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O54707

- KLRD1_MOUSE

UniProt

O54707 - KLRD1_MOUSE

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Protein

Natural killer cells antigen CD94

Gene

Klrd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiREACT_188185. DAP12 signaling.
REACT_188188. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Natural killer cells antigen CD94
Alternative name(s):
Killer cell lectin-like receptor subfamily D member 1
CD_antigen: CD94
Gene namesi
Name:Klrd1
Synonyms:Cd94
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1196275. Klrd1.

Subcellular locationi

Membrane By similarity; Single-pass type II membrane protein By similarity

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Natural killer cells antigen CD94PRO_0000378458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 70PROSITE-ProRule annotation
Disulfide bondi59 – 59Interchain (with C-116 in NGK2A)PROSITE-ProRule annotation
Disulfide bondi61 ↔ 72PROSITE-ProRule annotation
Disulfide bondi89 ↔ 174PROSITE-ProRule annotation
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi152 ↔ 166PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

PhosphoSiteiO54707.

Expressioni

Gene expression databases

BgeeiO54707.
ExpressionAtlasiO54707. baseline and differential.
GenevestigatoriO54707.

Interactioni

Subunit structurei

Can form disulfide-bonded heterodimer with NKG2 family members.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113399.

Structurei

3D structure databases

ProteinModelPortaliO54707.
SMRiO54707. Positions 58-176.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Topological domaini32 – 179148ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 175108C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256912.
GeneTreeiENSGT00730000110282.
HOGENOMiHOG000220925.
InParanoidiO54707.
KOiK06516.
OrthoDBiEOG71CFP0.
PhylomeDBiO54707.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54707-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVSRITRWR LMSVIFGIKC LFLMVTLGVL LINSFTIQNI QSTPSPTTTV
60 70 80 90 100
EFQEVSECCV CLDKWVGHQC NCYFISKEEK SWKRSRDFCA SQNSSLLQPQ
110 120 130 140 150
SRNELSFMNF SQTFFWIGMH YSEKRNAWLW EDGTVPSKDL FPEFSVIRPE
160 170
HCIVYSPSKS VSAESCENKN RYICKKLPI
Length:179
Mass (Da):20,808
Last modified:June 1, 1998 - v1
Checksum:iDD343419E93B3465
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831K → E.2 Publications

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030311 mRNA. Translation: AAC28243.1.
AF030312 mRNA. Translation: AAC28244.1.
AF057714 mRNA. Translation: AAC33713.1.
AF039025 mRNA. Translation: AAD02116.1.
AK136548 mRNA. Translation: BAE23039.1.
CH466523 Genomic DNA. Translation: EDK99936.1.
BC117112 mRNA. Translation: AAI17113.1.
BC120854 mRNA. Translation: AAI20855.1.
CCDSiCCDS57456.1.
RefSeqiNP_034784.1. NM_010654.3.
XP_006505718.1. XM_006505655.1.
UniGeneiMm.391515.

Genome annotation databases

EnsembliENSMUST00000112063; ENSMUSP00000107694; ENSMUSG00000030165.
GeneIDi16643.
KEGGimmu:16643.
UCSCiuc009egd.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF030311 mRNA. Translation: AAC28243.1 .
AF030312 mRNA. Translation: AAC28244.1 .
AF057714 mRNA. Translation: AAC33713.1 .
AF039025 mRNA. Translation: AAD02116.1 .
AK136548 mRNA. Translation: BAE23039.1 .
CH466523 Genomic DNA. Translation: EDK99936.1 .
BC117112 mRNA. Translation: AAI17113.1 .
BC120854 mRNA. Translation: AAI20855.1 .
CCDSi CCDS57456.1.
RefSeqi NP_034784.1. NM_010654.3.
XP_006505718.1. XM_006505655.1.
UniGenei Mm.391515.

3D structure databases

ProteinModelPortali O54707.
SMRi O54707. Positions 58-176.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000113399.

PTM databases

PhosphoSitei O54707.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000112063 ; ENSMUSP00000107694 ; ENSMUSG00000030165 .
GeneIDi 16643.
KEGGi mmu:16643.
UCSCi uc009egd.2. mouse.

Organism-specific databases

CTDi 3824.
MGIi MGI:1196275. Klrd1.

Phylogenomic databases

eggNOGi NOG256912.
GeneTreei ENSGT00730000110282.
HOGENOMi HOG000220925.
InParanoidi O54707.
KOi K06516.
OrthoDBi EOG71CFP0.
PhylomeDBi O54707.
TreeFami TF336674.

Enzyme and pathway databases

Reactomei REACT_188185. DAP12 signaling.
REACT_188188. DAP12 interactions.

Miscellaneous databases

NextBioi 290309.
PROi O54707.
SOURCEi Search...

Gene expression databases

Bgeei O54707.
ExpressionAtlasi O54707. baseline and differential.
Genevestigatori O54707.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells."
    Vance R.E., Tanamachi D.M., Hanke T., Raulet D.H.
    Eur. J. Immunol. 27:3236-3241(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-83.
    Strain: C57BL/6 and CB.17 SCID.
  2. "Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells."
    Ho E.L., Heusel J.W., Brown M.G., Matsumoto K., Scalzo A.A., Yokoyama W.M.
    Proc. Natl. Acad. Sci. U.S.A. 95:6320-6325(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "Mouse natural killer cell receptors homologous to human CD94 and NKG2-D."
    Butcher S., Cottage A., Cook G.P.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-83.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKLRD1_MOUSE
AccessioniPrimary (citable) accession number: O54707
Secondary accession number(s): O54708
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3