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O54803

- P2RX6_MOUSE

UniProt

O54803 - P2RX6_MOUSE

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Protein

P2X purinoceptor 6

Gene

P2rx6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.By similarity

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. extracellular ATP-gated cation channel activity Source: RefGenome
  3. purinergic nucleotide receptor activity Source: RefGenome

GO - Biological processi

  1. cation transmembrane transport Source: GOC
  2. cation transport Source: RefGenome
  3. ion transmembrane transport Source: RefGenome
  4. protein heterooligomerization Source: Ensembl
  5. protein homooligomerization Source: Ensembl
  6. purinergic nucleotide receptor signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 6
Short name:
P2X6
Alternative name(s):
ATP receptor
P2XM
Purinergic receptor
Purinergic receptor P2X-like 1
Gene namesi
Name:P2rx6
Synonyms:P2rxl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1337113. P2rx6.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. dendritic spine Source: Ensembl
  4. integral component of nuclear inner membrane Source: RefGenome
  5. integral component of plasma membrane Source: MGI
  6. neuronal cell body Source: Ensembl
  7. postsynaptic density Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379P2X purinoceptor 6PRO_0000161558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561PhosphotyrosineBy similarity
Disulfide bondi119 ↔ 169By similarity
Disulfide bondi130 ↔ 153By similarity
Disulfide bondi136 ↔ 163By similarity
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi220 ↔ 230By similarity
Disulfide bondi264 ↔ 273By similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiO54803.

PTM databases

PhosphoSiteiO54803.

Expressioni

Tissue specificityi

Predominantly expressed in skeletal muscle. Also expressed in lung.

Gene expression databases

BgeeiO54803.
ExpressionAtlasiO54803. baseline and differential.
GenevestigatoriO54803.

Interactioni

Subunit structurei

Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers.By similarity

Structurei

3D structure databases

ProteinModelPortaliO54803.
SMRiO54803. Positions 35-352.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini53 – 325273ExtracellularSequence AnalysisAdd
BLAST
Topological domaini347 – 37933CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei326 – 34621Helical; Name=2Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47843.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiO54803.
KOiK05221.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003049. P2X6_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01313. P2X6RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54803-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASAAAAALV SWGFLDYKTE KYVLTRNCRV GVSQRLLQLA VVVYVIGWAL
60 70 80 90 100
LAKKGYQERD LAPQTSVITK LKGVSVTQVK ELENRLWDVA DFVKPSQGEN
110 120 130 140 150
VFFLVTNFLV TPAQVQGRCP EHPSVPLANC WADEDCPEGE TGTYSHGIKT
160 170 180 190 200
GQCVVFNGTH RTCEIWSWCP VESGAVPRKP LLAQAKNFTL FIKNTVTFSK
210 220 230 240 250
FNFSRSNALL TWDNTYFKHC LYDPLSSPYC PVFRIGDLVA MAGGDFEDLA
260 270 280 290 300
LLGGAVGISI HWDCNLDTKG SDCCPQYSFQ LQQKGYNFRT ANHWWAASGV
310 320 330 340 350
ETRSLLKLYG IRFDILVTGQ AGKFALIPTA ITVGTGAAWL GMVTFLCDLL
360 370
LLYVDREAGF YWRTKYEEAR APKTTTNSS
Length:379
Mass (Da):42,101
Last modified:July 27, 2011 - v2
Checksum:i1C3CF265934134E5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti259 – 2591S → T in BAA24693. (PubMed:9852680)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010883 mRNA. Translation: BAA24693.1.
AK138541 mRNA. Translation: BAE23697.1.
RefSeqiNP_001153033.1. NM_001159561.1.
NP_035158.2. NM_011028.2.
UniGeneiMm.8032.

Genome annotation databases

GeneIDi18440.
KEGGimmu:18440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010883 mRNA. Translation: BAA24693.1 .
AK138541 mRNA. Translation: BAE23697.1 .
RefSeqi NP_001153033.1. NM_001159561.1.
NP_035158.2. NM_011028.2.
UniGenei Mm.8032.

3D structure databases

ProteinModelPortali O54803.
SMRi O54803. Positions 35-352.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 483.

PTM databases

PhosphoSitei O54803.

Proteomic databases

PRIDEi O54803.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 18440.
KEGGi mmu:18440.

Organism-specific databases

CTDi 9127.
MGIi MGI:1337113. P2rx6.

Phylogenomic databases

eggNOGi NOG47843.
HOGENOMi HOG000232042.
HOVERGENi HBG053086.
InParanoidi O54803.
KOi K05221.

Miscellaneous databases

NextBioi 294124.
PROi O54803.
SOURCEi Search...

Gene expression databases

Bgeei O54803.
ExpressionAtlasi O54803. baseline and differential.
Genevestigatori O54803.

Family and domain databases

Gene3Di 2.60.490.10. 1 hit.
InterProi IPR003049. P2X6_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view ]
PANTHERi PTHR10125. PTHR10125. 1 hit.
Pfami PF00864. P2X_receptor. 1 hit.
[Graphical view ]
PRINTSi PR01313. P2X6RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsi TIGR00863. P2X. 1 hit.
PROSITEi PS01212. P2X_RECEPTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the murine P2XM receptor gene."
    Nawa G., Urano T., Tokino T., Ochi T., Miyoshi Y.
    J. Hum. Genet. 43:262-267(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spinal cord.

Entry informationi

Entry nameiP2RX6_MOUSE
AccessioniPrimary (citable) accession number: O54803
Secondary accession number(s): Q3UUD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3