKVL VHCEAGVSRS PTICMAYLMK TKQFRLKEAF EYIKQRRSVV
310 320 330 340 350
SPNFGFMGQL LQYESEILPS TPTPQPPSCQ GEAASSTFIG HLQTLSPDMQ
360 370 380
GAYCTFPTSV LAPVPTHATV AELHRSPVAT ATSC
Length:384
Mass (Da):42,094
Last modified:May 31, 1998 - v1
Checksum:i5644069B8D348700
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013144 mRNA. Translation: AAB94858.1.
RefSeqiNP_598262.1. NM_133578.1.
UniGeneiRn.10877.

Genome annotation databases

GeneIDi171109.
KEGGirno:171109.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013144 mRNA. Translation: AAB94858.1.
RefSeqiNP_598262.1. NM_133578.1.
UniGeneiRn.10877.

3D structure databases

ProteinModelPortaliO54838.
SMRiO54838. Positions 178-320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018889.

PTM databases

PhosphoSiteiO54838.

Proteomic databases

PRIDEiO54838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171109.
KEGGirno:171109.

Organism-specific databases

CTDi1847.
RGDi620854. Dusp5.

Phylogenomic databases

eggNOGiCOG2453.
HOGENOMiHOG000294080.
HOVERGENiHBG007347.
InParanoidiO54838.
KOiK04459.
PhylomeDBiO54838.

Miscellaneous databases

NextBioi621812.
PROiO54838.

Gene expression databases

GenevestigatoriO54838.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiDUS5_RAT
AccessioniPrimary (citable) accession number: O54838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1999
Last sequence update: May 31, 1998
Last modified: February 3, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.