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Protein

Prolactin-7A2

Gene

Prl7a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin-7A2
Alternative name(s):
Placental prolactin-like protein F
Short name:
PLP-F
Short name:
PRL-like protein F
Gene namesi
Name:Prl7a2
Synonyms:Prlpf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1206571. Prl7a2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 253223Prolactin-7A2PRO_0000045130Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi101 ↔ 218By similarity
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi235 ↔ 244By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO54831.
PRIDEiO54831.

Expressioni

Tissue specificityi

Expression restricted to the placental tissue. Expressed only in the spongiotrophoblasts.1 Publication

Developmental stagei

Not detected until later in gestation.

Gene expression databases

BgeeiO54831.
CleanExiMM_PRL7A2.
ExpressionAtlasiO54831. baseline and differential.
GenevisibleiO54831. MM.

Interactioni

Protein-protein interaction databases

IntActiO54831. 1 interaction.
MINTiMINT-4105031.
STRINGi10090.ENSMUSP00000006660.

Structurei

3D structure databases

ProteinModelPortaliO54831.
SMRiO54831. Positions 43-237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi183 – 1864Poly-Thr

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00730000110805.
HOVERGENiHBG104895.
InParanoidiO54831.
OMAiCCHNYSI.
OrthoDBiEOG7WQ7XH.
PhylomeDBiO54831.
TreeFamiTF332592.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O54831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSFSQPCP SGALLLVVVS SLLLWENVAS VPLSSNETDG YPLSINGLFH
60 70 80 90 100
NAMRLTWNIK NLNMELRKTY TVNQVSEKLY ENYMLDFIED MEYLVKALTC
110 120 130 140 150
CHNYSIKTPE NLDEAQQIPF NEFPKLILSR MWAWNETSKV LLTTLRSIPG
160 170 180 190 200
MHDDVISLAK NIETKLAELF EYTQSILNSI YGTTTTGNVE YTVFSGLEDL
210 220 230 240 250
KSSDEEFSLF DLCKFSYCLR VDIHMVELYL KLLECVVYVS SDVCLSKNIR

DAS
Length:253
Mass (Da):28,921
Last modified:June 1, 1998 - v1
Checksum:iD48CC781E5CE5299
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011382 mRNA. Translation: AAB92398.1.
AK005455 mRNA. Translation: BAB24047.1.
AK131665 mRNA. Translation: BAE20752.1.
AL590522 Genomic DNA. Translation: CAI23987.1.
BC099468 mRNA. Translation: AAH99468.1.
CCDSiCCDS26404.1.
RefSeqiNP_035298.1. NM_011168.4.
UniGeneiMm.153999.

Genome annotation databases

EnsembliENSMUST00000006660; ENSMUSP00000006660; ENSMUSG00000046899.
GeneIDi19114.
KEGGimmu:19114.
UCSCiuc007pya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011382 mRNA. Translation: AAB92398.1.
AK005455 mRNA. Translation: BAB24047.1.
AK131665 mRNA. Translation: BAE20752.1.
AL590522 Genomic DNA. Translation: CAI23987.1.
BC099468 mRNA. Translation: AAH99468.1.
CCDSiCCDS26404.1.
RefSeqiNP_035298.1. NM_011168.4.
UniGeneiMm.153999.

3D structure databases

ProteinModelPortaliO54831.
SMRiO54831. Positions 43-237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO54831. 1 interaction.
MINTiMINT-4105031.
STRINGi10090.ENSMUSP00000006660.

Proteomic databases

PaxDbiO54831.
PRIDEiO54831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006660; ENSMUSP00000006660; ENSMUSG00000046899.
GeneIDi19114.
KEGGimmu:19114.
UCSCiuc007pya.1. mouse.

Organism-specific databases

CTDi19114.
MGIiMGI:1206571. Prl7a2.

Phylogenomic databases

GeneTreeiENSGT00730000110805.
HOVERGENiHBG104895.
InParanoidiO54831.
OMAiCCHNYSI.
OrthoDBiEOG7WQ7XH.
PhylomeDBiO54831.
TreeFamiTF332592.

Miscellaneous databases

PROiO54831.
SOURCEiSearch...

Gene expression databases

BgeeiO54831.
CleanExiMM_PRL7A2.
ExpressionAtlasiO54831. baseline and differential.
GenevisibleiO54831. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel members of the prolactin/growth hormone family are expressed in the mouse placenta."
    Lin J., Poole J., Linzer D.I.
    Endocrinology 138:5535-5540(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiPR7A2_MOUSE
AccessioniPrimary (citable) accession number: O54831
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.