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Protein

Forkhead box protein F2

Gene

Foxf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcription activator for a number of lung-specific genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi100 – 194Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • embryonic camera-type eye morphogenesis Source: BHF-UCL
  • embryonic digestive tract development Source: MGI
  • establishment of planar polarity of embryonic epithelium Source: MGI
  • extracellular matrix organization Source: MGI
  • genitalia development Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • palate development Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein F2
Alternative name(s):
Protein LUN
Gene namesi
Name:Foxf2
Synonyms:Lun
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1347479 Foxf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003229811 – 446Forkhead box protein F2Add BLAST446

Proteomic databases

MaxQBiO54743
PaxDbiO54743
PeptideAtlasiO54743
PRIDEiO54743

PTM databases

PhosphoSitePlusiO54743

Expressioni

Tissue specificityi

Uniquely expressed in the bronchiolar epithelium and in type II pneumocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000038402
CleanExiMM_FOXF2
GenevisibleiO54743 MM

Interactioni

Subunit structurei

Interacts with the transcription factors TBP and TFIIB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046789

Structurei

3D structure databases

ProteinModelPortaliO54743
SMRiO54743
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 39Pro-richAdd BLAST33
Compositional biasi45 – 78Ser-richAdd BLAST34
Compositional biasi213 – 311Gly-richAdd BLAST99
Compositional biasi262 – 275His-richAdd BLAST14
Compositional biasi314 – 317Poly-Ser4
Compositional biasi431 – 434Poly-His4

Domaini

Two activation domains, AD1 and AD2, C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.By similarity

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00900000140781
HOGENOMiHOG000060124
HOVERGENiHBG051644
InParanoidiO54743
KOiK09399
OMAiMMPAGYD
OrthoDBiEOG091G11UK
TreeFamiTF351598

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

O54743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEGGPPPP PPRPPPAPLR RACSPAPGAL QAALMSPPPA ATLESTSSSS
60 70 80 90 100
SSSSASCASS SSNSVSASAG ACKSAASSGG AGAGSGGTKK ATSGLRRPEK
110 120 130 140 150
PPYSYIALIV MAIQSSPSKR LTLSEIYQFL QARFPFFRGA YQGWKNSVRH
160 170 180 190 200
NLSLNECFIK LPKGLGRPGK GHYWTIDPAS EFMFEEGSFR RRPRGFRRKC
210 220 230 240 250
QALKPMYHRV VSGLGFGASL LPQGFDFQAP PSAPLGCHGQ GGYGGLDMMP
260 270 280 290 300
AGYDTGAGAP GHAHPHHLHH HHVPHMSPNP GSTYMASCPV PAGPAGVGAA
310 320 330 340 350
AGGGGGGGDY GPDSSSSPVP SSPAMASAIE CHSPYTSPAA HWSSPGASPY
360 370 380 390 400
LKQPPALTPS SNPAASAGLH PSMSSYSLEQ SYLHQNARED LSVGLPRYQH
410 420 430 440
HSTPVCDRKD FVLNFNGISS FHPSASGSYY HHHHQSVCQD IKPCVM
Length:446
Mass (Da):46,383
Last modified:July 27, 2011 - v2
Checksum:i390A03EB325DAAEB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti266H → Q in CAA72972 (PubMed:9676429).Curated1
Sequence conflicti266H → Q in CAA72035 (PubMed:9676429).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12293, Y12294 Genomic DNA Translation: CAA72972.1
Y11148 mRNA Translation: CAA72035.1
AK132385 mRNA Translation: BAE21137.1
BC137947 mRNA Translation: AAI37948.1
BC137949 mRNA Translation: AAI37950.1
CCDSiCCDS26424.1
RefSeqiNP_034355.2, NM_010225.2
UniGeneiMm.125548

Genome annotation databases

EnsembliENSMUST00000042054; ENSMUSP00000046789; ENSMUSG00000038402
GeneIDi14238
KEGGimmu:14238
UCSCiuc007pzo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFOXF2_MOUSE
AccessioniPrimary (citable) accession number: O54743
Secondary accession number(s): B2RQI5, Q3V1L3, Q78DW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health