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Protein

Cone-rod homeobox protein

Gene

Crx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi39 – 98HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Sensory transduction, Transcription, Transcription regulation, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Cone-rod homeobox protein
Gene namesi
Name:Crx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1194883. Crx.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • transcription factor complex Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488631 – 299Cone-rod homeobox proteinAdd BLAST299

Proteomic databases

PaxDbiO54751.
PRIDEiO54751.

PTM databases

PhosphoSitePlusiO54751.

Expressioni

Tissue specificityi

Retina.1 Publication

Developmental stagei

At 17.5 dpc, expressed in a narrow zone in the peripheral outer nuclear layer of the retina. At P12, expressed over the entire photoreceptor layer.1 Publication

Gene expression databases

BgeeiENSMUSG00000041578.
CleanExiMM_CRX.
ExpressionAtlasiO54751. baseline and differential.
GenevisibleiO54751. MM.

Interactioni

Subunit structurei

Interacts (via the homeobox) with NRL (via the leucine-zipper domain). Interacts with PDC, RAX2, RORB and SCA7.1 Publication

GO - Molecular functioni

  • leucine zipper domain binding Source: MGI
  • nuclear hormone receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi198905. 3 interactors.
STRINGi10090.ENSMUSP00000126642.

Structurei

3D structure databases

ProteinModelPortaliO54751.
SMRiO54751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2251. Eukaryota.
ENOG4111XIJ. LUCA.
GeneTreeiENSGT00820000126963.
HOGENOMiHOG000082677.
HOVERGENiHBG004028.
InParanoidiO54751.
KOiK09337.
PhylomeDBiO54751.
TreeFamiTF351179.

Family and domain databases

InterProiView protein in InterPro
IPR032966. CRX.
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR013851. Otx_TF_C.
PANTHERiPTHR24329:SF394. PTHR24329:SF394. 1 hit.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O54751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAYMNPGPH YSVNALALSG PNVDLMHQAV PYSSAPRKQR RERTTFTRSQ
60 70 80 90 100
LEELEALFAK TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ
110 120 130 140 150
QKQQQQPPGA QTKARPAKRK AGTSPRPSTD VCTDPLGISD SYSPSLPGPS
160 170 180 190 200
GSPTTAVATV SIWSPASEAP LPEAQRAGLV ASGPSLTSAP YAMTYAPASA
210 220 230 240 250
FCSSPSAYAS PSSYFSGLDP YLSPMVPQLG GPALSPLSGP SVGPSLAQSP
260 270 280 290
TSLSGQSYST YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL
Length:299
Mass (Da):32,374
Last modified:June 1, 1998 - v1
Checksum:i4FE2C27D8070B524
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77615 mRNA. Translation: AAB88585.1.
BC016502 mRNA. Translation: AAH16502.1.
CCDSiCCDS20840.1.
RefSeqiNP_001106801.1. NM_001113330.1.
NP_031796.1. NM_007770.4.
UniGeneiMm.441911.

Genome annotation databases

EnsembliENSMUST00000044434; ENSMUSP00000043436; ENSMUSG00000041578.
GeneIDi12951.
KEGGimmu:12951.
UCSCiuc009fgm.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCRX_MOUSE
AccessioniPrimary (citable) accession number: O54751
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: May 10, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families