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Protein

Neuromedin-B receptor

Gene

Nmbr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for neuromedin-B.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-B receptor
Short name:
NMB-R
Alternative name(s):
Neuromedin-B-preferring bombesin receptor
Gene namesi
Name:Nmbr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1100525. Nmbr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 65Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini66 – 79CytoplasmicSequence analysisAdd BLAST14
Transmembranei80 – 99Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini100 – 117ExtracellularSequence analysisAdd BLAST18
Transmembranei118 – 139Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini140 – 156CytoplasmicSequence analysisAdd BLAST17
Transmembranei157 – 177Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini178 – 211ExtracellularSequence analysisAdd BLAST34
Transmembranei212 – 235Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini236 – 266CytoplasmicSequence analysisAdd BLAST31
Transmembranei267 – 287Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini288 – 299ExtracellularSequence analysisAdd BLAST12
Transmembranei300 – 327Helical; Name=7Sequence analysisAdd BLAST28
Topological domaini328 – 390CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699041 – 390Neuromedin-B receptorAdd BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi116 ↔ 198PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Lipidationi341S-palmitoyl cysteineBy similarity1
Modified residuei352PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiO54799.
PRIDEiO54799.

PTM databases

iPTMnetiO54799.
PhosphoSitePlusiO54799.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019865.
CleanExiMM_NMBR.
ExpressionAtlasiO54799. baseline and differential.
GenevisibleiO54799. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020015.

Structurei

3D structure databases

ProteinModelPortaliO54799.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiO54799.
KOiK04168.
OMAiTLMKIFI.
OrthoDBiEOG091G085Y.
PhylomeDBiO54799.
TreeFamiTF331292.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001642. NeuroB_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
PR00639. NEUROMEDINBR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54799-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPRSLSNLS FPTEANESEL VPEVWEKDFL PDSDGTTAEL VIRCVIPSLY
60 70 80 90 100
LIIISVGLLG NIMLVKIFLT NSAMRNVPNI FISNLAAGDL LLLLTCVPVD
110 120 130 140 150
ASRYFFDEWV FGKLGCKLIP AIQLTSVGVS VFTLTALSAD RYRAIVNPMD
160 170 180 190 200
MQTSGVLLWT SLKAVGIWVV SVLLAVPEAV FSEVARIGSL DNSSFTACIP
210 220 230 240 250
YPQTDELHPK IHSVLIFLVY FLIPLVIISI YYYHIAKTLI KSAHNLPGEY
260 270 280 290 300
NEHTKKQMET RKRLAKIVLV FVGCFVFCWF PNHVLYLYRS FNYKEIDPSL
310 320 330 340 350
GHMIVTLVAR VLSFSNSCVN PFALYLLSES FRKHFNSQLC CGRKSYPERS
360 370 380 390
TSYLLSSSAV RMTSLKSNTK NVVTNSVLLN GHSTKQEIAL
Length:390
Mass (Da):43,623
Last modified:June 1, 1998 - v1
Checksum:i2EA733B1DF108B42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010281 Genomic DNA. Translation: BAA24405.1.
CCDSiCCDS23707.1.
RefSeqiNP_032729.1. NM_008703.2.
UniGeneiMm.487342.

Genome annotation databases

EnsembliENSMUST00000020015; ENSMUSP00000020015; ENSMUSG00000019865.
GeneIDi18101.
KEGGimmu:18101.
UCSCiuc007elp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010281 Genomic DNA. Translation: BAA24405.1.
CCDSiCCDS23707.1.
RefSeqiNP_032729.1. NM_008703.2.
UniGeneiMm.487342.

3D structure databases

ProteinModelPortaliO54799.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020015.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO54799.
PhosphoSitePlusiO54799.

Proteomic databases

PaxDbiO54799.
PRIDEiO54799.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020015; ENSMUSP00000020015; ENSMUSG00000019865.
GeneIDi18101.
KEGGimmu:18101.
UCSCiuc007elp.1. mouse.

Organism-specific databases

CTDi4829.
MGIiMGI:1100525. Nmbr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiO54799.
KOiK04168.
OMAiTLMKIFI.
OrthoDBiEOG091G085Y.
PhylomeDBiO54799.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiO54799.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019865.
CleanExiMM_NMBR.
ExpressionAtlasiO54799. baseline and differential.
GenevisibleiO54799. MM.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001642. NeuroB_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
PR00639. NEUROMEDINBR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNMBR_MOUSE
AccessioniPrimary (citable) accession number: O54799
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.