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O54814

- CCR3_RAT

UniProt

O54814 - CCR3_RAT

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Protein
C-C chemokine receptor type 3
Gene
Ccr3, Cmkbr3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level By similarity.

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: InterPro
  2. chemokine receptor activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. ERK1 and ERK2 cascade Source: RGD
  2. angioblast cell migration Source: RGD
  3. chemokine-mediated signaling pathway Source: GOC
  4. eosinophil chemotaxis Source: RGD
  5. inflammatory response Source: RGD
  6. mast cell chemotaxis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 3
Short name:
C-C CKR-3
Short name:
CC-CKR-3
Short name:
CCR-3
Short name:
CCR3
Short name:
CKR3
Alternative name(s):
CD_antigen: CD193
Gene namesi
Name:Ccr3
Synonyms:Cmkbr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620593. Ccr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343Extracellular Reviewed prediction
Add
BLAST
Transmembranei44 – 6421Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini65 – 7410Cytoplasmic Reviewed prediction
Transmembranei75 – 9521Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini96 – 11217Extracellular Reviewed prediction
Add
BLAST
Transmembranei113 – 13321Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini134 – 15421Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei155 – 17521Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini176 – 20631Extracellular Reviewed prediction
Add
BLAST
Transmembranei207 – 22721Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini228 – 24316Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei244 – 26421Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini265 – 28824Extracellular Reviewed prediction
Add
BLAST
Transmembranei289 – 30921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini310 – 35950Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endosome Source: RGD
  2. extracellular space Source: RGD
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359C-C chemokine receptor type 3
PRO_0000069243Add
BLAST

Proteomic databases

PRIDEiO54814.

Expressioni

Tissue specificityi

Expressed in spleen but not in astrocytes or microglia.1 Publication

Gene expression databases

GenevestigatoriO54814.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008809.

Structurei

3D structure databases

ProteinModelPortaliO54814.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO54814.
KOiK04178.
OrthoDBiEOG738051.
PhylomeDBiO54814.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF13. PTHR24227:SF13. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54814-1 [UniParc]FASTAAdd to Basket

« Hide

MASNEEELKT VVETFETTPY EYEWAPPCEK VSIRELGSWL LPPLYSLVFI    50
VGLLGNMMVV LILIKYRKLQ IMTNIYLLNL AISDLLFLFT VPFWIHYVLW 100
NEWGFGHCMC KMLSGLYYLA LYSEIFFIIL LTIDRYLAIV HAVLALRART 150
VTFATITSII TWGFAVLAAL PEFIFHESQD NFGDLSCSPR YPEGEEDSWK 200
RFHALRMNIF GLALPLLIMV ICYSGIIKTL LRCPNKKKHK AIQLIFVVMI 250
VFFIFWTPYN LVLLLSAFHS TFLETSCQQS IHLDLAMQVT EVITHTHCCI 300
NPIIYAFVGE RFRKHLRLFF HRNVAIYLRK YISFLPGEKL ERTSSVSPST 350
GEQEISVVF 359
Length:359
Mass (Da):41,643
Last modified:June 1, 1998 - v1
Checksum:i880F682984F501DA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti164 – 1641F → L in CAA73830. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003954 Genomic DNA. Translation: AAC03337.1.
Y13400 mRNA. Translation: CAA73830.1.
RefSeqiNP_446410.1. NM_053958.1.
UniGeneiRn.9890.

Genome annotation databases

GeneIDi117027.
KEGGirno:117027.
UCSCiRGD:620593. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003954 Genomic DNA. Translation: AAC03337.1 .
Y13400 mRNA. Translation: CAA73830.1 .
RefSeqi NP_446410.1. NM_053958.1.
UniGenei Rn.9890.

3D structure databases

ProteinModelPortali O54814.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000008809.

Chemistry

BindingDBi O54814.
ChEMBLi CHEMBL3928.
GuidetoPHARMACOLOGYi 60.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi O54814.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 117027.
KEGGi rno:117027.
UCSCi RGD:620593. rat.

Organism-specific databases

CTDi 1232.
RGDi 620593. Ccr3.

Phylogenomic databases

eggNOGi NOG148353.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi O54814.
KOi K04178.
OrthoDBi EOG738051.
PhylomeDBi O54814.
TreeFami TF330966.

Miscellaneous databases

NextBioi 619801.
PROi O54814.

Gene expression databases

Genevestigatori O54814.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF13. PTHR24227:SF13. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis."
    Jiang Y., Salafranca M.N., Adhikari S., Xia Y., Feng L., Sonntag M.K., deFiebre C.M., Pennell N.A., Streit W.J., Harrison J.K.
    J. Neuroimmunol. 86:1-12(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Spleen.
  2. Harrington P.M., Newton D.J., Coleman J.W., Flanagan B.F.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
    Tissue: Spleen.

Entry informationi

Entry nameiCCR3_RAT
AccessioniPrimary (citable) accession number: O54814
Secondary accession number(s): O55169
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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