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O54814

- CCR3_RAT

UniProt

O54814 - CCR3_RAT

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Protein

C-C chemokine receptor type 3

Gene

Ccr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level (By similarity).By similarity

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: InterPro
  2. chemokine receptor activity Source: RGD

GO - Biological processi

  1. angioblast cell migration Source: RGD
  2. chemokine-mediated signaling pathway Source: GOC
  3. eosinophil chemotaxis Source: RGD
  4. ERK1 and ERK2 cascade Source: RGD
  5. inflammatory response Source: RGD
  6. mast cell chemotaxis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 3
Short name:
C-C CKR-3
Short name:
CC-CKR-3
Short name:
CCR-3
Short name:
CCR3
Short name:
CKR3
Alternative name(s):
CD_antigen: CD193
Gene namesi
Name:Ccr3
Synonyms:Cmkbr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620593. Ccr3.

Subcellular locationi

GO - Cellular componenti

  1. endosome Source: RGD
  2. extracellular space Source: RGD
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359C-C chemokine receptor type 3PRO_0000069243Add
BLAST

Proteomic databases

PRIDEiO54814.

Expressioni

Tissue specificityi

Expressed in spleen but not in astrocytes or microglia.1 Publication

Gene expression databases

GenevestigatoriO54814.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008809.

Structurei

3D structure databases

ProteinModelPortaliO54814.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
BLAST
Topological domaini65 – 7410CytoplasmicSequence Analysis
Topological domaini96 – 11217ExtracellularSequence AnalysisAdd
BLAST
Topological domaini134 – 15421CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini176 – 20631ExtracellularSequence AnalysisAdd
BLAST
Topological domaini228 – 24316CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini265 – 28824ExtracellularSequence AnalysisAdd
BLAST
Topological domaini310 – 35950CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei207 – 22721Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei289 – 30921Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO54814.
KOiK04178.
OrthoDBiEOG738051.
PhylomeDBiO54814.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF13. PTHR24227:SF13. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54814-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASNEEELKT VVETFETTPY EYEWAPPCEK VSIRELGSWL LPPLYSLVFI
60 70 80 90 100
VGLLGNMMVV LILIKYRKLQ IMTNIYLLNL AISDLLFLFT VPFWIHYVLW
110 120 130 140 150
NEWGFGHCMC KMLSGLYYLA LYSEIFFIIL LTIDRYLAIV HAVLALRART
160 170 180 190 200
VTFATITSII TWGFAVLAAL PEFIFHESQD NFGDLSCSPR YPEGEEDSWK
210 220 230 240 250
RFHALRMNIF GLALPLLIMV ICYSGIIKTL LRCPNKKKHK AIQLIFVVMI
260 270 280 290 300
VFFIFWTPYN LVLLLSAFHS TFLETSCQQS IHLDLAMQVT EVITHTHCCI
310 320 330 340 350
NPIIYAFVGE RFRKHLRLFF HRNVAIYLRK YISFLPGEKL ERTSSVSPST

GEQEISVVF
Length:359
Mass (Da):41,643
Last modified:June 1, 1998 - v1
Checksum:i880F682984F501DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti164 – 1641F → L in CAA73830. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003954 Genomic DNA. Translation: AAC03337.1.
Y13400 mRNA. Translation: CAA73830.1.
RefSeqiNP_446410.1. NM_053958.1.
UniGeneiRn.9890.

Genome annotation databases

GeneIDi117027.
KEGGirno:117027.
UCSCiRGD:620593. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003954 Genomic DNA. Translation: AAC03337.1 .
Y13400 mRNA. Translation: CAA73830.1 .
RefSeqi NP_446410.1. NM_053958.1.
UniGenei Rn.9890.

3D structure databases

ProteinModelPortali O54814.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000008809.

Chemistry

BindingDBi O54814.
ChEMBLi CHEMBL3928.
GuidetoPHARMACOLOGYi 60.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi O54814.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 117027.
KEGGi rno:117027.
UCSCi RGD:620593. rat.

Organism-specific databases

CTDi 1232.
RGDi 620593. Ccr3.

Phylogenomic databases

eggNOGi NOG148353.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi O54814.
KOi K04178.
OrthoDBi EOG738051.
PhylomeDBi O54814.
TreeFami TF330966.

Miscellaneous databases

NextBioi 619801.
PROi O54814.

Gene expression databases

Genevestigatori O54814.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF13. PTHR24227:SF13. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis."
    Jiang Y., Salafranca M.N., Adhikari S., Xia Y., Feng L., Sonntag M.K., deFiebre C.M., Pennell N.A., Streit W.J., Harrison J.K.
    J. Neuroimmunol. 86:1-12(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Spleen.
  2. Harrington P.M., Newton D.J., Coleman J.W., Flanagan B.F.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
    Tissue: Spleen.

Entry informationi

Entry nameiCCR3_RAT
AccessioniPrimary (citable) accession number: O54814
Secondary accession number(s): O55169
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: October 1, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3