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Protein

Transcription factor MafF

Gene

Maff

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it self-dimerizes. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response.

GO - Molecular functioni

GO - Biological processi

  • in utero embryonic development Source: MGI
  • regulation of epidermal cell differentiation Source: MGI
  • skeletal muscle cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_280010. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafF
Alternative name(s):
V-maf musculoaponeurotic fibrosarcoma oncogene homolog F
Gene namesi
Name:Maff
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96910. Maff.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Transcription factor MafFPRO_0000076498Add
BLAST

Proteomic databases

MaxQBiO54791.
PRIDEiO54791.

Expressioni

Tissue specificityi

Highly expressed in the lung, lower expression in the brain, thymus, liver, spleen, intestine, kidney, heart, muscle, and ovary. Not significantly expressed in hematopoietic cells.

Developmental stagei

Detected at 6.5 dpc in the boundary between the extraembryonic and embryonic regions. At 8.5 dpc, weakly expressed in the future gut, allantois, yolk sac endoderm and the ectoplacental cone. At 9.5 dpc, strong expression in the primordial gut and presumptive fetal liver, in the floorplate of the myelencephalon, neural crest cells, spongiotrophoblasts, and giant cells of the placenta. At 12.5 dpc, detected in hepotocytes, in the outflow tract of the heart in a specific subset of dorsal root ganglia, in the cranial nerve ganglia, in the lung primordium, and in the epithelium of the expiratory tract. In newborn, strongly expressed in keratinocytes, in the cartilage, in bronchial epithelia, and bone membrane.1 Publication

Gene expression databases

BgeeiO54791.
ExpressionAtlasiO54791. baseline and differential.
GenevestigatoriO54791.

Interactioni

Subunit structurei

Monomer and homo- or heterodimer. Interacts with MIP (By similarity).By similarity

Protein-protein interaction databases

BioGridi201282. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO54791.
SMRiO54791. Positions 24-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 11464bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 7626Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni79 – 9315Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG315640.
HOGENOMiHOG000045475.
HOVERGENiHBG001725.
InParanoidiO54791.
KOiK09037.
OMAiHGPASCS.
OrthoDBiEOG7BGHMQ.
PhylomeDBiO54791.
TreeFamiTF325689.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf.
[Graphical view]
PANTHERiPTHR10129. PTHR10129. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54791-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDPLSSKA LKVKRELSEN TPHLSDEALM GLSVRELNRN LRGLSAEEVT
60 70 80 90 100
RLKQRRRTLK NRGYAASCRV KRVCQKEELQ KQKSELEREV DKLARENAAM
110 120 130 140 150
RLELDALRGK CEALQGFARS VAAARGPAAL VAPASVITIV KSAPGPAPAA

DPAPCS
Length:156
Mass (Da):16,955
Last modified:June 1, 1998 - v1
Checksum:i574DD05499819037
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009694 Genomic DNA. Translation: BAA24029.1.
BC022952 mRNA. Translation: AAH22952.1.
CCDSiCCDS27638.1.
RefSeqiNP_034885.1. NM_010755.4.
XP_006520609.2. XM_006520546.2.
XP_006520613.1. XM_006520550.2.
UniGeneiMm.86646.

Genome annotation databases

EnsembliENSMUST00000096350; ENSMUSP00000094076; ENSMUSG00000042622.
ENSMUST00000163691; ENSMUSP00000131628; ENSMUSG00000042622.
GeneIDi17133.
KEGGimmu:17133.
UCSCiuc007wth.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009694 Genomic DNA. Translation: BAA24029.1.
BC022952 mRNA. Translation: AAH22952.1.
CCDSiCCDS27638.1.
RefSeqiNP_034885.1. NM_010755.4.
XP_006520609.2. XM_006520546.2.
XP_006520613.1. XM_006520550.2.
UniGeneiMm.86646.

3D structure databases

ProteinModelPortaliO54791.
SMRiO54791. Positions 24-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201282. 1 interaction.

Proteomic databases

MaxQBiO54791.
PRIDEiO54791.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096350; ENSMUSP00000094076; ENSMUSG00000042622.
ENSMUST00000163691; ENSMUSP00000131628; ENSMUSG00000042622.
GeneIDi17133.
KEGGimmu:17133.
UCSCiuc007wth.1. mouse.

Organism-specific databases

CTDi23764.
MGIiMGI:96910. Maff.

Phylogenomic databases

eggNOGiNOG315640.
HOGENOMiHOG000045475.
HOVERGENiHBG001725.
InParanoidiO54791.
KOiK09037.
OMAiHGPASCS.
OrthoDBiEOG7BGHMQ.
PhylomeDBiO54791.
TreeFamiTF325689.

Enzyme and pathway databases

ReactomeiREACT_280010. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi291336.
PROiO54791.
SOURCEiSearch...

Gene expression databases

BgeeiO54791.
ExpressionAtlasiO54791. baseline and differential.
GenevestigatoriO54791.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf.
[Graphical view]
PANTHERiPTHR10129. PTHR10129. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
    Strain: 129/SvJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiMAFF_MOUSE
AccessioniPrimary (citable) accession number: O54791
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 1, 1998
Last modified: April 1, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.