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Protein

Prolactin-7A1

Gene

Prl7a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin-7A1
Alternative name(s):
Placental prolactin-like protein E
Short name:
PLP-E
Short name:
PRL-like protein E
Placental prolactin-like protein G
Short name:
PLP-G
Short name:
PRL-like protein G
Gene namesi
Name:Prl7a1
Synonyms:Prlpe, Prlpg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1206572. Prl7a1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 266236Prolactin-7A1PRO_0000045211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 231By similarity
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence analysis
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi248 ↔ 257By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO54830.
PRIDEiO54830.

Expressioni

Tissue specificityi

Expressed specifically in the placenta. Detected only in the trophoblast giant cells.

Developmental stagei

Highest expression at mid-pregnancy.

Gene expression databases

BgeeiO54830.
CleanExiMM_PRL7A1.
GenevisibleiO54830. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093614.

Structurei

3D structure databases

ProteinModelPortaliO54830.
SMRiO54830. Positions 89-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00730000110805.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiO54830.
OMAiHAMILSK.
OrthoDBiEOG7WQ7XH.
PhylomeDBiO54830.
TreeFamiTF332592.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 2 hits.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 2 hits.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O54830-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLSFTQPCS SGALLLLVVS NLLLWENVAC LPLSSNDTDD DPLSIKGLLD
60 70 80 90 100
HAMILSKNIT DLNMELRRIF TISEMSAKLI DKFLSSSSSS DSYDQFMLEF
110 120 130 140 150
LGQQELLTKN LTYCHKYSIK VPEDIEEAQN VISLEDFPIL ILSRMQAWNE
160 170 180 190 200
TLKNRINLSE GTPGIDDDIL PIYKNIETKI AELLEDSKSI LSQAYGATEN
210 220 230 240 250
VADYTLWSGL EDLQSSDEET RFLALCKLSY CLHVDIHTAN FYLQFLRCVA
260
LVNSDSCLSS KTGNDS
Length:266
Mass (Da):29,828
Last modified:December 20, 2005 - v2
Checksum:i293432EBC98F22A6
GO
Isoform 2 (identifier: O54830-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-12: SG → W

Show »
Length:265
Mass (Da):29,870
Checksum:iD4D7F9ACC4954478
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581N → S in AAH51671 (PubMed:15489334).Curated
Sequence conflicti213 – 2131L → F in AAH51671 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei11 – 122SG → W in isoform 2. 2 PublicationsVSP_016678

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011381 mRNA. Translation: AAB92397.1.
AF020525 mRNA. Translation: AAB80729.1.
AK141309 mRNA. Translation: BAE24644.1.
AL590522 Genomic DNA. Translation: CAI23986.1.
AL590522 Genomic DNA. Translation: CAI23985.1.
BC051671 mRNA. Translation: AAH51671.1.
CCDSiCCDS26403.1. [O54830-2]
CCDS49224.1. [O54830-1]
RefSeqiNP_001157530.1. NM_001164058.1. [O54830-1]
NP_032956.1. NM_008930.2. [O54830-2]
UniGeneiMm.196424.

Genome annotation databases

EnsembliENSMUST00000006659; ENSMUSP00000006659; ENSMUSG00000006488. [O54830-2]
ENSMUST00000095924; ENSMUSP00000093614; ENSMUSG00000006488. [O54830-1]
GeneIDi19113.
KEGGimmu:19113.
UCSCiuc007pxy.2. mouse. [O54830-2]
uc007pxz.2. mouse. [O54830-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011381 mRNA. Translation: AAB92397.1.
AF020525 mRNA. Translation: AAB80729.1.
AK141309 mRNA. Translation: BAE24644.1.
AL590522 Genomic DNA. Translation: CAI23986.1.
AL590522 Genomic DNA. Translation: CAI23985.1.
BC051671 mRNA. Translation: AAH51671.1.
CCDSiCCDS26403.1. [O54830-2]
CCDS49224.1. [O54830-1]
RefSeqiNP_001157530.1. NM_001164058.1. [O54830-1]
NP_032956.1. NM_008930.2. [O54830-2]
UniGeneiMm.196424.

3D structure databases

ProteinModelPortaliO54830.
SMRiO54830. Positions 89-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093614.

Proteomic databases

PaxDbiO54830.
PRIDEiO54830.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006659; ENSMUSP00000006659; ENSMUSG00000006488. [O54830-2]
ENSMUST00000095924; ENSMUSP00000093614; ENSMUSG00000006488. [O54830-1]
GeneIDi19113.
KEGGimmu:19113.
UCSCiuc007pxy.2. mouse. [O54830-2]
uc007pxz.2. mouse. [O54830-1]

Organism-specific databases

CTDi19113.
MGIiMGI:1206572. Prl7a1.

Phylogenomic databases

GeneTreeiENSGT00730000110805.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiO54830.
OMAiHAMILSK.
OrthoDBiEOG7WQ7XH.
PhylomeDBiO54830.
TreeFamiTF332592.

Miscellaneous databases

NextBioi295690.
PROiO54830.
SOURCEiSearch...

Gene expression databases

BgeeiO54830.
CleanExiMM_PRL7A1.
GenevisibleiO54830. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 2 hits.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 2 hits.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel members of the prolactin/growth hormone family are expressed in the mouse placenta."
    Lin J., Poole J., Linzer D.I.
    Endocrinology 138:5535-5540(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
  2. "Identification of two new members of the mouse prolactin gene family."
    Mueller H., Orwig K.E., Soares M.J.
    Biochim. Biophys. Acta 1396:251-258(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiPR7A1_MOUSE
AccessioniPrimary (citable) accession number: O54830
Secondary accession number(s): O35334, Q80X21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: May 11, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.