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Protein

Cytochrome P450 2J6

Gene

Cyp2j6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. arachidonic acid 11,12-epoxygenase activity Source: MGI
  2. arachidonic acid 14,15-epoxygenase activity Source: MGI
  3. arachidonic acid epoxygenase activity Source: MGI
  4. aromatase activity Source: UniProtKB-EC
  5. heme binding Source: GO_Central
  6. iron ion binding Source: InterPro
  7. linoleic acid epoxygenase activity Source: MGI
  8. NADPH-hemoprotein reductase activity Source: Ensembl
  9. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
  10. oxygen binding Source: GO_Central
  11. steroid hydroxylase activity Source: GO_Central

GO - Biological processi

  1. arachidonic acid metabolic process Source: GO_Central
  2. epoxygenase P450 pathway Source: MGI
  3. exogenous drug catabolic process Source: GO_Central
  4. female pregnancy Source: Ensembl
  5. linoleic acid metabolic process Source: MGI
  6. response to organic cyclic compound Source: Ensembl
  7. retinoid metabolic process Source: Ensembl
  8. xenobiotic metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_295859. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_331519. Fatty acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2J6 (EC:1.14.14.1)
Alternative name(s):
Arachidonic acid epoxygenase
CYPIIJ6
Gene namesi
Name:Cyp2j6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1270148. Cyp2j6.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Cytochrome P450 2J6PRO_0000051772Add
BLAST

Proteomic databases

MaxQBiO54750.
PaxDbiO54750.
PRIDEiO54750.

Expressioni

Gene expression databases

BgeeiO54750.
GenevestigatoriO54750.

Structurei

3D structure databases

ProteinModelPortaliO54750.
SMRiO54750. Positions 44-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiO54750.
KOiK07418.
OMAiMYLETTM.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAATGSLLA TIWAALHPRT LLVAAVTFLL LADYFKNRRP KNYPPGPWGL
60 70 80 90 100
PFVGNIFQLD FGQPHLSIQP LVKKYGNIFS LNLGDITSVV ITGLPLIKEA
110 120 130 140 150
LTQMEQNIMN RPLSVMQERI SNKNGLIFSS GQIWKEQRRF ALMTLRNFGL
160 170 180 190 200
GKKSLEERMQ EEASHLVEAI REEEGKPFNP HFSINNAVSN IICSVTFGER
210 220 230 240 250
FDYHDSRFQE MLRLLDEVMY LETTMISQLY NIFPWIMKYI PGSHQKVFRN
260 270 280 290 300
WEKLKLFVSC MIDDHRKDWN PDEPRDFIDA FLKEMTKYPE KTTSFNEENL
310 320 330 340 350
ICSTLDLFFA GTETTSTTLR WALLYMALYP EVQEKVQAEI DRVIGQKRAA
360 370 380 390 400
RLADRESMPY TNAVIHEVQR MGNIIPLNVP REVAMDTNLN GFHLPKGTMV
410 420 430 440 450
LTNLTALHRD PKEWATPDVF NPEHFLENGQ FKKRESFLPF SMGKRACLGE
460 470 480 490 500
QLARSELFIF FTSLMQKFTF NPPINEKLSP KFRNGLTLSP VSHRICAVPR

Q
Length:501
Mass (Da):57,792
Last modified:July 27, 2011 - v2
Checksum:i4E5A257C5C9C1CE7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti369 – 3691Q → R in AAB87636 (PubMed:9570962).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62295 mRNA. Translation: AAB87636.1.
AK045421 mRNA. Translation: BAC32356.1.
AK165663 mRNA. Translation: BAE38325.1.
AL683816 Genomic DNA. Translation: CAM13966.1.
CH466527 Genomic DNA. Translation: EDL30913.1.
BC050832 mRNA. Translation: AAH50832.1.
CCDSiCCDS18369.1.
RefSeqiNP_034138.3. NM_010008.4.
UniGeneiMm.98200.

Genome annotation databases

EnsembliENSMUST00000030303; ENSMUSP00000030303; ENSMUSG00000052914.
GeneIDi13110.
KEGGimmu:13110.
UCSCiuc008tti.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62295 mRNA. Translation: AAB87636.1.
AK045421 mRNA. Translation: BAC32356.1.
AK165663 mRNA. Translation: BAE38325.1.
AL683816 Genomic DNA. Translation: CAM13966.1.
CH466527 Genomic DNA. Translation: EDL30913.1.
BC050832 mRNA. Translation: AAH50832.1.
CCDSiCCDS18369.1.
RefSeqiNP_034138.3. NM_010008.4.
UniGeneiMm.98200.

3D structure databases

ProteinModelPortaliO54750.
SMRiO54750. Positions 44-500.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiO54750.
PaxDbiO54750.
PRIDEiO54750.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030303; ENSMUSP00000030303; ENSMUSG00000052914.
GeneIDi13110.
KEGGimmu:13110.
UCSCiuc008tti.2. mouse.

Organism-specific databases

CTDi13110.
MGIiMGI:1270148. Cyp2j6.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiO54750.
KOiK07418.
OMAiMYLETTM.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiREACT_295859. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_331519. Fatty acids.

Miscellaneous databases

ChiTaRSiCyp2j6. mouse.
NextBioi283118.
PROiO54750.
SOURCEiSearch...

Gene expression databases

BgeeiO54750.
GenevestigatoriO54750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4."
    Ma J., Ramachandran S., Fiedorek F.T. Jr., Zeldin D.C.
    Genomics 49:152-155(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.

Entry informationi

Entry nameiCP2J6_MOUSE
AccessioniPrimary (citable) accession number: O54750
Secondary accession number(s): Q8BR78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: April 1, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.