ID   CHKB_RAT                Reviewed;         394 AA.
AC   O54783;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 57.
DE   RecName: Full=Choline/ethanolamine kinase;
DE   AltName: Full=choline/ethanolamine kinase beta;
DE            Short=CKEKB;
DE   Includes:
DE     RecName: Full=Choline kinase beta;
DE              Short=CKB;
DE              Short=CK;
DE              EC=2.7.1.32;
DE   Includes:
DE     RecName: Full=Ethanolamine kinase;
DE              Short=EK;
DE              EC=2.7.1.82;
GN   Name=Chkb; Synonyms=Chetk, Chkl;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=Sprague-Dawley; TISSUE=Kidney;
RX   MEDLINE=98155185; PubMed=9487136; DOI=10.1016/S0005-2760(97)00177-X;
RA   Aoyama C., Nakashima K., Matsui M., Ishidate K.;
RT   "Complementary DNA sequence for a 42 kDa rat kidney
RT   choline/ethanolamine kinase.";
RL   Biochim. Biophys. Acta 1390:1-7(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: ATP + choline = ADP + O-phosphocholine.
CC   -!- CATALYTIC ACTIVITY: ATP + ethanolamine = ADP + O-
CC       phosphoethanolamine.
CC   -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
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DR   EMBL; AB006607; BAA24366.1; -; mRNA.
DR   EMBL; BC060515; AAH60515.1; -; mRNA.
DR   IPI; IPI00198119; -.
DR   RefSeq; NP_058873.1; -.
DR   UniGene; Rn.1302; -.
DR   SMR; O54783; 41-389, 42-390.
DR   Ensembl; ENSRNOG00000011404; Rattus norvegicus.
DR   GeneID; 29367; -.
DR   KEGG; rno:29367; -.
DR   RGD; 61826; Chkb.
DR   HOVERGEN; O54783; -.
DR   OMA; O54783; GAWRRVQ.
DR   BRENDA; 2.7.1.32; 248.
DR   BRENDA; 2.7.1.82; 248.
DR   NextBio; 608914; -.
DR   ArrayExpress; O54783; -.
DR   GermOnline; ENSRNOG00000011404; Rattus norvegicus.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004103; F:choline kinase activity; IDA:RGD.
DR   GO; GO:0004305; F:ethanolamine kinase activity; IEA:EC.
DR   InterPro; IPR002573; Choline/ethanolamine_kinase.
DR   PANTHER; PTHR22603; Choline/ethanolamine_kinase; 1.
DR   Pfam; PF01633; Choline_kinase; 1.
PE   1: Evidence at protein level;
KW   Acetylation; ATP-binding; Direct protein sequencing; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Transferase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    394       Choline/ethanolamine kinase.
FT                                /FTId=PRO_0000206224.
FT   ACT_SITE    240    240       By similarity.
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
FT   MOD_RES      39     39       Phosphoserine (By similarity).
FT   MOD_RES      42     42       Phosphoserine (By similarity).
SQ   SEQUENCE   394 AA;  45100 MW;  A2E99EB055E3959E CRC64;
     MAADGTGVVG GGAVGGPLSK DGLLDAKCPE PIPNRRRSSS LSRDAQRRAY QWCREYLGGA
     WRRARPEELS VCPVSGGLSN LLFRCSLPNH VPSMGGEPRE VLLRLYGAIL QGVDSLVLES
     VMFAILAERS LGPQLYGVFP EGRLEQYLPS RPLKTQELRD PVLSGAIATK MARFHGMEMP
     FTKEPRWLFG TMERYLKQIQ DLPSTSLPQM NLVEMYSLKD EMNHLRTLLD ATPSPVVFCH
     NDIQEGNILL LSEPDSDDNL MLVDFEYSSY NYRGFDIGNH FCEWVYDYTY EEWPFYKARP
     ADYPTREQQL LFIRHYLAEV QKGEVLSEEE QKKQEEDLLI EISRYALASH FFWGLWSTLQ
     ASMSTIEFGY LEYAQSRFQF YFQQKGQLTS FLSP
//