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O54750

- CP2J6_MOUSE

UniProt

O54750 - CP2J6_MOUSE

Protein

Cytochrome P450 2J6

Gene

Cyp2j6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. NADPH-hemoprotein reductase activity Source: Ensembl

    GO - Biological processi

    1. arachidonic acid metabolic process Source: Ensembl
    2. female pregnancy Source: Ensembl
    3. response to organic cyclic compound Source: Ensembl
    4. retinoid metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2J6 (EC:1.14.14.1)
    Alternative name(s):
    Arachidonic acid epoxygenase
    CYPIIJ6
    Gene namesi
    Name:Cyp2j6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1270148. Cyp2j6.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Cytochrome P450 2J6PRO_0000051772Add
    BLAST

    Proteomic databases

    MaxQBiO54750.
    PaxDbiO54750.
    PRIDEiO54750.

    Expressioni

    Gene expression databases

    BgeeiO54750.
    GenevestigatoriO54750.

    Structurei

    3D structure databases

    ProteinModelPortaliO54750.
    SMRiO54750. Positions 44-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117618.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiQ8BR78.
    KOiK07418.
    OMAiMYLETTM.
    OrthoDBiEOG7RBZ85.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01688. EP450ICYP2J.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54750-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAATGSLLA TIWAALHPRT LLVAAVTFLL LADYFKNRRP KNYPPGPWGL    50
    PFVGNIFQLD FGQPHLSIQP LVKKYGNIFS LNLGDITSVV ITGLPLIKEA 100
    LTQMEQNIMN RPLSVMQERI SNKNGLIFSS GQIWKEQRRF ALMTLRNFGL 150
    GKKSLEERMQ EEASHLVEAI REEEGKPFNP HFSINNAVSN IICSVTFGER 200
    FDYHDSRFQE MLRLLDEVMY LETTMISQLY NIFPWIMKYI PGSHQKVFRN 250
    WEKLKLFVSC MIDDHRKDWN PDEPRDFIDA FLKEMTKYPE KTTSFNEENL 300
    ICSTLDLFFA GTETTSTTLR WALLYMALYP EVQEKVQAEI DRVIGQKRAA 350
    RLADRESMPY TNAVIHEVQR MGNIIPLNVP REVAMDTNLN GFHLPKGTMV 400
    LTNLTALHRD PKEWATPDVF NPEHFLENGQ FKKRESFLPF SMGKRACLGE 450
    QLARSELFIF FTSLMQKFTF NPPINEKLSP KFRNGLTLSP VSHRICAVPR 500
    Q 501
    Length:501
    Mass (Da):57,792
    Last modified:July 27, 2011 - v2
    Checksum:i4E5A257C5C9C1CE7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti369 – 3691Q → R in AAB87636. (PubMed:9570962)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62295 mRNA. Translation: AAB87636.1.
    AK045421 mRNA. Translation: BAC32356.1.
    AK165663 mRNA. Translation: BAE38325.1.
    AL683816 Genomic DNA. Translation: CAM13966.1.
    CH466527 Genomic DNA. Translation: EDL30913.1.
    BC050832 mRNA. Translation: AAH50832.1.
    CCDSiCCDS18369.1.
    RefSeqiNP_034138.3. NM_010008.4.
    UniGeneiMm.98200.

    Genome annotation databases

    EnsembliENSMUST00000030303; ENSMUSP00000030303; ENSMUSG00000052914.
    GeneIDi13110.
    KEGGimmu:13110.
    UCSCiuc008tti.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62295 mRNA. Translation: AAB87636.1 .
    AK045421 mRNA. Translation: BAC32356.1 .
    AK165663 mRNA. Translation: BAE38325.1 .
    AL683816 Genomic DNA. Translation: CAM13966.1 .
    CH466527 Genomic DNA. Translation: EDL30913.1 .
    BC050832 mRNA. Translation: AAH50832.1 .
    CCDSi CCDS18369.1.
    RefSeqi NP_034138.3. NM_010008.4.
    UniGenei Mm.98200.

    3D structure databases

    ProteinModelPortali O54750.
    SMRi O54750. Positions 44-500.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi O54750.
    PaxDbi O54750.
    PRIDEi O54750.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030303 ; ENSMUSP00000030303 ; ENSMUSG00000052914 .
    GeneIDi 13110.
    KEGGi mmu:13110.
    UCSCi uc008tti.2. mouse.

    Organism-specific databases

    CTDi 13110.
    MGIi MGI:1270148. Cyp2j6.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117618.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi Q8BR78.
    KOi K07418.
    OMAi MYLETTM.
    OrthoDBi EOG7RBZ85.
    TreeFami TF352043.

    Enzyme and pathway databases

    Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).

    Miscellaneous databases

    ChiTaRSi Cyp2j6. mouse.
    NextBioi 283118.
    PROi O54750.
    SOURCEi Search...

    Gene expression databases

    Bgeei O54750.
    Genevestigatori O54750.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01688. EP450ICYP2J.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4."
      Ma J., Ramachandran S., Fiedorek F.T. Jr., Zeldin D.C.
      Genomics 49:152-155(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Corpora quadrigemina.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Limb.

    Entry informationi

    Entry nameiCP2J6_MOUSE
    AccessioniPrimary (citable) accession number: O54750
    Secondary accession number(s): Q8BR78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3