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O54814 (CCR3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 3
Short name=C-C CKR-3
Short name=CC-CKR-3
Short name=CCR-3
Short name=CCR3
Short name=CKR3
Alternative name(s):
CD_antigen=CD193
Gene names
Name:Ccr3
Synonyms:Cmkbr3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in spleen but not in astrocytes or microglia. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359C-C chemokine receptor type 3
PRO_0000069243

Regions

Topological domain1 – 4343Extracellular Potential
Transmembrane44 – 6421Helical; Name=1; Potential
Topological domain65 – 7410Cytoplasmic Potential
Transmembrane75 – 9521Helical; Name=2; Potential
Topological domain96 – 11217Extracellular Potential
Transmembrane113 – 13321Helical; Name=3; Potential
Topological domain134 – 15421Cytoplasmic Potential
Transmembrane155 – 17521Helical; Name=4; Potential
Topological domain176 – 20631Extracellular Potential
Transmembrane207 – 22721Helical; Name=5; Potential
Topological domain228 – 24316Cytoplasmic Potential
Transmembrane244 – 26421Helical; Name=6; Potential
Topological domain265 – 28824Extracellular Potential
Transmembrane289 – 30921Helical; Name=7; Potential
Topological domain310 – 35950Cytoplasmic Potential

Experimental info

Sequence conflict1641F → L in CAA73830. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O54814 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 880F682984F501DA

FASTA35941,643
        10         20         30         40         50         60 
MASNEEELKT VVETFETTPY EYEWAPPCEK VSIRELGSWL LPPLYSLVFI VGLLGNMMVV 

        70         80         90        100        110        120 
LILIKYRKLQ IMTNIYLLNL AISDLLFLFT VPFWIHYVLW NEWGFGHCMC KMLSGLYYLA 

       130        140        150        160        170        180 
LYSEIFFIIL LTIDRYLAIV HAVLALRART VTFATITSII TWGFAVLAAL PEFIFHESQD 

       190        200        210        220        230        240 
NFGDLSCSPR YPEGEEDSWK RFHALRMNIF GLALPLLIMV ICYSGIIKTL LRCPNKKKHK 

       250        260        270        280        290        300 
AIQLIFVVMI VFFIFWTPYN LVLLLSAFHS TFLETSCQQS IHLDLAMQVT EVITHTHCCI 

       310        320        330        340        350 
NPIIYAFVGE RFRKHLRLFF HRNVAIYLRK YISFLPGEKL ERTSSVSPST GEQEISVVF

« Hide

References

[1]"Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis."
Jiang Y., Salafranca M.N., Adhikari S., Xia Y., Feng L., Sonntag M.K., deFiebre C.M., Pennell N.A., Streit W.J., Harrison J.K.
J. Neuroimmunol. 86:1-12(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, TISSUE SPECIFICITY.
Strain: Wistar.
Tissue: Spleen.
[2]Harrington P.M., Newton D.J., Coleman J.W., Flanagan B.F.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Wistar.
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF003954 Genomic DNA. Translation: AAC03337.1.
Y13400 mRNA. Translation: CAA73830.1.
IPIIPI00325174.
RefSeqNP_446410.1. NM_053958.1.
UniGeneRn.9890.

3D structure databases

ProteinModelPortalO54814.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000008809.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEO54814.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID117027.
KEGGrno:117027.
UCSCRGD:620593. rat.

Organism-specific databases

CTD1232.
RGD620593. Ccr3.

Phylogenomic databases

eggNOGNOG148353.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidO54814.
KOK04178.
OrthoDBEOG4S1T7D.

Gene expression databases

GenevestigatorO54814.

Family and domain databases

InterProIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF13. PTHR24227:SF13. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBO54814.
ChEMBLCHEMBL3928.
NextBio619801.

Entry information

Entry nameCCR3_RAT
AccessionPrimary (citable) accession number: O54814
Secondary accession number(s): O55169
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: May 29, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents