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Protein
Submitted name:

Chloride channel 2

Gene

Clcn2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Chloride channel 2Imported
Gene namesi
Name:Clcn2Imported
Synonyms:ClC-2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2361. Clcn2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei97 – 11923HelicalSequence analysisAdd
BLAST
Transmembranei140 – 16223HelicalSequence analysisAdd
BLAST
Transmembranei214 – 23320HelicalSequence analysisAdd
BLAST
Transmembranei245 – 26925HelicalSequence analysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST
Transmembranei327 – 34923HelicalSequence analysisAdd
BLAST
Transmembranei370 – 38920HelicalSequence analysisAdd
BLAST
Transmembranei437 – 45923HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO54823.
PRIDEiO54823.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066524.

Structurei

3D structure databases

ProteinModelPortaliO54823.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0476. Eukaryota.
COG0038. LUCA.
HOGENOMiHOG000186048.
HOVERGENiHBG103734.

Family and domain databases

Gene3Di1.10.3080.10. 1 hit.
InterProiIPR002244. Cl-channel-2.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
[Graphical view]
PfamiPF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
PR01113. CLCHANNEL2.
SUPFAMiSSF81340. SSF81340. 1 hit.

Sequencei

Sequence statusi: Complete.

O54823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAATAAAAT VAGEGMEPRA LQYEQTLMYG RYTQELGAFA KEEAARIRLG
60 70 80 90 100
GPEPWKGSPS ARATPDLLEY GQSRCARCRI CSVRCHKFLV SRVGEDWIFL
110 120 130 140 150
VLLGLLMALV SWAMDYAIAV CLQAQQWMSR GLNTNILLQY LAWVTYPVVL
160 170 180 190 200
ITFSAGFTQI LAPQAVGSGI PEMKTILRGV VLKEYLTLKT FVAKVIGLTC
210 220 230 240 250
ALGSGMPLGK EGPFVHIASM CAALLSKFLS LFGGIYENES RNTEMLAAAC
260 270 280 290 300
AVGVGCCFAA PIGGVLFSIE VTSTFFAVRN YWRGFFAATF SAFIFRVLAV
310 320 330 340 350
WNRDEETITA LFKTRFRLDF PFDLQELPAF AVIGIASGFG GALFVYLNRK
360 370 380 390 400
IVQVMRKQKT INRFLMKKRL LFPALVTLLI STLTFPPGFG QFMAGQLSQK
410 420 430 440 450
ETLVTLFDNR TWVRQGLVED LGAPSTSQAW SPPRANVFLT LVIFILMKHL
460 470 480 490
AGWWARAWLP GSQMGFTRIA VPTGLYLEAM PWSGQLHLQE Q
Length:491
Mass (Da):54,239
Last modified:June 1, 1998 - v1
Checksum:i9D8CAD2CA737291B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005720 Genomic DNA. Translation: AAC06345.1.
UniGeneiRn.11073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005720 Genomic DNA. Translation: AAC06345.1.
UniGeneiRn.11073.

3D structure databases

ProteinModelPortaliO54823.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066524.

Proteomic databases

PaxDbiO54823.
PRIDEiO54823.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi2361. Clcn2.

Phylogenomic databases

eggNOGiKOG0476. Eukaryota.
COG0038. LUCA.
HOGENOMiHOG000186048.
HOVERGENiHBG103734.

Family and domain databases

Gene3Di1.10.3080.10. 1 hit.
InterProiIPR002244. Cl-channel-2.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
[Graphical view]
PfamiPF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
PR01113. CLCHANNEL2.
SUPFAMiSSF81340. SSF81340. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A short CIC-2 mRNA transcript is produced by exon skipping."
    Chu S., Murray C.B., Liu M.M., Zeitlin P.L.
    Nucleic Acids Res. 24:3453-3457(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Alternative mRNA splice variants of the rat ClC-2 chloride channel gene are expressed in lung: genomic sequence and organization of ClC-2."
    Chu S., Zeitlin P.L.
    Nucleic Acids Res. 25:4153-4159(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO54823_RAT
AccessioniPrimary (citable) accession number: O54823
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: March 16, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.