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O54791

- MAFF_MOUSE

UniProt

O54791 - MAFF_MOUSE

Protein

Transcription factor MafF

Gene

Maff

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it self-dimerizes. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response.

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. in utero embryonic development Source: MGI
    2. regulation of epidermal cell differentiation Source: MGI
    3. skeletal muscle cell differentiation Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor MafF
    Alternative name(s):
    V-maf musculoaponeurotic fibrosarcoma oncogene homolog F
    Gene namesi
    Name:Maff
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:96910. Maff.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 156156Transcription factor MafFPRO_0000076498Add
    BLAST

    Proteomic databases

    PRIDEiO54791.

    Expressioni

    Tissue specificityi

    Highly expressed in the lung, lower expression in the brain, thymus, liver, spleen, intestine, kidney, heart, muscle, and ovary. Not significantly expressed in hematopoietic cells.

    Developmental stagei

    Detected at 6.5 dpc in the boundary between the extraembryonic and embryonic regions. At 8.5 dpc, weakly expressed in the future gut, allantois, yolk sac endoderm and the ectoplacental cone. At 9.5 dpc, strong expression in the primordial gut and presumptive fetal liver, in the floorplate of the myelencephalon, neural crest cells, spongiotrophoblasts, and giant cells of the placenta. At 12.5 dpc, detected in hepotocytes, in the outflow tract of the heart in a specific subset of dorsal root ganglia, in the cranial nerve ganglia, in the lung primordium, and in the epithelium of the expiratory tract. In newborn, strongly expressed in keratinocytes, in the cartilage, in bronchial epithelia, and bone membrane.1 Publication

    Gene expression databases

    ArrayExpressiO54791.
    BgeeiO54791.
    GenevestigatoriO54791.

    Interactioni

    Subunit structurei

    Monomer and homo- or heterodimer. Interacts with MIP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi201282. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO54791.
    SMRiO54791. Positions 24-110.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 11464bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni51 – 7626Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni79 – 9315Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. Maf subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG315640.
    HOGENOMiHOG000045475.
    HOVERGENiHBG001725.
    InParanoidiO54791.
    KOiK09037.
    OMAiHGPASCS.
    OrthoDBiEOG7BGHMQ.
    PhylomeDBiO54791.
    TreeFamiTF325689.

    Family and domain databases

    Gene3Di1.10.880.10. 1 hit.
    InterProiIPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR008917. TF_DNA-bd.
    IPR024874. Transciption_factor_Maf.
    [Graphical view]
    PANTHERiPTHR10129. PTHR10129. 1 hit.
    PfamiPF03131. bZIP_Maf. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47454. SSF47454. 1 hit.
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54791-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVDPLSSKA LKVKRELSEN TPHLSDEALM GLSVRELNRN LRGLSAEEVT    50
    RLKQRRRTLK NRGYAASCRV KRVCQKEELQ KQKSELEREV DKLARENAAM 100
    RLELDALRGK CEALQGFARS VAAARGPAAL VAPASVITIV KSAPGPAPAA 150
    DPAPCS 156
    Length:156
    Mass (Da):16,955
    Last modified:June 1, 1998 - v1
    Checksum:i574DD05499819037
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009694 Genomic DNA. Translation: BAA24029.1.
    BC022952 mRNA. Translation: AAH22952.1.
    CCDSiCCDS27638.1.
    RefSeqiNP_034885.1. NM_010755.3.
    XP_006520612.1. XM_006520549.1.
    XP_006520613.1. XM_006520550.1.
    UniGeneiMm.86646.

    Genome annotation databases

    EnsembliENSMUST00000096350; ENSMUSP00000094076; ENSMUSG00000042622.
    ENSMUST00000163691; ENSMUSP00000131628; ENSMUSG00000042622.
    GeneIDi17133.
    KEGGimmu:17133.
    UCSCiuc007wth.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009694 Genomic DNA. Translation: BAA24029.1 .
    BC022952 mRNA. Translation: AAH22952.1 .
    CCDSi CCDS27638.1.
    RefSeqi NP_034885.1. NM_010755.3.
    XP_006520612.1. XM_006520549.1.
    XP_006520613.1. XM_006520550.1.
    UniGenei Mm.86646.

    3D structure databases

    ProteinModelPortali O54791.
    SMRi O54791. Positions 24-110.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201282. 1 interaction.

    Proteomic databases

    PRIDEi O54791.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000096350 ; ENSMUSP00000094076 ; ENSMUSG00000042622 .
    ENSMUST00000163691 ; ENSMUSP00000131628 ; ENSMUSG00000042622 .
    GeneIDi 17133.
    KEGGi mmu:17133.
    UCSCi uc007wth.1. mouse.

    Organism-specific databases

    CTDi 23764.
    MGIi MGI:96910. Maff.

    Phylogenomic databases

    eggNOGi NOG315640.
    HOGENOMi HOG000045475.
    HOVERGENi HBG001725.
    InParanoidi O54791.
    KOi K09037.
    OMAi HGPASCS.
    OrthoDBi EOG7BGHMQ.
    PhylomeDBi O54791.
    TreeFami TF325689.

    Enzyme and pathway databases

    Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    NextBioi 291336.
    PROi O54791.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O54791.
    Bgeei O54791.
    Genevestigatori O54791.

    Family and domain databases

    Gene3Di 1.10.880.10. 1 hit.
    InterProi IPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR008917. TF_DNA-bd.
    IPR024874. Transciption_factor_Maf.
    [Graphical view ]
    PANTHERi PTHR10129. PTHR10129. 1 hit.
    Pfami PF03131. bZIP_Maf. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47454. SSF47454. 1 hit.
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
      Strain: 129/SvJ.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiMAFF_MOUSE
    AccessioniPrimary (citable) accession number: O54791
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3