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Protein

Fibroblast growth factor 16

Gene

Fgf16

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.By similarity1 Publication

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: MGI

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: MGI
  • positive regulation of brown fat cell proliferation Source: MGI
  • positive regulation of endothelial cell chemotaxis to fibroblast growth factor Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-RNO-109704. PI3K Cascade.
R-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-190322. FGFR4 ligand binding and activation.
R-RNO-190372. FGFR3c ligand binding and activation.
R-RNO-190375. FGFR2c ligand binding and activation.
R-RNO-5654221. Phospholipase C-mediated cascade, FGFR2.
R-RNO-5654227. Phospholipase C-mediated cascade, FGFR3.
R-RNO-5654228. Phospholipase C-mediated cascade, FGFR4.
R-RNO-5654695. PI-3K cascade:FGFR2.
R-RNO-5654699. SHC-mediated cascade:FGFR2.
R-RNO-5654700. FRS-mediated FGFR2 signaling.
R-RNO-5654704. SHC-mediated cascade:FGFR3.
R-RNO-5654706. FRS-mediated FGFR3 signaling.
R-RNO-5654710. PI-3K cascade:FGFR3.
R-RNO-5654712. FRS-mediated FGFR4 signaling.
R-RNO-5654719. SHC-mediated cascade:FGFR4.
R-RNO-5654720. PI-3K cascade:FGFR4.
R-RNO-5654727. Negative regulation of FGFR2 signaling.
R-RNO-5654732. Negative regulation of FGFR3 signaling.
R-RNO-5654733. Negative regulation of FGFR4 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 16
Short name:
FGF-16
Gene namesi
Name:Fgf16
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi71052. Fgf16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476151 – 207Fibroblast growth factor 16Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1
Modified residuei111PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO54769.

Expressioni

Tissue specificityi

In adult, predominantly expressed in heart, in the cardiac myocytes. Not detected in brain, lung, liver, kidney and white adipose tissue. In embryos, predominantly expressed in the brown adipose tissue.1 Publication

Developmental stagei

Expression in brown adipose tissue decreased greatly after birth.1 Publication

Gene expression databases

BgeeiENSRNOG00000002560.
GenevisibleiO54769. RN.

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2.By similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: MGI

Protein-protein interaction databases

DIPiDIP-6040N.
STRINGi10116.ENSRNOP00000003463.

Structurei

3D structure databases

ProteinModelPortaliO54769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiO54769.
KOiK04358.
OMAiNRTKKHQ.
OrthoDBiEOG091G0NAY.
PhylomeDBiO54769.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028285. FGF16.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF27. PTHR11486:SF27. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVGGVFAS LDWDLQGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP
60 70 80 90 100
TDFAHLKGIL RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA
110 120 130 140 150
VGLISIRGVD SGLYLGMNER GELFGSKKLT RECVFREQFE ENWYNTYAST
160 170 180 190 200
LYKHSDSERQ YYVALNKDGS PREGYRTKRH QKFTHFLPRP VDPSKLPSMS

RDLFRYR
Length:207
Mass (Da):23,753
Last modified:June 1, 1998 - v1
Checksum:i1C7A11C8BA3164BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002561 mRNA. Translation: BAA24947.1.
BC085738 mRNA. Translation: AAH85738.1.
PIRiJC5940.
RefSeqiNP_068639.1. NM_021867.3.
UniGeneiRn.44348.

Genome annotation databases

EnsembliENSRNOT00000090665; ENSRNOP00000071308; ENSRNOG00000061530.
GeneIDi60464.
KEGGirno:60464.
UCSCiRGD:71052. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002561 mRNA. Translation: BAA24947.1.
BC085738 mRNA. Translation: AAH85738.1.
PIRiJC5940.
RefSeqiNP_068639.1. NM_021867.3.
UniGeneiRn.44348.

3D structure databases

ProteinModelPortaliO54769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6040N.
STRINGi10116.ENSRNOP00000003463.

Proteomic databases

PaxDbiO54769.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000090665; ENSRNOP00000071308; ENSRNOG00000061530.
GeneIDi60464.
KEGGirno:60464.
UCSCiRGD:71052. rat.

Organism-specific databases

CTDi8823.
RGDi71052. Fgf16.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiO54769.
KOiK04358.
OMAiNRTKKHQ.
OrthoDBiEOG091G0NAY.
PhylomeDBiO54769.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiR-RNO-109704. PI3K Cascade.
R-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-190322. FGFR4 ligand binding and activation.
R-RNO-190372. FGFR3c ligand binding and activation.
R-RNO-190375. FGFR2c ligand binding and activation.
R-RNO-5654221. Phospholipase C-mediated cascade, FGFR2.
R-RNO-5654227. Phospholipase C-mediated cascade, FGFR3.
R-RNO-5654228. Phospholipase C-mediated cascade, FGFR4.
R-RNO-5654695. PI-3K cascade:FGFR2.
R-RNO-5654699. SHC-mediated cascade:FGFR2.
R-RNO-5654700. FRS-mediated FGFR2 signaling.
R-RNO-5654704. SHC-mediated cascade:FGFR3.
R-RNO-5654706. FRS-mediated FGFR3 signaling.
R-RNO-5654710. PI-3K cascade:FGFR3.
R-RNO-5654712. FRS-mediated FGFR4 signaling.
R-RNO-5654719. SHC-mediated cascade:FGFR4.
R-RNO-5654720. PI-3K cascade:FGFR4.
R-RNO-5654727. Negative regulation of FGFR2 signaling.
R-RNO-5654732. Negative regulation of FGFR3 signaling.
R-RNO-5654733. Negative regulation of FGFR4 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Miscellaneous databases

PROiO54769.

Gene expression databases

BgeeiENSRNOG00000002560.
GenevisibleiO54769. RN.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028285. FGF16.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF27. PTHR11486:SF27. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF16_RAT
AccessioniPrimary (citable) accession number: O54769
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.