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Protein

V-type proton ATPase subunit S1

Gene

Atp6ap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit S1
Short name:
V-ATPase subunit S1
Alternative name(s):
C7-1 protein
V-ATPase Ac45 subunit
V-ATPase S1 accessory protein
Vacuolar proton pump subunit S1
Gene namesi
Name:Atp6ap1
Synonyms:Atp6ip1, Atp6s1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620423. Atp6ap1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 412VacuolarSequence analysisAdd BLAST380
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 463CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000000254533 – 463V-type proton ATPase subunit S1Add BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Glycosylationi255N-linked (GlcNAc...)Sequence analysis1
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1
Glycosylationi290N-linked (GlcNAc...)Sequence analysis1
Glycosylationi297N-linked (GlcNAc...)Sequence analysis1
Glycosylationi344N-linked (GlcNAc...)Sequence analysis1
Glycosylationi351N-linked (GlcNAc...)Sequence analysis1
Glycosylationi399N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO54715.
PRIDEiO54715.

PTM databases

iPTMnetiO54715.
PhosphoSitePlusiO54715.

Interactioni

Subunit structurei

Composed of at least 10 subunits.

GO - Molecular functioni

Protein-protein interaction databases

IntActiO54715. 1 interactor.
STRINGi10116.ENSRNOP00000053134.

Family & Domainsi

Sequence similaritiesi

Belongs to the vacuolar ATPase subunit S1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3868. Eukaryota.
ENOG410XTHY. LUCA.
HOGENOMiHOG000000706.
HOVERGENiHBG001090.
InParanoidiO54715.
KOiK03662.
PhylomeDBiO54715.

Family and domain databases

InterProiIPR008388. ATPase_V1-cplx_s1su.
IPR024722. ATPase_V1_suS1_fam.
[Graphical view]
PANTHERiPTHR12471. PTHR12471. 1 hit.
PfamiPF05827. ATP-synt_S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O54715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAATVVSRI RTGTRWAPVL WLLLSLVAVA AAVAAEQQVP LVLWSSDRDL
60 70 80 90 100
WAPVADTHEG HITSDMQLST YLDPALELGP RNVLLFLQDK LSIEDFTAYG
110 120 130 140 150
GVFGNKQDSA FSNLENALDL APSSLVLPAV DWYAISTLTT YLQEKLGASP
160 170 180 190 200
LHVDLATLKE LKLNASLPAL LLIRLPYTAS SGLMAPREVL TGNDEVIGQV
210 220 230 240 250
LSTLESEDVP YTAALTAVRP SRVARDVAMV AGGLGRQLLQ TQVASPAIHP
260 270 280 290 300
PVSYNDTAPR ILFWAQNFSV AYKDEWKDLT SLTFGVENLN LTGSFWNDSF
310 320 330 340 350
AMLSLTYEPL FGATVTFKFI LASRFYPVSA RYWFTMERLE IHSNGSVAHF
360 370 380 390 400
NVSQVTGPSI YSFHCEYVSS LSKKGSLLVT NVPSLWQMTL HNFQIQAFNV
410 420 430 440 450
TGEQFSYASD CAGFFSPGIW MGLLTTLFML FIFTYGLHMI LSLKTMDRFD
460
DRKGPTITLT QIV
Length:463
Mass (Da):51,123
Last modified:June 1, 1998 - v1
Checksum:i6086B8C368A81CC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035387 mRNA. Translation: AAB88008.1.
RefSeqiNP_113973.1. NM_031785.1.
UniGeneiRn.93045.

Genome annotation databases

GeneIDi83615.
KEGGirno:83615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035387 mRNA. Translation: AAB88008.1.
RefSeqiNP_113973.1. NM_031785.1.
UniGeneiRn.93045.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO54715. 1 interactor.
STRINGi10116.ENSRNOP00000053134.

PTM databases

iPTMnetiO54715.
PhosphoSitePlusiO54715.

Proteomic databases

PaxDbiO54715.
PRIDEiO54715.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi83615.
KEGGirno:83615.

Organism-specific databases

CTDi537.
RGDi620423. Atp6ap1.

Phylogenomic databases

eggNOGiKOG3868. Eukaryota.
ENOG410XTHY. LUCA.
HOGENOMiHOG000000706.
HOVERGENiHBG001090.
InParanoidiO54715.
KOiK03662.
PhylomeDBiO54715.

Miscellaneous databases

PROiO54715.

Family and domain databases

InterProiIPR008388. ATPase_V1-cplx_s1su.
IPR024722. ATPase_V1_suS1_fam.
[Graphical view]
PANTHERiPTHR12471. PTHR12471. 1 hit.
PfamiPF05827. ATP-synt_S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVAS1_RAT
AccessioniPrimary (citable) accession number: O54715
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.