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Protein

Natural killer cells antigen CD94

Gene

Klrd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiREACT_301936. DAP12 signaling.
REACT_320278. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Natural killer cells antigen CD94
Alternative name(s):
Killer cell lectin-like receptor subfamily D member 1
CD_antigen: CD94
Gene namesi
Name:Klrd1
Synonyms:Cd94
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1196275. Klrd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Transmembranei11 – 3121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini32 – 179148ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Natural killer cells antigen CD94PRO_0000378458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 70PROSITE-ProRule annotation
Disulfide bondi59 – 59Interchain (with C-116 in NGK2A)PROSITE-ProRule annotation
Disulfide bondi61 ↔ 72PROSITE-ProRule annotation
Disulfide bondi89 ↔ 174PROSITE-ProRule annotation
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi152 ↔ 166PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

PhosphoSiteiO54707.

Expressioni

Gene expression databases

BgeeiO54707.
ExpressionAtlasiO54707. baseline and differential.
GenevisibleiO54707. MM.

Interactioni

Subunit structurei

Can form disulfide-bonded heterodimer with NKG2 family members.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107694.

Structurei

3D structure databases

ProteinModelPortaliO54707.
SMRiO54707. Positions 58-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 175108C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256912.
GeneTreeiENSGT00730000110282.
HOGENOMiHOG000220925.
InParanoidiO54707.
KOiK06516.
OrthoDBiEOG71CFP0.
PhylomeDBiO54707.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSRITRWR LMSVIFGIKC LFLMVTLGVL LINSFTIQNI QSTPSPTTTV
60 70 80 90 100
EFQEVSECCV CLDKWVGHQC NCYFISKEEK SWKRSRDFCA SQNSSLLQPQ
110 120 130 140 150
SRNELSFMNF SQTFFWIGMH YSEKRNAWLW EDGTVPSKDL FPEFSVIRPE
160 170
HCIVYSPSKS VSAESCENKN RYICKKLPI
Length:179
Mass (Da):20,808
Last modified:June 1, 1998 - v1
Checksum:iDD343419E93B3465
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831K → E.2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030311 mRNA. Translation: AAC28243.1.
AF030312 mRNA. Translation: AAC28244.1.
AF057714 mRNA. Translation: AAC33713.1.
AF039025 mRNA. Translation: AAD02116.1.
AK136548 mRNA. Translation: BAE23039.1.
CH466523 Genomic DNA. Translation: EDK99936.1.
BC117112 mRNA. Translation: AAI17113.1.
BC120854 mRNA. Translation: AAI20855.1.
CCDSiCCDS57456.1.
RefSeqiNP_034784.1. NM_010654.3.
XP_006505718.1. XM_006505655.1.
UniGeneiMm.391515.

Genome annotation databases

EnsembliENSMUST00000112063; ENSMUSP00000107694; ENSMUSG00000030165.
GeneIDi16643.
KEGGimmu:16643.
UCSCiuc009egd.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030311 mRNA. Translation: AAC28243.1.
AF030312 mRNA. Translation: AAC28244.1.
AF057714 mRNA. Translation: AAC33713.1.
AF039025 mRNA. Translation: AAD02116.1.
AK136548 mRNA. Translation: BAE23039.1.
CH466523 Genomic DNA. Translation: EDK99936.1.
BC117112 mRNA. Translation: AAI17113.1.
BC120854 mRNA. Translation: AAI20855.1.
CCDSiCCDS57456.1.
RefSeqiNP_034784.1. NM_010654.3.
XP_006505718.1. XM_006505655.1.
UniGeneiMm.391515.

3D structure databases

ProteinModelPortaliO54707.
SMRiO54707. Positions 58-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107694.

PTM databases

PhosphoSiteiO54707.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112063; ENSMUSP00000107694; ENSMUSG00000030165.
GeneIDi16643.
KEGGimmu:16643.
UCSCiuc009egd.2. mouse.

Organism-specific databases

CTDi3824.
MGIiMGI:1196275. Klrd1.

Phylogenomic databases

eggNOGiNOG256912.
GeneTreeiENSGT00730000110282.
HOGENOMiHOG000220925.
InParanoidiO54707.
KOiK06516.
OrthoDBiEOG71CFP0.
PhylomeDBiO54707.
TreeFamiTF336674.

Enzyme and pathway databases

ReactomeiREACT_301936. DAP12 signaling.
REACT_320278. DAP12 interactions.

Miscellaneous databases

NextBioi290309.
PROiO54707.
SOURCEiSearch...

Gene expression databases

BgeeiO54707.
ExpressionAtlasiO54707. baseline and differential.
GenevisibleiO54707. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells."
    Vance R.E., Tanamachi D.M., Hanke T., Raulet D.H.
    Eur. J. Immunol. 27:3236-3241(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-83.
    Strain: C57BL/6 and CB.17 SCID.
  2. "Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells."
    Ho E.L., Heusel J.W., Brown M.G., Matsumoto K., Scalzo A.A., Yokoyama W.M.
    Proc. Natl. Acad. Sci. U.S.A. 95:6320-6325(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "Mouse natural killer cell receptors homologous to human CD94 and NKG2-D."
    Butcher S., Cottage A., Cook G.P.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-83.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKLRD1_MOUSE
AccessioniPrimary (citable) accession number: O54707
Secondary accession number(s): O54708
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: June 1, 1998
Last modified: June 24, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.