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Protein
Submitted name:

Paired-like homeodomain containing protein

Gene

Esx1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • blood vessel development Source: MGI
  • labyrinthine layer blood vessel development Source: MGI
  • labyrinthine layer morphogenesis Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Paired-like homeodomain containing proteinImported
Gene namesi
Name:Esx1Imported
Synonyms:EtxImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1096388. Esx1.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiO54817.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074262.

Structurei

3D structure databases

ProteinModelPortaliO54817.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 17661Homeobox DNA-bindingInterPro annotationAdd
BLAST

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotationImported

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOVERGENiHBG052987.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENSLFNSMF LEEANYQEPE GFEPSRGEAA APVAEAPQAW NGNENLGGGF
60 70 80 90 100
LEANAQLGEA DAAPVRQSLM RPLMQPVAQS SPQPLPANPL QAPQQPEEQE
110 120 130 140 150
EEEEEQPGEE QPQQEPKPRR YRICFTPIQL QELEAFFQRV QYPDLFARVE
160 170 180 190 200
LARRLGLPEP RVQVWFQNRR AKWRRLRRAQ AFRNMVPVAM SPPVGVYLDD
210 220 230 240 250
HYGPIPIVEV IWKCYPMVPR PMHPQMMPLP PRPPPGFRMP PPFRPPPLPP
260 270 280 290 300
FPWPPVPPDA HIPNAAREYN PFPFPFPFPF PFPNPFPNPN PNPNPNPNPN
310
PNPNQNFAGP RYRY
Length:314
Mass (Da):35,969
Last modified:June 1, 1998 - v1
Checksum:i72568F81DA4AA246
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004211 mRNA. Translation: AAB94670.1.
UniGeneiMm.8017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004211 mRNA. Translation: AAB94670.1.
UniGeneiMm.8017.

3D structure databases

ProteinModelPortaliO54817.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074262.

Proteomic databases

PaxDbiO54817.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1096388. Esx1.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOVERGENiHBG052987.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Esx1, a novel X chromosome-linked homeobox gene expressed in mouse extraembryonic tissues and male germ cells."
    Li Y., Lemaire P., Behringer R.R.
    Dev. Biol. 188:85-95(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SwissImported.
  2. Li Y.-H., Lemaire P., Behringer R.R.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SwissImported.

Entry informationi

Entry nameiO54817_MOUSE
AccessioniPrimary (citable) accession number: O54817
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.