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O54749

- CP2J5_MOUSE

UniProt

O54749 - CP2J5_MOUSE

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Protein

Cytochrome P450 2J5

Gene

Cyp2j5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
  2. positive regulation of estrogen secretion Source: MGI
  3. regulation of systemic arterial blood pressure by hormone Source: MGI
  4. renal tubular secretion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2J5 (EC:1.14.14.1)
Alternative name(s):
Arachidonic acid epoxygenase
CYPIIJ5
Gene namesi
Name:Cyp2j5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1270149. Cyp2j5.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Cytochrome P450 2J5PRO_0000051771Add
BLAST

Proteomic databases

MaxQBiO54749.
PaxDbiO54749.
PRIDEiO54749.

PTM databases

PhosphoSiteiO54749.

Expressioni

Gene expression databases

BgeeiO54749.
ExpressionAtlasiO54749. baseline and differential.
GenevestigatoriO54749.

Interactioni

Protein-protein interaction databases

IntActiO54749. 3 interactions.
MINTiMINT-4091722.
STRINGi10090.ENSMUSP00000030299.

Structurei

3D structure databases

ProteinModelPortaliO54749.
SMRiO54749. Positions 44-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiO54749.
KOiK07418.
OrthoDBiEOG7PK8ZF.
PhylomeDBiO54749.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54749-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIMFLSSLVT TFWEALHLKT LVLAVVTFLF LINILRSRHP KNYPPGPWRL
60 70 80 90 100
PFVGNFFQID TKQTHLVLQQ FVKKYGNVFS LELGQSPVVV VSGLPLIKEM
110 120 130 140 150
FTHLDQNFVN RFMTPVRERI TGKNGLVVSN GQTWKEQRRL ALMALRNFGL
160 170 180 190 200
GKKSLEERIQ EETHHLVEAI REEGGQPFNP HLKLINAVSN IICSVTFGER
210 220 230 240 250
FDYEDCQFQE LLQLLDETMH LMGSSAGQLY NGFPCIMKYL PGPHQKIFRN
260 270 280 290 300
WGKLKLFVSH IVKKHEKDWN PDEPRDFIDA FLIEMQKDPD RTTSFNEENL
310 320 330 340 350
ISTTLDLFLG GTETTSSTLR WALLYMSSYP EIQENVQAEI DRVIGHKRQV
360 370 380 390 400
SLSDRESMPY TNAVIHEVQR MGNIVPLNSS REVTVDTKFN GFHLPKGTMI
410 420 430 440 450
LTNLTALHRD PKEWATPEVF NPEHFLENGQ FKKRESFLPF SMGKRACLGE
460 470 480 490 500
QLAKSELFIF FSALMQKFTF KPPINEKLSL KFRMGLILSP ASYRICAIPR

V
Length:501
Mass (Da):57,784
Last modified:June 1, 1998 - v1
Checksum:iC67F2E79DD64AF99
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62294 mRNA. Translation: AAB87635.1.
BC021624 mRNA. Translation: AAH21624.1.
CCDSiCCDS18371.1.
RefSeqiNP_034137.1. NM_010007.4.
UniGeneiMm.12838.

Genome annotation databases

EnsembliENSMUST00000030299; ENSMUSP00000030299; ENSMUSG00000052520.
GeneIDi13109.
KEGGimmu:13109.
UCSCiuc008ttl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62294 mRNA. Translation: AAB87635.1 .
BC021624 mRNA. Translation: AAH21624.1 .
CCDSi CCDS18371.1.
RefSeqi NP_034137.1. NM_010007.4.
UniGenei Mm.12838.

3D structure databases

ProteinModelPortali O54749.
SMRi O54749. Positions 44-499.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O54749. 3 interactions.
MINTi MINT-4091722.
STRINGi 10090.ENSMUSP00000030299.

PTM databases

PhosphoSitei O54749.

Proteomic databases

MaxQBi O54749.
PaxDbi O54749.
PRIDEi O54749.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030299 ; ENSMUSP00000030299 ; ENSMUSG00000052520 .
GeneIDi 13109.
KEGGi mmu:13109.
UCSCi uc008ttl.1. mouse.

Organism-specific databases

CTDi 13109.
MGIi MGI:1270149. Cyp2j5.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi O54749.
KOi K07418.
OrthoDBi EOG7PK8ZF.
PhylomeDBi O54749.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).

Miscellaneous databases

NextBioi 283114.
PROi O54749.
SOURCEi Search...

Gene expression databases

Bgeei O54749.
ExpressionAtlasi O54749. baseline and differential.
Genevestigatori O54749.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008071. Cyt_P450_E_grp-I_CYP2J-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01688. EP450ICYP2J.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4."
    Ma J., Ramachandran S., Fiedorek F.T. Jr., Zeldin D.C.
    Genomics 49:152-155(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP2J5_MOUSE
AccessioniPrimary (citable) accession number: O54749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3