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O54707

- KLRD1_MOUSE

UniProt

O54707 - KLRD1_MOUSE

Protein

Natural killer cells antigen CD94

Gene

Klrd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.By similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    Lectin

    Enzyme and pathway databases

    ReactomeiREACT_188185. DAP12 signaling.
    REACT_188188. DAP12 interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Natural killer cells antigen CD94
    Alternative name(s):
    Killer cell lectin-like receptor subfamily D member 1
    CD_antigen: CD94
    Gene namesi
    Name:Klrd1
    Synonyms:Cd94
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1196275. Klrd1.

    Subcellular locationi

    Membrane By similarity; Single-pass type II membrane protein By similarity

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179Natural killer cells antigen CD94PRO_0000378458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 70PROSITE-ProRule annotation
    Disulfide bondi59 – 59Interchain (with C-116 in NGK2A)PROSITE-ProRule annotation
    Disulfide bondi61 ↔ 72PROSITE-ProRule annotation
    Disulfide bondi89 ↔ 174PROSITE-ProRule annotation
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi152 ↔ 166PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    PTM databases

    PhosphoSiteiO54707.

    Expressioni

    Gene expression databases

    ArrayExpressiO54707.
    BgeeiO54707.
    GenevestigatoriO54707.

    Interactioni

    Subunit structurei

    Can form disulfide-bonded heterodimer with NKG2 family members.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000113399.

    Structurei

    3D structure databases

    ProteinModelPortaliO54707.
    SMRiO54707. Positions 58-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 179148ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini68 – 175108C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256912.
    GeneTreeiENSGT00730000110282.
    HOGENOMiHOG000220925.
    KOiK06516.
    OrthoDBiEOG71CFP0.
    PhylomeDBiO54707.
    TreeFamiTF336674.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54707-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVSRITRWR LMSVIFGIKC LFLMVTLGVL LINSFTIQNI QSTPSPTTTV    50
    EFQEVSECCV CLDKWVGHQC NCYFISKEEK SWKRSRDFCA SQNSSLLQPQ 100
    SRNELSFMNF SQTFFWIGMH YSEKRNAWLW EDGTVPSKDL FPEFSVIRPE 150
    HCIVYSPSKS VSAESCENKN RYICKKLPI 179
    Length:179
    Mass (Da):20,808
    Last modified:June 1, 1998 - v1
    Checksum:iDD343419E93B3465
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831K → E.2 Publications

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030311 mRNA. Translation: AAC28243.1.
    AF030312 mRNA. Translation: AAC28244.1.
    AF057714 mRNA. Translation: AAC33713.1.
    AF039025 mRNA. Translation: AAD02116.1.
    AK136548 mRNA. Translation: BAE23039.1.
    CH466523 Genomic DNA. Translation: EDK99936.1.
    BC117112 mRNA. Translation: AAI17113.1.
    BC120854 mRNA. Translation: AAI20855.1.
    CCDSiCCDS57456.1.
    RefSeqiNP_034784.1. NM_010654.3.
    XP_006505718.1. XM_006505655.1.
    UniGeneiMm.391515.

    Genome annotation databases

    EnsembliENSMUST00000112063; ENSMUSP00000107694; ENSMUSG00000030165.
    GeneIDi16643.
    KEGGimmu:16643.
    UCSCiuc009egd.2. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030311 mRNA. Translation: AAC28243.1 .
    AF030312 mRNA. Translation: AAC28244.1 .
    AF057714 mRNA. Translation: AAC33713.1 .
    AF039025 mRNA. Translation: AAD02116.1 .
    AK136548 mRNA. Translation: BAE23039.1 .
    CH466523 Genomic DNA. Translation: EDK99936.1 .
    BC117112 mRNA. Translation: AAI17113.1 .
    BC120854 mRNA. Translation: AAI20855.1 .
    CCDSi CCDS57456.1.
    RefSeqi NP_034784.1. NM_010654.3.
    XP_006505718.1. XM_006505655.1.
    UniGenei Mm.391515.

    3D structure databases

    ProteinModelPortali O54707.
    SMRi O54707. Positions 58-176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000113399.

    PTM databases

    PhosphoSitei O54707.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000112063 ; ENSMUSP00000107694 ; ENSMUSG00000030165 .
    GeneIDi 16643.
    KEGGi mmu:16643.
    UCSCi uc009egd.2. mouse.

    Organism-specific databases

    CTDi 3824.
    MGIi MGI:1196275. Klrd1.

    Phylogenomic databases

    eggNOGi NOG256912.
    GeneTreei ENSGT00730000110282.
    HOGENOMi HOG000220925.
    KOi K06516.
    OrthoDBi EOG71CFP0.
    PhylomeDBi O54707.
    TreeFami TF336674.

    Enzyme and pathway databases

    Reactomei REACT_188185. DAP12 signaling.
    REACT_188188. DAP12 interactions.

    Miscellaneous databases

    NextBioi 290309.
    PROi O54707.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O54707.
    Bgeei O54707.
    Genevestigatori O54707.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells."
      Vance R.E., Tanamachi D.M., Hanke T., Raulet D.H.
      Eur. J. Immunol. 27:3236-3241(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-83.
      Strain: C57BL/6 and CB.17 SCID.
    2. "Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells."
      Ho E.L., Heusel J.W., Brown M.G., Matsumoto K., Scalzo A.A., Yokoyama W.M.
      Proc. Natl. Acad. Sci. U.S.A. 95:6320-6325(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    3. "Mouse natural killer cell receptors homologous to human CD94 and NKG2-D."
      Butcher S., Cottage A., Cook G.P.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cecum.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-83.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiKLRD1_MOUSE
    AccessioniPrimary (citable) accession number: O54707
    Secondary accession number(s): O54708
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3