Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O54751

- CRX_MOUSE

UniProt

O54751 - CRX_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cone-rod homeobox protein

Gene

Crx

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi39 – 9860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. nuclear hormone receptor binding Source: UniProtKB
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
  3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  4. regulation of transcription, DNA-templated Source: UniProtKB
  5. response to stimulus Source: UniProtKB-KW
  6. retina development in camera-type eye Source: MGI
  7. transcription, DNA-templated Source: UniProtKB-KW
  8. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Sensory transduction, Transcription, Transcription regulation, Vision

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cone-rod homeobox protein
Gene namesi
Name:Crx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1194883. Crx.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Cone-rod homeobox proteinPRO_0000048863Add
BLAST

Proteomic databases

PRIDEiO54751.

PTM databases

PhosphoSiteiO54751.

Expressioni

Tissue specificityi

Retina.1 Publication

Developmental stagei

At 17.5 dpc, expressed in a narrow zone in the peripheral outer nuclear layer of the retina. At P12, expressed over the entire photoreceptor layer.1 Publication

Gene expression databases

BgeeiO54751.
CleanExiMM_CRX.
ExpressionAtlasiO54751. baseline.
GenevestigatoriO54751.

Interactioni

Subunit structurei

Interacts (via the homeobox) with NRL (via the leucine-zipper domain). Interacts with PDC, RAX2, RORB and SCA7.1 Publication

Protein-protein interaction databases

BioGridi198905. 2 interactions.
STRINGi10090.ENSMUSP00000043436.

Structurei

3D structure databases

ProteinModelPortaliO54751.
SMRiO54751. Positions 34-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG324074.
HOGENOMiHOG000082677.
HOVERGENiHBG004028.
InParanoidiO54751.
KOiK09337.
OrthoDBiEOG74J98P.
PhylomeDBiO54751.
TreeFamiTF351179.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54751-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMAYMNPGPH YSVNALALSG PNVDLMHQAV PYSSAPRKQR RERTTFTRSQ
60 70 80 90 100
LEELEALFAK TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ
110 120 130 140 150
QKQQQQPPGA QTKARPAKRK AGTSPRPSTD VCTDPLGISD SYSPSLPGPS
160 170 180 190 200
GSPTTAVATV SIWSPASEAP LPEAQRAGLV ASGPSLTSAP YAMTYAPASA
210 220 230 240 250
FCSSPSAYAS PSSYFSGLDP YLSPMVPQLG GPALSPLSGP SVGPSLAQSP
260 270 280 290
TSLSGQSYST YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL
Length:299
Mass (Da):32,374
Last modified:June 1, 1998 - v1
Checksum:i4FE2C27D8070B524
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77615 mRNA. Translation: AAB88585.1.
BC016502 mRNA. Translation: AAH16502.1.
CCDSiCCDS20840.1.
RefSeqiNP_001106801.1. NM_001113330.1.
NP_031796.1. NM_007770.4.
UniGeneiMm.441911.

Genome annotation databases

EnsembliENSMUST00000044434; ENSMUSP00000043436; ENSMUSG00000041578.
GeneIDi12951.
KEGGimmu:12951.
UCSCiuc009fgm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77615 mRNA. Translation: AAB88585.1 .
BC016502 mRNA. Translation: AAH16502.1 .
CCDSi CCDS20840.1.
RefSeqi NP_001106801.1. NM_001113330.1.
NP_031796.1. NM_007770.4.
UniGenei Mm.441911.

3D structure databases

ProteinModelPortali O54751.
SMRi O54751. Positions 34-95.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198905. 2 interactions.
STRINGi 10090.ENSMUSP00000043436.

PTM databases

PhosphoSitei O54751.

Proteomic databases

PRIDEi O54751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044434 ; ENSMUSP00000043436 ; ENSMUSG00000041578 .
GeneIDi 12951.
KEGGi mmu:12951.
UCSCi uc009fgm.2. mouse.

Organism-specific databases

CTDi 1406.
MGIi MGI:1194883. Crx.

Phylogenomic databases

eggNOGi NOG324074.
HOGENOMi HOG000082677.
HOVERGENi HBG004028.
InParanoidi O54751.
KOi K09337.
OrthoDBi EOG74J98P.
PhylomeDBi O54751.
TreeFami TF351179.

Miscellaneous databases

NextBioi 282658.
PROi O54751.
SOURCEi Search...

Gene expression databases

Bgeei O54751.
CleanExi MM_CRX.
ExpressionAtlasi O54751. baseline.
Genevestigatori O54751.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR013851. Otx_TF_C.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation."
    Furukawa T., Morrow E.M., Cepko C.L.
    Cell 91:531-541(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta."
    Srinivas M., Ng L., Liu H., Jia L., Forrest D.
    Mol. Endocrinol. 20:1728-1741(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS TRANSCRIPTION ACTIVATOR, SUBCELLULAR LOCATION, DNA-BINDING, INTERACTION WITH NRL AND RORB, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Embryonic eye.

Entry informationi

Entry nameiCRX_MOUSE
AccessioniPrimary (citable) accession number: O54751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3