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O54751

- CRX_MOUSE

UniProt

O54751 - CRX_MOUSE

Protein

Cone-rod homeobox protein

Gene

Crx

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi39 – 9860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. nuclear hormone receptor binding Source: UniProtKB
    3. protein binding Source: MGI
    4. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. circadian rhythm Source: Ensembl
    2. positive regulation of photoreceptor cell differentiation Source: Ensembl
    3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    4. regulation of transcription, DNA-templated Source: UniProtKB
    5. response to stimulus Source: UniProtKB-KW
    6. retina development in camera-type eye Source: MGI
    7. transcription, DNA-templated Source: UniProtKB-KW
    8. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Sensory transduction, Transcription, Transcription regulation, Vision

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cone-rod homeobox protein
    Gene namesi
    Name:Crx
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1194883. Crx.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Cone-rod homeobox proteinPRO_0000048863Add
    BLAST

    Proteomic databases

    PRIDEiO54751.

    PTM databases

    PhosphoSiteiO54751.

    Expressioni

    Tissue specificityi

    Retina.1 Publication

    Developmental stagei

    At 17.5 dpc, expressed in a narrow zone in the peripheral outer nuclear layer of the retina. At P12, expressed over the entire photoreceptor layer.1 Publication

    Gene expression databases

    BgeeiO54751.
    CleanExiMM_CRX.
    GenevestigatoriO54751.

    Interactioni

    Subunit structurei

    Interacts (via the homeobox) with NRL (via the leucine-zipper domain). Interacts with PDC, RAX2, RORB and SCA7.1 Publication

    Protein-protein interaction databases

    BioGridi198905. 2 interactions.
    STRINGi10090.ENSMUSP00000043436.

    Structurei

    3D structure databases

    ProteinModelPortaliO54751.
    SMRiO54751. Positions 34-95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the paired homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG324074.
    HOGENOMiHOG000082677.
    HOVERGENiHBG004028.
    InParanoidiO54751.
    KOiK09337.
    OrthoDBiEOG74J98P.
    PhylomeDBiO54751.
    TreeFamiTF351179.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR013851. Otx_TF_C.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF03529. TF_Otx. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54751-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMAYMNPGPH YSVNALALSG PNVDLMHQAV PYSSAPRKQR RERTTFTRSQ    50
    LEELEALFAK TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ 100
    QKQQQQPPGA QTKARPAKRK AGTSPRPSTD VCTDPLGISD SYSPSLPGPS 150
    GSPTTAVATV SIWSPASEAP LPEAQRAGLV ASGPSLTSAP YAMTYAPASA 200
    FCSSPSAYAS PSSYFSGLDP YLSPMVPQLG GPALSPLSGP SVGPSLAQSP 250
    TSLSGQSYST YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL 299
    Length:299
    Mass (Da):32,374
    Last modified:June 1, 1998 - v1
    Checksum:i4FE2C27D8070B524
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77615 mRNA. Translation: AAB88585.1.
    BC016502 mRNA. Translation: AAH16502.1.
    CCDSiCCDS20840.1.
    RefSeqiNP_001106801.1. NM_001113330.1.
    NP_031796.1. NM_007770.4.
    UniGeneiMm.441911.

    Genome annotation databases

    EnsembliENSMUST00000044434; ENSMUSP00000043436; ENSMUSG00000041578.
    GeneIDi12951.
    KEGGimmu:12951.
    UCSCiuc009fgm.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77615 mRNA. Translation: AAB88585.1 .
    BC016502 mRNA. Translation: AAH16502.1 .
    CCDSi CCDS20840.1.
    RefSeqi NP_001106801.1. NM_001113330.1.
    NP_031796.1. NM_007770.4.
    UniGenei Mm.441911.

    3D structure databases

    ProteinModelPortali O54751.
    SMRi O54751. Positions 34-95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198905. 2 interactions.
    STRINGi 10090.ENSMUSP00000043436.

    PTM databases

    PhosphoSitei O54751.

    Proteomic databases

    PRIDEi O54751.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044434 ; ENSMUSP00000043436 ; ENSMUSG00000041578 .
    GeneIDi 12951.
    KEGGi mmu:12951.
    UCSCi uc009fgm.2. mouse.

    Organism-specific databases

    CTDi 1406.
    MGIi MGI:1194883. Crx.

    Phylogenomic databases

    eggNOGi NOG324074.
    HOGENOMi HOG000082677.
    HOVERGENi HBG004028.
    InParanoidi O54751.
    KOi K09337.
    OrthoDBi EOG74J98P.
    PhylomeDBi O54751.
    TreeFami TF351179.

    Miscellaneous databases

    NextBioi 282658.
    PROi O54751.
    SOURCEi Search...

    Gene expression databases

    Bgeei O54751.
    CleanExi MM_CRX.
    Genevestigatori O54751.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR013851. Otx_TF_C.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF03529. TF_Otx. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation."
      Furukawa T., Morrow E.M., Cepko C.L.
      Cell 91:531-541(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    3. "Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta."
      Srinivas M., Ng L., Liu H., Jia L., Forrest D.
      Mol. Endocrinol. 20:1728-1741(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS TRANSCRIPTION ACTIVATOR, SUBCELLULAR LOCATION, DNA-BINDING, INTERACTION WITH NRL AND RORB, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Embryonic eye.

    Entry informationi

    Entry nameiCRX_MOUSE
    AccessioniPrimary (citable) accession number: O54751
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3