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Protein

Protein AF-10

Gene

Mllt10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in transcriptional regulation. Binds to cruciform DNA (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 74PHD-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri79 – 112C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri135 – 198PHD-type 2PROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AF-10
Gene namesi
Name:Mllt10
Synonyms:Af10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1329038. Mllt10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159361 – 1068Protein AF-10Add BLAST1068

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217PhosphoserineBy similarity1
Modified residuei252PhosphoserineBy similarity1
Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei436PhosphoserineCombined sources1
Modified residuei532PhosphoserineCombined sources1
Modified residuei686PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei691PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO54826.
MaxQBiO54826.
PaxDbiO54826.
PRIDEiO54826.

PTM databases

iPTMnetiO54826.
PhosphoSitePlusiO54826.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026743.
ExpressionAtlasiO54826. baseline and differential.
GenevisibleiO54826. MM.

Interactioni

Subunit structurei

Self-associates. Interacts with FSTL3; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with YEATS4. Interacts with SS18. Interacts with DOT1L (By similarity).By similarity

Protein-protein interaction databases

BioGridi201436. 5 interactors.
DIPiDIP-58954N.
IntActiO54826. 1 interactor.
MINTiMINT-4087317.
STRINGi10090.ENSMUSP00000028076.

Structurei

3D structure databases

ProteinModelPortaliO54826.
SMRiO54826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni752 – 780Leucine-zipperAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi229 – 250Glu/Lys-richAdd BLAST22
Compositional biasi966 – 1018Gln-richAdd BLAST53

Sequence similaritiesi

Contains 1 C2HC pre-PHD-type zinc finger.PROSITE-ProRule annotation
Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 74PHD-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri79 – 112C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri135 – 198PHD-type 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0956. Eukaryota.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000033831.
HOVERGENiHBG004186.
InParanoidiO54826.
OMAiKSPHLGN.
OrthoDBiEOG091G069E.
TreeFamiTF316118.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51805. EPHD. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSDRPVSL EDEVSHSMKE MIGGCCVCSD ERGWAENPLV YCDGHGCSVA
60 70 80 90 100
VHQACYGIVQ VPTGPWFCRK CESQERAARV RCELCPHKDG ALKRTDNGGW
110 120 130 140 150
AHVVCALYIP EVQFANVSTM EPIVLQSVPH DRYNKTCYIC DEQGRESKAA
160 170 180 190 200
TGACMTCNKH GCRQAFHVTC AQFAGLLCEE EGNGADNVQY CGYCKYHFSK
210 220 230 240 250
LKKSKRGSNR SYEQSLSDSS SHSQDKHHEK EKKKYKEKDK HKQKHKKQPE
260 270 280 290 300
PSPALVPSLT VTTEKTYTST SNNSISGSLK RLEDTAARFT NANFQEVSAH
310 320 330 340 350
TSSGKDVSEA RGSEGKGKKS SAHSSGQRGR KPGAGRNPGT AVSASSPFPQ
360 370 380 390 400
GSFSGTPGSV KSSSGSSVQS PQDFLSFTDS DLRSDSYTHT QQPSSTKDVH
410 420 430 440 450
KGESGSQEAA VNSFSSLVGH PVTSTVISQP KSFDNSPGEL GSSSLPTAGY
460 470 480 490 500
KRAQTSGIEE EAVKEKKRKG NKQSKHGPGR PKGNKNQENV SHLSVSSASP
510 520 530 540 550
TSSVASAAGS VTSSSLQKSP TLLRNGSLQS LSVGSSPVGS EISMQYRHDG
560 570 580 590 600
ACPTTTFSEL LNAIHNGIYN SNDVAVSFPN VVSGSGSSTP VSSSHIPQQS
610 620 630 640 650
SGHLQQVGAL SPSAASSVTP AAATTQANTV SGSSLSQAPA HMYGSRLNQN
660 670 680 690 700
PSMAVLIAQS ESSQTDQDLG DNARSLGGRG SSPRGSLSPR SPVSNLQLRY
710 720 730 740 750
DQPSNSSLET VPPVAASIEQ LLERQWSEGQ QFLLEQGTPG DILGMLKSLH
760 770 780 790 800
QLQVENRRLE EQIKNLTAKK ERLQLLNAQL SVPFPAITTN PSPSHQMHTY
810 820 830 840 850
TAQTAPPPDS LNSSKSPHIG NSFLPDNSLP VLNQDLTSSG QSTSSSSALS
860 870 880 890 900
TPPPAGQSPA QQSSGVSGVQ QVNGVTVGAL ASGMQTVTST IPAVSAVGGI
910 920 930 940 950
IGALPGNQLA INGIVGALNG VIQTPVTISQ NPAPLTHTSV PPNAAHPMPA
960 970 980 990 1000
AALTNSASGL GLLSDQQRQM FIQQQQFQQL LNSQQLTPEQ HQAFLYQLMQ
1010 1020 1030 1040 1050
QQHHPPELQQ LQLPGPTQIP INNLLAGAQA PPLHTATTNP FLTIHGDSTS
1060
QKVTRLSDKT GPVAQEKS
Length:1,068
Mass (Da):113,029
Last modified:June 28, 2011 - v2
Checksum:iBC88501BE15E4D8B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti280K → N in AAD11570 (PubMed:9878787).Curated1
Sequence conflicti363S → P in AAD11570 (PubMed:9878787).Curated1
Sequence conflicti374F → L in AAD11570 (PubMed:9878787).Curated1
Sequence conflicti437P → T in AAD11570 (PubMed:9878787).Curated1
Sequence conflicti445L → F in AAD11570 (PubMed:9878787).Curated1
Sequence conflicti709E → G in AAD11570 (PubMed:9878787).Curated1
Sequence conflicti991 – 993HQA → NKT in AAD11570 (PubMed:9878787).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010135 mRNA. Translation: AAD11570.1.
AL928557, AL928589 Genomic DNA. Translation: CAM21748.1.
AL928589, AL928557 Genomic DNA. Translation: CAM21799.1.
CH466542 Genomic DNA. Translation: EDL08096.1.
CH466542 Genomic DNA. Translation: EDL08097.1.
BC070475 mRNA. Translation: AAH70475.1.
CCDSiCCDS15708.1.
RefSeqiNP_001239489.1. NM_001252560.1.
NP_034934.2. NM_010804.4.
XP_006497440.2. XM_006497377.3.
UniGeneiMm.209175.

Genome annotation databases

EnsembliENSMUST00000028076; ENSMUSP00000028076; ENSMUSG00000026743.
ENSMUST00000114680; ENSMUSP00000110328; ENSMUSG00000026743.
GeneIDi17354.
KEGGimmu:17354.
UCSCiuc008ilm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010135 mRNA. Translation: AAD11570.1.
AL928557, AL928589 Genomic DNA. Translation: CAM21748.1.
AL928589, AL928557 Genomic DNA. Translation: CAM21799.1.
CH466542 Genomic DNA. Translation: EDL08096.1.
CH466542 Genomic DNA. Translation: EDL08097.1.
BC070475 mRNA. Translation: AAH70475.1.
CCDSiCCDS15708.1.
RefSeqiNP_001239489.1. NM_001252560.1.
NP_034934.2. NM_010804.4.
XP_006497440.2. XM_006497377.3.
UniGeneiMm.209175.

3D structure databases

ProteinModelPortaliO54826.
SMRiO54826.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201436. 5 interactors.
DIPiDIP-58954N.
IntActiO54826. 1 interactor.
MINTiMINT-4087317.
STRINGi10090.ENSMUSP00000028076.

PTM databases

iPTMnetiO54826.
PhosphoSitePlusiO54826.

Proteomic databases

EPDiO54826.
MaxQBiO54826.
PaxDbiO54826.
PRIDEiO54826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028076; ENSMUSP00000028076; ENSMUSG00000026743.
ENSMUST00000114680; ENSMUSP00000110328; ENSMUSG00000026743.
GeneIDi17354.
KEGGimmu:17354.
UCSCiuc008ilm.2. mouse.

Organism-specific databases

CTDi8028.
MGIiMGI:1329038. Mllt10.

Phylogenomic databases

eggNOGiKOG0956. Eukaryota.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000033831.
HOVERGENiHBG004186.
InParanoidiO54826.
OMAiKSPHLGN.
OrthoDBiEOG091G069E.
TreeFamiTF316118.

Miscellaneous databases

ChiTaRSiMllt10. mouse.
PROiO54826.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026743.
ExpressionAtlasiO54826. baseline and differential.
GenevisibleiO54826. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51805. EPHD. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAF10_MOUSE
AccessioniPrimary (citable) accession number: O54826
Secondary accession number(s): Q6NS43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 28, 2011
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.