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O54827 (AT10A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable phospholipid-transporting ATPase VA

EC=3.6.3.1
Alternative name(s):
ATPase class V type 10A
P-locus fat-associated ATPase
Gene names
Name:Atp10a
Synonyms:Atpc5, Pfatp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1508 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane By similarity. Note: Exit from the endoplasmic reticulum requires the presence of TMEM30A By similarity.

Tissue specificity

Found in testis and in white adipose tissue. Also detected in fetal tissues. Ref.5

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15081508Probable phospholipid-transporting ATPase VA
PRO_0000046380

Regions

Topological domain1 – 7979Cytoplasmic Potential
Transmembrane80 – 10122Helical; Potential
Topological domain102 – 1076Extracellular Potential
Transmembrane108 – 12922Helical; Potential
Topological domain130 – 313184Cytoplasmic Potential
Transmembrane314 – 33522Helical; Potential
Topological domain336 – 36631Extracellular Potential
Transmembrane367 – 38822Helical; Potential
Topological domain389 – 1101713Cytoplasmic Potential
Transmembrane1102 – 112221Helical; Potential
Topological domain1123 – 113412Extracellular Potential
Transmembrane1135 – 115420Helical; Potential
Topological domain1155 – 118430Cytoplasmic Potential
Transmembrane1185 – 120622Helical; Potential
Topological domain1207 – 12137Extracellular Potential
Transmembrane1214 – 123623Helical; Potential
Topological domain1237 – 12426Cytoplasmic Potential
Transmembrane1243 – 126321Helical; Potential
Topological domain1264 – 128118Extracellular Potential
Transmembrane1282 – 130625Helical; Potential
Topological domain1307 – 1508202Cytoplasmic Potential
Compositional bias17 – 237Poly-Arg
Compositional bias471 – 4744Poly-Glu

Sites

Active site43114-aspartylphosphate intermediate By similarity
Metal binding10451Magnesium By similarity
Metal binding10491Magnesium By similarity

Experimental info

Sequence conflict16 – 227WRRPRRR → KLAAAKK in AAC02902. Ref.2
Sequence conflict4351T → L in AAC02902. Ref.2
Sequence conflict5541I → V in AAM20894. Ref.3
Sequence conflict6871E → D in AAF09447. Ref.1
Sequence conflict840 – 8423CWL → TRP in AAH25643. Ref.4
Sequence conflict9781T → A in AAM20894. Ref.3
Sequence conflict11131F → S in AAF09447. Ref.1
Sequence conflict14341T → S in AAF09447. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O54827 [UniParc].

Last modified May 10, 2005. Version 4.
Checksum: B542F86C9CD80E5B

FASTA1,508168,788
        10         20         30         40         50         60 
MERELPAAEE SASSGWRRPR RRRWEGRTRT VRSNLLPPLG TEDSTIGAPK GERLLMRGCI 

        70         80         90        100        110        120 
QHLADNRLKT TKYTLLSFLP KNLFEQFHRL ANVYFVFIAL LNFVPAVNAF QPGLALAPVL 

       130        140        150        160        170        180 
FILAVTAIKD LWEDYSRHRS DHEINHLGCL VFSREEKKYV NRYWKEIRVG DFVRLCCNEI 

       190        200        210        220        230        240 
IPADILLLSS SDPDGLCHIE TANLDGETNL KRRQVVRGFS ELVSEFNPLT FTSVIECEKP 

       250        260        270        280        290        300 
NNDLSRFRGY IMHSNGEKAG LHKENLLLRG CTIRNTEAVA GIVIYAGHET KALLNNSGPR 

       310        320        330        340        350        360 
YKRSQLERQM NCDVLWCVLL LVCISLFSAV GHGLWVRRYQ EKKALFDVPE SDGSSLSPAT 

       370        380        390        400        410        420 
AAVYSFFTMI IVLQVLIPIS LYVSIEIVKV CQVYFINQDI ELYDEETDSQ LQCRALNITE 

       430        440        450        460        470        480 
DLGQIKYIFS DKTGTLTENK MVFRRCTVSG IEYSHDANAQ RLARYQEADS EEEEVVSKVG 

       490        500        510        520        530        540 
TISHRGSTGS HQSIWMTHKT QSIKSHRRTG SRAEAKRASM LSKHTAFSSP MEKDITPDPK 

       550        560        570        580        590        600 
LLEKVSECDR FLAIARHQEH PLAHLSPELS DVFDFFIALT ICNTVVVTSP DQPRQKVRVR 

       610        620        630        640        650        660 
FELKSPVKTI EDFLRRFTPS RLASGCSSIG NLSTSKSSHK SGSAFLPSLS QDSMLLGLEE 

       670        680        690        700        710        720 
KLGQTAPSIA SNGYASQAGQ EESWASECTT DQKCPGEQRE QQEGELRYEA ESPDEAALVY 

       730        740        750        760        770        780 
AARAYNCALV DRLHDQVSVE LPHLGRLTFE LLHTLGFDSI RKRMSVVIRH PLTDEINVYT 

       790        800        810        820        830        840 
KGADSVVMDL LLPCSSDDAR GRHQKKIRSK TQNYLNLYAV EGLRTLCIAK RVLSKEEYAC 

       850        860        870        880        890        900 
WLQSHIEAEA SVESREELLF QSAVRLETNL HLLGATGIED RLQEGVPETI AKLRQAGLQI 

       910        920        930        940        950        960 
WVLTGDKQET AINIAYACKL LDHGEEVITL NADSQEACAA LLDQCLSYVQ SRNPRSTLQN 

       970        980        990       1000       1010       1020 
SESNLSVGFS FNPVSTSTDA SPSPSLVIDG RSLAYALEKS LEDKFLFLAK QCRSVLCCRS 

      1030       1040       1050       1060       1070       1080 
TPLQKSMVVK LVRSKLKAMT LAIGDGANDV SMIQVADVGV GISGQEGMQA VMASDFAVPR 

      1090       1100       1110       1120       1130       1140 
FRYLERLLIV HGHWCYSRLA NMVLYFFYKN TMFVGLLFWF QFYCGFSASA MIDQWYLIFF 

      1150       1160       1170       1180       1190       1200 
NLLFSSLPQL VTGVLDKDVP ADMLLREPQL YKSGQNMEEY RPRAFWLNMV DAAFQSLVCF 

      1210       1220       1230       1240       1250       1260 
FIPYLAYYDS DVDVFTWGTP VTAIALFTFL LHLGIETKTW TWLNWLACGF STFLFFSVAL 

      1270       1280       1290       1300       1310       1320 
IYNTSCATCY PPSNPYWTMQ TLLGDPLFYL TCLIAPIAAL LPRLFFKALQ GSLFPTQLQL 

      1330       1340       1350       1360       1370       1380 
GRQLAKKPLN KFSDPKETFA QGQPPGHSET ELSERKTMGP FETLPRDCAS QASQFTQQLT 

      1390       1400       1410       1420       1430       1440 
CSPEASGEPS AVDTNMPLRE NTLLEGLGSQ ASGSSMPRGA ISEVCPGDSK RQSTSASQTA 

      1450       1460       1470       1480       1490       1500 
RLSSLFHLPS FGSLNWISSL SLASGLGSVL QLSGSSLQMD KQDGEFLSNP PQPEQDLHSF 


QGQVTGYL 

« Hide

References

« Hide 'large scale' references
[1]"Differential expression of putative transbilayer amphipath transporters."
Halleck M.S., Lawler J.F. Jr., Blackshaw S., Gao L., Nagarajan P., Hacker C., Pyle S., Newman J.T., Nakanishi Y., Ando H., Weinstock D., Williamson P.L., Schlegel R.A.
Physiol. Genomics 1:139-150(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Teratocarcinoma.
[2]"Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs."
Halleck M.S., Pradhan D., Blackman C.F., Berkes C., Williamson P.L., Schlegel R.A.
Genome Res. 8:354-361(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-435.
[3]"An aminophospholipid translocase associated with body fat and type 2 diabetes phenotypes."
Dhar M., Hauser L., Johnson D.
Obes. Res. 10:695-702(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 155-1508.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 840-1508.
[5]"A novel ATPase on mouse chromosome 7 is a candidate gene for increased body fat."
Dhar M., Webb L.S., Smith L., Hauser L., Johnson D., West D.B.
Physiol. Genomics 4:93-100(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF156549 mRNA. Translation: AAF09447.1.
AF011337 mRNA. Translation: AAC02902.1.
AF372979 Genomic DNA. Translation: AAM20894.1.
BC025643 mRNA. Translation: AAH25643.1.
RefSeqNP_033858.2. NM_009728.2.
XP_006540643.1. XM_006540580.1.
XP_006540644.1. XM_006540581.1.
UniGeneMm.135129.

3D structure databases

ProteinModelPortalO54827.
SMRO54827. Positions 757-1079.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO54827.

Proteomic databases

PRIDEO54827.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000168747; ENSMUSP00000129811; ENSMUSG00000025324.
GeneID11982.
KEGGmmu:11982.
UCSCuc009hef.2. mouse.

Organism-specific databases

CTD57194.
MGIMGI:1330809. Atp10a.

Phylogenomic databases

eggNOGCOG0474.
HOVERGENHBG107129.
InParanoidO54827.
KOK01530.
OMACAQHLAD.
OrthoDBEOG76471S.
PhylomeDBO54827.
TreeFamTF354252.

Gene expression databases

ArrayExpressO54827.
BgeeO54827.
CleanExMM_ATP10A.
GenevestigatorO54827.

Family and domain databases

Gene3D2.70.150.10. 2 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 2 hits.
InterProIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transp.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PANTHERPTHR24092. PTHR24092. 1 hit.
PfamPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SUPFAMSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsTIGR01652. ATPase-Plipid. 2 hits.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280129.
PROO54827.
SOURCESearch...

Entry information

Entry nameAT10A_MOUSE
AccessionPrimary (citable) accession number: O54827
Secondary accession number(s): Q8R3B8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 126 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot