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Protein

Bombesin receptor subtype-3

Gene

Brs3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Bombesin receptor subtype-3
Short name:
BRS-3
Gene namesi
Name:Brs3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1100501. Brs3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence analysisAdd
BLAST
Transmembranei42 – 6322Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 8219CytoplasmicSequence analysisAdd
BLAST
Transmembranei83 – 10321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini104 – 12118ExtracellularSequence analysisAdd
BLAST
Transmembranei122 – 14322Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini144 – 16320CytoplasmicSequence analysisAdd
BLAST
Transmembranei164 – 18421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini185 – 22036ExtracellularSequence analysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini242 – 27231CytoplasmicSequence analysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini294 – 31320ExtracellularSequence analysisAdd
BLAST
Transmembranei314 – 33320Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini334 – 39966CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1075140.
GuidetoPHARMACOLOGYi40.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Bombesin receptor subtype-3PRO_0000069198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi120 ↔ 203PROSITE-ProRule annotation
Lipidationi347 – 3471S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO54798.
PRIDEiO54798.

PTM databases

PhosphoSiteiO54798.

Expressioni

Gene expression databases

BgeeiO54798.
CleanExiMM_BRS3.
GenevisibleiO54798. MM.

Interactioni

Subunit structurei

Interacts with C6orf89.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033464.

Chemistry

BindingDBiO54798.

Structurei

3D structure databases

ProteinModelPortaliO54798.
SMRiO54798. Positions 50-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiO54798.
KOiK04170.
OMAiTIEACTS.
OrthoDBiEOG73V6KG.
PhylomeDBiO54798.
TreeFamiTF331292.

Family and domain databases

InterProiIPR001560. Bombesin_rcpt_3.
IPR001556. Bombsn_rcpt-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00637. BOMBESIN3R.
PR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRQSQSPN QTLISITNDT ETSSSVVSND TTHKGWTGDN SPGIEALCAI
60 70 80 90 100
YITYAGIISV GILGNAILIK VFFKTKSMQT VPNIFITSLA FGDLLLLLTC
110 120 130 140 150
VPVDATHYLA EGWLFGKVGC KVLSFIRLTS VGVSVFTLTI LSADRYKAVV
160 170 180 190 200
KPLERQPPNA ILKTCAKAGG IWIVSMIFAL PEAIFSNVYT FQDPNRNVTF
210 220 230 240 250
ESCNSYPISE RLLQEIHSLL CFLVFYIIPL SIISVYYSLI ARTLYKSTLN
260 270 280 290 300
IPTEEQSHAR KQIESRKRIA KTVLVLVALF ALCWLPNHLL YLYHSFTYES
310 320 330 340 350
YANHSDVPFV IIIFSRVLAF SNSCVNPFAL YWLSKTFQQH FKAQLCCLKA
360 370 380 390
EQPEPPLGDI PLNNLTVMGR VPATGSAHVS EISVTLFSGS SAKKGEDKV
Length:399
Mass (Da):44,229
Last modified:June 1, 1998 - v1
Checksum:i9E2DE5BD8E5567BF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 282VS → AP in AAC40133 (PubMed:9573346).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010280 Genomic DNA. Translation: BAA24404.1.
U84901, U84899, U84900 Genomic DNA. Translation: AAC40133.1.
AK038616 mRNA. Translation: BAC30064.1.
BC106961 mRNA. Translation: AAI06962.1.
BC106962 mRNA. Translation: AAI06963.1.
CCDSiCCDS30150.1.
RefSeqiNP_033896.2. NM_009766.3.
UniGeneiMm.10687.

Genome annotation databases

EnsembliENSMUST00000033464; ENSMUSP00000033464; ENSMUSG00000031130.
GeneIDi12209.
KEGGimmu:12209.
UCSCiuc009tgu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010280 Genomic DNA. Translation: BAA24404.1.
U84901, U84899, U84900 Genomic DNA. Translation: AAC40133.1.
AK038616 mRNA. Translation: BAC30064.1.
BC106961 mRNA. Translation: AAI06962.1.
BC106962 mRNA. Translation: AAI06963.1.
CCDSiCCDS30150.1.
RefSeqiNP_033896.2. NM_009766.3.
UniGeneiMm.10687.

3D structure databases

ProteinModelPortaliO54798.
SMRiO54798. Positions 50-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033464.

Chemistry

BindingDBiO54798.
ChEMBLiCHEMBL1075140.
GuidetoPHARMACOLOGYi40.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO54798.

Proteomic databases

PaxDbiO54798.
PRIDEiO54798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033464; ENSMUSP00000033464; ENSMUSG00000031130.
GeneIDi12209.
KEGGimmu:12209.
UCSCiuc009tgu.1. mouse.

Organism-specific databases

CTDi680.
MGIiMGI:1100501. Brs3.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiO54798.
KOiK04170.
OMAiTIEACTS.
OrthoDBiEOG73V6KG.
PhylomeDBiO54798.
TreeFamiTF331292.

Miscellaneous databases

PROiO54798.
SOURCEiSearch...

Gene expression databases

BgeeiO54798.
CleanExiMM_BRS3.
GenevisibleiO54798. MM.

Family and domain databases

InterProiIPR001560. Bombesin_rcpt_3.
IPR001556. Bombsn_rcpt-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00637. BOMBESIN3R.
PR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse."
    Ohki-Hamazaki H., Wada E., Matsui K., Wada K.
    Brain Res. 762:165-172(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Liver.
  2. "Structure and chromosomal localization of the mouse bombesin receptor subtype 3 gene."
    Weber H.C., Hampton L.L., Jensen R.T., Battey J.F.
    Gene 211:125-131(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiBRS3_MOUSE
AccessioniPrimary (citable) accession number: O54798
Secondary accession number(s): O88790, Q544G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.