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Protein

Equilibrative nucleoside transporter 1

Gene

Slc29a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs).1 Publication

GO - Molecular functioni

  • nucleoside transmembrane transporter activity Source: RGD

GO - Biological processi

  • cellular response to glucose stimulus Source: RGD
  • cellular response to hypoxia Source: RGD
  • excitatory postsynaptic potential Source: RGD
  • lactation Source: RGD
  • nucleoside transport Source: RGD
  • sleep Source: RGD
  • uridine transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-83936. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Protein family/group databases

TCDBi2.A.57.1.3. the equilibrative nucleoside transporter (ent) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Equilibrative nucleoside transporter 1
Alternative name(s):
Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter
Short name:
Equilibrative NBMPR-sensitive nucleoside transporter
Nucleoside transporter, es-type
Solute carrier family 29 member 1
Gene namesi
Name:Slc29a1
Synonyms:Ent1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi61899. Slc29a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 12CytoplasmicSequence analysisAdd BLAST11
Transmembranei13 – 29HelicalSequence analysisAdd BLAST17
Topological domaini30 – 82ExtracellularSequence analysisAdd BLAST53
Transmembranei83 – 107HelicalSequence analysisAdd BLAST25
Topological domaini108 – 111CytoplasmicSequence analysis4
Transmembranei112 – 130HelicalSequence analysisAdd BLAST19
Topological domaini131 – 138ExtracellularSequence analysis8
Transmembranei139 – 157HelicalSequence analysisAdd BLAST19
Topological domaini158 – 174CytoplasmicSequence analysisAdd BLAST17
Transmembranei175 – 199HelicalSequence analysisAdd BLAST25
Topological domaini200 – 206ExtracellularSequence analysis7
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 291CytoplasmicSequence analysisAdd BLAST64
Transmembranei292 – 311HelicalSequence analysisAdd BLAST20
Topological domaini312 – 323ExtracellularSequence analysisAdd BLAST12
Transmembranei324 – 343HelicalSequence analysisAdd BLAST20
Topological domaini344 – 360CytoplasmicSequence analysisAdd BLAST17
Transmembranei361 – 379HelicalSequence analysisAdd BLAST19
Topological domaini380 – 394ExtracellularSequence analysisAdd BLAST15
Transmembranei395 – 414HelicalSequence analysisAdd BLAST20
Topological domaini415 – 432CytoplasmicSequence analysisAdd BLAST18
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Topological domaini454 – 457ExtracellularSequence analysis4

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4604.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002093392 – 457Equilibrative nucleoside transporter 1Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Modified residuei254PhosphoserineCombined sources1
Modified residuei273PhosphoserineBy similarity1

Post-translational modificationi

Glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO54698.
PRIDEiO54698.

PTM databases

iPTMnetiO54698.
PhosphoSitePlusiO54698.

Expressioni

Tissue specificityi

Expressed in jejunum, liver and lung.

Gene expression databases

BgeeiENSRNOG00000019752.
GenevisibleiO54698. RN.

Interactioni

Subunit structurei

Identified in a complex with STOM.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026831.

Chemistry databases

BindingDBiO54698.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1479. Eukaryota.
ENOG410Y3MT. LUCA.
GeneTreeiENSGT00390000002232.
HOGENOMiHOG000007684.
HOVERGENiHBG074626.
InParanoidiO54698.
KOiK15014.
OMAiSTWERYF.
OrthoDBiEOG091G09WB.
PhylomeDBiO54698.

Family and domain databases

InterProiIPR030195. ENT1.
IPR002259. Eqnu_transpt.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR10332. PTHR10332. 2 hits.
PTHR10332:SF9. PTHR10332:SF9. 2 hits.
PfamiPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF016379. ENT. 1 hit.
PRINTSiPR01130. DERENTRNSPRT.
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00939. 2a57. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O54698-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSHQPQDR YKAVWLIFFV LGLGTLLPWN FFITATQYFT SRLNTSQNIS
60 70 80 90 100
LVTNQSCEST EALADPSVSL PARSSLSAIF NNVMTLCAML PLLIFTCLNS
110 120 130 140 150
FLHQKVSQSL RILGSLLAIL LVFLVTATLV KVQMDALSFF IITMIKIVLI
160 170 180 190 200
NSFGAILQAS LFGLAGVLPA NYTAPIMSGQ GLAGFFTSVA MICAVASGSK
210 220 230 240 250
LSESAFGYFI TACAVVILAI LCYLALPWME FYRHYLQLNL AGPAEQETKL
260 270 280 290 300
DLISEGEEPR GGREESGVPG PNSLPANRNQ SIKAILKSIW VLALSVCFIF
310 320 330 340 350
TVTIGLFPAV TAEVESSIAG TSPWKNCYFI PVACFLNFNV FDWLGRSLTA
360 370 380 390 400
ICMWPGQDSR WLPVLVACRV VFIPLLMLCN VKQHHYLPSL FKHDVWFITF
410 420 430 440 450
MAAFAFSNGY LASLCMCFGP KKVKPAEAET AGNIMSFFLC LGLALGAVLS

FLLRALV
Length:457
Mass (Da):50,017
Last modified:January 23, 2007 - v3
Checksum:iA9DDF4F0D7F8D70A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015304 mRNA. Translation: AAB88049.1.
BC078789 mRNA. Translation: AAH78789.1.
RefSeqiNP_113872.1. NM_031684.2.
XP_006244622.1. XM_006244560.2.
XP_006244623.1. XM_006244561.2.
XP_006244624.1. XM_006244562.3.
XP_006244625.1. XM_006244563.3.
XP_017452108.1. XM_017596619.1.
UniGeneiRn.5814.

Genome annotation databases

EnsembliENSRNOT00000026831; ENSRNOP00000026831; ENSRNOG00000019752.
GeneIDi63997.
KEGGirno:63997.
UCSCiRGD:61899. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015304 mRNA. Translation: AAB88049.1.
BC078789 mRNA. Translation: AAH78789.1.
RefSeqiNP_113872.1. NM_031684.2.
XP_006244622.1. XM_006244560.2.
XP_006244623.1. XM_006244561.2.
XP_006244624.1. XM_006244562.3.
XP_006244625.1. XM_006244563.3.
XP_017452108.1. XM_017596619.1.
UniGeneiRn.5814.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026831.

Chemistry databases

BindingDBiO54698.
ChEMBLiCHEMBL4604.

Protein family/group databases

TCDBi2.A.57.1.3. the equilibrative nucleoside transporter (ent) family.

PTM databases

iPTMnetiO54698.
PhosphoSitePlusiO54698.

Proteomic databases

PaxDbiO54698.
PRIDEiO54698.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026831; ENSRNOP00000026831; ENSRNOG00000019752.
GeneIDi63997.
KEGGirno:63997.
UCSCiRGD:61899. rat.

Organism-specific databases

CTDi2030.
RGDi61899. Slc29a1.

Phylogenomic databases

eggNOGiKOG1479. Eukaryota.
ENOG410Y3MT. LUCA.
GeneTreeiENSGT00390000002232.
HOGENOMiHOG000007684.
HOVERGENiHBG074626.
InParanoidiO54698.
KOiK15014.
OMAiSTWERYF.
OrthoDBiEOG091G09WB.
PhylomeDBiO54698.

Enzyme and pathway databases

ReactomeiR-RNO-83936. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Miscellaneous databases

PROiO54698.

Gene expression databases

BgeeiENSRNOG00000019752.
GenevisibleiO54698. RN.

Family and domain databases

InterProiIPR030195. ENT1.
IPR002259. Eqnu_transpt.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR10332. PTHR10332. 2 hits.
PTHR10332:SF9. PTHR10332:SF9. 2 hits.
PfamiPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF016379. ENT. 1 hit.
PRINTSiPR01130. DERENTRNSPRT.
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00939. 2a57. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS29A1_RAT
AccessioniPrimary (citable) accession number: O54698
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.