Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome P450 2J6

Gene

Cyp2j6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi447Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211935 Fatty acids
R-MMU-211981 Xenobiotics
R-MMU-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2J6 (EC:1.14.14.1)
Alternative name(s):
Arachidonic acid epoxygenase
CYPIIJ6
Gene namesi
Name:Cyp2j6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1270148 Cyp2j6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517721 – 501Cytochrome P450 2J6Add BLAST501

Proteomic databases

MaxQBiO54750
PaxDbiO54750
PeptideAtlasiO54750
PRIDEiO54750

PTM databases

iPTMnetiO54750
PhosphoSitePlusiO54750

Expressioni

Gene expression databases

BgeeiENSMUSG00000052914
GenevisibleiO54750 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030303

Structurei

3D structure databases

ProteinModelPortaliO54750
SMRiO54750
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140799
HOGENOMiHOG000036991
HOVERGENiHBG015789
InParanoidiO54750
KOiK07418
OMAiRTIFSCN
OrthoDBiEOG091G0BT8
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008071 Cyt_P450_E_grp-I_CYP2J-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01688 EP450ICYP2J
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

O54750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAATGSLLA TIWAALHPRT LLVAAVTFLL LADYFKNRRP KNYPPGPWGL
60 70 80 90 100
PFVGNIFQLD FGQPHLSIQP LVKKYGNIFS LNLGDITSVV ITGLPLIKEA
110 120 130 140 150
LTQMEQNIMN RPLSVMQERI SNKNGLIFSS GQIWKEQRRF ALMTLRNFGL
160 170 180 190 200
GKKSLEERMQ EEASHLVEAI REEEGKPFNP HFSINNAVSN IICSVTFGER
210 220 230 240 250
FDYHDSRFQE MLRLLDEVMY LETTMISQLY NIFPWIMKYI PGSHQKVFRN
260 270 280 290 300
WEKLKLFVSC MIDDHRKDWN PDEPRDFIDA FLKEMTKYPE KTTSFNEENL
310 320 330 340 350
ICSTLDLFFA GTETTSTTLR WALLYMALYP EVQEKVQAEI DRVIGQKRAA
360 370 380 390 400
RLADRESMPY TNAVIHEVQR MGNIIPLNVP REVAMDTNLN GFHLPKGTMV
410 420 430 440 450
LTNLTALHRD PKEWATPDVF NPEHFLENGQ FKKRESFLPF SMGKRACLGE
460 470 480 490 500
QLARSELFIF FTSLMQKFTF NPPINEKLSP KFRNGLTLSP VSHRICAVPR

Q
Length:501
Mass (Da):57,792
Last modified:July 27, 2011 - v2
Checksum:i4E5A257C5C9C1CE7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti369Q → R in AAB87636 (PubMed:9570962).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62295 mRNA Translation: AAB87636.1
AK045421 mRNA Translation: BAC32356.1
AK165663 mRNA Translation: BAE38325.1
AL683816 Genomic DNA Translation: CAM13966.1
CH466527 Genomic DNA Translation: EDL30913.1
BC050832 mRNA Translation: AAH50832.1
CCDSiCCDS18369.1
RefSeqiNP_034138.3, NM_010008.4
UniGeneiMm.98200

Genome annotation databases

EnsembliENSMUST00000030303; ENSMUSP00000030303; ENSMUSG00000052914
GeneIDi13110
KEGGimmu:13110
UCSCiuc008tti.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCP2J6_MOUSE
AccessioniPrimary (citable) accession number: O54750
Secondary accession number(s): Q8BR78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health