O54799 (NMBR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuromedin-B receptor
Short name=NMB-R

Alternative name(s):
Neuromedin-B-preferring bombesin receptor

Gene names

Name:

Nmbr

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for neuromedin-B.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	bombesin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Neuromedin-B receptor		PRO_0000069904
Regions
	Topological domain	1 – 41	41	Extracellular Potential
	Transmembrane	42 – 65	24	Helical; Name=1; Potential
	Topological domain	66 – 79	14	Cytoplasmic Potential
	Transmembrane	80 – 99	20	Helical; Name=2; Potential
	Topological domain	100 – 117	18	Extracellular Potential
	Transmembrane	118 – 139	22	Helical; Name=3; Potential
	Topological domain	140 – 156	17	Cytoplasmic Potential
	Transmembrane	157 – 177	21	Helical; Name=4; Potential
	Topological domain	178 – 211	34	Extracellular Potential
	Transmembrane	212 – 235	24	Helical; Name=5; Potential
	Topological domain	236 – 266	31	Cytoplasmic Potential
	Transmembrane	267 – 287	21	Helical; Name=6; Potential
	Topological domain	288 – 299	12	Extracellular Potential
	Transmembrane	300 – 327	28	Helical; Name=7; Potential
	Topological domain	328 – 390	63	Cytoplasmic Potential
Amino acid modifications
	Lipidation	341	1	S-palmitoyl cysteine By similarity
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Glycosylation	16	1	N-linked (GlcNAc...) Potential
	Glycosylation	192	1	N-linked (GlcNAc...) Potential
	Disulfide bond	116 ↔ 198		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O54799 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 2EA733B1DF108B42	FASTA	390	43,623
	10 20 30 40 50 60 MPPRSLSNLS FPTEANESEL VPEVWEKDFL PDSDGTTAEL VIRCVIPSLY LIIISVGLLG 70 80 90 100 110 120 NIMLVKIFLT NSAMRNVPNI FISNLAAGDL LLLLTCVPVD ASRYFFDEWV FGKLGCKLIP 130 140 150 160 170 180 AIQLTSVGVS VFTLTALSAD RYRAIVNPMD MQTSGVLLWT SLKAVGIWVV SVLLAVPEAV 190 200 210 220 230 240 FSEVARIGSL DNSSFTACIP YPQTDELHPK IHSVLIFLVY FLIPLVIISI YYYHIAKTLI 250 260 270 280 290 300 KSAHNLPGEY NEHTKKQMET RKRLAKIVLV FVGCFVFCWF PNHVLYLYRS FNYKEIDPSL 310 320 330 340 350 360 GHMIVTLVAR VLSFSNSCVN PFALYLLSES FRKHFNSQLC CGRKSYPERS TSYLLSSSAV 370 380 390 RMTSLKSNTK NVVTNSVLLN GHSTKQEIAL

References

[1]	"Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse." Ohki-Hamazaki H., Wada E., Matsui K., Wada K. Brain Res. 762:165-172(1997) [PubMed: 9262170] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB010281 Genomic DNA. Translation: BAA24405.1.
IPI	IPI00117887.
RefSeq	NP_032729.1. NM_008703.2.
3D structure databases
ProteinModelPortal	O54799.
SMR	O54799. Positions 43-342.
ModBase	Search...
Protein-protein interaction databases
STRING	O54799.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O54799.
Proteomic databases
PRIDE	O54799.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000020015; ENSMUSP00000020015; ENSMUSG00000019865.
GeneID	18101.
KEGG	mmu:18101.
Organism-specific databases
CTD	4829.
MGI	MGI:1100525. Nmbr.
Phylogenomic databases
eggNOG	roNOG10589.
HOGENOM	HBG713709.
HOVERGEN	HBG004898.
InParanoid	O54799.
OMA	IKSAHNL.
OrthoDB	EOG4M398N.
PhylomeDB	O54799.
Gene expression databases
ArrayExpress	O54799.
Bgee	O54799.
CleanEx	MM_NMBR.
Genevestigator	O54799.
GermOnline	ENSMUSG00000019865. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR001556. Bombsn_rcpt. IPR017452. GPCR_Rhodpsn_supfam. IPR001642. NeuroB_rcpt. [Graphical view]
KO	K04168.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00358. BOMBESINR. PR00237. GPCRRHODOPSN. PR00639. NEUROMEDINBR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	293267.
SOURCE	Search...

Entry information

Entry name

NMBR_MOUSE

Accession

Primary (citable) accession number: O54799

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	November 16, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program