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O54800 (CADH8_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin-8
Gene names
Name:Cdh8
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length799 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similarities

Contains 5 cadherin domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O54800-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O54800-2)

The sequence of this isoform differs from the canonical sequence as follows:
     514-532: IQTVSAMDKDDPKNGHFFL → NISMLLILNMFVYNCFLVN
     533-799: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Propeptide30 – 6132 Potential
PRO_0000003777
Chain62 – 799738Cadherin-8
PRO_0000003778

Regions

Topological domain62 – 621560Extracellular Potential
Transmembrane622 – 64221Helical; Potential
Topological domain643 – 799157Cytoplasmic Potential
Domain62 – 167106Cadherin 1
Domain168 – 276109Cadherin 2
Domain277 – 391115Cadherin 3
Domain392 – 494103Cadherin 4
Domain495 – 616122Cadherin 5

Amino acid modifications

Glycosylation1881N-linked (GlcNAc...) Potential
Glycosylation4631N-linked (GlcNAc...) Potential
Glycosylation4731N-linked (GlcNAc...) Potential
Glycosylation5441N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence514 – 53219IQTVS…GHFFL → NISMLLILNMFVYNCFLVN in isoform 2.
VSP_000638
Alternative sequence533 – 799267Missing in isoform 2.
VSP_000639

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: F01D145A80966CB6

FASTA79988,333
        10         20         30         40         50         60 
MPERLAETLL DLWTPLIILW ITLPSFVYMA PMNQAHVLTT GSPLELSRQS EEMRILNRSK 

        70         80         90        100        110        120 
RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL SGDGAGTIFQ INDITGDIHA 

       130        140        150        160        170        180 
IKRLDREEKA EYTLTAQAVD WETNKPLEPP SEFIIKVQDI NDNAPEFLNG PYHATVPEMS 

       190        200        210        220        230        240 
ILGTSVTNVT ATDADDPVYG NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY 

       250        260        270        280        290        300 
LVVIQAKDMG GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA 

       310        320        330        340        350        360 
NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGVIRLR KPLDFETKKS YTLKVEAANI 

       370        380        390        400        410        420 
HIDPRFSGRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV HENAALNSVI GQVTARDPDI 

       430        440        450        460        470        480 
TSSPIRFSID RHTDLERQFN INADDGKITL ATPLDRELSV WHNISIIATE IRNHSQISRV 

       490        500        510        520        530        540 
PVAIKVLDVN DNAPEFASEY EAFLCENGKP GQVIQTVSAM DKDDPKNGHF FLYSLLPEMV 

       550        560        570        580        590        600 
NNPNFTIKKN EDNSLSILAK HNGFNRQKQE VYLLPIVISD SGNPPLSSTS TLTIRVCGCS 

       610        620        630        640        650        660 
NDGVVQSCNV EPYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE PLIIKDDEDV 

       670        680        690        700        710        720 
RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI KPDLQFMPRQ GLAPVPNGVD 

       730        740        750        760        770        780 
VDEFINVRLH EADNDPTAPP YDSIQIYGYE GRGSVAGSLS SLESTTSDSD QNFDYLSDWG 

       790 
PRFKRLGELY SVGESDKET 

« Hide

Isoform 2 [UniParc].

Checksum: 47CAC544F1B773B3
Show »

FASTA53258,973

References

[1]"Molecular properties and chromosomal location of cadherin-8."
Kido M., Obata S., Tanihara H., Rochelle J.M., Seldin M.F., Taketani S., Suzuki S.T.
Genomics 48:186-194(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB010436 mRNA. Translation: BAA24452.1.
AB010437 mRNA. Translation: BAA24453.1.
UniGeneRn.214220.

3D structure databases

ProteinModelPortalO54800.
SMRO54800. Positions 63-383, 729-790.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000062147.

Proteomic databases

PaxDbO54800.
PRIDEO54800.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:69286. rat. [O54800-1]

Organism-specific databases

RGD69286. Cdh8.

Phylogenomic databases

eggNOGNOG330572.
HOGENOMHOG000231252.
HOVERGENHBG005217.
PhylomeDBO54800.

Gene expression databases

GenevestigatorO54800.

Family and domain databases

Gene3D2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 5 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 5 hits.
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

PROO54800.

Entry information

Entry nameCADH8_RAT
AccessionPrimary (citable) accession number: O54800
Secondary accession number(s): O54801
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families