Reviewed, UniProtKB/Swiss-Prot O54798 (BRS3_MOUSE)

Names and origin

Protein names

Recommended name:
    Bombesin receptor subtype-3
      Short name=BRS-3

Gene names

Name:

Brs3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	bombesin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Bombesin receptor subtype-3		PRO_0000069198
Regions
	Topological domain	1 – 41	41	Extracellular Potential
	Transmembrane	42 – 63	22	1 Potential
	Topological domain	64 – 82	19	Cytoplasmic Potential
	Transmembrane	83 – 103	21	2 Potential
	Topological domain	104 – 121	18	Extracellular Potential
	Transmembrane	122 – 143	22	3 Potential
	Topological domain	144 – 163	20	Cytoplasmic Potential
	Transmembrane	164 – 184	21	4 Potential
	Topological domain	185 – 220	36	Extracellular Potential
	Transmembrane	221 – 241	21	5 Potential
	Topological domain	242 – 272	31	Cytoplasmic Potential
	Transmembrane	273 – 293	21	6 Potential
	Topological domain	294 – 313	20	Extracellular Potential
	Transmembrane	314 – 333	20	7 Potential
	Topological domain	334 – 399	66	Cytoplasmic Potential
Amino acid modifications
	Lipidation	347	1	S-palmitoyl cysteine By similarity
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Glycosylation	29	1	N-linked (GlcNAc...) Potential
	Disulfide bond	120 ↔ 203		By similarity
Experimental info
	Sequence conflict	27 – 28	2	VS → AP in AAC40133. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O54798-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 9E2DE5BD8E5567BF	FASTA	399	44,229
	10 20 30 40 50 60 MSQRQSQSPN QTLISITNDT ETSSSVVSND TTHKGWTGDN SPGIEALCAI YITYAGIISV 70 80 90 100 110 120 GILGNAILIK VFFKTKSMQT VPNIFITSLA FGDLLLLLTC VPVDATHYLA EGWLFGKVGC 130 140 150 160 170 180 KVLSFIRLTS VGVSVFTLTI LSADRYKAVV KPLERQPPNA ILKTCAKAGG IWIVSMIFAL 190 200 210 220 230 240 PEAIFSNVYT FQDPNRNVTF ESCNSYPISE RLLQEIHSLL CFLVFYIIPL SIISVYYSLI 250 260 270 280 290 300 ARTLYKSTLN IPTEEQSHAR KQIESRKRIA KTVLVLVALF ALCWLPNHLL YLYHSFTYES 310 320 330 340 350 360 YANHSDVPFV IIIFSRVLAF SNSCVNPFAL YWLSKTFQQH FKAQLCCLKA EQPEPPLGDI 370 380 390 PLNNLTVMGR VPATGSAHVS EISVTLFSGS SAKKGEDKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse." Ohki-Hamazaki H., Wada E., Matsui K., Wada K. Brain Res. 762:165-172(1997) [PubMed: 9262170] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv. Tissue: Liver.
[2]	"Structure and chromosomal localization of the mouse bombesin receptor subtype 3 gene." Weber H.C., Hampton L.L., Jensen R.T., Battey J.F. Gene 211:125-131(1998) [PubMed: 9573346] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Hypothalamus.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB010280 Genomic DNA. Translation: BAA24404.1. U84901, U84899, U84900 Genomic DNA. Translation: AAC40133.1. AK038616 mRNA. Translation: BAC30064.1. BC106961 mRNA. Translation: AAI06962.1. BC106962 mRNA. Translation: AAI06963.1.
IPI	IPI00309702.
RefSeq	NP_033896.2.
UniGene	Mm.10687
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSMUSG00000031130. Mus musculus. [Contig view]
GeneID	12209.
KEGG	mmu:12209.
Organism-specific databases
MGI	MGI:1100501. Brs3.
Phylogenomic databases
HOGENOM	O54798.
HOVERGEN	O54798.
OMA	O54798. FIRLTSV.
Gene expression databases
ArrayExpress	O54798.
Bgee	O54798.
CleanEx	MM_BRS3.
GermOnline	ENSMUSG00000031130. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR001560. Bombesin_rcpt_3. IPR001556. Bombsn_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
PANTHER	PTHR19264:SF239. Bombsn_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00637. BOMBESIN3R. PR00358. BOMBESINR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	280601.
SOURCE	Search...

Entry information

Entry name

BRS3_MOUSE

Accession

Primary (citable) accession number: O54798
Secondary accession number(s): O88790, Q544G9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)