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Protein

Bystin

Gene

Bysl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.2 Publications

GO - Molecular functioni

GO - Biological processi

  • blastocyst formation Source: MGI
  • cell adhesion Source: MGI
  • cell proliferation Source: MGI
  • in utero embryonic development Source: MGI
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: MGI
  • trophectodermal cell differentiation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bystin
Gene namesi
Name:Bysl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1858419. Bysl.

Subcellular locationi

GO - Cellular componenti

  • apical part of cell Source: MGI
  • cytoplasm Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • membrane Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice show embryonic lethality around stage E6.5 shortly after implantation. Mice lacking maternal Bysl transcript upon injection of siRNA into fertilized eggs are arrested at the 16-cell stage, fail to induce trophectoderm, and show altered morphology of developing nucleoli. Embryonic stem cells lacking Bysl show accumulation of pre-20S rRNA precursors and a reduction of 40S ribosomal subunits in the cytoplasm.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861151 – 436BystinAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40Omega-N-methylarginineBy similarity1
Modified residuei54PhosphoserineBy similarity1
Modified residuei97PhosphoserineCombined sources1
Modified residuei155PhosphothreonineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei413PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO54825.
MaxQBiO54825.
PaxDbiO54825.
PeptideAtlasiO54825.
PRIDEiO54825.

PTM databases

iPTMnetiO54825.
PhosphoSitePlusiO54825.

Expressioni

Tissue specificityi

High levels in preimplantation embryos, bone marrow, brain, testis and ovary.1 Publication

Developmental stagei

High levels of maternal transcript in unfertilized eggs. High levels up to blastocyst stage.1 Publication

Gene expression databases

BgeeiENSMUSG00000023988.
CleanExiMM_BYSL.
GenevisibleiO54825. MM.

Interactioni

Subunit structurei

Binds trophinin, tastin and cytokeratins.By similarity

Protein-protein interaction databases

BioGridi207308. 1 interactor.
IntActiO54825. 2 interactors.
STRINGi10090.ENSMUSP00000024783.

Structurei

3D structure databases

ProteinModelPortaliO54825.
SMRiO54825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bystin family.Curated

Phylogenomic databases

eggNOGiKOG3871. Eukaryota.
ENOG410XPH5. LUCA.
GeneTreeiENSGT00390000007241.
HOGENOMiHOG000178028.
HOVERGENiHBG024425.
InParanoidiO54825.
KOiK14797.
OMAiMTGAGHH.
OrthoDBiEOG091G08JE.
PhylomeDBiO54825.
TreeFamiTF312968.

Family and domain databases

InterProiIPR007955. Bystin.
[Graphical view]
PANTHERiPTHR12821. PTHR12821. 1 hit.
PfamiPF05291. Bystin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKFKVTRGA SNREKHAPLA EQILAGNAVR AGTREKRRGR EVEEEEEYVG
60 70 80 90 100
PRLSRRILQQ ARQQQEELET DHGAGDRSAP PRERATRLGP GLPQDGSDEE
110 120 130 140 150
DEEWPTLEKA AKMAGVDHQA EVIVDPEDER AIEMFMNKNP PVRRTLADII
160 170 180 190 200
MEKLTEKQTE VETVMSEVSG FPMPQLDPRV LEVYRGVREV LCKYRSGKLP
210 220 230 240 250
KAFKVIPALS NWEQILYVTE PEAWTAAAMY QATRIFASNL KERMAQRFYN
260 270 280 290 300
LVLLPRVRDD IAEYKRLNFH LYMALKKALF KPGAWFKGIL IPLCESGTCT
310 320 330 340 350
LREAIIVGSI ITKCSIPVLH SSAAMLKIAE MEYSGANSIF LRLLLDKKYA
360 370 380 390 400
LPYRVLDALV FHFLAFRTEK RQLPVLWHQC LLTLAQRYKA DLATEQKEAL
410 420 430
LELLRLQPHP QLSPEIRREL QSAVPRDVED GGVTME
Length:436
Mass (Da):49,784
Last modified:May 30, 2006 - v3
Checksum:iEFA148BED2072B72
GO

Sequence cautioni

The sequence AAH17530 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB31619 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC38736 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti284A → V in BAE40242 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019239 mRNA. Translation: BAB31619.2. Different initiation.
AK083033 mRNA. Translation: BAC38736.1. Different initiation.
AK143027 mRNA. Translation: BAE25255.1.
AK168301 mRNA. Translation: BAE40242.1.
BC017530 mRNA. Translation: AAH17530.3. Different initiation.
AF007802 mRNA. Translation: AAB94491.1.
CCDSiCCDS50132.1.
RefSeqiNP_058555.3. NM_016859.3.
UniGeneiMm.472101.

Genome annotation databases

EnsembliENSMUST00000024783; ENSMUSP00000024783; ENSMUSG00000023988.
GeneIDi53414.
KEGGimmu:53414.
UCSCiuc008cvq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019239 mRNA. Translation: BAB31619.2. Different initiation.
AK083033 mRNA. Translation: BAC38736.1. Different initiation.
AK143027 mRNA. Translation: BAE25255.1.
AK168301 mRNA. Translation: BAE40242.1.
BC017530 mRNA. Translation: AAH17530.3. Different initiation.
AF007802 mRNA. Translation: AAB94491.1.
CCDSiCCDS50132.1.
RefSeqiNP_058555.3. NM_016859.3.
UniGeneiMm.472101.

3D structure databases

ProteinModelPortaliO54825.
SMRiO54825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207308. 1 interactor.
IntActiO54825. 2 interactors.
STRINGi10090.ENSMUSP00000024783.

PTM databases

iPTMnetiO54825.
PhosphoSitePlusiO54825.

Proteomic databases

EPDiO54825.
MaxQBiO54825.
PaxDbiO54825.
PeptideAtlasiO54825.
PRIDEiO54825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024783; ENSMUSP00000024783; ENSMUSG00000023988.
GeneIDi53414.
KEGGimmu:53414.
UCSCiuc008cvq.2. mouse.

Organism-specific databases

CTDi705.
MGIiMGI:1858419. Bysl.

Phylogenomic databases

eggNOGiKOG3871. Eukaryota.
ENOG410XPH5. LUCA.
GeneTreeiENSGT00390000007241.
HOGENOMiHOG000178028.
HOVERGENiHBG024425.
InParanoidiO54825.
KOiK14797.
OMAiMTGAGHH.
OrthoDBiEOG091G08JE.
PhylomeDBiO54825.
TreeFamiTF312968.

Miscellaneous databases

ChiTaRSiBysl. mouse.
PROiO54825.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023988.
CleanExiMM_BYSL.
GenevisibleiO54825. MM.

Family and domain databases

InterProiIPR007955. Bystin.
[Graphical view]
PANTHERiPTHR12821. PTHR12821. 1 hit.
PfamiPF05291. Bystin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBYST_MOUSE
AccessioniPrimary (citable) accession number: O54825
Secondary accession number(s): Q3THF4, Q3UPY9, Q8VD68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 30, 2006
Last modified: November 2, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.