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Protein

Transcription factor HES-2

Gene

Hes2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription.

GO - Molecular functioni

  • double-stranded DNA binding Source: Ensembl
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-2
Alternative name(s):
Hairy and enhancer of split 2
Gene namesi
Name:Hes2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1098624. Hes2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272071 – 157Transcription factor HES-2Add BLAST157

Proteomic databases

PaxDbiO54792.
PRIDEiO54792.

PTM databases

iPTMnetiO54792.
PhosphoSitePlusiO54792.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028940.
CleanExiMM_HES2.
GenevisibleiO54792. MM.

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030782.

Structurei

3D structure databases

ProteinModelPortaliO54792.
SMRiO54792.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 70bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini86 – 119OrangePROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi154 – 157WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 148Pro-rich10

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 1 Orange domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4304. Eukaryota.
ENOG4111F0X. LUCA.
GeneTreeiENSGT00700000104168.
HOGENOMiHOG000236346.
HOVERGENiHBG005960.
InParanoidiO54792.
KOiK09087.
OMAiACSVLEP.
OrthoDBiEOG091G0GBN.
TreeFamiTF351373.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003650. Orange_dom.
[Graphical view]
PfamiPF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPRRVEDA AELRKNLKPL LEKRRRARIN ESLSQLKGLV LPLLGAETSR
60 70 80 90 100
SSKLEKADIL EMTVRFLQEQ PATLYSSAAP GPLNSYLEGY RACLARLARV
110 120 130 140 150
LPACSVLEPA VSARLLEHLR QRTVSDDSPS LTLPPAPAPA PSPPVPPPGS

SGLWRPW
Length:157
Mass (Da):17,259
Last modified:October 3, 2012 - v2
Checksum:iA6600DDD4FE93E7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12 – 13EL → DV in BAA24091 (PubMed:9570950).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009967 Genomic DNA. Translation: BAA24091.1.
AK053792 mRNA. Translation: BAC35525.1.
AL772240 Genomic DNA. Translation: CAM19694.1.
CH466594 Genomic DNA. Translation: EDL14928.1.
BC138112 mRNA. Translation: AAI38113.1.
CCDSiCCDS18995.1.
RefSeqiNP_001288734.1. NM_001301805.1.
NP_032262.2. NM_008236.4.
XP_017175471.1. XM_017319982.1.
UniGeneiMm.57038.

Genome annotation databases

EnsembliENSMUST00000030782; ENSMUSP00000030782; ENSMUSG00000028940.
GeneIDi15206.
KEGGimmu:15206.
UCSCiuc008vzw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009967 Genomic DNA. Translation: BAA24091.1.
AK053792 mRNA. Translation: BAC35525.1.
AL772240 Genomic DNA. Translation: CAM19694.1.
CH466594 Genomic DNA. Translation: EDL14928.1.
BC138112 mRNA. Translation: AAI38113.1.
CCDSiCCDS18995.1.
RefSeqiNP_001288734.1. NM_001301805.1.
NP_032262.2. NM_008236.4.
XP_017175471.1. XM_017319982.1.
UniGeneiMm.57038.

3D structure databases

ProteinModelPortaliO54792.
SMRiO54792.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030782.

PTM databases

iPTMnetiO54792.
PhosphoSitePlusiO54792.

Proteomic databases

PaxDbiO54792.
PRIDEiO54792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030782; ENSMUSP00000030782; ENSMUSG00000028940.
GeneIDi15206.
KEGGimmu:15206.
UCSCiuc008vzw.1. mouse.

Organism-specific databases

CTDi54626.
MGIiMGI:1098624. Hes2.

Phylogenomic databases

eggNOGiKOG4304. Eukaryota.
ENOG4111F0X. LUCA.
GeneTreeiENSGT00700000104168.
HOGENOMiHOG000236346.
HOVERGENiHBG005960.
InParanoidiO54792.
KOiK09087.
OMAiACSVLEP.
OrthoDBiEOG091G0GBN.
TreeFamiTF351373.

Miscellaneous databases

PROiO54792.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028940.
CleanExiMM_HES2.
GenevisibleiO54792. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003650. Orange_dom.
[Graphical view]
PfamiPF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHES2_MOUSE
AccessioniPrimary (citable) accession number: O54792
Secondary accession number(s): Q8BKA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.