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O54692

- ZW10_MOUSE

UniProt

O54692 - ZW10_MOUSE

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Protein

Centromere/kinetochore protein zw10 homolog

Gene

Zw10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (By similarity).By similarity

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: HGNC
  2. establishment of mitotic spindle orientation Source: Ensembl
  3. mitotic cell cycle checkpoint Source: HGNC
  4. mitotic metaphase plate congression Source: Ensembl
  5. mitotic sister chromatid segregation Source: HGNC
  6. protein complex assembly Source: HGNC
  7. protein localization to kinetochore Source: Ensembl
  8. protein transport Source: UniProtKB-KW
  9. regulation of exit from mitosis Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, ER-Golgi transport, Mitosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.
REACT_256756. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere/kinetochore protein zw10 homolog
Gene namesi
Name:Zw10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1349478. Zw10.

Subcellular locationi

Cytoplasm By similarity. Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity. Chromosomecentromerekinetochore By similarity. Cytoplasmcytoskeletonspindle By similarity
Note: Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm (By similarity). In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone (By similarity).By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: HGNC
  2. kinetochore Source: HGNC
  3. kinetochore microtubule Source: HGNC
  4. membrane Source: UniProtKB-KW
  5. nucleus Source: HGNC
  6. spindle pole Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Kinetochore, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 779778Centromere/kinetochore protein zw10 homologPRO_0000184958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei777 – 7771N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO54692.
PaxDbiO54692.
PRIDEiO54692.

PTM databases

PhosphoSiteiO54692.

Expressioni

Gene expression databases

BgeeiO54692.
GenevestigatoriO54692.

Interactioni

Subunit structurei

Associated with a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B through direct interaction with RINT1/TIP20L bound to BNIP1/SEC20L. Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH. Interacts with C19orf25, KNTC1 and ZWINT (By similarity).By similarity

Protein-protein interaction databases

BioGridi205086. 9 interactions.
IntActiO54692. 9 interactions.

Structurei

3D structure databases

ProteinModelPortaliO54692.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 317316Interaction with RINT1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili14 – 130117Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the ZW10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG299329.
GeneTreeiENSGT00390000016427.
HOGENOMiHOG000007982.
HOVERGENiHBG004603.
InParanoidiO54692.
KOiK11578.
OMAiVVNLEPE.
OrthoDBiEOG718KBR.
PhylomeDBiO54692.
TreeFamiTF105966.

Family and domain databases

InterProiIPR009361. RZZ-complex_Zw10.
[Graphical view]
PfamiPF06248. Zw10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O54692-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASFVTEVLA HSGSLEKEDL GTRISRLTRR VEEIKGEVCN MISKKYSEFL
60 70 80 90 100
PTMQSAQALV TQVDTLSNDI DQLKSRIETE VCRDLHISTV EFTNLKQQLE
110 120 130 140 150
RDSVVLTLLK QLQEFSSAIE EYNSALAEKK YIPAARHLEE AQECLKLLKS
160 170 180 190 200
RKCFDLKMLK SLSMELTVQK QNILYHLGED WQKLVVWKFP PAKDTSSLES
210 220 230 240 250
CLQTELHLCT EQPEKEDMTP LPSISSVLLA FSILGELPTK LKSFGQMLLK
260 270 280 290 300
YILKPLVTCP SLHAVIERQP SSVSICFESL TTDLEHPSPP EAFAKIRLVL
310 320 330 340 350
EVLQKQLLDL PLDADLEIGK VPGIVLAEML GEGIWEDLSE CLIRNCLVYS
360 370 380 390 400
IPTNSSKLQE YEEIIQSTEE FEKFLKEMRF LKGDTTDLLK YARNINSHFA
410 420 430 440 450
NKKCQDVIVA ARNLMTSEIH NTVKIGPDCK EALPDLPSPD ADHKLQVQTV
460 470 480 490 500
CKAQFTDAGN LEPETSLDPQ SFSLPTCRIS EAVKKLMELA YQTLLEATTS
510 520 530 540 550
SDQCAVQLFY SVRNIFHLFH DVVPTYHKEN LRKLPQLAAI HHNNCMYIAH
560 570 580 590 600
HLLTLGHQFR LRLAPILCDG TTTFVDLVPG FRRLGTECFL AQMQAQKGEL
610 620 630 640 650
LERLSSARSF ANMDDEENYS AASKAVRQVL HQLRRLGIVW QDVLPVNIYC
660 670 680 690 700
KAMGTLLNTA IAEMMSRITA LEDISTEDGD RLYSLCKTVM DEGPQVFAPL
710 720 730 740 750
SDENKNKKYQ EEVPVYVSKW MPFKELMIML QASLQEIGDR WADGKGPLAT
760 770
AFPSSEVKAL IRALFQNTER RAAALAKIK
Length:779
Mass (Da):88,063
Last modified:January 23, 2007 - v3
Checksum:i5C02CF77FDF5B13B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431E → A in BAE26337. (PubMed:16141072)Curated
Sequence conflicti281 – 2811T → A in BAE26337. (PubMed:16141072)Curated
Sequence conflicti281 – 2811T → A in BAE39941. (PubMed:16141072)Curated
Sequence conflicti292 – 2921A → T in BAE39941. (PubMed:16141072)Curated
Sequence conflicti449 – 4491T → K in BAE26337. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145270 mRNA. Translation: BAE26337.1.
AK167251 mRNA. Translation: BAE39372.1.
AK167937 mRNA. Translation: BAE39941.1.
AK168479 mRNA. Translation: BAE40368.1.
BC012435 mRNA. Translation: AAH12435.1.
AF003951 mRNA. Translation: AAB88256.1.
CCDSiCCDS23161.1.
RefSeqiNP_036169.1. NM_012039.2.
UniGeneiMm.24791.

Genome annotation databases

EnsembliENSMUST00000034803; ENSMUSP00000034803; ENSMUSG00000032264.
GeneIDi26951.
KEGGimmu:26951.
UCSCiuc009piu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145270 mRNA. Translation: BAE26337.1 .
AK167251 mRNA. Translation: BAE39372.1 .
AK167937 mRNA. Translation: BAE39941.1 .
AK168479 mRNA. Translation: BAE40368.1 .
BC012435 mRNA. Translation: AAH12435.1 .
AF003951 mRNA. Translation: AAB88256.1 .
CCDSi CCDS23161.1.
RefSeqi NP_036169.1. NM_012039.2.
UniGenei Mm.24791.

3D structure databases

ProteinModelPortali O54692.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 205086. 9 interactions.
IntActi O54692. 9 interactions.

PTM databases

PhosphoSitei O54692.

Proteomic databases

MaxQBi O54692.
PaxDbi O54692.
PRIDEi O54692.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034803 ; ENSMUSP00000034803 ; ENSMUSG00000032264 .
GeneIDi 26951.
KEGGi mmu:26951.
UCSCi uc009piu.2. mouse.

Organism-specific databases

CTDi 9183.
MGIi MGI:1349478. Zw10.

Phylogenomic databases

eggNOGi NOG299329.
GeneTreei ENSGT00390000016427.
HOGENOMi HOG000007982.
HOVERGENi HBG004603.
InParanoidi O54692.
KOi K11578.
OMAi VVNLEPE.
OrthoDBi EOG718KBR.
PhylomeDBi O54692.
TreeFami TF105966.

Enzyme and pathway databases

Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.
REACT_256756. Mitotic Prometaphase.

Miscellaneous databases

NextBioi 304895.
PROi O54692.
SOURCEi Search...

Gene expression databases

Bgeei O54692.
Genevestigatori O54692.

Family and domain databases

InterProi IPR009361. RZZ-complex_Zw10.
[Graphical view ]
Pfami PF06248. Zw10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Kidney and Mammary gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 522-779.

Entry informationi

Entry nameiZW10_MOUSE
AccessioniPrimary (citable) accession number: O54692
Secondary accession number(s): Q3TIA5, Q3ULW1, Q921H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3