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O54751 (CRX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cone-rod homeobox protein
Gene names
Name:Crx
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. Ref.3

Subunit structure

Interacts (via the homeobox) with NRL (via the leucine-zipper domain). Interacts with PDC, RAX2, RORB and SCA7. Ref.3

Subcellular location

Nucleus Ref.3.

Tissue specificity

Retina. Ref.3

Developmental stage

At 17.5 dpc, expressed in a narrow zone in the peripheral outer nuclear layer of the retina. At P12, expressed over the entire photoreceptor layer. Ref.3

Sequence similarities

Belongs to the paired homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
Sensory transduction
Transcription
Transcription regulation
Vision
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcircadian rhythm

Inferred from electronic annotation. Source: Ensembl

positive regulation of photoreceptor cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 12407160PubMed 14613968PubMed 15689355PubMed 16539743PubMed 20026326. Source: MGI

regulation of transcription, DNA-templated

Inferred from direct assay Ref.3. Source: UniProtKB

response to stimulus

Inferred from electronic annotation. Source: UniProtKB-KW

retina development in camera-type eye

Inferred from mutant phenotype PubMed 21052544. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

visual perception

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay Ref.3. Source: UniProtKB

transcription factor complex

Inferred from direct assay PubMed 15689355. Source: MGI

   Molecular_functionchromatin binding

Inferred from direct assay PubMed 14613968. Source: MGI

nuclear hormone receptor binding

Inferred from physical interaction Ref.3. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 14613968PubMed 15689355. Source: MGI

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from direct assay Ref.3. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Cone-rod homeobox protein
PRO_0000048863

Regions

DNA binding39 – 9860Homeobox Ref.3

Sequences

Sequence LengthMass (Da)Tools
O54751 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 4FE2C27D8070B524

FASTA29932,374
        10         20         30         40         50         60 
MMAYMNPGPH YSVNALALSG PNVDLMHQAV PYSSAPRKQR RERTTFTRSQ LEELEALFAK 

        70         80         90        100        110        120 
TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ QKQQQQPPGA QTKARPAKRK 

       130        140        150        160        170        180 
AGTSPRPSTD VCTDPLGISD SYSPSLPGPS GSPTTAVATV SIWSPASEAP LPEAQRAGLV 

       190        200        210        220        230        240 
ASGPSLTSAP YAMTYAPASA FCSSPSAYAS PSSYFSGLDP YLSPMVPQLG GPALSPLSGP 

       250        260        270        280        290 
SVGPSLAQSP TSLSGQSYST YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL 

« Hide

References

« Hide 'large scale' references
[1]"Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation."
Furukawa T., Morrow E.M., Cepko C.L.
Cell 91:531-541(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[3]"Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta."
Srinivas M., Ng L., Liu H., Jia L., Forrest D.
Mol. Endocrinol. 20:1728-1741(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS TRANSCRIPTION ACTIVATOR, SUBCELLULAR LOCATION, DNA-BINDING, INTERACTION WITH NRL AND RORB, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
Strain: C57BL/6.
Tissue: Embryonic eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U77615 mRNA. Translation: AAB88585.1.
BC016502 mRNA. Translation: AAH16502.1.
CCDSCCDS20840.1.
RefSeqNP_001106801.1. NM_001113330.1.
NP_031796.1. NM_007770.4.
UniGeneMm.441911.

3D structure databases

ProteinModelPortalO54751.
SMRO54751. Positions 34-95.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198905. 2 interactions.
STRING10090.ENSMUSP00000043436.

PTM databases

PhosphoSiteO54751.

Proteomic databases

PRIDEO54751.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044434; ENSMUSP00000043436; ENSMUSG00000041578.
GeneID12951.
KEGGmmu:12951.
UCSCuc009fgm.2. mouse.

Organism-specific databases

CTD1406.
MGIMGI:1194883. Crx.

Phylogenomic databases

eggNOGNOG324074.
HOGENOMHOG000082677.
HOVERGENHBG004028.
InParanoidO54751.
KOK09337.
OrthoDBEOG74J98P.
PhylomeDBO54751.
TreeFamTF351179.

Gene expression databases

BgeeO54751.
CleanExMM_CRX.
GenevestigatorO54751.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR013851. Otx_TF_C.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282658.
PROO54751.
SOURCESearch...

Entry information

Entry nameCRX_MOUSE
AccessionPrimary (citable) accession number: O54751
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot