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O54829 (RGS7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 7

Short name=RGS7
Gene names
Name:Rgs7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations and in synaptic vesicle exocytosis By similarity.

Subunit structure

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Interacts with SNAPIN By similarity. Ref.3 Ref.4

Post-translational modification

Palmitoylated By similarity.

Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity By similarity.

Sequence similarities

Contains 1 DEP domain.

Contains 1 G protein gamma domain.

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469Regulator of G-protein signaling 7
PRO_0000204197

Regions

Domain37 – 11276DEP
Domain255 – 31662G protein gamma
Domain333 – 448116RGS

Amino acid modifications

Modified residue4341Phosphoserine By similarity

Experimental info

Sequence conflict4611R → S in AAC99483. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O54829 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: AE4B91280D87F211

FASTA46954,792
        10         20         30         40         50         60 
MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL SKIPSVFSGS 

        70         80         90        100        110        120 
DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT LKDDGTFYRF QTPYFWPSNC 

       130        140        150        160        170        180 
WEPENTDYAV YLCKRTMQNK ARLELADYEA ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK 

       190        200        210        220        230        240 
RDKIERKILD SQERAFWDVH RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH 

       250        260        270        280        290        300 
SPTHTPTPET KPPTEDELHQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY VEYDPFLVPP 

       310        320        330        340        350        360 
DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF LESEFSSENL 

       370        380        390        400        410        420 
RFWLAVEDLK RRPIREVPSR VQEIWQEFLA PGAPSAINLD SKSYDKTTQN VKEPGRYTFE 

       430        440        450        460 
DAQEHIYKLM KSDSYPRFIR SSAYQELLQA KRKGKTLTSK RLTSLVQSY 

« Hide

References

« Hide 'large scale' references
[1]"RGS9, a GTPase accelerator for phototransduction."
He W., Cowan C.W., Wensel T.G.
Neuron 20:95-102(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family."
Martemyanov K.A., Yoo P.J., Skiba N.P., Arshavsky V.Y.
J. Biol. Chem. 280:5133-5136(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RGS7BP.
[4]"Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family."
Drenan R.M., Doupnik C.A., Boyle M.P., Muglia L.J., Huettner J.E., Linder M.E., Blumer K.J.
J. Cell Biol. 169:623-633(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RGS7BP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF011360 mRNA. Translation: AAC99483.1.
AC102499 Genomic DNA. No translation available.
AC113050 Genomic DNA. No translation available.
AC117693 Genomic DNA. No translation available.
AC117734 Genomic DNA. No translation available.
AC159973 Genomic DNA. No translation available.
RefSeqNP_036010.2. NM_011880.3.
UniGeneMm.7956.

3D structure databases

ProteinModelPortalO54829.
SMRO54829. Positions 19-450.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204852. 1 interaction.
IntActO54829. 2 interactions.
MINTMINT-4132332.

PTM databases

PhosphoSiteO54829.

Proteomic databases

PaxDbO54829.
PRIDEO54829.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027812; ENSMUSP00000027812; ENSMUSG00000026527.
GeneID24012.
KEGGmmu:24012.
UCSCuc007dtk.2. mouse.

Organism-specific databases

CTD6000.
MGIMGI:1346089. Rgs7.

Phylogenomic databases

eggNOGNOG327614.
GeneTreeENSGT00700000104259.
HOGENOMHOG000220864.
HOVERGENHBG007404.
KOK16449.
OMAWIMKNLD.
OrthoDBEOG7BZVS5.
TreeFamTF351956.

Gene expression databases

BgeeO54829.
CleanExMM_RGS7.
GenevestigatorO54829.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRGS7. mouse.
NextBio303939.
PROO54829.
SOURCESearch...

Entry information

Entry nameRGS7_MOUSE
AccessionPrimary (citable) accession number: O54829
Secondary accession number(s): E9QLB9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot