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O54803

- P2RX6_MOUSE

UniProt

O54803 - P2RX6_MOUSE

Protein

P2X purinoceptor 6

Gene

P2rx6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for ATP that acts as a ligand-gated ion channel.By similarity

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. extracellular ATP-gated cation channel activity Source: RefGenome
    3. purinergic nucleotide receptor activity Source: RefGenome

    GO - Biological processi

    1. cation transport Source: RefGenome
    2. ion transmembrane transport Source: RefGenome
    3. protein heterooligomerization Source: Ensembl
    4. protein homooligomerization Source: Ensembl
    5. purinergic nucleotide receptor signaling pathway Source: GOC

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2X purinoceptor 6
    Short name:
    P2X6
    Alternative name(s):
    ATP receptor
    P2XM
    Purinergic receptor
    Purinergic receptor P2X-like 1
    Gene namesi
    Name:P2rx6
    Synonyms:P2rxl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1337113. P2rx6.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. dendritic spine Source: Ensembl
    4. integral component of nuclear inner membrane Source: RefGenome
    5. integral component of plasma membrane Source: MGI
    6. neuronal cell body Source: Ensembl
    7. postsynaptic density Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379P2X purinoceptor 6PRO_0000161558Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei56 – 561PhosphotyrosineBy similarity
    Disulfide bondi119 ↔ 169By similarity
    Disulfide bondi130 ↔ 153By similarity
    Disulfide bondi136 ↔ 163By similarity
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi220 ↔ 230By similarity
    Disulfide bondi264 ↔ 273By similarity

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiO54803.

    PTM databases

    PhosphoSiteiO54803.

    Expressioni

    Tissue specificityi

    Predominantly expressed in skeletal muscle. Also expressed in lung.

    Gene expression databases

    ArrayExpressiO54803.
    BgeeiO54803.
    GenevestigatoriO54803.

    Interactioni

    Subunit structurei

    Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO54803.
    SMRiO54803. Positions 35-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini53 – 325273ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini347 – 37933CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621Helical; Name=2Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the P2X receptor family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47843.
    HOGENOMiHOG000232042.
    HOVERGENiHBG053086.
    InParanoidiQ3UUD0.
    KOiK05221.

    Family and domain databases

    Gene3Di2.60.490.10. 1 hit.
    InterProiIPR003049. P2X6_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view]
    PANTHERiPTHR10125. PTHR10125. 1 hit.
    PfamiPF00864. P2X_receptor. 1 hit.
    [Graphical view]
    PRINTSiPR01313. P2X6RECEPTOR.
    PR01307. P2XRECEPTOR.
    TIGRFAMsiTIGR00863. P2X. 1 hit.
    PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54803-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASAAAAALV SWGFLDYKTE KYVLTRNCRV GVSQRLLQLA VVVYVIGWAL    50
    LAKKGYQERD LAPQTSVITK LKGVSVTQVK ELENRLWDVA DFVKPSQGEN 100
    VFFLVTNFLV TPAQVQGRCP EHPSVPLANC WADEDCPEGE TGTYSHGIKT 150
    GQCVVFNGTH RTCEIWSWCP VESGAVPRKP LLAQAKNFTL FIKNTVTFSK 200
    FNFSRSNALL TWDNTYFKHC LYDPLSSPYC PVFRIGDLVA MAGGDFEDLA 250
    LLGGAVGISI HWDCNLDTKG SDCCPQYSFQ LQQKGYNFRT ANHWWAASGV 300
    ETRSLLKLYG IRFDILVTGQ AGKFALIPTA ITVGTGAAWL GMVTFLCDLL 350
    LLYVDREAGF YWRTKYEEAR APKTTTNSS 379
    Length:379
    Mass (Da):42,101
    Last modified:July 27, 2011 - v2
    Checksum:i1C3CF265934134E5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti259 – 2591S → T in BAA24693. (PubMed:9852680)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010883 mRNA. Translation: BAA24693.1.
    AK138541 mRNA. Translation: BAE23697.1.
    RefSeqiNP_001153033.1. NM_001159561.1.
    NP_035158.2. NM_011028.2.
    UniGeneiMm.8032.

    Genome annotation databases

    GeneIDi18440.
    KEGGimmu:18440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010883 mRNA. Translation: BAA24693.1 .
    AK138541 mRNA. Translation: BAE23697.1 .
    RefSeqi NP_001153033.1. NM_001159561.1.
    NP_035158.2. NM_011028.2.
    UniGenei Mm.8032.

    3D structure databases

    ProteinModelPortali O54803.
    SMRi O54803. Positions 35-352.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 483.

    PTM databases

    PhosphoSitei O54803.

    Proteomic databases

    PRIDEi O54803.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 18440.
    KEGGi mmu:18440.

    Organism-specific databases

    CTDi 9127.
    MGIi MGI:1337113. P2rx6.

    Phylogenomic databases

    eggNOGi NOG47843.
    HOGENOMi HOG000232042.
    HOVERGENi HBG053086.
    InParanoidi Q3UUD0.
    KOi K05221.

    Miscellaneous databases

    NextBioi 294124.
    PROi O54803.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O54803.
    Bgeei O54803.
    Genevestigatori O54803.

    Family and domain databases

    Gene3Di 2.60.490.10. 1 hit.
    InterProi IPR003049. P2X6_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view ]
    PANTHERi PTHR10125. PTHR10125. 1 hit.
    Pfami PF00864. P2X_receptor. 1 hit.
    [Graphical view ]
    PRINTSi PR01313. P2X6RECEPTOR.
    PR01307. P2XRECEPTOR.
    TIGRFAMsi TIGR00863. P2X. 1 hit.
    PROSITEi PS01212. P2X_RECEPTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the murine P2XM receptor gene."
      Nawa G., Urano T., Tokino T., Ochi T., Miyoshi Y.
      J. Hum. Genet. 43:262-267(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Spinal cord.

    Entry informationi

    Entry nameiP2RX6_MOUSE
    AccessioniPrimary (citable) accession number: O54803
    Secondary accession number(s): Q3UUD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3