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O54800

- CADH8_RAT

UniProt

O54800 - CADH8_RAT

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Protein

Cadherin-8

Gene

Cdh8

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  2. single organismal cell-cell adhesion Source: RGD
  3. spermatogenesis Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-8
Gene namesi
Name:Cdh8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi69286. Cdh8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini62 – 621560ExtracellularSequence AnalysisAdd
BLAST
Transmembranei622 – 64221HelicalSequence AnalysisAdd
BLAST
Topological domaini643 – 799157CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Propeptidei30 – 6132Sequence AnalysisPRO_0000003777Add
BLAST
Chaini62 – 799738Cadherin-8PRO_0000003778Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi544 – 5441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiO54800.
PRIDEiO54800.

Expressioni

Gene expression databases

GenevestigatoriO54800.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062147.

Structurei

3D structure databases

ProteinModelPortaliO54800.
SMRiO54800. Positions 63-383, 729-790.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 167106Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini168 – 276109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini277 – 391115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini392 – 494103Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini495 – 616122Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG330572.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiO54800.
PhylomeDBiO54800.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O54800-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPERLAETLL DLWTPLIILW ITLPSFVYMA PMNQAHVLTT GSPLELSRQS
60 70 80 90 100
EEMRILNRSK RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL
110 120 130 140 150
SGDGAGTIFQ INDITGDIHA IKRLDREEKA EYTLTAQAVD WETNKPLEPP
160 170 180 190 200
SEFIIKVQDI NDNAPEFLNG PYHATVPEMS ILGTSVTNVT ATDADDPVYG
210 220 230 240 250
NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY LVVIQAKDMG
260 270 280 290 300
GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA
310 320 330 340 350
NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGVIRLR KPLDFETKKS
360 370 380 390 400
YTLKVEAANI HIDPRFSGRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV
410 420 430 440 450
HENAALNSVI GQVTARDPDI TSSPIRFSID RHTDLERQFN INADDGKITL
460 470 480 490 500
ATPLDRELSV WHNISIIATE IRNHSQISRV PVAIKVLDVN DNAPEFASEY
510 520 530 540 550
EAFLCENGKP GQVIQTVSAM DKDDPKNGHF FLYSLLPEMV NNPNFTIKKN
560 570 580 590 600
EDNSLSILAK HNGFNRQKQE VYLLPIVISD SGNPPLSSTS TLTIRVCGCS
610 620 630 640 650
NDGVVQSCNV EPYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE
660 670 680 690 700
PLIIKDDEDV RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI
710 720 730 740 750
KPDLQFMPRQ GLAPVPNGVD VDEFINVRLH EADNDPTAPP YDSIQIYGYE
760 770 780 790
GRGSVAGSLS SLESTTSDSD QNFDYLSDWG PRFKRLGELY SVGESDKET
Length:799
Mass (Da):88,333
Last modified:June 1, 1998 - v1
Checksum:iF01D145A80966CB6
GO
Isoform 2 (identifier: O54800-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-532: IQTVSAMDKDDPKNGHFFL → NISMLLILNMFVYNCFLVN
     533-799: Missing.

Show »
Length:532
Mass (Da):58,973
Checksum:i47CAC544F1B773B3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei514 – 53219IQTVS…GHFFL → NISMLLILNMFVYNCFLVN in isoform 2. CuratedVSP_000638Add
BLAST
Alternative sequencei533 – 799267Missing in isoform 2. CuratedVSP_000639Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010436 mRNA. Translation: BAA24452.1.
AB010437 mRNA. Translation: BAA24453.1.
UniGeneiRn.214220.

Genome annotation databases

UCSCiRGD:69286. rat. [O54800-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010436 mRNA. Translation: BAA24452.1 .
AB010437 mRNA. Translation: BAA24453.1 .
UniGenei Rn.214220.

3D structure databases

ProteinModelPortali O54800.
SMRi O54800. Positions 63-383, 729-790.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000062147.

Proteomic databases

PaxDbi O54800.
PRIDEi O54800.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:69286. rat. [O54800-1 ]

Organism-specific databases

RGDi 69286. Cdh8.

Phylogenomic databases

eggNOGi NOG330572.
HOGENOMi HOG000231252.
HOVERGENi HBG005217.
InParanoidi O54800.
PhylomeDBi O54800.

Miscellaneous databases

PROi O54800.

Gene expression databases

Genevestigatori O54800.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular properties and chromosomal location of cadherin-8."
    Kido M., Obata S., Tanihara H., Rochelle J.M., Seldin M.F., Taketani S., Suzuki S.T.
    Genomics 48:186-194(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
    Tissue: Brain.

Entry informationi

Entry nameiCADH8_RAT
AccessioniPrimary (citable) accession number: O54800
Secondary accession number(s): O54801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3