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Protein

Protein AF-10

Gene

Mllt10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in transcriptional regulation. Binds to cruciform DNA (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 74PHD-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri79 – 112C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri135 – 198PHD-type 2PROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AF-10
Gene namesi
Name:Mllt10
Synonyms:Af10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1329038 Mllt10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159361 – 1068Protein AF-10Add BLAST1068

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217PhosphoserineBy similarity1
Modified residuei252PhosphoserineBy similarity1
Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei436PhosphoserineCombined sources1
Modified residuei532PhosphoserineCombined sources1
Modified residuei686PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei691PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO54826
MaxQBiO54826
PaxDbiO54826
PRIDEiO54826

PTM databases

iPTMnetiO54826
PhosphoSitePlusiO54826

Expressioni

Gene expression databases

BgeeiENSMUSG00000026743
ExpressionAtlasiO54826 baseline and differential
GenevisibleiO54826 MM

Interactioni

Subunit structurei

Self-associates. Interacts with FSTL3; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with YEATS4. Interacts with SS18. Interacts with DOT1L (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi201436, 5 interactors
DIPiDIP-58954N
IntActiO54826, 3 interactors
MINTiO54826
STRINGi10090.ENSMUSP00000028076

Structurei

3D structure databases

ProteinModelPortaliO54826
SMRiO54826
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni752 – 780Leucine-zipperAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi229 – 250Glu/Lys-richAdd BLAST22
Compositional biasi966 – 1018Gln-richAdd BLAST53

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 74PHD-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri79 – 112C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri135 – 198PHD-type 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0956 Eukaryota
COG5141 LUCA
GeneTreeiENSGT00740000114866
HOGENOMiHOG000033831
HOVERGENiHBG004186
InParanoidiO54826
OMAiQYCGYCK
OrthoDBiEOG091G069E
TreeFamiTF316118

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR034732 EPHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

O54826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSDRPVSL EDEVSHSMKE MIGGCCVCSD ERGWAENPLV YCDGHGCSVA
60 70 80 90 100
VHQACYGIVQ VPTGPWFCRK CESQERAARV RCELCPHKDG ALKRTDNGGW
110 120 130 140 150
AHVVCALYIP EVQFANVSTM EPIVLQSVPH DRYNKTCYIC DEQGRESKAA
160 170 180 190 200
TGACMTCNKH GCRQAFHVTC AQFAGLLCEE EGNGADNVQY CGYCKYHFSK
210 220 230 240 250
LKKSKRGSNR SYEQSLSDSS SHSQDKHHEK EKKKYKEKDK HKQKHKKQPE
260 270 280 290 300
PSPALVPSLT VTTEKTYTST SNNSISGSLK RLEDTAARFT NANFQEVSAH
310 320 330 340 350
TSSGKDVSEA RGSEGKGKKS SAHSSGQRGR KPGAGRNPGT AVSASSPFPQ
360 370 380 390 400
GSFSGTPGSV KSSSGSSVQS PQDFLSFTDS DLRSDSYTHT QQPSSTKDVH
410 420 430 440 450
KGESGSQEAA VNSFSSLVGH PVTSTVISQP KSFDNSPGEL GSSSLPTAGY
460 470 480 490 500
KRAQTSGIEE EAVKEKKRKG NKQSKHGPGR PKGNKNQENV SHLSVSSASP
510 520 530 540 550
TSSVASAAGS VTSSSLQKSP TLLRNGSLQS LSVGSSPVGS EISMQYRHDG
560 570 580 590 600
ACPTTTFSEL LNAIHNGIYN SNDVAVSFPN VVSGSGSSTP VSSSHIPQQS
610 620 630 640 650
SGHLQQVGAL SPSAASSVTP AAATTQANTV SGSSLSQAPA HMYGSRLNQN
660 670 680 690 700
PSMAVLIAQS ESSQTDQDLG DNARSLGGRG SSPRGSLSPR SPVSNLQLRY
710 720 730 740 750
DQPSNSSLET VPPVAASIEQ LLERQWSEGQ QFLLEQGTPG DILGMLKSLH
760 770 780 790 800
QLQVENRRLE EQIKNLTAKK ERLQLLNAQL SVPFPAITTN PSPSHQMHTY
810 820 830 840 850
TAQTAPPPDS LNSSKSPHIG NSFLPDNSLP VLNQDLTSSG QSTSSSSALS
860 870 880 890 900
TPPPAGQSPA QQSSGVSGVQ QVNGVTVGAL ASGMQTVTST IPAVSAVGGI
910 920 930 940 950
IGALPGNQLA INGIVGALNG VIQTPVTISQ NPAPLTHTSV PPNAAHPMPA
960 970 980 990 1000
AALTNSASGL GLLSDQQRQM FIQQQQFQQL LNSQQLTPEQ HQAFLYQLMQ
1010 1020 1030 1040 1050
QQHHPPELQQ LQLPGPTQIP INNLLAGAQA PPLHTATTNP FLTIHGDSTS
1060
QKVTRLSDKT GPVAQEKS
Length:1,068
Mass (Da):113,029
Last modified:June 28, 2011 - v2
Checksum:iBC88501BE15E4D8B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti280K → N in AAD11570 (PubMed:9878787).Curated1
Sequence conflicti363S → P in AAD11570 (PubMed:9878787).Curated1
Sequence conflicti374F → L in AAD11570 (PubMed:9878787).Curated1
Sequence conflicti437P → T in AAD11570 (PubMed:9878787).Curated1
Sequence conflicti445L → F in AAD11570 (PubMed:9878787).Curated1
Sequence conflicti709E → G in AAD11570 (PubMed:9878787).Curated1
Sequence conflicti991 – 993HQA → NKT in AAD11570 (PubMed:9878787).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010135 mRNA Translation: AAD11570.1
AL928557, AL928589 Genomic DNA Translation: CAM21748.1
AL928589, AL928557 Genomic DNA Translation: CAM21799.1
CH466542 Genomic DNA Translation: EDL08096.1
CH466542 Genomic DNA Translation: EDL08097.1
BC070475 mRNA Translation: AAH70475.1
CCDSiCCDS15708.1
RefSeqiNP_001239489.1, NM_001252560.1
NP_034934.2, NM_010804.4
XP_006497440.2, XM_006497377.3
UniGeneiMm.209175

Genome annotation databases

EnsembliENSMUST00000028076; ENSMUSP00000028076; ENSMUSG00000026743
ENSMUST00000114680; ENSMUSP00000110328; ENSMUSG00000026743
GeneIDi17354
KEGGimmu:17354
UCSCiuc008ilm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAF10_MOUSE
AccessioniPrimary (citable) accession number: O54826
Secondary accession number(s): Q6NS43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health