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Protein

Neuromedin-B receptor

Gene

Nmbr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for neuromedin-B.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-B receptor
Short name:
NMB-R
Alternative name(s):
Neuromedin-B-preferring bombesin receptor
Gene namesi
Name:Nmbr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1100525. Nmbr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence analysisAdd
BLAST
Transmembranei42 – 6524Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini66 – 7914CytoplasmicSequence analysisAdd
BLAST
Transmembranei80 – 9920Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini100 – 11718ExtracellularSequence analysisAdd
BLAST
Transmembranei118 – 13922Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini140 – 15617CytoplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini178 – 21134ExtracellularSequence analysisAdd
BLAST
Transmembranei212 – 23524Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini236 – 26631CytoplasmicSequence analysisAdd
BLAST
Transmembranei267 – 28721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini288 – 29912ExtracellularSequence analysisAdd
BLAST
Transmembranei300 – 32728Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini328 – 39063CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Neuromedin-B receptorPRO_0000069904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence analysis
Disulfide bondi116 ↔ 198PROSITE-ProRule annotation
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Lipidationi341 – 3411S-palmitoyl cysteineBy similarity
Modified residuei352 – 3521PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiO54799.
PRIDEiO54799.

PTM databases

iPTMnetiO54799.
PhosphoSiteiO54799.

Expressioni

Gene expression databases

BgeeiO54799.
CleanExiMM_NMBR.
ExpressionAtlasiO54799. baseline and differential.
GenevisibleiO54799. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020015.

Structurei

3D structure databases

ProteinModelPortaliO54799.
SMRiO54799. Positions 40-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiO54799.
KOiK04168.
OMAiTLMKIFI.
OrthoDBiEOG73V6KG.
PhylomeDBiO54799.
TreeFamiTF331292.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001642. NeuroB_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
PR00639. NEUROMEDINBR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54799-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPRSLSNLS FPTEANESEL VPEVWEKDFL PDSDGTTAEL VIRCVIPSLY
60 70 80 90 100
LIIISVGLLG NIMLVKIFLT NSAMRNVPNI FISNLAAGDL LLLLTCVPVD
110 120 130 140 150
ASRYFFDEWV FGKLGCKLIP AIQLTSVGVS VFTLTALSAD RYRAIVNPMD
160 170 180 190 200
MQTSGVLLWT SLKAVGIWVV SVLLAVPEAV FSEVARIGSL DNSSFTACIP
210 220 230 240 250
YPQTDELHPK IHSVLIFLVY FLIPLVIISI YYYHIAKTLI KSAHNLPGEY
260 270 280 290 300
NEHTKKQMET RKRLAKIVLV FVGCFVFCWF PNHVLYLYRS FNYKEIDPSL
310 320 330 340 350
GHMIVTLVAR VLSFSNSCVN PFALYLLSES FRKHFNSQLC CGRKSYPERS
360 370 380 390
TSYLLSSSAV RMTSLKSNTK NVVTNSVLLN GHSTKQEIAL
Length:390
Mass (Da):43,623
Last modified:June 1, 1998 - v1
Checksum:i2EA733B1DF108B42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010281 Genomic DNA. Translation: BAA24405.1.
CCDSiCCDS23707.1.
RefSeqiNP_032729.1. NM_008703.2.
UniGeneiMm.487342.

Genome annotation databases

EnsembliENSMUST00000020015; ENSMUSP00000020015; ENSMUSG00000019865.
GeneIDi18101.
KEGGimmu:18101.
UCSCiuc007elp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010281 Genomic DNA. Translation: BAA24405.1.
CCDSiCCDS23707.1.
RefSeqiNP_032729.1. NM_008703.2.
UniGeneiMm.487342.

3D structure databases

ProteinModelPortaliO54799.
SMRiO54799. Positions 40-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020015.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO54799.
PhosphoSiteiO54799.

Proteomic databases

PaxDbiO54799.
PRIDEiO54799.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020015; ENSMUSP00000020015; ENSMUSG00000019865.
GeneIDi18101.
KEGGimmu:18101.
UCSCiuc007elp.1. mouse.

Organism-specific databases

CTDi4829.
MGIiMGI:1100525. Nmbr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiO54799.
KOiK04168.
OMAiTLMKIFI.
OrthoDBiEOG73V6KG.
PhylomeDBiO54799.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiO54799.
SOURCEiSearch...

Gene expression databases

BgeeiO54799.
CleanExiMM_NMBR.
ExpressionAtlasiO54799. baseline and differential.
GenevisibleiO54799. MM.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001642. NeuroB_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
PR00639. NEUROMEDINBR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse."
    Ohki-Hamazaki H., Wada E., Matsui K., Wada K.
    Brain Res. 762:165-172(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Liver.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiNMBR_MOUSE
AccessioniPrimary (citable) accession number: O54799
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.