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O54749

- CP2J5_MOUSE

UniProt

O54749 - CP2J5_MOUSE

Protein

Cytochrome P450 2J5

Gene

Cyp2j5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
    2. positive regulation of estrogen secretion Source: MGI
    3. regulation of systemic arterial blood pressure by hormone Source: MGI
    4. renal tubular secretion Source: MGI

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2J5 (EC:1.14.14.1)
    Alternative name(s):
    Arachidonic acid epoxygenase
    CYPIIJ5
    Gene namesi
    Name:Cyp2j5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1270149. Cyp2j5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Cytochrome P450 2J5PRO_0000051771Add
    BLAST

    Proteomic databases

    MaxQBiO54749.
    PaxDbiO54749.
    PRIDEiO54749.

    PTM databases

    PhosphoSiteiO54749.

    Expressioni

    Gene expression databases

    BgeeiO54749.
    GenevestigatoriO54749.

    Interactioni

    Protein-protein interaction databases

    IntActiO54749. 3 interactions.
    MINTiMINT-4091722.
    STRINGi10090.ENSMUSP00000030299.

    Structurei

    3D structure databases

    ProteinModelPortaliO54749.
    SMRiO54749. Positions 44-499.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiO54749.
    KOiK07418.
    OrthoDBiEOG7PK8ZF.
    PhylomeDBiO54749.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01688. EP450ICYP2J.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54749-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIMFLSSLVT TFWEALHLKT LVLAVVTFLF LINILRSRHP KNYPPGPWRL    50
    PFVGNFFQID TKQTHLVLQQ FVKKYGNVFS LELGQSPVVV VSGLPLIKEM 100
    FTHLDQNFVN RFMTPVRERI TGKNGLVVSN GQTWKEQRRL ALMALRNFGL 150
    GKKSLEERIQ EETHHLVEAI REEGGQPFNP HLKLINAVSN IICSVTFGER 200
    FDYEDCQFQE LLQLLDETMH LMGSSAGQLY NGFPCIMKYL PGPHQKIFRN 250
    WGKLKLFVSH IVKKHEKDWN PDEPRDFIDA FLIEMQKDPD RTTSFNEENL 300
    ISTTLDLFLG GTETTSSTLR WALLYMSSYP EIQENVQAEI DRVIGHKRQV 350
    SLSDRESMPY TNAVIHEVQR MGNIVPLNSS REVTVDTKFN GFHLPKGTMI 400
    LTNLTALHRD PKEWATPEVF NPEHFLENGQ FKKRESFLPF SMGKRACLGE 450
    QLAKSELFIF FSALMQKFTF KPPINEKLSL KFRMGLILSP ASYRICAIPR 500
    V 501
    Length:501
    Mass (Da):57,784
    Last modified:June 1, 1998 - v1
    Checksum:iC67F2E79DD64AF99
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62294 mRNA. Translation: AAB87635.1.
    BC021624 mRNA. Translation: AAH21624.1.
    CCDSiCCDS18371.1.
    RefSeqiNP_034137.1. NM_010007.4.
    UniGeneiMm.12838.

    Genome annotation databases

    EnsembliENSMUST00000030299; ENSMUSP00000030299; ENSMUSG00000052520.
    GeneIDi13109.
    KEGGimmu:13109.
    UCSCiuc008ttl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62294 mRNA. Translation: AAB87635.1 .
    BC021624 mRNA. Translation: AAH21624.1 .
    CCDSi CCDS18371.1.
    RefSeqi NP_034137.1. NM_010007.4.
    UniGenei Mm.12838.

    3D structure databases

    ProteinModelPortali O54749.
    SMRi O54749. Positions 44-499.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O54749. 3 interactions.
    MINTi MINT-4091722.
    STRINGi 10090.ENSMUSP00000030299.

    PTM databases

    PhosphoSitei O54749.

    Proteomic databases

    MaxQBi O54749.
    PaxDbi O54749.
    PRIDEi O54749.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030299 ; ENSMUSP00000030299 ; ENSMUSG00000052520 .
    GeneIDi 13109.
    KEGGi mmu:13109.
    UCSCi uc008ttl.1. mouse.

    Organism-specific databases

    CTDi 13109.
    MGIi MGI:1270149. Cyp2j5.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi O54749.
    KOi K07418.
    OrthoDBi EOG7PK8ZF.
    PhylomeDBi O54749.
    TreeFami TF352043.

    Enzyme and pathway databases

    Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).

    Miscellaneous databases

    NextBioi 283114.
    PROi O54749.
    SOURCEi Search...

    Gene expression databases

    Bgeei O54749.
    Genevestigatori O54749.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01688. EP450ICYP2J.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4."
      Ma J., Ramachandran S., Fiedorek F.T. Jr., Zeldin D.C.
      Genomics 49:152-155(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2J5_MOUSE
    AccessioniPrimary (citable) accession number: O54749
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3