true1998-12-152024-01-24180RGS9_MOUSERGS9, a GTPase accelerator for phototransduction.He W.Cowan C.W.Wensel T.G.doi:10.1016/s0896-6273(00)80437-71998Neuron2095-102NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)Cloning and characterization of RGS9-2: a striatal-enriched alternatively spliced product of the RGS9 gene.Rahman Z.Gold S.J.Potenza M.N.Cowan C.W.Ni Y.G.He W.Wensel T.G.Nestler E.J.doi:10.1523/jneurosci.19-06-02016.19991999J. Neurosci.192016-2026NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)C57BL/6JForebrainLineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M.Goodstadt L.Hillier L.W.Zody M.C.Goldstein S.She X.Bult C.J.Agarwala R.Cherry J.L.DiCuccio M.Hlavina W.Kapustin Y.Meric P.Maglott D.Birtle Z.Marques A.C.Graves T.Zhou S.Teague B.Potamousis K.Churas C.Place M.Herschleb J.Runnheim R.Forrest D.Amos-Landgraf J.Schwartz D.C.Cheng Z.Lindblad-Toh K.Eichler E.E.Ponting C.P.doi:10.1371/journal.pbio.10001122009PLoS Biol.7E1000112NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Mural R.J.Adams M.D.Myers E.W.Smith H.O.Venter J.C.2005-07EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project Teamdoi:10.1101/gr.25965042004Genome Res.142121-2127NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments.Hu G.Jang G.F.Cowan C.W.Wensel T.G.Palczewski K.doi:10.1074/jbc.m0115392002001J. Biol. Chem.27622287-22295PHOSPHORYLATION OF ISOFORM 1R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1.Hu G.Wensel T.G.doi:10.1073/pnas.1520947992002Proc. Natl. Acad. Sci. U.S.A.999755-9760INTERACTION WITH RGS9BPC57BL/6 X 129RetinaIdentification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor-specific RGS9-1 at Ser475.Sokal I.Hu G.Liang Y.Mao M.Wensel T.G.Palczewski K.doi:10.1074/jbc.m2117822002003J. Biol. Chem.2788316-8325INTERACTION WITH RGS9BPThe DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo.Martemyanov K.A.Lishko P.V.Calero N.Keresztes G.Sokolov M.Strissel K.J.Leskov I.B.Hopp J.A.Kolesnikov A.V.Chen C.-K.Lem J.Heller S.Burns M.E.Arshavsky V.Y.doi:10.1523/jneurosci.23-32-10175.20032003J. Neurosci.2310175-10181INTERACTION WITH RGS9BPR7BP, a novel neuronal protein interacting with RGS proteins of the R7 family.Martemyanov K.A.Yoo P.J.Skiba N.P.Arshavsky V.Y.doi:10.1074/jbc.c4005962002005J. Biol. Chem.2805133-5136INTERACTION WITH RGS7BPPalmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family.Drenan R.M.Doupnik C.A.Boyle M.P.Muglia L.J.Huettner J.E.Linder M.E.Blumer K.J.doi:10.1083/jcb.2005020072005J. Cell Biol.169623-633INTERACTION WITH RGS7BPRGS expression rate-limits recovery of rod photoresponses.Krispel C.M.Chen D.Melling N.Chen Y.-J.Martemyanov K.A.Quillinan N.Arshavsky V.Y.Wensel T.G.Chen C.-K.Burns M.E.doi:10.1016/j.neuron.2006.07.0102006Neuron51409-416INTERACTION WITH RGS9BP1.95A/C=1-422551 site, 1 O-linked glycan (1 site)183 antibodies from 29 providersmouseRgs9EukaryotaInactivation, recovery and regulation of the phototransduction cascadeG alpha (i) signalling eventsCooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding5 hits in 80 CRISPR screensmouseProteinExpressed in retinal neural layer and 111 other cell types or tissuesbaseline and differentialDEP_RGS7-likeGGLRGS_RGS9Regulator of G-protein Signalling 4, domain 2Transducin (heterotrimeric G protein), gamma chainWinged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domainDEP_domG-protein_gamma-like_domGGL_sfRGSRGS6/7/9/11RGS6/7/9/11_DHEX_sfRGS9_RGSRGS_DHEXRGS_sfRGS_subdomain_2WH-like_DNA-bd_sfWH_DNA-bd_sfLP21163PREGULATOR OF G-PROTEIN SIGNALING 9DEPG-gammaRGSRGS_DHEXRGSPROTEINDEPG_gammaGGLRGSRegulator of G-protein signaling, RGSTransducin (heterotrimeric G protein), gamma chainWinged helix' DNA-binding domainDEPRGSMMRegulator of G-protein signaling 9RGS9Rgs9Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction.Heterodimer with GNB5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (PubMed:15632198, PubMed:15897264). Component of the RGS9-1-Gbeta5 complex composed of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP (PubMed:12119397, PubMed:12499365, PubMed:14614075, PubMed:16908407). Interacts with PDE6G and GNAT1 (By similarity).Isoform 1 is targeted to the membrane via its interaction with RGS9BP.Isoform 1 is expressed in photoreceptor outer segments. Isoform 2 is expressed in brain striatum.Retinal isoform 1 is light-dependent phosphorylated at 'Ser-475'. Phosphorylation is decreased by light exposition. Interaction with RGS9BP is decreased when isoform 1 is phosphorylated at 'Ser-475'.Regulator of G-protein signaling 9769781675DEP30105G protein gamma222283RGS299414Disordered524571Disordered637662In isoform 1.VMSKLDRRSQLKKELPPK467484In isoform 1.485L76LR161R16273252636779828896981001031061081181301321341381501521541551691741912072092192342402542552572592622692722762802902952962983003053073193253373403423433543673763823853863984004054084162011-07-27376978a6667b14d29f9b7b13fc777230e5b3612RGS9-2MTIRHQGQQYRPRMAFLQKIEALVKDMQNPETGVRMHNQRVLVTSVPHAMTGGDVLQWITQRLWISNLEAQNLGNFIVKYGYIYPLQDPKNLILKPDSSLYRFQTPYFWPTQQWPAEDTDYAIYLAKRNIKKKGILEEYEKENYDFLNKKINYKWDFVIMQAKEQYRTGKERNKADRYALDCQEKAYWLVHRSPPGMNNVLDYGLDRVTNPNEVKKQTVTAVRKEIMYYQQALMRSTVKSSVSLGGIVKYSEQFSSNDAIMSGCLPSNPWITDDTQFWDLNAKLVEIPTKMRVERWAFNFSELIRDPKGRQSFQYFLKKEFSGENLGFWEACEDLKYGDQSKVKEKAEEIYKLFLAPGARRWINIDGKTMDITVKGLRHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKEMLAKAIEPQETTKRSSTLPFMRRHLRSSPSPVILRQLEEEEKAREAANTVDITQPGQHLAPSPHLAVYTGTCVPPSPSSPFSPSCRSPRKPFASPSRFIRRPSIAICPSPSRVALEGSSGLEPKGEASWSGANSGPSVTENREPSADHSRPQPRAPPKARAALSLGRFLRRGCLASPVFARLSPKCPSVSHGKVQPLGDMGQQLPRLKPKKVANFFQIKMEMPTDSGTCLMDSDDPRAGESGDQTTEKEVICPWESLAEGKAG1RGS9-1MTIRHQGQQYRPRMAFLQKIEALVKDMQNPETGVRMHNQRVLVTSVPHAMTGGDVLQWITQRLWISNLEAQNLGNFIVKYGYIYPLQDPKNLILKPDSSLYRFQTPYFWPTQQWPAEDTDYAIYLAKRNIKKKGILEEYEKENYDFLNKKINYKWDFVIMQAKEQYRTGKERNKADRYALDCQEKAYWLVHRSPPGMNNVLDYGLDRVTNPNEVKKQTVTAVRKEIMYYQQALMRSTVKSSVSLGGIVKYSEQFSSNDAIMSGCLPSNPWITDDTQFWDLNAKLVEIPTKMRVERWAFNFSELIRDPKGRQSFQYFLKKEFSGENLGFWEACEDLKYGDQSKVKEKAEEIYKLFLAPGARRWINIDGKTMDITVKGLRHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKEMLAKAIEPQETTKRSSTLPFMRRHLRSSPSPVILRQLEEEEKAREAANTVDITQVMSKLDRRSQLKKELPPKtruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetrue