Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O54774

- AP3D1_MOUSE

UniProt

O54774 - AP3D1_MOUSE

Protein

AP-3 complex subunit delta-1

Gene

Ap3d1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes By similarity. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.By similarity1 Publication

    GO - Molecular functioni

    1. protein transporter activity Source: InterPro

    GO - Biological processi

    1. anterograde axon cargo transport Source: UniProtKB
    2. anterograde synaptic vesicle transport Source: UniProtKB
    3. antigen processing and presentation Source: MGI
    4. antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: MGI
    5. intracellular protein transport Source: MGI
    6. positive regulation of NK T cell differentiation Source: MGI
    7. protein localization to organelle Source: MGI
    8. regulation of sequestering of zinc ion Source: BHF-UCL
    9. synaptic vesicle membrane organization Source: MGI
    10. vesicle-mediated transport Source: MGI
    11. zinc ion transport Source: BHF-UCL

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AP-3 complex subunit delta-1
    Alternative name(s):
    AP-3 complex subunit delta
    Adaptor-related protein complex 3 subunit delta-1
    Delta-adaptin
    Short name:
    mBLVR1
    Gene namesi
    Name:Ap3d1
    Synonyms:Ap3d
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:107734. Ap3d1.

    Subcellular locationi

    Cytoplasm By similarity. Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. axon Source: MGI
    2. endosome membrane Source: UniProtKB
    3. Golgi membrane Source: UniProtKB-SubCell
    4. lysosomal membrane Source: Ensembl
    5. membrane coat Source: InterPro
    6. terminal bouton Source: MGI
    7. trans-Golgi network Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 11991198AP-3 complex subunit delta-1PRO_0000193767Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei632 – 6321Phosphoserine2 Publications
    Modified residuei634 – 6341Phosphoserine2 Publications
    Modified residuei636 – 6361Phosphoserine2 Publications
    Modified residuei688 – 6881PhosphoserineBy similarity
    Modified residuei754 – 7541PhosphoserineBy similarity
    Modified residuei755 – 7551Phosphoserine2 Publications
    Modified residuei758 – 7581Phosphothreonine3 Publications
    Modified residuei760 – 7601Phosphoserine4 Publications
    Modified residuei784 – 7841Phosphoserine2 Publications
    Modified residuei825 – 8251Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO54774.
    PaxDbiO54774.
    PRIDEiO54774.

    PTM databases

    PhosphoSiteiO54774.

    Expressioni

    Gene expression databases

    BgeeiO54774.
    GenevestigatoriO54774.

    Interactioni

    Subunit structurei

    Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) By similarity. AP-3 associates with the BLOC-1 complex.By similarity

    Protein-protein interaction databases

    BioGridi198134. 6 interactions.
    DIPiDIP-32163N.
    IntActiO54774. 4 interactions.
    MINTiMINT-4104952.

    Structurei

    3D structure databases

    ProteinModelPortaliO54774.
    SMRiO54774. Positions 18-595, 697-729.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati34 – 7138HEAT 1Add
    BLAST
    Repeati142 – 17938HEAT 2Add
    BLAST
    Repeati180 – 21637HEAT 3Add
    BLAST
    Repeati218 – 25437HEAT 4Add
    BLAST
    Repeati257 – 29640HEAT 5Add
    BLAST
    Repeati298 – 33639HEAT 6Add
    BLAST
    Repeati337 – 37337HEAT 7Add
    BLAST
    Repeati375 – 40935HEAT 8Add
    BLAST
    Repeati521 – 55838HEAT 9Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili659 – 67921Sequence AnalysisAdd
    BLAST
    Coiled coili722 – 75029Sequence AnalysisAdd
    BLAST
    Coiled coili843 – 86321Sequence AnalysisAdd
    BLAST
    Coiled coili911 – 93424Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi836 – 944109Lys-richAdd
    BLAST
    Compositional biasi956 – 9605Poly-Glu

    Sequence similaritiesi

    Contains 9 HEAT repeats.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG5096.
    GeneTreeiENSGT00550000075067.
    HOGENOMiHOG000000981.
    HOVERGENiHBG050520.
    InParanoidiO54774.
    KOiK12396.
    OMAiKANAVCK.
    OrthoDBiEOG79SDWG.
    PhylomeDBiO54774.
    TreeFamiTF105666.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR017105. AP3_complex_dsu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR010474. BLV_receptor.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    [Graphical view]
    PfamiPF01602. Adaptin_N. 1 hit.
    PF06375. BLVR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037092. AP3_complex_delta. 1 hit.
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O54774-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD     50
    NIAVKANAVC KLTYLQMLGY DISWAAFNII EVMSASKFTF KRVGYLAASQ 100
    CFHEGTDVIM LTTNQIRKDL SSPSQYDTGV ALTGLSCFVT PDLARDLAND 150
    IMTLMSHTKP YIRKKAVLIM YKVFLKYPES LRPAFPRLKE KLEDPDPGVQ 200
    SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK IIKLFGALTP 250
    LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS 300
    IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD 350
    DKDESIRLRA LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI 400
    IDICSQSNYQ HITNFEWYIS ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA 450
    IRKFAVSQMS SLLDSAHLVA SSTQRNGICE VLYAAAWICG EFSEHLQGPQ 500
    QTLEAMLRPK VTTLPGHIQA VYVQNVVKLY ASILQQKEQA ADTEAAQEVT 550
    QLLVERLPQF VQSADLEVQE RASCILQLVK HVQKLQAKGV PVAEEVSALF 600
    AGELNPVAPK AQKKVPVPEG LDLDAWINEP PSDSESEDEK PKAIFHEEEP 650
    RHTRRRQPEE DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDAPGVE 700
    HIPVVQIDLS VPLKVPGMPM SDQYVKLEEQ RRHRQRLEKD KKRKKKEKGK 750
    RRHSSLPTES DEDIAPAQRV DIITEEMPEN ALPSDEDDKD PNDPYRALDI 800
    DLDKPLADSE KLPVQKHRNA EAVKSPEKEG VLGVEKKSKK PKKKEKKTKE 850
    REREKKDKKG EDLDFWLSTT PPPAAAPIPA PSTEELAAST ITSPKDECEV 900
    LKGEEEDHVD HDQERKSSRH KKKKHRKEKE KEERPRDKKK AKKKQVAPLE 950
    NGAAAEEEEE PIPPMSSYCL LAESPYIKVT YDIQASLQKD SQVTVSIILE 1000
    NQSSSFLKNM ELNVLDSLNT KMTRPEGSSV HDGVPVPFQL PPGVSNEAQF 1050
    VFTIQSIVMA QKLKGTLSFI AKDDEGATHE KLDFRLHFSC SSYLITTPCY 1100
    SDAFAKLLES GDLSMNSIKV DGISMSFQNL LAKICFYHHF SVVERVDSCA 1150
    SMYSRSIQGH HVCLLVKKGE SSVSVDGKCS DATLLSSLLE EMKTTLAQC 1199
    Length:1,199
    Mass (Da):135,081
    Last modified:June 1, 1998 - v1
    Checksum:i29D2D036B36C3B05
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004305 mRNA. Translation: BAA24578.1.
    BC048786 mRNA. Translation: AAH48786.1.
    BC053066 mRNA. Translation: AAH53066.1.
    CCDSiCCDS35984.1.
    PIRiT13946.
    RefSeqiNP_031486.1. NM_007460.1.
    UniGeneiMm.209294.

    Genome annotation databases

    EnsembliENSMUST00000020420; ENSMUSP00000020420; ENSMUSG00000020198.
    GeneIDi11776.
    KEGGimmu:11776.
    UCSCiuc007gek.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004305 mRNA. Translation: BAA24578.1 .
    BC048786 mRNA. Translation: AAH48786.1 .
    BC053066 mRNA. Translation: AAH53066.1 .
    CCDSi CCDS35984.1.
    PIRi T13946.
    RefSeqi NP_031486.1. NM_007460.1.
    UniGenei Mm.209294.

    3D structure databases

    ProteinModelPortali O54774.
    SMRi O54774. Positions 18-595, 697-729.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198134. 6 interactions.
    DIPi DIP-32163N.
    IntActi O54774. 4 interactions.
    MINTi MINT-4104952.

    PTM databases

    PhosphoSitei O54774.

    Proteomic databases

    MaxQBi O54774.
    PaxDbi O54774.
    PRIDEi O54774.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020420 ; ENSMUSP00000020420 ; ENSMUSG00000020198 .
    GeneIDi 11776.
    KEGGi mmu:11776.
    UCSCi uc007gek.1. mouse.

    Organism-specific databases

    CTDi 8943.
    MGIi MGI:107734. Ap3d1.

    Phylogenomic databases

    eggNOGi COG5096.
    GeneTreei ENSGT00550000075067.
    HOGENOMi HOG000000981.
    HOVERGENi HBG050520.
    InParanoidi O54774.
    KOi K12396.
    OMAi KANAVCK.
    OrthoDBi EOG79SDWG.
    PhylomeDBi O54774.
    TreeFami TF105666.

    Miscellaneous databases

    ChiTaRSi AP3D1. mouse.
    NextBioi 279571.
    PROi O54774.
    SOURCEi Search...

    Gene expression databases

    Bgeei O54774.
    Genevestigatori O54774.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR017105. AP3_complex_dsu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR010474. BLV_receptor.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    [Graphical view ]
    Pfami PF01602. Adaptin_N. 1 hit.
    PF06375. BLVR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037092. AP3_complex_delta. 1 hit.
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The mouse homolog of the bovine leukemia virus receptor is closely related to the delta subunit of adaptor-related protein complex AP-3, not associated with the cell surface."
      Suzuki T., Ikeda H.
      J. Virol. 72:593-599(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Eye.
    3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-825, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632; SER-634; SER-636; SER-755; THR-758; SER-760; SER-784 AND SER-825, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-760, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632; SER-634; SER-636; SER-755; THR-758; SER-760 AND SER-784, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-758 AND SER-760, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    8. "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."
      Larimore J., Tornieri K., Ryder P.V., Gokhale A., Zlatic S.A., Craige B., Lee J.D., Talbot K., Pare J.F., Smith Y., Faundez V.
      Mol. Biol. Cell 22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ASSOCIATION WITH THE BLOC-1 COMPLEX.

    Entry informationi

    Entry nameiAP3D1_MOUSE
    AccessioniPrimary (citable) accession number: O54774
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3