Regulator of G-protein signaling 7 - Mus musculus (Mouse)

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O54829 (RGS7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 7
Short name=RGS7

Gene names

Name:

Rgs7

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations and in synaptic vesicle exocytosis By similarity.
Subunit structure	Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Interacts with SNAPIN By similarity. Ref.3 Ref.4
Post-translational modification	Palmitoylated By similarity. Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity By similarity.
Sequence similarities	Contains 1 DEP domain. Contains 1 G protein gamma domain. Contains 1 RGS domain.

Ontologies

Keywords
Molecular function	Signal transduction inhibitor
PTM	Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from direct assay Ref.4. Source: MGI intracellular signal transduction Inferred from electronic annotation. Source: InterPro regulation of G-protein coupled receptor protein signaling pathway Inferred from direct assay PubMed 22689652. Source: MGI termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome cytosol Inferred from electronic annotation. Source: Compara dendrite terminus Inferred from direct assay PubMed 22689652. Source: MGI heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro nucleus Inferred from direct assay Ref.4. Source: MGI plasma membrane Inferred from direct assay Ref.4. Source: MGI
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 469

469

Regulator of G-protein signaling 7

PRO_0000204197

Regions

Domain

37 – 112

DEP

Domain

255 – 316

G protein gamma

Domain

333 – 448

116

RGS

Amino acid modifications

Modified residue

229

Phosphoserine Ref.5

Modified residue

434

Phosphoserine By similarity

Experimental info

Sequence conflict

461

R → S in AAC99483. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

O54829 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: AE4B91280D87F211
Show »

FASTA

469

54,792

        10         20         30         40         50         60 
MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL SKIPSVFSGS 

        70         80         90        100        110        120 
DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT LKDDGTFYRF QTPYFWPSNC 

       130        140        150        160        170        180 
WEPENTDYAV YLCKRTMQNK ARLELADYEA ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK 

       190        200        210        220        230        240 
RDKIERKILD SQERAFWDVH RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH 

       250        260        270        280        290        300 
SPTHTPTPET KPPTEDELHQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY VEYDPFLVPP 

       310        320        330        340        350        360 
DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF LESEFSSENL 

       370        380        390        400        410        420 
RFWLAVEDLK RRPIREVPSR VQEIWQEFLA PGAPSAINLD SKSYDKTTQN VKEPGRYTFE 

       430        440        450        460 
DAQEHIYKLM KSDSYPRFIR SSAYQELLQA KRKGKTLTSK RLTSLVQSY

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"RGS9, a GTPase accelerator for phototransduction." He W., Cowan C.W., Wensel T.G. Neuron 20:95-102(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family." Martemyanov K.A., Yoo P.J., Skiba N.P., Arshavsky V.Y. J. Biol. Chem. 280:5133-5136(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RGS7BP.
[4]	"Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family." Drenan R.M., Doupnik C.A., Boyle M.P., Muglia L.J., Huettner J.E., Linder M.E., Blumer K.J. J. Cell Biol. 169:623-633(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RGS7BP.
[5]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF011360 mRNA. Translation: AAC99483.1. AC102499 Genomic DNA. No translation available. AC113050 Genomic DNA. No translation available. AC117693 Genomic DNA. No translation available. AC117734 Genomic DNA. No translation available. AC159973 Genomic DNA. No translation available.
IPI	IPI00627029.
RefSeq	NP_036010.2. NM_011880.3.
UniGene	Mm.7956.
3D structure databases
ProteinModelPortal	O54829.
SMR	O54829. Positions 19-450.
ModBase	Search...
Protein-protein interaction databases
IntAct	O54829. 1 interaction.
PTM databases
PhosphoSite	O54829.
Proteomic databases
PaxDb	O54829.
PRIDE	O54829.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027812; ENSMUSP00000027812; ENSMUSG00000026527.
GeneID	24012.
KEGG	mmu:24012.
Organism-specific databases
CTD	6000.
MGI	MGI:1346089. Rgs7.
Phylogenomic databases
eggNOG	NOG327614.
GeneTree	ENSGT00700000104259.
HOGENOM	HOG000220864.
HOVERGEN	HBG007404.
KO	K16449.
OMA	AHVYHLM.
OrthoDB	EOG41ZF9K.
Gene expression databases
Bgee	O54829.
CleanEx	MM_RGS7.
Genevestigator	O54829.
GermOnline	ENSMUSG00000026527. Mus musculus.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 1.10.196.10. 1 hit. 4.10.260.10. 1 hit.
InterPro	IPR000591. DEP_dom. IPR015898. G-protein_gamma-like_dom. IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00610. DEP. 1 hit. PF00631. G-gamma. 1 hit. PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00049. DEP. 1 hit. SM00224. GGL. 1 hit. SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit. SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50186. DEP. 1 hit. PS50058. G_PROTEIN_GAMMA. False negative. PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RGS7. mouse.
NextBio	303939.
SOURCE	Search...

Entry information

Entry name

RGS7_MOUSE

Accession

Primary (citable) accession number: O54829
Secondary accession number(s): E9QLB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents