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Protein

Forkhead box protein F2

Gene

Foxf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription activator for a number of lung-specific genes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi100 – 19495Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • embryonic camera-type eye morphogenesis Source: BHF-UCL
  • embryonic digestive tract development Source: MGI
  • establishment of planar polarity of embryonic epithelium Source: MGI
  • extracellular matrix organization Source: MGI
  • genitalia development Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • palate development Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein F2
Alternative name(s):
Protein LUN
Gene namesi
Name:Foxf2
Synonyms:Lun
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1347479. Foxf2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Forkhead box protein F2PRO_0000322981Add
BLAST

Proteomic databases

PaxDbiO54743.
PeptideAtlasiO54743.
PRIDEiO54743.

PTM databases

PhosphoSiteiO54743.

Expressioni

Tissue specificityi

Uniquely expressed in the bronchiolar epithelium and in type II pneumocytes.1 Publication

Gene expression databases

BgeeiO54743.
CleanExiMM_FOXF2.
GenevisibleiO54743. MM.

Interactioni

Subunit structurei

Interacts with the transcription factors TBP and TFIIB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046789.

Structurei

3D structure databases

ProteinModelPortaliO54743.
SMRiO54743. Positions 100-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 3933Pro-richAdd
BLAST
Compositional biasi45 – 7834Ser-richAdd
BLAST
Compositional biasi213 – 31199Gly-richAdd
BLAST
Compositional biasi262 – 27514His-richAdd
BLAST
Compositional biasi314 – 3174Poly-Ser
Compositional biasi431 – 4344Poly-His

Domaini

Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.By similarity

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000060124.
HOVERGENiHBG051644.
InParanoidiO54743.
KOiK09399.
OMAiEYGPDSS.
OrthoDBiEOG7D59PX.
TreeFamiTF351598.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEGGPPPP PPRPPPAPLR RACSPAPGAL QAALMSPPPA ATLESTSSSS
60 70 80 90 100
SSSSASCASS SSNSVSASAG ACKSAASSGG AGAGSGGTKK ATSGLRRPEK
110 120 130 140 150
PPYSYIALIV MAIQSSPSKR LTLSEIYQFL QARFPFFRGA YQGWKNSVRH
160 170 180 190 200
NLSLNECFIK LPKGLGRPGK GHYWTIDPAS EFMFEEGSFR RRPRGFRRKC
210 220 230 240 250
QALKPMYHRV VSGLGFGASL LPQGFDFQAP PSAPLGCHGQ GGYGGLDMMP
260 270 280 290 300
AGYDTGAGAP GHAHPHHLHH HHVPHMSPNP GSTYMASCPV PAGPAGVGAA
310 320 330 340 350
AGGGGGGGDY GPDSSSSPVP SSPAMASAIE CHSPYTSPAA HWSSPGASPY
360 370 380 390 400
LKQPPALTPS SNPAASAGLH PSMSSYSLEQ SYLHQNARED LSVGLPRYQH
410 420 430 440
HSTPVCDRKD FVLNFNGISS FHPSASGSYY HHHHQSVCQD IKPCVM
Length:446
Mass (Da):46,383
Last modified:July 27, 2011 - v2
Checksum:i390A03EB325DAAEB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti266 – 2661H → Q in CAA72972 (PubMed:9676429).Curated
Sequence conflicti266 – 2661H → Q in CAA72035 (PubMed:9676429).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12293, Y12294 Genomic DNA. Translation: CAA72972.1.
Y11148 mRNA. Translation: CAA72035.1.
AK132385 mRNA. Translation: BAE21137.1.
BC137947 mRNA. Translation: AAI37948.1.
BC137949 mRNA. Translation: AAI37950.1.
CCDSiCCDS26424.1.
RefSeqiNP_034355.2. NM_010225.2.
UniGeneiMm.125548.

Genome annotation databases

EnsembliENSMUST00000042054; ENSMUSP00000046789; ENSMUSG00000038402.
GeneIDi14238.
KEGGimmu:14238.
UCSCiuc007pzo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12293, Y12294 Genomic DNA. Translation: CAA72972.1.
Y11148 mRNA. Translation: CAA72035.1.
AK132385 mRNA. Translation: BAE21137.1.
BC137947 mRNA. Translation: AAI37948.1.
BC137949 mRNA. Translation: AAI37950.1.
CCDSiCCDS26424.1.
RefSeqiNP_034355.2. NM_010225.2.
UniGeneiMm.125548.

3D structure databases

ProteinModelPortaliO54743.
SMRiO54743. Positions 100-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046789.

PTM databases

PhosphoSiteiO54743.

Proteomic databases

PaxDbiO54743.
PeptideAtlasiO54743.
PRIDEiO54743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042054; ENSMUSP00000046789; ENSMUSG00000038402.
GeneIDi14238.
KEGGimmu:14238.
UCSCiuc007pzo.2. mouse.

Organism-specific databases

CTDi2295.
MGIiMGI:1347479. Foxf2.

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000060124.
HOVERGENiHBG051644.
InParanoidiO54743.
KOiK09399.
OMAiEYGPDSS.
OrthoDBiEOG7D59PX.
TreeFamiTF351598.

Miscellaneous databases

PROiO54743.
SOURCEiSearch...

Gene expression databases

BgeeiO54743.
CleanExiMM_FOXF2.
GenevisibleiO54743. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse forkhead (winged helix) gene LUN encodes a transactivator that acts in the lung."
    Miura N., Kakinuma H., Sato M., Aiba N., Terada K., Sugiyama T.
    Genomics 50:346-356(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [MRNA] OF 11-446, FUNCTION, TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiFOXF2_MOUSE
AccessioniPrimary (citable) accession number: O54743
Secondary accession number(s): B2RQI5, Q3V1L3, Q78DW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.