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O54774

- AP3D1_MOUSE

UniProt

O54774 - AP3D1_MOUSE

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Protein
AP-3 complex subunit delta-1
Gene
Ap3d1, Ap3d
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes By similarity. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.1 Publication

GO - Molecular functioni

  1. protein transporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. anterograde axon cargo transport Source: UniProtKB
  2. anterograde synaptic vesicle transport Source: UniProtKB
  3. antigen processing and presentation Source: MGI
  4. antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: MGI
  5. intracellular protein transport Source: MGI
  6. positive regulation of NK T cell differentiation Source: MGI
  7. protein localization to organelle Source: MGI
  8. regulation of sequestering of zinc ion Source: BHF-UCL
  9. synaptic vesicle membrane organization Source: MGI
  10. vesicle-mediated transport Source: MGI
  11. zinc ion transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit delta-1
Alternative name(s):
AP-3 complex subunit delta
Adaptor-related protein complex 3 subunit delta-1
Delta-adaptin
Short name:
mBLVR1
Gene namesi
Name:Ap3d1
Synonyms:Ap3d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:107734. Ap3d1.

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. axon Source: MGI
  3. endosome membrane Source: UniProtKB
  4. lysosomal membrane Source: Ensembl
  5. membrane coat Source: InterPro
  6. terminal bouton Source: MGI
  7. trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 11991198AP-3 complex subunit delta-1
PRO_0000193767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei632 – 6321Phosphoserine2 Publications
Modified residuei634 – 6341Phosphoserine2 Publications
Modified residuei636 – 6361Phosphoserine2 Publications
Modified residuei688 – 6881Phosphoserine By similarity
Modified residuei754 – 7541Phosphoserine By similarity
Modified residuei755 – 7551Phosphoserine2 Publications
Modified residuei758 – 7581Phosphothreonine3 Publications
Modified residuei760 – 7601Phosphoserine4 Publications
Modified residuei784 – 7841Phosphoserine2 Publications
Modified residuei825 – 8251Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO54774.
PaxDbiO54774.
PRIDEiO54774.

PTM databases

PhosphoSiteiO54774.

Expressioni

Gene expression databases

BgeeiO54774.
GenevestigatoriO54774.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) By similarity. AP-3 associates with the BLOC-1 complex.

Protein-protein interaction databases

BioGridi198134. 6 interactions.
DIPiDIP-32163N.
IntActiO54774. 2 interactions.
MINTiMINT-4104952.

Structurei

3D structure databases

ProteinModelPortaliO54774.
SMRiO54774. Positions 18-595, 697-729.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 7138HEAT 1
Add
BLAST
Repeati142 – 17938HEAT 2
Add
BLAST
Repeati180 – 21637HEAT 3
Add
BLAST
Repeati218 – 25437HEAT 4
Add
BLAST
Repeati257 – 29640HEAT 5
Add
BLAST
Repeati298 – 33639HEAT 6
Add
BLAST
Repeati337 – 37337HEAT 7
Add
BLAST
Repeati375 – 40935HEAT 8
Add
BLAST
Repeati521 – 55838HEAT 9
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili659 – 67921 Reviewed prediction
Add
BLAST
Coiled coili722 – 75029 Reviewed prediction
Add
BLAST
Coiled coili843 – 86321 Reviewed prediction
Add
BLAST
Coiled coili911 – 93424 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi836 – 944109Lys-rich
Add
BLAST
Compositional biasi956 – 9605Poly-Glu

Sequence similaritiesi

Contains 9 HEAT repeats.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG5096.
GeneTreeiENSGT00550000075067.
HOGENOMiHOG000000981.
HOVERGENiHBG050520.
InParanoidiO54774.
KOiK12396.
OMAiKANAVCK.
OrthoDBiEOG79SDWG.
PhylomeDBiO54774.
TreeFamiTF105666.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR017105. AP3_complex_dsu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR010474. BLV_receptor.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF06375. BLVR. 1 hit.
[Graphical view]
PIRSFiPIRSF037092. AP3_complex_delta. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O54774-1 [UniParc]FASTAAdd to Basket

« Hide

MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD     50
NIAVKANAVC KLTYLQMLGY DISWAAFNII EVMSASKFTF KRVGYLAASQ 100
CFHEGTDVIM LTTNQIRKDL SSPSQYDTGV ALTGLSCFVT PDLARDLAND 150
IMTLMSHTKP YIRKKAVLIM YKVFLKYPES LRPAFPRLKE KLEDPDPGVQ 200
SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK IIKLFGALTP 250
LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS 300
IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD 350
DKDESIRLRA LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI 400
IDICSQSNYQ HITNFEWYIS ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA 450
IRKFAVSQMS SLLDSAHLVA SSTQRNGICE VLYAAAWICG EFSEHLQGPQ 500
QTLEAMLRPK VTTLPGHIQA VYVQNVVKLY ASILQQKEQA ADTEAAQEVT 550
QLLVERLPQF VQSADLEVQE RASCILQLVK HVQKLQAKGV PVAEEVSALF 600
AGELNPVAPK AQKKVPVPEG LDLDAWINEP PSDSESEDEK PKAIFHEEEP 650
RHTRRRQPEE DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDAPGVE 700
HIPVVQIDLS VPLKVPGMPM SDQYVKLEEQ RRHRQRLEKD KKRKKKEKGK 750
RRHSSLPTES DEDIAPAQRV DIITEEMPEN ALPSDEDDKD PNDPYRALDI 800
DLDKPLADSE KLPVQKHRNA EAVKSPEKEG VLGVEKKSKK PKKKEKKTKE 850
REREKKDKKG EDLDFWLSTT PPPAAAPIPA PSTEELAAST ITSPKDECEV 900
LKGEEEDHVD HDQERKSSRH KKKKHRKEKE KEERPRDKKK AKKKQVAPLE 950
NGAAAEEEEE PIPPMSSYCL LAESPYIKVT YDIQASLQKD SQVTVSIILE 1000
NQSSSFLKNM ELNVLDSLNT KMTRPEGSSV HDGVPVPFQL PPGVSNEAQF 1050
VFTIQSIVMA QKLKGTLSFI AKDDEGATHE KLDFRLHFSC SSYLITTPCY 1100
SDAFAKLLES GDLSMNSIKV DGISMSFQNL LAKICFYHHF SVVERVDSCA 1150
SMYSRSIQGH HVCLLVKKGE SSVSVDGKCS DATLLSSLLE EMKTTLAQC 1199
Length:1,199
Mass (Da):135,081
Last modified:June 1, 1998 - v1
Checksum:i29D2D036B36C3B05
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004305 mRNA. Translation: BAA24578.1.
BC048786 mRNA. Translation: AAH48786.1.
BC053066 mRNA. Translation: AAH53066.1.
CCDSiCCDS35984.1.
PIRiT13946.
RefSeqiNP_031486.1. NM_007460.1.
UniGeneiMm.209294.

Genome annotation databases

EnsembliENSMUST00000020420; ENSMUSP00000020420; ENSMUSG00000020198.
GeneIDi11776.
KEGGimmu:11776.
UCSCiuc007gek.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004305 mRNA. Translation: BAA24578.1 .
BC048786 mRNA. Translation: AAH48786.1 .
BC053066 mRNA. Translation: AAH53066.1 .
CCDSi CCDS35984.1.
PIRi T13946.
RefSeqi NP_031486.1. NM_007460.1.
UniGenei Mm.209294.

3D structure databases

ProteinModelPortali O54774.
SMRi O54774. Positions 18-595, 697-729.
ModBasei Search...

Protein-protein interaction databases

BioGridi 198134. 6 interactions.
DIPi DIP-32163N.
IntActi O54774. 2 interactions.
MINTi MINT-4104952.

PTM databases

PhosphoSitei O54774.

Proteomic databases

MaxQBi O54774.
PaxDbi O54774.
PRIDEi O54774.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020420 ; ENSMUSP00000020420 ; ENSMUSG00000020198 .
GeneIDi 11776.
KEGGi mmu:11776.
UCSCi uc007gek.1. mouse.

Organism-specific databases

CTDi 8943.
MGIi MGI:107734. Ap3d1.

Phylogenomic databases

eggNOGi COG5096.
GeneTreei ENSGT00550000075067.
HOGENOMi HOG000000981.
HOVERGENi HBG050520.
InParanoidi O54774.
KOi K12396.
OMAi KANAVCK.
OrthoDBi EOG79SDWG.
PhylomeDBi O54774.
TreeFami TF105666.

Miscellaneous databases

ChiTaRSi AP3D1. mouse.
NextBioi 279571.
PROi O54774.
SOURCEi Search...

Gene expression databases

Bgeei O54774.
Genevestigatori O54774.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR017105. AP3_complex_dsu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR010474. BLV_receptor.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view ]
Pfami PF01602. Adaptin_N. 1 hit.
PF06375. BLVR. 1 hit.
[Graphical view ]
PIRSFi PIRSF037092. AP3_complex_delta. 1 hit.
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse homolog of the bovine leukemia virus receptor is closely related to the delta subunit of adaptor-related protein complex AP-3, not associated with the cell surface."
    Suzuki T., Ikeda H.
    J. Virol. 72:593-599(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Eye.
  3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-825, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632; SER-634; SER-636; SER-755; THR-758; SER-760; SER-784 AND SER-825, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-760, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632; SER-634; SER-636; SER-755; THR-758; SER-760 AND SER-784, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-758 AND SER-760, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  8. "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."
    Larimore J., Tornieri K., Ryder P.V., Gokhale A., Zlatic S.A., Craige B., Lee J.D., Talbot K., Pare J.F., Smith Y., Faundez V.
    Mol. Biol. Cell 22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ASSOCIATION WITH THE BLOC-1 COMPLEX.

Entry informationi

Entry nameiAP3D1_MOUSE
AccessioniPrimary (citable) accession number: O54774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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