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Protein

Aquaporin-7

Gene

Aqp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms a channel for water and glycerol.

GO - Molecular functioni

GO - Biological processi

  • carbohydrate transmembrane transport Source: GO_Central
  • cellular water homeostasis Source: GO_Central
  • glycerol transport Source: MGI
  • ion transmembrane transport Source: GO_Central
  • renal water absorption Source: MGI
  • response to drug Source: Ensembl
  • spermatogenesis Source: Ensembl
  • urea transmembrane transport Source: GO_Central
  • water transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-MMU-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-7
Short name:
AQP-7
Alternative name(s):
Aquaglyceroporin-7
Gene namesi
Name:Aqp7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1314647. Aqp7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 52ExtracellularSequence analysis6
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 98CytoplasmicSequence analysisAdd BLAST25
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 155ExtracellularSequence analysisAdd BLAST36
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 189CytoplasmicSequence analysisAdd BLAST13
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 240ExtracellularSequence analysisAdd BLAST30
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 303CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639591 – 303Aquaporin-7Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO54794.
PRIDEiO54794.

PTM databases

iPTMnetiO54794.
PhosphoSitePlusiO54794.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028427.
CleanExiMM_AQP7.
ExpressionAtlasiO54794. baseline and differential.
GenevisibleiO54794. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030136.

Structurei

3D structure databases

ProteinModelPortaliO54794.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi79 – 81NPA 13
Motifi211 – 213NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiO54794.
KOiK08771.
OMAiYLGAIIY.
OrthoDBiEOG091G0FMS.
PhylomeDBiO54794.
TreeFamiTF313173.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR015686. Aquaporin_7.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PTHR19139:SF16. PTHR19139:SF16. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.

Sequencei

Sequence statusi: Complete.

O54794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRSVLETI QSVLQKNMVR EFLAEFLSTY VMMVFGLGSV AHMVLGENSG
60 70 80 90 100
SYLGVNLGFG FGVTMGVHVA GGISGAHMNA AVTFTNCALG RMTWKKFPVY
110 120 130 140 150
VLGQFLGSFS AAATTYLIFY GAINHFAGGD LLVTGSKATA NIFATYLPEY
160 170 180 190 200
MTLWRGFLDE AFVTGMLQLC LFAITDKKNS PALQGTEPLV IGILVTVLGV
210 220 230 240 250
SLGMNSGYAI NPSRDLPPRL FTFIAGWGKQ VFRAGNNWWW VPVVAPLLGA
260 270 280 290 300
YLGGIVYLGL IHPSIPQDPQ RLENFTARDQ KVTASYKNAA SANISGSVPL

EHF
Length:303
Mass (Da):32,667
Last modified:June 1, 1998 - v1
Checksum:iDC4C0A57FC61E575
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180S → R in BAC36431 (PubMed:16141072).Curated1
Sequence conflicti279D → Y in BAC36431 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010100 mRNA. Translation: BAA24537.1.
AK076642 mRNA. Translation: BAC36431.1.
BC022223 mRNA. Translation: AAH22223.1.
CCDSiCCDS18055.1.
RefSeqiNP_031499.1. NM_007473.4.
XP_006537623.2. XM_006537560.3.
UniGeneiMm.8728.

Genome annotation databases

EnsembliENSMUST00000030136; ENSMUSP00000030136; ENSMUSG00000028427.
ENSMUST00000054945; ENSMUSP00000093007; ENSMUSG00000028427.
GeneIDi11832.
KEGGimmu:11832.
UCSCiuc008sif.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010100 mRNA. Translation: BAA24537.1.
AK076642 mRNA. Translation: BAC36431.1.
BC022223 mRNA. Translation: AAH22223.1.
CCDSiCCDS18055.1.
RefSeqiNP_031499.1. NM_007473.4.
XP_006537623.2. XM_006537560.3.
UniGeneiMm.8728.

3D structure databases

ProteinModelPortaliO54794.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030136.

PTM databases

iPTMnetiO54794.
PhosphoSitePlusiO54794.

Proteomic databases

PaxDbiO54794.
PRIDEiO54794.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030136; ENSMUSP00000030136; ENSMUSG00000028427.
ENSMUST00000054945; ENSMUSP00000093007; ENSMUSG00000028427.
GeneIDi11832.
KEGGimmu:11832.
UCSCiuc008sif.1. mouse.

Organism-specific databases

CTDi364.
MGIiMGI:1314647. Aqp7.

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiO54794.
KOiK08771.
OMAiYLGAIIY.
OrthoDBiEOG091G0FMS.
PhylomeDBiO54794.
TreeFamiTF313173.

Enzyme and pathway databases

ReactomeiR-MMU-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-MMU-432047. Passive transport by Aquaporins.

Miscellaneous databases

PROiO54794.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028427.
CleanExiMM_AQP7.
ExpressionAtlasiO54794. baseline and differential.
GenevisibleiO54794. MM.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR015686. Aquaporin_7.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PTHR19139:SF16. PTHR19139:SF16. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAQP7_MOUSE
AccessioniPrimary (citable) accession number: O54794
Secondary accession number(s): Q8C630
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.