Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

AP-3 complex subunit delta-1

Gene

Ap3d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.By similarity1 Publication

GO - Biological processi

  • anterograde axonal transport Source: UniProtKB
  • anterograde synaptic vesicle transport Source: UniProtKB
  • antigen processing and presentation Source: MGI
  • antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: MGI
  • endosome to melanosome transport Source: MGI
  • intracellular protein transport Source: MGI
  • positive regulation of NK T cell differentiation Source: MGI
  • protein localization to membrane Source: MGI
  • protein localization to organelle Source: MGI
  • regulation of sequestering of zinc ion Source: BHF-UCL
  • synaptic vesicle membrane organization Source: MGI
  • vesicle-mediated transport Source: MGI
  • zinc II ion transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit delta-1
Alternative name(s):
AP-3 complex subunit delta
Adaptor-related protein complex 3 subunit delta-1
Delta-adaptin
Short name:
mBLVR1
Gene namesi
Name:Ap3d1
Synonyms:Ap3d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:107734. Ap3d1.

Subcellular locationi

GO - Cellular componenti

  • AP-3 adaptor complex Source: InterPro
  • axon Source: MGI
  • axon cytoplasm Source: GOC
  • endosome membrane Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: MGI
  • membrane Source: MGI
  • nucleoplasm Source: MGI
  • terminal bouton Source: MGI
  • trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001937672 – 1199AP-3 complex subunit delta-1Add BLAST1198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei632PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei688PhosphoserineBy similarity1
Modified residuei754PhosphoserineCombined sources1
Modified residuei755PhosphoserineCombined sources1
Modified residuei758PhosphothreonineCombined sources1
Modified residuei760PhosphoserineCombined sources1
Modified residuei784PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO54774.
MaxQBiO54774.
PaxDbiO54774.
PeptideAtlasiO54774.
PRIDEiO54774.

PTM databases

iPTMnetiO54774.
PhosphoSitePlusiO54774.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020198.
GenevisibleiO54774. MM.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). AP-3 associates with the BLOC-1 complex. Interacts with SLC30A2.By similarity

Protein-protein interaction databases

BioGridi198134. 2 interactors.
DIPiDIP-32163N.
IntActiO54774. 6 interactors.
MINTiMINT-4104952.
STRINGi10090.ENSMUSP00000020420.

Structurei

3D structure databases

ProteinModelPortaliO54774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 71HEAT 1Add BLAST38
Repeati142 – 179HEAT 2Add BLAST38
Repeati180 – 216HEAT 3Add BLAST37
Repeati218 – 254HEAT 4Add BLAST37
Repeati257 – 296HEAT 5Add BLAST40
Repeati298 – 336HEAT 6Add BLAST39
Repeati337 – 373HEAT 7Add BLAST37
Repeati375 – 409HEAT 8Add BLAST35
Repeati521 – 558HEAT 9Add BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili659 – 679Sequence analysisAdd BLAST21
Coiled coili722 – 750Sequence analysisAdd BLAST29
Coiled coili843 – 863Sequence analysisAdd BLAST21
Coiled coili911 – 934Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi836 – 944Lys-richAdd BLAST109
Compositional biasi956 – 960Poly-Glu5

Sequence similaritiesi

Contains 9 HEAT repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1059. Eukaryota.
ENOG410XQFB. LUCA.
GeneTreeiENSGT00550000075067.
HOGENOMiHOG000000981.
HOVERGENiHBG050520.
InParanoidiO54774.
KOiK12396.
OMAiKMTYDIQ.
OrthoDBiEOG091G04IL.
PhylomeDBiO54774.
TreeFamiTF105666.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR010474. AP3D1.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF06375. AP3D1. 1 hit.
[Graphical view]
SMARTiSM01354. BLVR. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O54774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD
60 70 80 90 100
NIAVKANAVC KLTYLQMLGY DISWAAFNII EVMSASKFTF KRVGYLAASQ
110 120 130 140 150
CFHEGTDVIM LTTNQIRKDL SSPSQYDTGV ALTGLSCFVT PDLARDLAND
160 170 180 190 200
IMTLMSHTKP YIRKKAVLIM YKVFLKYPES LRPAFPRLKE KLEDPDPGVQ
210 220 230 240 250
SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK IIKLFGALTP
260 270 280 290 300
LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS
310 320 330 340 350
IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD
360 370 380 390 400
DKDESIRLRA LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI
410 420 430 440 450
IDICSQSNYQ HITNFEWYIS ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA
460 470 480 490 500
IRKFAVSQMS SLLDSAHLVA SSTQRNGICE VLYAAAWICG EFSEHLQGPQ
510 520 530 540 550
QTLEAMLRPK VTTLPGHIQA VYVQNVVKLY ASILQQKEQA ADTEAAQEVT
560 570 580 590 600
QLLVERLPQF VQSADLEVQE RASCILQLVK HVQKLQAKGV PVAEEVSALF
610 620 630 640 650
AGELNPVAPK AQKKVPVPEG LDLDAWINEP PSDSESEDEK PKAIFHEEEP
660 670 680 690 700
RHTRRRQPEE DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDAPGVE
710 720 730 740 750
HIPVVQIDLS VPLKVPGMPM SDQYVKLEEQ RRHRQRLEKD KKRKKKEKGK
760 770 780 790 800
RRHSSLPTES DEDIAPAQRV DIITEEMPEN ALPSDEDDKD PNDPYRALDI
810 820 830 840 850
DLDKPLADSE KLPVQKHRNA EAVKSPEKEG VLGVEKKSKK PKKKEKKTKE
860 870 880 890 900
REREKKDKKG EDLDFWLSTT PPPAAAPIPA PSTEELAAST ITSPKDECEV
910 920 930 940 950
LKGEEEDHVD HDQERKSSRH KKKKHRKEKE KEERPRDKKK AKKKQVAPLE
960 970 980 990 1000
NGAAAEEEEE PIPPMSSYCL LAESPYIKVT YDIQASLQKD SQVTVSIILE
1010 1020 1030 1040 1050
NQSSSFLKNM ELNVLDSLNT KMTRPEGSSV HDGVPVPFQL PPGVSNEAQF
1060 1070 1080 1090 1100
VFTIQSIVMA QKLKGTLSFI AKDDEGATHE KLDFRLHFSC SSYLITTPCY
1110 1120 1130 1140 1150
SDAFAKLLES GDLSMNSIKV DGISMSFQNL LAKICFYHHF SVVERVDSCA
1160 1170 1180 1190
SMYSRSIQGH HVCLLVKKGE SSVSVDGKCS DATLLSSLLE EMKTTLAQC
Length:1,199
Mass (Da):135,081
Last modified:June 1, 1998 - v1
Checksum:i29D2D036B36C3B05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004305 mRNA. Translation: BAA24578.1.
BC048786 mRNA. Translation: AAH48786.1.
BC053066 mRNA. Translation: AAH53066.1.
CCDSiCCDS35984.1.
PIRiT13946.
RefSeqiNP_031486.1. NM_007460.1.
UniGeneiMm.209294.
Mm.27082.

Genome annotation databases

EnsembliENSMUST00000020420; ENSMUSP00000020420; ENSMUSG00000020198.
GeneIDi11776.
KEGGimmu:11776.
UCSCiuc007gek.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004305 mRNA. Translation: BAA24578.1.
BC048786 mRNA. Translation: AAH48786.1.
BC053066 mRNA. Translation: AAH53066.1.
CCDSiCCDS35984.1.
PIRiT13946.
RefSeqiNP_031486.1. NM_007460.1.
UniGeneiMm.209294.
Mm.27082.

3D structure databases

ProteinModelPortaliO54774.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198134. 2 interactors.
DIPiDIP-32163N.
IntActiO54774. 6 interactors.
MINTiMINT-4104952.
STRINGi10090.ENSMUSP00000020420.

PTM databases

iPTMnetiO54774.
PhosphoSitePlusiO54774.

Proteomic databases

EPDiO54774.
MaxQBiO54774.
PaxDbiO54774.
PeptideAtlasiO54774.
PRIDEiO54774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020420; ENSMUSP00000020420; ENSMUSG00000020198.
GeneIDi11776.
KEGGimmu:11776.
UCSCiuc007gek.1. mouse.

Organism-specific databases

CTDi8943.
MGIiMGI:107734. Ap3d1.

Phylogenomic databases

eggNOGiKOG1059. Eukaryota.
ENOG410XQFB. LUCA.
GeneTreeiENSGT00550000075067.
HOGENOMiHOG000000981.
HOVERGENiHBG050520.
InParanoidiO54774.
KOiK12396.
OMAiKMTYDIQ.
OrthoDBiEOG091G04IL.
PhylomeDBiO54774.
TreeFamiTF105666.

Miscellaneous databases

ChiTaRSiAp3d1. mouse.
PROiO54774.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020198.
GenevisibleiO54774. MM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR010474. AP3D1.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF06375. AP3D1. 1 hit.
[Graphical view]
SMARTiSM01354. BLVR. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAP3D1_MOUSE
AccessioniPrimary (citable) accession number: O54774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.