O54749 (CP2J5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 2J5
EC=1.14.14.1

Alternative name(s):
Arachidonic acid epoxygenase
CYPIIJ5

Gene names

Name:

Cyp2j5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	Cytochrome P450 2J5		PRO_0000051771
Sites
	Metal binding	447	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O54749 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: C67F2E79DD64AF99	FASTA	501	57,784
	10 20 30 40 50 60 MIMFLSSLVT TFWEALHLKT LVLAVVTFLF LINILRSRHP KNYPPGPWRL PFVGNFFQID 70 80 90 100 110 120 TKQTHLVLQQ FVKKYGNVFS LELGQSPVVV VSGLPLIKEM FTHLDQNFVN RFMTPVRERI 130 140 150 160 170 180 TGKNGLVVSN GQTWKEQRRL ALMALRNFGL GKKSLEERIQ EETHHLVEAI REEGGQPFNP 190 200 210 220 230 240 HLKLINAVSN IICSVTFGER FDYEDCQFQE LLQLLDETMH LMGSSAGQLY NGFPCIMKYL 250 260 270 280 290 300 PGPHQKIFRN WGKLKLFVSH IVKKHEKDWN PDEPRDFIDA FLIEMQKDPD RTTSFNEENL 310 320 330 340 350 360 ISTTLDLFLG GTETTSSTLR WALLYMSSYP EIQENVQAEI DRVIGHKRQV SLSDRESMPY 370 380 390 400 410 420 TNAVIHEVQR MGNIVPLNSS REVTVDTKFN GFHLPKGTMI LTNLTALHRD PKEWATPEVF 430 440 450 460 470 480 NPEHFLENGQ FKKRESFLPF SMGKRACLGE QLAKSELFIF FSALMQKFTF KPPINEKLSL 490 500 KFRMGLILSP ASYRICAIPR V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4." Ma J., Ramachandran S., Fiedorek F.T. Jr., Zeldin D.C. Genomics 49:152-155(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U62294 mRNA. Translation: AAB87635.1. BC021624 mRNA. Translation: AAH21624.1.
IPI	IPI00117741.
RefSeq	NP_034137.1. NM_010007.4.
UniGene	Mm.12838.
3D structure databases
ProteinModelPortal	O54749.
SMR	O54749. Positions 44-499.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4091722.
STRING	10090.ENSMUSP00000030299.
PTM databases
PhosphoSite	O54749.
Proteomic databases
PaxDb	O54749.
PRIDE	O54749.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030299; ENSMUSP00000030299; ENSMUSG00000052520.
GeneID	13109.
KEGG	mmu:13109.
UCSC	uc008ttl.1. mouse.
Organism-specific databases
CTD	13109.
MGI	MGI:1270149. Cyp2j5.
Phylogenomic databases
eggNOG	COG2124.
HOGENOM	HOG000036991.
HOVERGEN	HBG015789.
InParanoid	O54749.
KO	K07418.
OrthoDB	EOG4QVCBZ.
Gene expression databases
ArrayExpress	O54749.
Bgee	O54749.
Genevestigator	O54749.
GermOnline	ENSMUSG00000052520. Mus musculus.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008071. Cyt_P450_E_grp-I_CYP2J-like. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01688. EP450ICYP2J. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	283114.
SOURCE	Search...

Entry information

Entry name

CP2J5_MOUSE

Accession

Primary (citable) accession number: O54749

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	May 29, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program