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Protein

C-C chemokine receptor type 3

Gene

Ccr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level (By similarity).By similarity

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: InterPro
  2. chemokine receptor activity Source: RGD

GO - Biological processi

  1. angioblast cell migration Source: RGD
  2. chemokine-mediated signaling pathway Source: GOC
  3. eosinophil chemotaxis Source: RGD
  4. ERK1 and ERK2 cascade Source: RGD
  5. inflammatory response Source: RGD
  6. mast cell chemotaxis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 3
Short name:
C-C CKR-3
Short name:
CC-CKR-3
Short name:
CCR-3
Short name:
CCR3
Short name:
CKR3
Alternative name(s):
CD_antigen: CD193
Gene namesi
Name:Ccr3
Synonyms:Cmkbr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620593. Ccr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini65 – 7410CytoplasmicSequence Analysis
Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini96 – 11217ExtracellularSequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini134 – 15421CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini176 – 20631ExtracellularSequence AnalysisAdd
BLAST
Transmembranei207 – 22721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini228 – 24316CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini265 – 28824ExtracellularSequence AnalysisAdd
BLAST
Transmembranei289 – 30921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini310 – 35950CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endosome Source: RGD
  2. extracellular space Source: RGD
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359C-C chemokine receptor type 3PRO_0000069243Add
BLAST

Proteomic databases

PRIDEiO54814.

Expressioni

Tissue specificityi

Expressed in spleen but not in astrocytes or microglia.1 Publication

Gene expression databases

GenevestigatoriO54814.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008809.

Structurei

3D structure databases

ProteinModelPortaliO54814.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO54814.
KOiK04178.
OrthoDBiEOG738051.
PhylomeDBiO54814.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF13. PTHR24227:SF13. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNEEELKT VVETFETTPY EYEWAPPCEK VSIRELGSWL LPPLYSLVFI
60 70 80 90 100
VGLLGNMMVV LILIKYRKLQ IMTNIYLLNL AISDLLFLFT VPFWIHYVLW
110 120 130 140 150
NEWGFGHCMC KMLSGLYYLA LYSEIFFIIL LTIDRYLAIV HAVLALRART
160 170 180 190 200
VTFATITSII TWGFAVLAAL PEFIFHESQD NFGDLSCSPR YPEGEEDSWK
210 220 230 240 250
RFHALRMNIF GLALPLLIMV ICYSGIIKTL LRCPNKKKHK AIQLIFVVMI
260 270 280 290 300
VFFIFWTPYN LVLLLSAFHS TFLETSCQQS IHLDLAMQVT EVITHTHCCI
310 320 330 340 350
NPIIYAFVGE RFRKHLRLFF HRNVAIYLRK YISFLPGEKL ERTSSVSPST

GEQEISVVF
Length:359
Mass (Da):41,643
Last modified:June 1, 1998 - v1
Checksum:i880F682984F501DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti164 – 1641F → L in CAA73830 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003954 Genomic DNA. Translation: AAC03337.1.
Y13400 mRNA. Translation: CAA73830.1.
RefSeqiNP_446410.1. NM_053958.1.
UniGeneiRn.9890.

Genome annotation databases

GeneIDi117027.
KEGGirno:117027.
UCSCiRGD:620593. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003954 Genomic DNA. Translation: AAC03337.1.
Y13400 mRNA. Translation: CAA73830.1.
RefSeqiNP_446410.1. NM_053958.1.
UniGeneiRn.9890.

3D structure databases

ProteinModelPortaliO54814.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008809.

Chemistry

BindingDBiO54814.
ChEMBLiCHEMBL3928.
GuidetoPHARMACOLOGYi60.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiO54814.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117027.
KEGGirno:117027.
UCSCiRGD:620593. rat.

Organism-specific databases

CTDi1232.
RGDi620593. Ccr3.

Phylogenomic databases

eggNOGiNOG148353.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO54814.
KOiK04178.
OrthoDBiEOG738051.
PhylomeDBiO54814.
TreeFamiTF330966.

Miscellaneous databases

NextBioi619801.
PROiO54814.

Gene expression databases

GenevestigatoriO54814.

Family and domain databases

InterProiIPR002238. Chemokine_CCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF13. PTHR24227:SF13. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01108. CHEMOKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis."
    Jiang Y., Salafranca M.N., Adhikari S., Xia Y., Feng L., Sonntag M.K., deFiebre C.M., Pennell N.A., Streit W.J., Harrison J.K.
    J. Neuroimmunol. 86:1-12(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Spleen.
  2. Harrington P.M., Newton D.J., Coleman J.W., Flanagan B.F.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
    Tissue: Spleen.

Entry informationi

Entry nameiCCR3_RAT
AccessioniPrimary (citable) accession number: O54814
Secondary accession number(s): O55169
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: January 7, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.