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O54800

- CADH8_RAT

UniProt

O54800 - CADH8_RAT

Protein

Cadherin-8

Gene

Cdh8

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro
    2. single organismal cell-cell adhesion Source: RGD
    3. spermatogenesis Source: RGD

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-8
    Gene namesi
    Name:Cdh8
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi69286. Cdh8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Propeptidei30 – 6132Sequence AnalysisPRO_0000003777Add
    BLAST
    Chaini62 – 799738Cadherin-8PRO_0000003778Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi544 – 5441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    PaxDbiO54800.
    PRIDEiO54800.

    Expressioni

    Gene expression databases

    GenevestigatoriO54800.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000062147.

    Structurei

    3D structure databases

    ProteinModelPortaliO54800.
    SMRiO54800. Positions 63-383, 729-790.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini62 – 621560ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini643 – 799157CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei622 – 64221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 167106Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini168 – 276109Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini277 – 391115Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini392 – 494103Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini495 – 616122Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG330572.
    HOGENOMiHOG000231252.
    HOVERGENiHBG005217.
    PhylomeDBiO54800.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O54800-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPERLAETLL DLWTPLIILW ITLPSFVYMA PMNQAHVLTT GSPLELSRQS    50
    EEMRILNRSK RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL 100
    SGDGAGTIFQ INDITGDIHA IKRLDREEKA EYTLTAQAVD WETNKPLEPP 150
    SEFIIKVQDI NDNAPEFLNG PYHATVPEMS ILGTSVTNVT ATDADDPVYG 200
    NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY LVVIQAKDMG 250
    GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA 300
    NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGVIRLR KPLDFETKKS 350
    YTLKVEAANI HIDPRFSGRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV 400
    HENAALNSVI GQVTARDPDI TSSPIRFSID RHTDLERQFN INADDGKITL 450
    ATPLDRELSV WHNISIIATE IRNHSQISRV PVAIKVLDVN DNAPEFASEY 500
    EAFLCENGKP GQVIQTVSAM DKDDPKNGHF FLYSLLPEMV NNPNFTIKKN 550
    EDNSLSILAK HNGFNRQKQE VYLLPIVISD SGNPPLSSTS TLTIRVCGCS 600
    NDGVVQSCNV EPYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE 650
    PLIIKDDEDV RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI 700
    KPDLQFMPRQ GLAPVPNGVD VDEFINVRLH EADNDPTAPP YDSIQIYGYE 750
    GRGSVAGSLS SLESTTSDSD QNFDYLSDWG PRFKRLGELY SVGESDKET 799
    Length:799
    Mass (Da):88,333
    Last modified:June 1, 1998 - v1
    Checksum:iF01D145A80966CB6
    GO
    Isoform 2 (identifier: O54800-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         514-532: IQTVSAMDKDDPKNGHFFL → NISMLLILNMFVYNCFLVN
         533-799: Missing.

    Show »
    Length:532
    Mass (Da):58,973
    Checksum:i47CAC544F1B773B3
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei514 – 53219IQTVS…GHFFL → NISMLLILNMFVYNCFLVN in isoform 2. CuratedVSP_000638Add
    BLAST
    Alternative sequencei533 – 799267Missing in isoform 2. CuratedVSP_000639Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010436 mRNA. Translation: BAA24452.1.
    AB010437 mRNA. Translation: BAA24453.1.
    UniGeneiRn.214220.

    Genome annotation databases

    UCSCiRGD:69286. rat. [O54800-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010436 mRNA. Translation: BAA24452.1 .
    AB010437 mRNA. Translation: BAA24453.1 .
    UniGenei Rn.214220.

    3D structure databases

    ProteinModelPortali O54800.
    SMRi O54800. Positions 63-383, 729-790.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000062147.

    Proteomic databases

    PaxDbi O54800.
    PRIDEi O54800.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:69286. rat. [O54800-1 ]

    Organism-specific databases

    RGDi 69286. Cdh8.

    Phylogenomic databases

    eggNOGi NOG330572.
    HOGENOMi HOG000231252.
    HOVERGENi HBG005217.
    PhylomeDBi O54800.

    Miscellaneous databases

    PROi O54800.

    Gene expression databases

    Genevestigatori O54800.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular properties and chromosomal location of cadherin-8."
      Kido M., Obata S., Tanihara H., Rochelle J.M., Seldin M.F., Taketani S., Suzuki S.T.
      Genomics 48:186-194(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
      Tissue: Brain.

    Entry informationi

    Entry nameiCADH8_RAT
    AccessioniPrimary (citable) accession number: O54800
    Secondary accession number(s): O54801
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3