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O54775

- WISP1_MOUSE

UniProt

O54775 - WISP1_MOUSE

Protein

WNT1-inducible-signaling pathway protein 1

Gene

Wisp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Downstream regulator in the Wnt/Frizzled-signaling pathway By similarity. Associated with cell survival. Adheres to skin and melanoma fibroblasts By similarity. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan By similarity. Suppresses tumor growth in vivo.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. regulation of cell growth Source: InterPro
    3. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WNT1-inducible-signaling pathway protein 1
    Short name:
    WISP-1
    Alternative name(s):
    CCN family member 4
    ELM-1
    Gene namesi
    Name:Wisp1
    Synonyms:Ccn4, Elm1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1197008. Wisp1.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 367345WNT1-inducible-signaling pathway protein 1PRO_0000014407Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi273 ↔ 310By similarity
    Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi290 ↔ 324By similarity
    Disulfide bondi301 ↔ 340By similarity
    Disulfide bondi304 ↔ 342By similarity
    Disulfide bondi309 ↔ 346By similarity
    Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO54775.

    PTM databases

    PhosphoSiteiO54775.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney and lung. Lower levels in heart, brain, spleen, liver, skeletal muscle and testis. Expressed in low metastatic melanoma cells.

    Gene expression databases

    ArrayExpressiO54775.
    BgeeiO54775.
    CleanExiMM_WISP1.
    GenevestigatoriO54775.

    Structurei

    3D structure databases

    ProteinModelPortaliO54775.
    SMRiO54775. Positions 282-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 11874IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini121 – 18666VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini215 – 26046TSP type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini273 – 34775CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG76761.
    GeneTreeiENSGT00750000117442.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiO54775.
    OMAiVDITKHI.
    OrthoDBiEOG7N8ZXB.
    PhylomeDBiO54775.
    TreeFamiTF326070.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O54775-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRWLLPWTLA AVAVLRVGNI LATALSPTPT TMTFTPAPLE ETTTRPEFCK    50
    WPCECPQSPP RCPLGVSLIT DGCECCKICA QQLGDNCTEA AICDPHRGLY 100
    CDYSGDRPRY AIGVCAQVVG VGCVLDGVRY TNGESFQPNC RYNCTCIDGT 150
    VGCTPLCLSP RPPRLWCRQP RHVRVPGQCC EQWVCDDDAR RPRQTALLDT 200
    RAFAASGAVE QRYENCIAYT SPWSPCSTTC GLGISTRISN VNARCWPEQE 250
    SRLCNLRPCD VDIQLHIKAG KKCLAVYQPE EATNFTLAGC VSTRTYRPKY 300
    CGVCTDNRCC IPYKSKTISV DFQCPEGPGF SRQVLWINAC FCNLSCRNPN 350
    DIFADLESYP DFEEIAN 367
    Length:367
    Mass (Da):40,703
    Last modified:June 1, 1998 - v1
    Checksum:i3B7C0569EFAB5E96
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti79 – 791C → R in AAH52677. (PubMed:15489334)Curated
    Sequence conflicti199 – 1991D → G in AAH52677. (PubMed:15489334)Curated
    Sequence conflicti316 – 3161K → R in AAH52677. (PubMed:15489334)Curated
    Sequence conflicti363 – 3631E → G in AAH52677. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004873 mRNA. Translation: BAA24949.1.
    AF100777 mRNA. Translation: AAC96319.1.
    BC048791 mRNA. Translation: AAH48791.1.
    BC052677 mRNA. Translation: AAH52677.1.
    CCDSiCCDS27510.1.
    RefSeqiNP_061353.1. NM_018865.2.
    UniGeneiMm.10222.

    Genome annotation databases

    EnsembliENSMUST00000005255; ENSMUSP00000005255; ENSMUSG00000005124.
    ENSMUST00000147079; ENSMUSP00000117402; ENSMUSG00000005124.
    GeneIDi22402.
    KEGGimmu:22402.
    UCSCiuc007wau.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004873 mRNA. Translation: BAA24949.1 .
    AF100777 mRNA. Translation: AAC96319.1 .
    BC048791 mRNA. Translation: AAH48791.1 .
    BC052677 mRNA. Translation: AAH52677.1 .
    CCDSi CCDS27510.1.
    RefSeqi NP_061353.1. NM_018865.2.
    UniGenei Mm.10222.

    3D structure databases

    ProteinModelPortali O54775.
    SMRi O54775. Positions 282-347.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O54775.

    Proteomic databases

    PRIDEi O54775.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005255 ; ENSMUSP00000005255 ; ENSMUSG00000005124 .
    ENSMUST00000147079 ; ENSMUSP00000117402 ; ENSMUSG00000005124 .
    GeneIDi 22402.
    KEGGi mmu:22402.
    UCSCi uc007wau.1. mouse.

    Organism-specific databases

    CTDi 8840.
    MGIi MGI:1197008. Wisp1.

    Phylogenomic databases

    eggNOGi NOG76761.
    GeneTreei ENSGT00750000117442.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi O54775.
    OMAi VDITKHI.
    OrthoDBi EOG7N8ZXB.
    PhylomeDBi O54775.
    TreeFami TF326070.

    Miscellaneous databases

    ChiTaRSi WISP1. mouse.
    NextBioi 302781.
    PROi O54775.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O54775.
    Bgeei O54775.
    CleanExi MM_WISP1.
    Genevestigatori O54775.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses In vivo tumor growth and metastasis of K-1735 murine melanoma cells."
      Hashimoto Y., Shindo-Okada N., Tani M., Nagamachi Y., Takeuchi K., Shiroishi T., Toma H., Yokota J.
      J. Exp. Med. 187:289-296(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: HeN.
    2. "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors."
      Pennica D., Swanson T.A., Welsh J.W., Roy M.A., Lawrence D.A., Lee J., Brush J., Taneyhill L.A., Deuel B., Lew M., Watanabe C., Cohen R.L., Melham M.F., Finley G.G., Quirke P., Goddard A.D., Hillan K.J., Gurney A.L., Botstein D., Levine A.J.
      Proc. Natl. Acad. Sci. U.S.A. 95:14717-14722(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Mammary gland.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C3H/HeN and FVB/N.
      Tissue: Colon and Mesenchymal cell.

    Entry informationi

    Entry nameiWISP1_MOUSE
    AccessioniPrimary (citable) accession number: O54775
    Secondary accession number(s): Q80ZL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3