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Protein

Cytochrome P450 2J5

Gene

Cyp2j5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi447Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
  • positive regulation of estrogen secretion Source: MGI
  • regulation of systemic arterial blood pressure by hormone Source: MGI
  • renal tubular secretion Source: MGI

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211935 Fatty acids
R-MMU-211981 Xenobiotics
R-MMU-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2J5 (EC:1.14.14.1)
Alternative name(s):
Arachidonic acid epoxygenase
CYPIIJ5
Gene namesi
Name:Cyp2j5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1270149 Cyp2j5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517711 – 501Cytochrome P450 2J5Add BLAST501

Proteomic databases

PaxDbiO54749
PeptideAtlasiO54749
PRIDEiO54749

PTM databases

iPTMnetiO54749
PhosphoSitePlusiO54749
SwissPalmiO54749

Expressioni

Gene expression databases

BgeeiENSMUSG00000052520
ExpressionAtlasiO54749 baseline and differential
GenevisibleiO54749 MM

Interactioni

Protein-protein interaction databases

IntActiO54749, 3 interactors
MINTiO54749
STRINGi10090.ENSMUSP00000030299

Structurei

3D structure databases

ProteinModelPortaliO54749
SMRiO54749
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140799
HOGENOMiHOG000036991
HOVERGENiHBG015789
InParanoidiO54749
KOiK07418
OMAiCNEVQRI
OrthoDBiEOG091G0BT8
PhylomeDBiO54749
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008071 Cyt_P450_E_grp-I_CYP2J-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01688 EP450ICYP2J
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

O54749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMFLSSLVT TFWEALHLKT LVLAVVTFLF LINILRSRHP KNYPPGPWRL
60 70 80 90 100
PFVGNFFQID TKQTHLVLQQ FVKKYGNVFS LELGQSPVVV VSGLPLIKEM
110 120 130 140 150
FTHLDQNFVN RFMTPVRERI TGKNGLVVSN GQTWKEQRRL ALMALRNFGL
160 170 180 190 200
GKKSLEERIQ EETHHLVEAI REEGGQPFNP HLKLINAVSN IICSVTFGER
210 220 230 240 250
FDYEDCQFQE LLQLLDETMH LMGSSAGQLY NGFPCIMKYL PGPHQKIFRN
260 270 280 290 300
WGKLKLFVSH IVKKHEKDWN PDEPRDFIDA FLIEMQKDPD RTTSFNEENL
310 320 330 340 350
ISTTLDLFLG GTETTSSTLR WALLYMSSYP EIQENVQAEI DRVIGHKRQV
360 370 380 390 400
SLSDRESMPY TNAVIHEVQR MGNIVPLNSS REVTVDTKFN GFHLPKGTMI
410 420 430 440 450
LTNLTALHRD PKEWATPEVF NPEHFLENGQ FKKRESFLPF SMGKRACLGE
460 470 480 490 500
QLAKSELFIF FSALMQKFTF KPPINEKLSL KFRMGLILSP ASYRICAIPR

V
Length:501
Mass (Da):57,784
Last modified:June 1, 1998 - v1
Checksum:iC67F2E79DD64AF99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62294 mRNA Translation: AAB87635.1
BC021624 mRNA Translation: AAH21624.1
CCDSiCCDS18371.1
RefSeqiNP_034137.1, NM_010007.4
UniGeneiMm.12838

Genome annotation databases

EnsembliENSMUST00000030299; ENSMUSP00000030299; ENSMUSG00000052520
GeneIDi13109
KEGGimmu:13109
UCSCiuc008ttl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCP2J5_MOUSE
AccessioniPrimary (citable) accession number: O54749
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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