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Protein

Equilibrative nucleoside transporter 2

Gene

Slc29a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is insensitive (EI) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. Specific for nucleosides, but may also transport hypoxanthine. May also play a role in the efflux of inosine and hypoxanthine from muscle cells during the net degradation of purine nucleotides that occurs during strenuous exercise and/or in the reuptake of these purines during the recovery process (By similarity).By similarity

GO - Molecular functioni

  • nucleoside transmembrane transporter activity Source: RGD

GO - Biological processi

  • adenine transport Source: RGD
  • cellular response to insulin stimulus Source: RGD
  • guanine transport Source: RGD
  • hypoxanthine transport Source: RGD
  • lactation Source: RGD
  • nucleoside transport Source: RGD
  • thymine transport Source: RGD
  • uridine transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-83936. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Protein family/group databases

TCDBi2.A.57.1.4. the equilibrative nucleoside transporter (ent) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Equilibrative nucleoside transporter 2
Alternative name(s):
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter
Short name:
Equilibrative NBMPR-insensitive nucleoside transporter
Nucleoside transporter, ei-type
Solute carrier family 29 member 2
Gene namesi
Name:Slc29a2
Synonyms:Ent2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi69296. Slc29a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 29HelicalSequence analysisAdd BLAST17
Topological domaini30 – 68ExtracellularSequence analysisAdd BLAST39
Transmembranei69 – 93HelicalSequence analysisAdd BLAST25
Topological domaini94 – 97CytoplasmicSequence analysis4
Transmembranei98 – 116HelicalSequence analysisAdd BLAST19
Topological domaini117 – 124ExtracellularSequence analysis8
Transmembranei125 – 143HelicalSequence analysisAdd BLAST19
Topological domaini144 – 160CytoplasmicSequence analysisAdd BLAST17
Transmembranei161 – 185HelicalSequence analysisAdd BLAST25
Topological domaini186 – 192ExtracellularSequence analysis7
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 291CytoplasmicSequence analysisAdd BLAST78
Transmembranei292 – 311HelicalSequence analysisAdd BLAST20
Topological domaini312 – 323ExtracellularSequence analysisAdd BLAST12
Transmembranei324 – 342HelicalSequence analysisAdd BLAST19
Topological domaini343 – 359CytoplasmicSequence analysisAdd BLAST17
Transmembranei360 – 378HelicalSequence analysisAdd BLAST19
Topological domaini379 – 393ExtracellularSequence analysisAdd BLAST15
Transmembranei394 – 413HelicalSequence analysisAdd BLAST20
Topological domaini414 – 431CytoplasmicSequence analysisAdd BLAST18
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 456ExtracellularSequence analysis4

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1287614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002093421 – 456Equilibrative nucleoside transporter 2Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Modified residuei251PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO54699.
PRIDEiO54699.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020025.
GenevisibleiO54699. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065813.

Chemistry databases

BindingDBiO54699.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1479. Eukaryota.
ENOG410Y3MT. LUCA.
GeneTreeiENSGT00390000002232.
HOGENOMiHOG000007684.
HOVERGENiHBG074626.
InParanoidiO54699.
KOiK15014.
OMAiINSFHEI.
OrthoDBiEOG091G09WB.
PhylomeDBiO54699.
TreeFamiTF313950.

Family and domain databases

InterProiIPR030197. ENT2.
IPR002259. Eqnu_transpt.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR10332. PTHR10332. 2 hits.
PTHR10332:SF8. PTHR10332:SF8. 2 hits.
PfamiPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF016379. ENT. 1 hit.
PRINTSiPR01130. DERENTRNSPRT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00939. 2a57. 1 hit.

Sequencei

Sequence statusi: Complete.

O54699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHGNAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ GRLAGTNSSA
60 70 80 90 100
ETPSTNHTSP TDTFNFNNWV TLLSQLPLLL FTLLNSFLYQ CIPESVRILG
110 120 130 140 150
SLLAILLLFA LTAALVKVDL SPGLFFSITM ASVWFINSFC AVLQGSLFGQ
160 170 180 190 200
LGTMPSTYST LFLSGQGLAG IFAALAMLTS LASGVDPQTS ALGYFITPCV
210 220 230 240 250
GILLSIICYL SLPHLKFARY YLTKKPQAPV QELETKAELL GADEKNGIPV
260 270 280 290 300
SPQQAGPTLD LDPEKELELG LEEPQKPGKP SVFVVFRKIW LTALCLVLVF
310 320 330 340 350
TVTLSVFPAI TAMVTTSSNS PGKWSQFFNP ICCFLLFNVM DWLGRSLTSY
360 370 380 390 400
FLWPDEDSQL LPLLVCLRFL FVPLFMLCHV PQRARLPIIF WQDAYFITFM
410 420 430 440 450
LLFAISNGYF VSLTMCLAPR QVLPHEREVA GALMTFFLAL GLSCGASLSF

LFKALL
Length:456
Mass (Da):50,265
Last modified:June 1, 1998 - v1
Checksum:iDA97C2C578E1EE9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015305 mRNA. Translation: AAB88050.1.
RefSeqiNP_113926.1. NM_031738.1.
XP_017445770.1. XM_017590281.1.
XP_017459751.1. XM_017604262.1.
UniGeneiRn.37517.

Genome annotation databases

EnsembliENSRNOT00000027178; ENSRNOP00000027178; ENSRNOG00000020025.
ENSRNOT00000071891; ENSRNOP00000065813; ENSRNOG00000050201.
GeneIDi108348052.
65194.
KEGGirno:100911721.
rno:65194.
UCSCiRGD:69296. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015305 mRNA. Translation: AAB88050.1.
RefSeqiNP_113926.1. NM_031738.1.
XP_017445770.1. XM_017590281.1.
XP_017459751.1. XM_017604262.1.
UniGeneiRn.37517.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065813.

Chemistry databases

BindingDBiO54699.
ChEMBLiCHEMBL1287614.

Protein family/group databases

TCDBi2.A.57.1.4. the equilibrative nucleoside transporter (ent) family.

Proteomic databases

PaxDbiO54699.
PRIDEiO54699.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027178; ENSRNOP00000027178; ENSRNOG00000020025.
ENSRNOT00000071891; ENSRNOP00000065813; ENSRNOG00000050201.
GeneIDi108348052.
65194.
KEGGirno:100911721.
rno:65194.
UCSCiRGD:69296. rat.

Organism-specific databases

CTDi3177.
RGDi69296. Slc29a2.

Phylogenomic databases

eggNOGiKOG1479. Eukaryota.
ENOG410Y3MT. LUCA.
GeneTreeiENSGT00390000002232.
HOGENOMiHOG000007684.
HOVERGENiHBG074626.
InParanoidiO54699.
KOiK15014.
OMAiINSFHEI.
OrthoDBiEOG091G09WB.
PhylomeDBiO54699.
TreeFamiTF313950.

Enzyme and pathway databases

ReactomeiR-RNO-83936. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Miscellaneous databases

PROiO54699.

Gene expression databases

BgeeiENSRNOG00000020025.
GenevisibleiO54699. RN.

Family and domain databases

InterProiIPR030197. ENT2.
IPR002259. Eqnu_transpt.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR10332. PTHR10332. 2 hits.
PTHR10332:SF8. PTHR10332:SF8. 2 hits.
PfamiPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF016379. ENT. 1 hit.
PRINTSiPR01130. DERENTRNSPRT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00939. 2a57. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS29A2_RAT
AccessioniPrimary (citable) accession number: O54699
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.