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O54775

- WISP1_MOUSE

UniProt

O54775 - WISP1_MOUSE

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Protein

WNT1-inducible-signaling pathway protein 1

Gene
Wisp1, Ccn4, Elm1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Downstream regulator in the Wnt/Frizzled-signaling pathway By similarity. Associated with cell survival. Adheres to skin and melanoma fibroblasts By similarity. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan By similarity. Suppresses tumor growth in vivo.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. regulation of cell growth Source: InterPro
  3. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
WNT1-inducible-signaling pathway protein 1
Short name:
WISP-1
Alternative name(s):
CCN family member 4
ELM-1
Gene namesi
Name:Wisp1
Synonyms:Ccn4, Elm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1197008. Wisp1.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 367345WNT1-inducible-signaling pathway protein 1PRO_0000014407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi143 – 1431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi273 ↔ 310 By similarity
Glycosylationi284 – 2841N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi290 ↔ 324 By similarity
Disulfide bondi301 ↔ 340 By similarity
Disulfide bondi304 ↔ 342 By similarity
Disulfide bondi309 ↔ 346 By similarity
Glycosylationi343 – 3431N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO54775.

PTM databases

PhosphoSiteiO54775.

Expressioni

Tissue specificityi

Highly expressed in kidney and lung. Lower levels in heart, brain, spleen, liver, skeletal muscle and testis. Expressed in low metastatic melanoma cells.

Gene expression databases

ArrayExpressiO54775.
BgeeiO54775.
CleanExiMM_WISP1.
GenevestigatoriO54775.

Structurei

3D structure databases

ProteinModelPortaliO54775.
SMRiO54775. Positions 282-347.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 11874IGFBP N-terminalAdd
BLAST
Domaini121 – 18666VWFCAdd
BLAST
Domaini215 – 26046TSP type-1Add
BLAST
Domaini273 – 34775CTCKAdd
BLAST

Sequence similaritiesi

Belongs to the CCN family.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG76761.
GeneTreeiENSGT00750000117442.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiO54775.
OMAiVDITKHI.
OrthoDBiEOG7N8ZXB.
PhylomeDBiO54775.
TreeFamiTF326070.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O54775-1 [UniParc]FASTAAdd to Basket

« Hide

MRWLLPWTLA AVAVLRVGNI LATALSPTPT TMTFTPAPLE ETTTRPEFCK    50
WPCECPQSPP RCPLGVSLIT DGCECCKICA QQLGDNCTEA AICDPHRGLY 100
CDYSGDRPRY AIGVCAQVVG VGCVLDGVRY TNGESFQPNC RYNCTCIDGT 150
VGCTPLCLSP RPPRLWCRQP RHVRVPGQCC EQWVCDDDAR RPRQTALLDT 200
RAFAASGAVE QRYENCIAYT SPWSPCSTTC GLGISTRISN VNARCWPEQE 250
SRLCNLRPCD VDIQLHIKAG KKCLAVYQPE EATNFTLAGC VSTRTYRPKY 300
CGVCTDNRCC IPYKSKTISV DFQCPEGPGF SRQVLWINAC FCNLSCRNPN 350
DIFADLESYP DFEEIAN 367
Length:367
Mass (Da):40,703
Last modified:June 1, 1998 - v1
Checksum:i3B7C0569EFAB5E96
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791C → R in AAH52677. 1 Publication
Sequence conflicti199 – 1991D → G in AAH52677. 1 Publication
Sequence conflicti316 – 3161K → R in AAH52677. 1 Publication
Sequence conflicti363 – 3631E → G in AAH52677. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004873 mRNA. Translation: BAA24949.1.
AF100777 mRNA. Translation: AAC96319.1.
BC048791 mRNA. Translation: AAH48791.1.
BC052677 mRNA. Translation: AAH52677.1.
CCDSiCCDS27510.1.
RefSeqiNP_061353.1. NM_018865.2.
UniGeneiMm.10222.

Genome annotation databases

EnsembliENSMUST00000005255; ENSMUSP00000005255; ENSMUSG00000005124.
ENSMUST00000147079; ENSMUSP00000117402; ENSMUSG00000005124.
GeneIDi22402.
KEGGimmu:22402.
UCSCiuc007wau.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004873 mRNA. Translation: BAA24949.1 .
AF100777 mRNA. Translation: AAC96319.1 .
BC048791 mRNA. Translation: AAH48791.1 .
BC052677 mRNA. Translation: AAH52677.1 .
CCDSi CCDS27510.1.
RefSeqi NP_061353.1. NM_018865.2.
UniGenei Mm.10222.

3D structure databases

ProteinModelPortali O54775.
SMRi O54775. Positions 282-347.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O54775.

Proteomic databases

PRIDEi O54775.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000005255 ; ENSMUSP00000005255 ; ENSMUSG00000005124 .
ENSMUST00000147079 ; ENSMUSP00000117402 ; ENSMUSG00000005124 .
GeneIDi 22402.
KEGGi mmu:22402.
UCSCi uc007wau.1. mouse.

Organism-specific databases

CTDi 8840.
MGIi MGI:1197008. Wisp1.

Phylogenomic databases

eggNOGi NOG76761.
GeneTreei ENSGT00750000117442.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi O54775.
OMAi VDITKHI.
OrthoDBi EOG7N8ZXB.
PhylomeDBi O54775.
TreeFami TF326070.

Miscellaneous databases

ChiTaRSi WISP1. mouse.
NextBioi 302781.
PROi O54775.
SOURCEi Search...

Gene expression databases

ArrayExpressi O54775.
Bgeei O54775.
CleanExi MM_WISP1.
Genevestigatori O54775.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses In vivo tumor growth and metastasis of K-1735 murine melanoma cells."
    Hashimoto Y., Shindo-Okada N., Tani M., Nagamachi Y., Takeuchi K., Shiroishi T., Toma H., Yokota J.
    J. Exp. Med. 187:289-296(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: HeN.
  2. "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors."
    Pennica D., Swanson T.A., Welsh J.W., Roy M.A., Lawrence D.A., Lee J., Brush J., Taneyhill L.A., Deuel B., Lew M., Watanabe C., Cohen R.L., Melham M.F., Finley G.G., Quirke P., Goddard A.D., Hillan K.J., Gurney A.L., Botstein D., Levine A.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:14717-14722(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary gland.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/HeN and FVB/N.
    Tissue: Colon and Mesenchymal cell.

Entry informationi

Entry nameiWISP1_MOUSE
AccessioniPrimary (citable) accession number: O54775
Secondary accession number(s): Q80ZL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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