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O54749 (CP2J5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2J5

EC=1.14.14.1
Alternative name(s):
Arachidonic acid epoxygenase
CYPIIJ5
Gene names
Name:Cyp2j5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Cytochrome P450 2J5
PRO_0000051771

Sites

Metal binding4471Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O54749 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: C67F2E79DD64AF99

FASTA50157,784
        10         20         30         40         50         60 
MIMFLSSLVT TFWEALHLKT LVLAVVTFLF LINILRSRHP KNYPPGPWRL PFVGNFFQID 

        70         80         90        100        110        120 
TKQTHLVLQQ FVKKYGNVFS LELGQSPVVV VSGLPLIKEM FTHLDQNFVN RFMTPVRERI 

       130        140        150        160        170        180 
TGKNGLVVSN GQTWKEQRRL ALMALRNFGL GKKSLEERIQ EETHHLVEAI REEGGQPFNP 

       190        200        210        220        230        240 
HLKLINAVSN IICSVTFGER FDYEDCQFQE LLQLLDETMH LMGSSAGQLY NGFPCIMKYL 

       250        260        270        280        290        300 
PGPHQKIFRN WGKLKLFVSH IVKKHEKDWN PDEPRDFIDA FLIEMQKDPD RTTSFNEENL 

       310        320        330        340        350        360 
ISTTLDLFLG GTETTSSTLR WALLYMSSYP EIQENVQAEI DRVIGHKRQV SLSDRESMPY 

       370        380        390        400        410        420 
TNAVIHEVQR MGNIVPLNSS REVTVDTKFN GFHLPKGTMI LTNLTALHRD PKEWATPEVF 

       430        440        450        460        470        480 
NPEHFLENGQ FKKRESFLPF SMGKRACLGE QLAKSELFIF FSALMQKFTF KPPINEKLSL 

       490        500 
KFRMGLILSP ASYRICAIPR V 

« Hide

References

« Hide 'large scale' references
[1]"Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4."
Ma J., Ramachandran S., Fiedorek F.T. Jr., Zeldin D.C.
Genomics 49:152-155(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X CBA.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U62294 mRNA. Translation: AAB87635.1.
BC021624 mRNA. Translation: AAH21624.1.
RefSeqNP_034137.1. NM_010007.4.
UniGeneMm.12838.

3D structure databases

ProteinModelPortalO54749.
SMRO54749. Positions 44-499.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO54749. 3 interactions.
MINTMINT-4091722.
STRING10090.ENSMUSP00000030299.

PTM databases

PhosphoSiteO54749.

Proteomic databases

PaxDbO54749.
PRIDEO54749.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030299; ENSMUSP00000030299; ENSMUSG00000052520.
GeneID13109.
KEGGmmu:13109.
UCSCuc008ttl.1. mouse.

Organism-specific databases

CTD13109.
MGIMGI:1270149. Cyp2j5.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036991.
HOVERGENHBG015789.
InParanoidO54749.
KOK07418.
OrthoDBEOG7PK8ZF.
PhylomeDBO54749.
TreeFamTF352043.

Gene expression databases

BgeeO54749.
GenevestigatorO54749.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283114.
PROO54749.
SOURCESearch...

Entry information

Entry nameCP2J5_MOUSE
AccessionPrimary (citable) accession number: O54749
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot