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O54699

- S29A2_RAT

UniProt

O54699 - S29A2_RAT

Protein

Equilibrative nucleoside transporter 2

Gene

Slc29a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is insensitive (EI) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. Specific for nucleosides, but may also transport hypoxanthine. May also play a role in the efflux of inosine and hypoxanthine from muscle cells during the net degradation of purine nucleotides that occurs during strenuous exercise and/or in the reuptake of these purines during the recovery process By similarity.By similarity

    GO - Molecular functioni

    1. nucleoside transmembrane transporter activity Source: RGD

    GO - Biological processi

    1. adenine transport Source: RGD
    2. cellular response to insulin stimulus Source: RGD
    3. guanine transport Source: RGD
    4. hypoxanthine transport Source: RGD
    5. lactation Source: RGD
    6. nucleoside transmembrane transport Source: GOC
    7. nucleoside transport Source: RGD
    8. thymine transport Source: RGD
    9. uridine transport Source: RGD

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.57.1.4. the equilibrative nucleoside transporter (ent) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Equilibrative nucleoside transporter 2
    Alternative name(s):
    Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter
    Short name:
    Equilibrative NBMPR-insensitive nucleoside transporter
    Nucleoside transporter, ei-type
    Solute carrier family 29 member 2
    Gene namesi
    Name:Slc29a2
    Synonyms:Ent2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi69296. Slc29a2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Equilibrative nucleoside transporter 2PRO_0000209342Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Modified residuei251 – 2511PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiO54699.

    Expressioni

    Gene expression databases

    GenevestigatoriO54699.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000027178.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini30 – 6839ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini94 – 974CytoplasmicSequence Analysis
    Topological domaini117 – 1248ExtracellularSequence Analysis
    Topological domaini144 – 16017CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini186 – 1927ExtracellularSequence Analysis
    Topological domaini214 – 29178CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini312 – 32312ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini343 – 35917CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini379 – 39315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini414 – 43118CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini453 – 4564ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 2917HelicalSequence AnalysisAdd
    BLAST
    Transmembranei69 – 9325HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11619HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14319HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 18525HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei292 – 31120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei324 – 34219HelicalSequence AnalysisAdd
    BLAST
    Transmembranei360 – 37819HelicalSequence AnalysisAdd
    BLAST
    Transmembranei394 – 41320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249415.
    GeneTreeiENSGT00390000002232.
    HOGENOMiHOG000007684.
    HOVERGENiHBG074626.
    InParanoidiO54699.
    KOiK15014.
    OMAiINSFCAI.
    OrthoDBiEOG7PP56W.
    PhylomeDBiO54699.
    TreeFamiTF313950.

    Family and domain databases

    InterProiIPR002259. Eqnu_transpt.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PANTHERiPTHR10332. PTHR10332. 1 hit.
    PfamiPF01733. Nucleoside_tran. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016379. ENT. 1 hit.
    PRINTSiPR01130. DERENTRNSPRT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00939. 2a57. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O54699-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHGNAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ GRLAGTNSSA    50
    ETPSTNHTSP TDTFNFNNWV TLLSQLPLLL FTLLNSFLYQ CIPESVRILG 100
    SLLAILLLFA LTAALVKVDL SPGLFFSITM ASVWFINSFC AVLQGSLFGQ 150
    LGTMPSTYST LFLSGQGLAG IFAALAMLTS LASGVDPQTS ALGYFITPCV 200
    GILLSIICYL SLPHLKFARY YLTKKPQAPV QELETKAELL GADEKNGIPV 250
    SPQQAGPTLD LDPEKELELG LEEPQKPGKP SVFVVFRKIW LTALCLVLVF 300
    TVTLSVFPAI TAMVTTSSNS PGKWSQFFNP ICCFLLFNVM DWLGRSLTSY 350
    FLWPDEDSQL LPLLVCLRFL FVPLFMLCHV PQRARLPIIF WQDAYFITFM 400
    LLFAISNGYF VSLTMCLAPR QVLPHEREVA GALMTFFLAL GLSCGASLSF 450
    LFKALL 456
    Length:456
    Mass (Da):50,265
    Last modified:June 1, 1998 - v1
    Checksum:iDA97C2C578E1EE9D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF015305 mRNA. Translation: AAB88050.1.
    RefSeqiNP_113926.1. NM_031738.1.
    XP_003749083.1. XM_003749035.2.
    UniGeneiRn.37517.

    Genome annotation databases

    EnsembliENSRNOT00000027178; ENSRNOP00000027178; ENSRNOG00000020025.
    ENSRNOT00000071891; ENSRNOP00000065813; ENSRNOG00000050201.
    GeneIDi100911721.
    65194.
    KEGGirno:100911721.
    rno:65194.
    UCSCiRGD:69296. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF015305 mRNA. Translation: AAB88050.1 .
    RefSeqi NP_113926.1. NM_031738.1.
    XP_003749083.1. XM_003749035.2.
    UniGenei Rn.37517.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000027178.

    Chemistry

    ChEMBLi CHEMBL1287614.

    Protein family/group databases

    TCDBi 2.A.57.1.4. the equilibrative nucleoside transporter (ent) family.

    Proteomic databases

    PRIDEi O54699.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000027178 ; ENSRNOP00000027178 ; ENSRNOG00000020025 .
    ENSRNOT00000071891 ; ENSRNOP00000065813 ; ENSRNOG00000050201 .
    GeneIDi 100911721.
    65194.
    KEGGi rno:100911721.
    rno:65194.
    UCSCi RGD:69296. rat.

    Organism-specific databases

    CTDi 3177.
    RGDi 69296. Slc29a2.

    Phylogenomic databases

    eggNOGi NOG249415.
    GeneTreei ENSGT00390000002232.
    HOGENOMi HOG000007684.
    HOVERGENi HBG074626.
    InParanoidi O54699.
    KOi K15014.
    OMAi INSFCAI.
    OrthoDBi EOG7PP56W.
    PhylomeDBi O54699.
    TreeFami TF313950.

    Miscellaneous databases

    NextBioi 614124.
    PROi O54699.

    Gene expression databases

    Genevestigatori O54699.

    Family and domain databases

    InterProi IPR002259. Eqnu_transpt.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    PANTHERi PTHR10332. PTHR10332. 1 hit.
    Pfami PF01733. Nucleoside_tran. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016379. ENT. 1 hit.
    PRINTSi PR01130. DERENTRNSPRT.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00939. 2a57. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues."
      Yao S.Y.M., Ng A.M.L., Muzyka W.R., Griffiths M., Cass C.E., Baldwin S.A., Young J.D.
      J. Biol. Chem. 272:28423-28430(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Jejunum.

    Entry informationi

    Entry nameiS29A2_RAT
    AccessioniPrimary (citable) accession number: O54699
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3