O54707 (KLRD1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Natural killer cells antigen CD94

Alternative name(s):
Killer cell lectin-like receptor subfamily D member 1
CD_antigen=CD94

Gene names

Name:	Klrd1
Synonyms:	Cd94

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells By similarity.
Subunit structure	Can form disulfide-bonded heterodimer with NKG2 family members By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Lectin
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	external side of plasma membrane Inferred from direct assay PubMed 14707119PubMed 16973387. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	Natural killer cells antigen CD94		PRO_0000378458
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	32 – 179	148	Extracellular Potential
	Domain	68 – 175	108	C-type lectin
Amino acid modifications
	Glycosylation	93	1	N-linked (GlcNAc...) Potential
	Glycosylation	109	1	N-linked (GlcNAc...) Potential
	Disulfide bond	58 ↔ 70		By similarity
	Disulfide bond	59		Interchain (with C-116 in NGK2A) By similarity
	Disulfide bond	61 ↔ 72		By similarity
	Disulfide bond	89 ↔ 174		By similarity
	Disulfide bond	152 ↔ 166		By similarity
Natural variations
	Natural variant	83	1	K → E. Ref.1 Ref.5

Sequences

	Sequence		Length	Mass (Da)
	O54707 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: DD343419E93B3465	FASTA	179	20,808
	10 20 30 40 50 60 MAVSRITRWR LMSVIFGIKC LFLMVTLGVL LINSFTIQNI QSTPSPTTTV EFQEVSECCV 70 80 90 100 110 120 CLDKWVGHQC NCYFISKEEK SWKRSRDFCA SQNSSLLQPQ SRNELSFMNF SQTFFWIGMH 130 140 150 160 170 YSEKRNAWLW EDGTVPSKDL FPEFSVIRPE HCIVYSPSKS VSAESCENKN RYICKKLPI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells." Vance R.E., Tanamachi D.M., Hanke T., Raulet D.H. Eur. J. Immunol. 27:3236-3241(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-83. Strain: C57BL/6 and CB.17 SCID.
[2]	"Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells." Ho E.L., Heusel J.W., Brown M.G., Matsumoto K., Scalzo A.A., Yokoyama W.M. Proc. Natl. Acad. Sci. U.S.A. 95:6320-6325(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J.
[3]	"Mouse natural killer cell receptors homologous to human CD94 and NKG2-D." Butcher S., Cottage A., Cook G.P. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Cecum.
[5]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-83.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF030311 mRNA. Translation: AAC28243.1. AF030312 mRNA. Translation: AAC28244.1. AF057714 mRNA. Translation: AAC33713.1. AF039025 mRNA. Translation: AAD02116.1. AK136548 mRNA. Translation: BAE23039.1. CH466523 Genomic DNA. Translation: EDK99936.1. BC117112 mRNA. Translation: AAI17113.1. BC120854 mRNA. Translation: AAI20855.1.
IPI	IPI00309587.
RefSeq	NP_034784.1. NM_010654.3.
UniGene	Mm.391515.
3D structure databases
HSSP	HSSP built from PDB template 1B6E based on UniProtKB Q13241.
ProteinModelPortal	O54707.
SMR	O54707. Positions 58-176.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000113399.
PTM databases
PhosphoSite	O54707.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000112063; ENSMUSP00000107694; ENSMUSG00000030165.
GeneID	16643.
KEGG	mmu:16643.
UCSC	uc009egd.1. mouse.
Organism-specific databases
CTD	3824.
MGI	MGI:1196275. Klrd1.
Phylogenomic databases
eggNOG	NOG256912.
GeneTree	ENSGT00680000099819.
HOGENOM	HOG000220925.
KO	K06516.
OrthoDB	EOG451DS3.
Gene expression databases
ArrayExpress	O54707.
Bgee	O54707.
Genevestigator	O54707.
Family and domain databases
Gene3D	3.10.100.10. 1 hit.
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. [Graphical view]
Pfam	PF00059. Lectin_C. 1 hit. [Graphical view]
SMART	SM00034. CLECT. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit.
PROSITE	PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	290309.
SOURCE	Search...

Entry information

Entry name

KLRD1_MOUSE

Accession

Primary (citable) accession number: O54707
Secondary accession number(s): O54708

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 7, 2009
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program