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O54829

- RGS7_MOUSE

UniProt

O54829 - RGS7_MOUSE

Protein

Regulator of G-protein signaling 7

Gene

Rgs7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations and in synaptic vesicle exocytosis By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome
    2. protein binding Source: MGI
    3. signal transducer activity Source: InterPro

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: MGI
    2. intracellular signal transduction Source: InterPro
    3. positive regulation of GTPase activity Source: GOC
    4. regulation of G-protein coupled receptor protein signaling pathway Source: MGI
    5. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 7
    Short name:
    RGS7
    Gene namesi
    Name:Rgs7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1346089. Rgs7.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytosol Source: Ensembl
    3. dendrite terminus Source: MGI
    4. heterotrimeric G-protein complex Source: InterPro
    5. nucleus Source: MGI
    6. plasma membrane Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469Regulator of G-protein signaling 7PRO_0000204197Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei434 – 4341PhosphoserineBy similarity

    Post-translational modificationi

    Palmitoylated.By similarity
    Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    MaxQBiO54829.
    PaxDbiO54829.
    PRIDEiO54829.

    PTM databases

    PhosphoSiteiO54829.

    Expressioni

    Gene expression databases

    BgeeiO54829.
    CleanExiMM_RGS7.
    GenevestigatoriO54829.

    Interactioni

    Subunit structurei

    Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Interacts with SNAPIN By similarity.By similarity

    Protein-protein interaction databases

    BioGridi204852. 1 interaction.
    IntActiO54829. 2 interactions.
    MINTiMINT-4132332.

    Structurei

    3D structure databases

    ProteinModelPortaliO54829.
    SMRiO54829. Positions 19-450.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 11276DEPPROSITE-ProRule annotationAdd
    BLAST
    Domaini255 – 31662G protein gammaAdd
    BLAST
    Domaini333 – 448116RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 G protein gamma domain.Curated
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327614.
    GeneTreeiENSGT00700000104259.
    HOGENOMiHOG000220864.
    HOVERGENiHBG007404.
    KOiK16449.
    OMAiWIMKNLD.
    OrthoDBiEOG7BZVS5.
    TreeFamiTF351956.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54829-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL    50
    SKIPSVFSGS DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT 100
    LKDDGTFYRF QTPYFWPSNC WEPENTDYAV YLCKRTMQNK ARLELADYEA 150
    ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK RDKIERKILD SQERAFWDVH 200
    RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH SPTHTPTPET 250
    KPPTEDELHQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY VEYDPFLVPP 300
    DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF 350
    LESEFSSENL RFWLAVEDLK RRPIREVPSR VQEIWQEFLA PGAPSAINLD 400
    SKSYDKTTQN VKEPGRYTFE DAQEHIYKLM KSDSYPRFIR SSAYQELLQA 450
    KRKGKTLTSK RLTSLVQSY 469
    Length:469
    Mass (Da):54,792
    Last modified:July 27, 2011 - v2
    Checksum:iAE4B91280D87F211
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti461 – 4611R → S in AAC99483. (PubMed:9459445)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF011360 mRNA. Translation: AAC99483.1.
    AC102499 Genomic DNA. No translation available.
    AC113050 Genomic DNA. No translation available.
    AC117693 Genomic DNA. No translation available.
    AC117734 Genomic DNA. No translation available.
    AC159973 Genomic DNA. No translation available.
    CCDSiCCDS15546.1.
    RefSeqiNP_036010.2. NM_011880.3.
    UniGeneiMm.7956.

    Genome annotation databases

    EnsembliENSMUST00000027812; ENSMUSP00000027812; ENSMUSG00000026527.
    GeneIDi24012.
    KEGGimmu:24012.
    UCSCiuc007dtk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF011360 mRNA. Translation: AAC99483.1 .
    AC102499 Genomic DNA. No translation available.
    AC113050 Genomic DNA. No translation available.
    AC117693 Genomic DNA. No translation available.
    AC117734 Genomic DNA. No translation available.
    AC159973 Genomic DNA. No translation available.
    CCDSi CCDS15546.1.
    RefSeqi NP_036010.2. NM_011880.3.
    UniGenei Mm.7956.

    3D structure databases

    ProteinModelPortali O54829.
    SMRi O54829. Positions 19-450.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204852. 1 interaction.
    IntActi O54829. 2 interactions.
    MINTi MINT-4132332.

    PTM databases

    PhosphoSitei O54829.

    Proteomic databases

    MaxQBi O54829.
    PaxDbi O54829.
    PRIDEi O54829.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027812 ; ENSMUSP00000027812 ; ENSMUSG00000026527 .
    GeneIDi 24012.
    KEGGi mmu:24012.
    UCSCi uc007dtk.2. mouse.

    Organism-specific databases

    CTDi 6000.
    MGIi MGI:1346089. Rgs7.

    Phylogenomic databases

    eggNOGi NOG327614.
    GeneTreei ENSGT00700000104259.
    HOGENOMi HOG000220864.
    HOVERGENi HBG007404.
    KOi K16449.
    OMAi WIMKNLD.
    OrthoDBi EOG7BZVS5.
    TreeFami TF351956.

    Miscellaneous databases

    ChiTaRSi RGS7. mouse.
    NextBioi 303939.
    PROi O54829.
    SOURCEi Search...

    Gene expression databases

    Bgeei O54829.
    CleanExi MM_RGS7.
    Genevestigatori O54829.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RGS9, a GTPase accelerator for phototransduction."
      He W., Cowan C.W., Wensel T.G.
      Neuron 20:95-102(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family."
      Martemyanov K.A., Yoo P.J., Skiba N.P., Arshavsky V.Y.
      J. Biol. Chem. 280:5133-5136(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RGS7BP.
    4. "Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family."
      Drenan R.M., Doupnik C.A., Boyle M.P., Muglia L.J., Huettner J.E., Linder M.E., Blumer K.J.
      J. Cell Biol. 169:623-633(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RGS7BP.

    Entry informationi

    Entry nameiRGS7_MOUSE
    AccessioniPrimary (citable) accession number: O54829
    Secondary accession number(s): E9QLB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3