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O54814

- CCR3_RAT

UniProt

O54814 - CCR3_RAT

Protein

C-C chemokine receptor type 3

Gene

Ccr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level By similarity.By similarity

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: InterPro
    2. chemokine receptor activity Source: RGD

    GO - Biological processi

    1. angioblast cell migration Source: RGD
    2. chemokine-mediated signaling pathway Source: GOC
    3. eosinophil chemotaxis Source: RGD
    4. ERK1 and ERK2 cascade Source: RGD
    5. inflammatory response Source: RGD
    6. mast cell chemotaxis Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 3
    Short name:
    C-C CKR-3
    Short name:
    CC-CKR-3
    Short name:
    CCR-3
    Short name:
    CCR3
    Short name:
    CKR3
    Alternative name(s):
    CD_antigen: CD193
    Gene namesi
    Name:Ccr3
    Synonyms:Cmkbr3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620593. Ccr3.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome Source: RGD
    2. extracellular space Source: RGD
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359C-C chemokine receptor type 3PRO_0000069243Add
    BLAST

    Proteomic databases

    PRIDEiO54814.

    Expressioni

    Tissue specificityi

    Expressed in spleen but not in astrocytes or microglia.1 Publication

    Gene expression databases

    GenevestigatoriO54814.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000008809.

    Structurei

    3D structure databases

    ProteinModelPortaliO54814.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini65 – 7410CytoplasmicSequence Analysis
    Topological domaini96 – 11217ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15421CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 20631ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini228 – 24316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 28824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 35950CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148353.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiO54814.
    KOiK04178.
    OrthoDBiEOG738051.
    PhylomeDBiO54814.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002238. Chemokine_CCR3.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF13. PTHR24227:SF13. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01108. CHEMOKINER3.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54814-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASNEEELKT VVETFETTPY EYEWAPPCEK VSIRELGSWL LPPLYSLVFI    50
    VGLLGNMMVV LILIKYRKLQ IMTNIYLLNL AISDLLFLFT VPFWIHYVLW 100
    NEWGFGHCMC KMLSGLYYLA LYSEIFFIIL LTIDRYLAIV HAVLALRART 150
    VTFATITSII TWGFAVLAAL PEFIFHESQD NFGDLSCSPR YPEGEEDSWK 200
    RFHALRMNIF GLALPLLIMV ICYSGIIKTL LRCPNKKKHK AIQLIFVVMI 250
    VFFIFWTPYN LVLLLSAFHS TFLETSCQQS IHLDLAMQVT EVITHTHCCI 300
    NPIIYAFVGE RFRKHLRLFF HRNVAIYLRK YISFLPGEKL ERTSSVSPST 350
    GEQEISVVF 359
    Length:359
    Mass (Da):41,643
    Last modified:June 1, 1998 - v1
    Checksum:i880F682984F501DA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti164 – 1641F → L in CAA73830. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF003954 Genomic DNA. Translation: AAC03337.1.
    Y13400 mRNA. Translation: CAA73830.1.
    RefSeqiNP_446410.1. NM_053958.1.
    UniGeneiRn.9890.

    Genome annotation databases

    GeneIDi117027.
    KEGGirno:117027.
    UCSCiRGD:620593. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF003954 Genomic DNA. Translation: AAC03337.1 .
    Y13400 mRNA. Translation: CAA73830.1 .
    RefSeqi NP_446410.1. NM_053958.1.
    UniGenei Rn.9890.

    3D structure databases

    ProteinModelPortali O54814.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000008809.

    Chemistry

    BindingDBi O54814.
    ChEMBLi CHEMBL3928.
    GuidetoPHARMACOLOGYi 60.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi O54814.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 117027.
    KEGGi rno:117027.
    UCSCi RGD:620593. rat.

    Organism-specific databases

    CTDi 1232.
    RGDi 620593. Ccr3.

    Phylogenomic databases

    eggNOGi NOG148353.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi O54814.
    KOi K04178.
    OrthoDBi EOG738051.
    PhylomeDBi O54814.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 619801.
    PROi O54814.

    Gene expression databases

    Genevestigatori O54814.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002238. Chemokine_CCR3.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF13. PTHR24227:SF13. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01108. CHEMOKINER3.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis."
      Jiang Y., Salafranca M.N., Adhikari S., Xia Y., Feng L., Sonntag M.K., deFiebre C.M., Pennell N.A., Streit W.J., Harrison J.K.
      J. Neuroimmunol. 86:1-12(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE, TISSUE SPECIFICITY.
      Strain: Wistar.
      Tissue: Spleen.
    2. Harrington P.M., Newton D.J., Coleman J.W., Flanagan B.F.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Wistar.
      Tissue: Spleen.

    Entry informationi

    Entry nameiCCR3_RAT
    AccessioniPrimary (citable) accession number: O54814
    Secondary accession number(s): O55169
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3