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Protein

Cytochrome P450 2J5

Gene

Cyp2j5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

  • angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
  • arachidonic acid metabolic process Source: GO_Central
  • exogenous drug catabolic process Source: GO_Central
  • oxidation-reduction process Source: GO_Central
  • positive regulation of estrogen secretion Source: MGI
  • regulation of systemic arterial blood pressure by hormone Source: MGI
  • renal tubular secretion Source: MGI
  • xenobiotic metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_295859. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_331519. Fatty acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2J5 (EC:1.14.14.1)
Alternative name(s):
Arachidonic acid epoxygenase
CYPIIJ5
Gene namesi
Name:Cyp2j5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1270149. Cyp2j5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Cytochrome P450 2J5PRO_0000051771Add
BLAST

Proteomic databases

MaxQBiO54749.
PaxDbiO54749.
PRIDEiO54749.

PTM databases

PhosphoSiteiO54749.

Expressioni

Gene expression databases

BgeeiO54749.
ExpressionAtlasiO54749. baseline and differential.
GenevisibleiO54749. MM.

Interactioni

Protein-protein interaction databases

IntActiO54749. 3 interactions.
MINTiMINT-4091722.
STRINGi10090.ENSMUSP00000030299.

Structurei

3D structure databases

ProteinModelPortaliO54749.
SMRiO54749. Positions 44-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiO54749.
KOiK07418.
OrthoDBiEOG7PK8ZF.
PhylomeDBiO54749.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMFLSSLVT TFWEALHLKT LVLAVVTFLF LINILRSRHP KNYPPGPWRL
60 70 80 90 100
PFVGNFFQID TKQTHLVLQQ FVKKYGNVFS LELGQSPVVV VSGLPLIKEM
110 120 130 140 150
FTHLDQNFVN RFMTPVRERI TGKNGLVVSN GQTWKEQRRL ALMALRNFGL
160 170 180 190 200
GKKSLEERIQ EETHHLVEAI REEGGQPFNP HLKLINAVSN IICSVTFGER
210 220 230 240 250
FDYEDCQFQE LLQLLDETMH LMGSSAGQLY NGFPCIMKYL PGPHQKIFRN
260 270 280 290 300
WGKLKLFVSH IVKKHEKDWN PDEPRDFIDA FLIEMQKDPD RTTSFNEENL
310 320 330 340 350
ISTTLDLFLG GTETTSSTLR WALLYMSSYP EIQENVQAEI DRVIGHKRQV
360 370 380 390 400
SLSDRESMPY TNAVIHEVQR MGNIVPLNSS REVTVDTKFN GFHLPKGTMI
410 420 430 440 450
LTNLTALHRD PKEWATPEVF NPEHFLENGQ FKKRESFLPF SMGKRACLGE
460 470 480 490 500
QLAKSELFIF FSALMQKFTF KPPINEKLSL KFRMGLILSP ASYRICAIPR

V
Length:501
Mass (Da):57,784
Last modified:June 1, 1998 - v1
Checksum:iC67F2E79DD64AF99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62294 mRNA. Translation: AAB87635.1.
BC021624 mRNA. Translation: AAH21624.1.
CCDSiCCDS18371.1.
RefSeqiNP_034137.1. NM_010007.4.
UniGeneiMm.12838.

Genome annotation databases

EnsembliENSMUST00000030299; ENSMUSP00000030299; ENSMUSG00000052520.
GeneIDi13109.
KEGGimmu:13109.
UCSCiuc008ttl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62294 mRNA. Translation: AAB87635.1.
BC021624 mRNA. Translation: AAH21624.1.
CCDSiCCDS18371.1.
RefSeqiNP_034137.1. NM_010007.4.
UniGeneiMm.12838.

3D structure databases

ProteinModelPortaliO54749.
SMRiO54749. Positions 44-499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO54749. 3 interactions.
MINTiMINT-4091722.
STRINGi10090.ENSMUSP00000030299.

PTM databases

PhosphoSiteiO54749.

Proteomic databases

MaxQBiO54749.
PaxDbiO54749.
PRIDEiO54749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030299; ENSMUSP00000030299; ENSMUSG00000052520.
GeneIDi13109.
KEGGimmu:13109.
UCSCiuc008ttl.1. mouse.

Organism-specific databases

CTDi13109.
MGIiMGI:1270149. Cyp2j5.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiO54749.
KOiK07418.
OrthoDBiEOG7PK8ZF.
PhylomeDBiO54749.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiREACT_295859. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_331519. Fatty acids.

Miscellaneous databases

NextBioi283114.
PROiO54749.
SOURCEiSearch...

Gene expression databases

BgeeiO54749.
ExpressionAtlasiO54749. baseline and differential.
GenevisibleiO54749. MM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4."
    Ma J., Ramachandran S., Fiedorek F.T. Jr., Zeldin D.C.
    Genomics 49:152-155(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP2J5_MOUSE
AccessioniPrimary (citable) accession number: O54749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: June 24, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.