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Protein

Transcription factor HES-2

Gene

Hes2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-2
Alternative name(s):
Hairy and enhancer of split 2
Gene namesi
Name:Hes2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1098624. Hes2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272071 – 157Transcription factor HES-2Add BLAST157

Proteomic databases

PaxDbiO54792.
PRIDEiO54792.

PTM databases

iPTMnetiO54792.
PhosphoSitePlusiO54792.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028940.
CleanExiMM_HES2.
GenevisibleiO54792. MM.

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

  • protein dimerization activity Source: InterPro
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

ELMiO54792.
STRINGi10090.ENSMUSP00000030782.

Structurei

3D structure databases

ProteinModelPortaliO54792.
SMRiO54792.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 70bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini86 – 119OrangePROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi154 – 157WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 148Pro-rich10

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Phylogenomic databases

eggNOGiKOG4304. Eukaryota.
ENOG4111F0X. LUCA.
GeneTreeiENSGT00700000104168.
HOGENOMiHOG000236346.
HOVERGENiHBG005960.
InParanoidiO54792.
KOiK09087.
OMAiEGYSACV.
OrthoDBiEOG091G0GBN.
TreeFamiTF351373.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR003650. Orange_dom.
PfamiView protein in Pfam
PF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.

Sequencei

Sequence statusi: Complete.

O54792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPRRVEDA AELRKNLKPL LEKRRRARIN ESLSQLKGLV LPLLGAETSR
60 70 80 90 100
SSKLEKADIL EMTVRFLQEQ PATLYSSAAP GPLNSYLEGY RACLARLARV
110 120 130 140 150
LPACSVLEPA VSARLLEHLR QRTVSDDSPS LTLPPAPAPA PSPPVPPPGS

SGLWRPW
Length:157
Mass (Da):17,259
Last modified:October 3, 2012 - v2
Checksum:iA6600DDD4FE93E7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12 – 13EL → DV in BAA24091 (PubMed:9570950).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009967 Genomic DNA. Translation: BAA24091.1.
AK053792 mRNA. Translation: BAC35525.1.
AL772240 Genomic DNA. Translation: CAM19694.1.
CH466594 Genomic DNA. Translation: EDL14928.1.
BC138112 mRNA. Translation: AAI38113.1.
CCDSiCCDS18995.1.
RefSeqiNP_001288734.1. NM_001301805.1.
NP_032262.2. NM_008236.4.
XP_017175471.1. XM_017319982.1.
UniGeneiMm.57038.

Genome annotation databases

EnsembliENSMUST00000030782; ENSMUSP00000030782; ENSMUSG00000028940.
GeneIDi15206.
KEGGimmu:15206.
UCSCiuc008vzw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiHES2_MOUSE
AccessioniPrimary (citable) accession number: O54792
Secondary accession number(s): Q8BKA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2012
Last modified: August 30, 2017
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot