Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

Gene

Smarcd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-3214858. RMTs methylate histone arginines.

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
Alternative name(s):
60 kDa BRG-1/Brm-associated factor subunit B
BRG1-associated factor 60B
Short name:
BAF60B
Gene namesi
Name:Smarcd2
Synonyms:Baf60b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi69289. Smarcd2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000719871 – 531SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81Asymmetric dimethylarginineBy similarity1
Modified residuei104Asymmetric dimethylarginineBy similarity1
Modified residuei203PhosphoserineBy similarity1
Modified residuei217PhosphothreonineBy similarity1

Post-translational modificationi

Ubiquitinated through a signaling process involving RAC1 and the RING finger protein UNKL.

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO54772.
PRIDEiO54772.

PTM databases

iPTMnetiO54772.
PhosphoSitePlusiO54772.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010557.
GenevisibleiO54772. RN.

Interactioni

Subunit structurei

Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. May interact with SMARCA4, the catalytic subunit of the SWI/SNF related nucleosome-remodeling complexes BRG1(I) and BRG1(II). The precise distribution of the related SMARCD1, SMARCD2 and SMARCD3 proteins among these and other SWI/SNF nucleosome-remodeling complexes is not fully known (By similarity). Interacts with UNKL (By similarity).By similarity

Protein-protein interaction databases

BioGridi249859. 1 interactor.
STRINGi10116.ENSRNOP00000014508.

Structurei

3D structure databases

ProteinModelPortaliO54772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini307 – 382SWIBAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 129Pro-richAdd BLAST120

Sequence similaritiesi

Belongs to the SMARCD family.Curated
Contains 1 SWIB domain.Curated

Phylogenomic databases

eggNOGiKOG2570. Eukaryota.
COG5531. LUCA.
GeneTreeiENSGT00390000017809.
HOGENOMiHOG000240746.
HOVERGENiHBG054046.
InParanoidiO54772.
KOiK11650.
OMAiMRFSEIP.
OrthoDBiEOG091G06WW.
PhylomeDBiO54772.
TreeFamiTF106486.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
InterProiIPR030090. BAF60B.
IPR019835. SWIB_domain.
IPR003121. SWIB_MDM2_domain.
[Graphical view]
PANTHERiPTHR13844:SF2. PTHR13844:SF2. 1 hit.
PfamiPF02201. SWIB. 1 hit.
[Graphical view]
SMARTiSM00151. SWIB. 1 hit.
[Graphical view]
SUPFAMiSSF47592. SSF47592. 1 hit.

Sequencei

Sequence statusi: Complete.

O54772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGAGGFP LPPLSPGGGA VAAALGAPPP PAGPGMLPNP ALRGPGPSGG
60 70 80 90 100
MGVPGAAAFR PMGPAGPAAQ YQRPGMSPGS RMPMAGLQVG PPAGSPFGTA
110 120 130 140 150
APLRPGMPPT MMDPFRKRLL VPQAQPPMPA QRRGLKRRKM ADKVLPQRIR
160 170 180 190 200
ELVPESQAYM DLLAFERKLD QTIARKRMEI QEAIKKPLTQ KRKLRIYISN
210 220 230 240 250
TFSPSKADGD NSGTAGTPGG TPAADKVASW ELRVEGKLLD DPSKQKRKFS
260 270 280 290 300
SFFKSLVIEL DKELYGPDNH LVEWHRMPTT QETDGFQVKR PGDLNVKCTL
310 320 330 340 350
LLMLDHQPPQ YKLDPRLARL LGVHTQTRAA IMQALWLYIK HNQLQDGHER
360 370 380 390 400
EYINCNRYFR QIFSCGRLRF SEIPMKLAGL LQHPDPIVIN HVISVDPNDQ
410 420 430 440 450
KKTACYDIDV EVDDPLKAQM SNFLASTTNQ QEIASLDVKI HETIESINQL
460 470 480 490 500
KTQRDFMLSF STEPQDFIQE WLRSQRRDLK IITDVIGNPE EERRAAFYHQ
510 520 530
PWAQEAVGRH IFAKVQQRRQ ELEQVLGIRL T
Length:531
Mass (Da):59,128
Last modified:February 8, 2011 - v3
Checksum:iD8E11A36B0201B73
GO

Sequence cautioni

The sequence BAA24105 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66G → A in BAA24105 (PubMed:9427560).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003504 mRNA. Translation: BAA24105.1. Different initiation.
AB003505 Genomic DNA. Translation: BAA24106.1.
BC062063 mRNA. Translation: AAH62063.1.
PIRiJC6508.
RefSeqiNP_114189.1. NM_031983.2.
UniGeneiRn.3053.

Genome annotation databases

EnsembliENSRNOT00000014508; ENSRNOP00000014508; ENSRNOG00000010557.
GeneIDi83833.
KEGGirno:83833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003504 mRNA. Translation: BAA24105.1. Different initiation.
AB003505 Genomic DNA. Translation: BAA24106.1.
BC062063 mRNA. Translation: AAH62063.1.
PIRiJC6508.
RefSeqiNP_114189.1. NM_031983.2.
UniGeneiRn.3053.

3D structure databases

ProteinModelPortaliO54772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249859. 1 interactor.
STRINGi10116.ENSRNOP00000014508.

PTM databases

iPTMnetiO54772.
PhosphoSitePlusiO54772.

Proteomic databases

PaxDbiO54772.
PRIDEiO54772.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014508; ENSRNOP00000014508; ENSRNOG00000010557.
GeneIDi83833.
KEGGirno:83833.

Organism-specific databases

CTDi6603.
RGDi69289. Smarcd2.

Phylogenomic databases

eggNOGiKOG2570. Eukaryota.
COG5531. LUCA.
GeneTreeiENSGT00390000017809.
HOGENOMiHOG000240746.
HOVERGENiHBG054046.
InParanoidiO54772.
KOiK11650.
OMAiMRFSEIP.
OrthoDBiEOG091G06WW.
PhylomeDBiO54772.
TreeFamiTF106486.

Enzyme and pathway databases

ReactomeiR-RNO-3214858. RMTs methylate histone arginines.

Miscellaneous databases

PROiO54772.

Gene expression databases

BgeeiENSRNOG00000010557.
GenevisibleiO54772. RN.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
InterProiIPR030090. BAF60B.
IPR019835. SWIB_domain.
IPR003121. SWIB_MDM2_domain.
[Graphical view]
PANTHERiPTHR13844:SF2. PTHR13844:SF2. 1 hit.
PfamiPF02201. SWIB. 1 hit.
[Graphical view]
SMARTiSM00151. SWIB. 1 hit.
[Graphical view]
SUPFAMiSSF47592. SSF47592. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSMRD2_RAT
AccessioniPrimary (citable) accession number: O54772
Secondary accession number(s): O54771
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: February 8, 2011
Last modified: November 30, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.