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O54750

- CP2J6_MOUSE

UniProt

O54750 - CP2J6_MOUSE

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Protein

Cytochrome P450 2J6

Gene

Cyp2j6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. arachidonic acid epoxygenase activity Source: MGI
  2. aromatase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro
  5. NADPH-hemoprotein reductase activity Source: Ensembl

GO - Biological processi

  1. arachidonic acid metabolic process Source: Ensembl
  2. female pregnancy Source: Ensembl
  3. response to organic cyclic compound Source: Ensembl
  4. retinoid metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2J6 (EC:1.14.14.1)
Alternative name(s):
Arachidonic acid epoxygenase
CYPIIJ6
Gene namesi
Name:Cyp2j6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1270148. Cyp2j6.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Cytochrome P450 2J6PRO_0000051772Add
BLAST

Proteomic databases

MaxQBiO54750.
PaxDbiO54750.
PRIDEiO54750.

Expressioni

Gene expression databases

BgeeiO54750.
GenevestigatoriO54750.

Structurei

3D structure databases

ProteinModelPortaliO54750.
SMRiO54750. Positions 44-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiO54750.
KOiK07418.
OMAiMYLETTM.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54750-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLAATGSLLA TIWAALHPRT LLVAAVTFLL LADYFKNRRP KNYPPGPWGL
60 70 80 90 100
PFVGNIFQLD FGQPHLSIQP LVKKYGNIFS LNLGDITSVV ITGLPLIKEA
110 120 130 140 150
LTQMEQNIMN RPLSVMQERI SNKNGLIFSS GQIWKEQRRF ALMTLRNFGL
160 170 180 190 200
GKKSLEERMQ EEASHLVEAI REEEGKPFNP HFSINNAVSN IICSVTFGER
210 220 230 240 250
FDYHDSRFQE MLRLLDEVMY LETTMISQLY NIFPWIMKYI PGSHQKVFRN
260 270 280 290 300
WEKLKLFVSC MIDDHRKDWN PDEPRDFIDA FLKEMTKYPE KTTSFNEENL
310 320 330 340 350
ICSTLDLFFA GTETTSTTLR WALLYMALYP EVQEKVQAEI DRVIGQKRAA
360 370 380 390 400
RLADRESMPY TNAVIHEVQR MGNIIPLNVP REVAMDTNLN GFHLPKGTMV
410 420 430 440 450
LTNLTALHRD PKEWATPDVF NPEHFLENGQ FKKRESFLPF SMGKRACLGE
460 470 480 490 500
QLARSELFIF FTSLMQKFTF NPPINEKLSP KFRNGLTLSP VSHRICAVPR

Q
Length:501
Mass (Da):57,792
Last modified:July 27, 2011 - v2
Checksum:i4E5A257C5C9C1CE7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti369 – 3691Q → R in AAB87636. (PubMed:9570962)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62295 mRNA. Translation: AAB87636.1.
AK045421 mRNA. Translation: BAC32356.1.
AK165663 mRNA. Translation: BAE38325.1.
AL683816 Genomic DNA. Translation: CAM13966.1.
CH466527 Genomic DNA. Translation: EDL30913.1.
BC050832 mRNA. Translation: AAH50832.1.
CCDSiCCDS18369.1.
RefSeqiNP_034138.3. NM_010008.4.
UniGeneiMm.98200.

Genome annotation databases

EnsembliENSMUST00000030303; ENSMUSP00000030303; ENSMUSG00000052914.
GeneIDi13110.
KEGGimmu:13110.
UCSCiuc008tti.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62295 mRNA. Translation: AAB87636.1 .
AK045421 mRNA. Translation: BAC32356.1 .
AK165663 mRNA. Translation: BAE38325.1 .
AL683816 Genomic DNA. Translation: CAM13966.1 .
CH466527 Genomic DNA. Translation: EDL30913.1 .
BC050832 mRNA. Translation: AAH50832.1 .
CCDSi CCDS18369.1.
RefSeqi NP_034138.3. NM_010008.4.
UniGenei Mm.98200.

3D structure databases

ProteinModelPortali O54750.
SMRi O54750. Positions 44-500.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi O54750.
PaxDbi O54750.
PRIDEi O54750.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030303 ; ENSMUSP00000030303 ; ENSMUSG00000052914 .
GeneIDi 13110.
KEGGi mmu:13110.
UCSCi uc008tti.2. mouse.

Organism-specific databases

CTDi 13110.
MGIi MGI:1270148. Cyp2j6.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi O54750.
KOi K07418.
OMAi MYLETTM.
OrthoDBi EOG7RBZ85.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).

Miscellaneous databases

ChiTaRSi Cyp2j6. mouse.
NextBioi 283118.
PROi O54750.
SOURCEi Search...

Gene expression databases

Bgeei O54750.
Genevestigatori O54750.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4."
    Ma J., Ramachandran S., Fiedorek F.T. Jr., Zeldin D.C.
    Genomics 49:152-155(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.

Entry informationi

Entry nameiCP2J6_MOUSE
AccessioniPrimary (citable) accession number: O54750
Secondary accession number(s): Q8BR78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3